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Multiscale Dynamic Monte Carlo / Continuum Modeling Of Drying And Curing In Sol-Gel Silica Films, Xin Li

University of Kentucky Doctoral Dissertations

Modeling the competition between drying and curing processes in polymerizing films is of great importance to many existing and developing materials synthesis processes. These processes involve multiple length and time scales ranging from molecular to macroscopic, and are challenging to fully model in situations where the polymerization is non-ideal, such as sol-gel silica thin film formation. A comprehensive model of sol-gel silica film formation should link macroscopic flow and drying (controlled by process parameters) to film microstructure (which dictates the properties of the films).

This dissertation describes a multiscale model in which dynamic Monte Carlo (DMC) polymerization simulations are coupled …

Roles Of Micrornas In Plant Abiotic Stress, Development And Viral Infection, Venugopal Mendu

University of Kentucky Doctoral Dissertations

Plant microRNAs play important roles in plant growth and development. Here we investigated the roles of miRNAs in the plant abiotic stress, development and viral infection. MicroRNA membrane array analysis using five different abiotic stress treatments resulted in the identification of 8 novel stress inducible miRNA-families. Functional studies on novel stress inducible miR168 revealed its functional relation with abiotic stress. Over expression of miR168 in Arabidopsis showed upregulation of four stress related miRNAs (miR163, miR167, miR398 and miR408). Analysis of 9 independent transgenic lines showed induction of miR398, an oxidative stress responsive miRNA with a corresponding down regulation of its …

Nitration And Inactivation Of Manganese Superoxide Dismutase Plays A Critical Role In Metabolic Switch, Muthuswamy Anantharaman

University of Kentucky Doctoral Dissertations

Alzheimer’s disease (AD) is a multifactorial, progressive, age-related neurodegenerative disease. Oxidative stress hypothesis is most prevalent and is gaining significant support. Inspite of the progress achieved on oxidative stress related damages in AD brain; the modification occurring on the various cellular antioxidant enzymes antioxidant has not been identified. Tyrosine nitration, a marker for peroxynitrite induced oxidative damage to protein is widespread in AD brain and Manganese superoxide dismutase (MnSOD), primary mitochondrial antioxidant enzyme is prone to peroxynitrite induced nitration and inactivation. Nitration of proteins involved in energy metabolism has been demonstrated in AD brain, which may explain the altered glucose …

Role Of The Reactive Oxygen Species Peroxynitrite In Traumatic Brain Injury, Ying Deng

University of Kentucky Doctoral Dissertations

Reactive oxygen species (ROS) is cytotoxic to the cell and is known to contribute to secondary cell death following primary traumatic brain injury (TBI). We described in our study that PN is the main mediator for both lipid peroxidation and protein nitration, and occurred almost immediately after injury. As a downstream factor to oxidative damage, the peak of Ca2+-dependent, calpainmediated cytoskeletal proteolysis preceded that of neurodegeneration, suggesting that calpain-mediated proteolysis is the common pathway leading to neuronal cell death. The time course study clearly elucidated the interrelationship of these cellular changes following TBI, provided window of opportunity for pharmacological intervention. …

Optimizing Learning Through Teacher-Student Relationships: A Test Of The Causal Process Student Understanding Model, Nicole Denise Dobransky

University of Kentucky Doctoral Dissertations

In many ways, higher educational systems in the United States are the most extraordinary in the world. Students come from all over to study in our institutes of higher learning. As our search for an explanation of how to facilitate student learning continues, the goal of this dissertation was to examine the heavily under-researched area of teacherstudent relationships as they relate to student understanding. Using the existing body of instructional communication research, the Student Understanding Model (SUM) is proposed and tested. Data collected from 302 undergraduate students was used to test the SUM. Results provide empirical support that relational messages …

Surfactant And Metal Sorption Studies By Functionalized Membranes And Quartz Crystal Microbalance, Abhay R. Ladhe

University of Kentucky Doctoral Dissertations

Functionalized membranes provide an elegant platform for selective separations and sorptions. In this dissertation, application of functionalized membranes for surfactant and metal sorption studies are discussed. Sorption behavior of surfactants is also studied using quartz crystal microbalance (QCM) and other techniques.

Adsorption of the ethoxylated surfactants on polymeric materials (cotton and polyester) and model gold surface was quantified from a non-aqueous siloxane based solvent (D5) and water. The role of ethylene oxide group and the effect of nature of polymeric materials on adsorption behavior was quantified and established. In the case of gold-water interface, the adsorption data was fitted to …

The Underlying Mechanism(S) Of Fasting Induced Neuroprotection After Moderate Traumatic Brain Injury, Laurie Michelle Helene Davis

University of Kentucky Doctoral Dissertations

Traumatic brain injury (TBI) is becoming a national epidemic, as it accounts for 1.5 million cases each year. This disorder affects primarily the young population and elderly. Currently, there is no treatment for TBI, which means that ~2% of the U.S. population is currently living with prolonged neurological damage and dysfunction. Recently, there have been many studies showing that TBI negatively impacts mitochondrial function. It has been proposed that in order to save the cell from destruction mitochondrial function must be preserved. The ketogenic diet, originally designed to mimic fasting physiology, is effective in treating epilepsy. Therefore, we have used …

Effect Of The SmartstepTm Stabilization System On Balance In Older Adults In An Independent Living Residence, Ann L. Livengood

University of Kentucky Doctoral Dissertations

An increase in postural sway is one of the risk factors that have been linked to an increased incidence of falls in the older adult population. Researchers have shown that peripheral sensation is crucial in maintaining a static posture for adults of all ages. It has been reported that older adults have decreased tactile sensation of the plantar surface of their feet. and when the sensory feedback was increased older adults had improved postural control. It was hypothesized that facilitation of the sole of the foot with the use of a semirigid foot orthotic would result in improved postural stability …

Carbon Nanotube Supported Metal Catalysts For NoX Reduction Using Hydrocarbon Reductants, Eduardo Santillan-Jimenez

University of Kentucky Doctoral Dissertations

Nitrogen oxides (NO_x) are atmospheric pollutants that pose a serious threat to both the environment and human health. Although catalytic deNO_x technologies for engines working under stoichiometric air-to-fuel ratios (i.e., most gasoline engines) are already available, their performance is unsatisfactory under excess air conditions like those under which diesel engines operate.

The selective catalytic reduction of NO_x with hydrocarbon reductants (HC-SCR) is a potential deNO_xsolution for diesel engines, whose operating temperatures are 150-500 ºC. Given that is unlikely for a single catalyst to show acceptable activity throughout this entire temperature span, the use of …

Matrix Decomposition For Data Disclosure Control And Data Mining Applications, Jie Wang

University of Kentucky Doctoral Dissertations

Access to huge amounts of various data with private information brings out a dual demand for preservation of data privacy and correctness of knowledge discovery, which are two apparently contradictory tasks. Low-rank approximations generated by matrix decompositions are a fundamental element in this dissertation for the privacy preserving data mining (PPDM) applications. Two categories of PPDM are studied: data value hiding (DVH) and data pattern hiding (DPH). A matrix-decomposition-based framework is designed to incorporate matrix decomposition techniques into data preprocessing to distort original data sets. With respect to the challenge in the DVH, how to protect sensitive/confidential attribute values without …

Linking The Structure And Mechanical Behavior Of Nanoporous Gold, Ye Sun

University of Kentucky Doctoral Dissertations

The structure of nanoporous gold (np-Au) provides a very limited volume for deformation to occur, and thus offers an opportunity to study the role of defects such as dislocations in nanoscale metal volumes. A practical goal is to understand mechanical properties of np-Au so that it can be can produced in stable form, for use in applications that require some mechanical integrity. Bulk and thin film np-Au have been fabricated and studied here.

Bulk np-Au was prepared by electrochemically dealloying Au-Ag alloys with 25 and 30 at.% Au. In the lower Au content material, cracks always formed during dealloying. When …

Microbial Community Structure Dynamics In Ohio River Sediments During Reductive Dechlorination Of Pcbs, Andres Enrique Nunez

University of Kentucky Doctoral Dissertations

The entire stretch of the Ohio River is under fish consumption advisories due to contamination with polychlorinated biphenyls (PCBs). In this study, natural attenuation and biostimulation of PCBs and microbial communities responsible for PCB transformations were investigated in Ohio River sediments.

Natural attenuation of PCBs was negligible in sediments, which was likely attributed to low temperature conditions during most of the year, as well as low amounts of available nitrogen, phosphorus, and organic carbon. Moreover, surface sediments were relatively oxidized, as indicated by the prevalence of aerobic bacteria such as beta- Proteobacteria, alpha-Proteobacteria, Sphingobacteria, and Nitrospira in 16S rRNA sediment …

The Interaction Of Haptic Imagery With Haptic Perception For Sighted And Visually Impaired Consumers, Shannon Bridgmon Rinaldo

University of Kentucky Doctoral Dissertations

Consumers evaluate products in the market place using their senses and often form mental representations of product properties. These mental representations have been studied extensively. Imagery has been shown to interact with perception within many perceptual modalities including vision, auditory, olfactory, and motor. This dissertation draws on the vast visual imagery literature to examine imagery in the haptic, or touch, modality. Two studies were undertaken to examine the relationship between haptic imagery and haptic perception The first study is based on studies from cognitive psychology that have used similar methods for examining visual imagery and visual perception. In study 1, …

Modular Fast Direct Analysis Using Non-Radiating Local-Global Solution Modes, Xin Xu

University of Kentucky Doctoral Dissertations

This dissertation proposes a modular fast direct (MFD) analysis method for a class of problems involving a large fixed platform region and a smaller, variable design region. A modular solution algorithm is obtained by first decomposing the problem geometry into platform and design regions. The two regions are effectively detached from one another using basic equivalence concepts. Equivalence principles allow the total system model to be constructed in terms of independent interaction modules associated with the platform and design regions. These modules include interactions with the equivalent surface that bounds the design region. This dissertation discusses how to analyze (fill …

Involvement Of Inflammation In Tau Pathology And Mechanisms That Drive Neurodegeneration In Alzheimer's Disease, Lisette T. Arnaud

Dissertations, Theses, and Capstone Projects

Two of the hallmarks of neurodegenerative disorders, such as Alzheimer's disease (AD), are (1) the appearance of proteinaceous deposits in inclusion bodies containing aggregates of ubiquitinated proteins and (2) activated microglia and astrocytes surrounding the diseased neurons. In Alzheimer's disease, the intracellular inclusion bodies are known as neurofibrilary tangles (NFT). The mechanisms leading to inclusion body formation and their role in the progression of neurodegeneration are still largely unknown.

Many of the proteins that accumulate in inclusion bodies depend on the ubiquitin/proteasome pathway (UPP) for their degradation. This pathway is responsible for the bulk (∼80%) of intracellular protein degradation. Because …

Meritocracy: A Socio-Educational Policy Conundrum Transversing Selected Works Of James Bryant Conant, Benjamin Enoma

Dissertations, Theses, and Capstone Projects

In the United States, adjacent strands of the meritocratic discourse intercept by accident of history. It occurs either in the Jeffersonian tradition of culling from all sectors of the populace a natural aristocracy of talents as proposed by James Conant through the development of Scholastic Aptitude Tests, or by expanding the structure of opportunity to all individuals and leveling uneven terrains through social policies like desegregation of schools and affirmative action. In other words, it is a case of policies based on the 'laissez-faire' doctrine versus those based on governmental intervention. "This interception to some degree has fused the strands …

Investigation Of Inosine And Hypoxanthine As Biomarkers Of Cardiac Ischemia In Plasma Of Non-Traumatic Chest Pain Patients And A Rapid Analytical System For Assessment, Don E. Farthing

Theses and Dissertations

Each year in the U.S., approximately 7-8 million patients with non-traumatic chest pain visit hospital emergency departments (ED) for medical evaluation. It is estimated that approximately 2-5% of these patients are experiencing acute cardiac ischemia, but due to the shortcomings of current test methods, they are incorrectly diagnosed and discharged without appropriate treatment provided, thus leading to poor patient outcome and potential medical malpractice litigation.The goals of this research were to evaluate plasma samples for potential biomarker(s) of acute cardiac ischemia prior to heart tissue necrosis, and to ultimately develop a rapid method for detection of the potential biomarker(s) in …

Voice By Design: Experiments In Redistributing Media, Bizhan Khodabandeh

Theses and Dissertations

In this project I conduct two experiments in redistributing media power and reflect upon how successful they were. The experiments include a poster campaign specific to Richmond and a project dealing with educating people about guerrilla media techniques.

Human Rights In The United States, Sarah H. Cleveland, Catherine Powell

Faculty Scholarship

This year marks the tenth anniversary of the founding of the Human Rights Institute (HRI) at Columbia Law School. Appropriately, it also marks the sixtieth anniversary of the Universal Declaration of Human Rights, the foundational instrument of the modern international human rights regime.

When HRI was founded in 1998, it was established as a crossroads for human rights at Columbia, which would bridge theory and practice, human rights and constitutional rights, and law and other disciplines. From its inception, HRI has been a partner with the university-wide Center for the Study of Human Rights, which was established twenty years earlier …

Courts, Constitutions, And Public Finance: Some Recent Experiences From The States, Richard Briffault

Faculty Scholarship

Unlike the federal Constitution, virtually all state constitutions give detailed attention to questions of public finance. State constitutions limit spending, mandate certain types of spending, constrain taxation and debt, and require special procedures for enacting a budget. One consequence of the constitutionalization of the state fisc is its judicialization, as these measures trigger litigation. Fiscal and political conflicts turn into legal disputes, with courts joining governors and legislatures in shaping state budgets and making state fiscal policy.

This chapter provides an early-21st-century snapshot of the state constitutional law of state finance through a survey of six recent state supreme court …

A House Still Divided, Clare Huntington

Faculty Scholarship

In response to Adam B. Cox, Immigration Law's Organizing Principles, 157 U. PA. L. REv. 341 (2008).

Adam Cox's Immigration Law's Organizing Principles contests the traditional view that immigration law and alienage law – in his terms, "selection rules" and "regulation rules" – are distinct categories with legal and moral salience. Building upon prior scholarship that also called the distinction into question, Cox offers important insights into why this dividing line does not have the sharp conceptual edges that the jurisprudence would suggest exist. Despite the analytical persuasiveness of Cox's argument, I am not convinced that it will destabilize the …

Hiding Out: Creative Resistance Among Anonymous Workbloggers, Abigail Schoneboom

Dissertations, Theses, and Capstone Projects

Anonymous workbloggers—employees who write online diaries about their work—are often simultaneously productive workers and savage critics of the corporate cultures in which they toil. Writing under an assumed identity, these workers create satirical portraits of their supervisors and colleagues, rail against management gurus and corporate buzzwords, celebrate time-wasting capers, and daydream about quitting. Their irreverent and fictionalized accounts of work, which are shielded from the gaze of co-workers and supervisors, reveal how office workers critically negotiate a labor process that, increasingly, demands their hearts and minds.

This study, which comprises an overview of media and organizational responses to the phenomenon, …

Intuition, Morals, And The Legal Conversation About Gay Rights, Suzanne B. Goldberg

Faculty Scholarship

When lawyers and judges converse in litigation, factual and legal analysis typically takes center stage. Yet, when the legal conversation turns to the rights of lesbians, gay men, and bisexuals, the ground shifts. Intuition and morals rationales often displace evidence-based reasoning. More specifically, arguments to limit the rights of lesbians and gay men tend to depend explicitly on intuition, and sometimes morality, in ways that contemporary arguments to restrict the rights of other social groups rarely do.

In addressing this dissonance, this essay has two central aims. The first is simply to observe the disproportionate openness to arguments based on …

Scandal, Sukyandaru, And Chouwen, Benjamin L. Liebman

Faculty Scholarship

Jose Canseco's use of steroids, the sale of used girls' underwear in Japan, penile mutilation, and the moral failings of both Bill Clinton and former Japanese Prime Minister Sosuke Uno are not topics that often appear side by side, much less in a scholarly work of comparative law. And few law professors have the chance to publish a book whose jacket features a picture of a scantily clad woman. In Secrets, Sex and Spectacle, Mark West does both. He also does much more, unraveling the interplay of social and legal rules that influence the formation of scandal and spectacle …

Longing For Loving, Katherine M. Franke

Faculty Scholarship

Our task in this Symposium is to place Loving v. Virginia in a contemporary context: to interpret, if not reinterpret, its meaning in light of the settings in which race, sexuality, and intimacy are being negotiated and renegotiated today. So we might ask, in what way are Mildred and Richard Loving role models for us today? How, if at all, does the legal movement for marriage equality for interracial couples help us think through our arguments and strategies as we struggle today for marriage equality for same-sex couples?

One way to frame these questions is to ask whether there is …

Separating The Sony Sheep From The Grokster Goats: Reckoning The Future Business Plans Of Copyright-Dependent Technology Entrepeneurs, Jane C. Ginsburg

Faculty Scholarship

In MGM v. Grokster, the U.S. Supreme Court established that businesses built from the start on inducing copyright infringement will be held liable, as judges will frown on drawing one's start-up capital from other people's copyrights. The Court's elucidation of the elements of inducement suggests that even businesses not initially built on infringement, but in which infringement comes to play an increasingly profitable part, may find themselves liable unless they take good faith measures to forestall infringements. This Article addresses the evolution of the U.S. judge-made rules of secondary liability for copyright infringement, and the possible emergence of an obligation …

Mccain Vs. Obama On Environment, Energy, And Resources, Michael B. Gerrard

Faculty Scholarship

For the first time in living memory, the environment is receiving significant attention in a presidential election. Both Senator John McCain (R-AZ) and Senator Barack Obama (D-IL) have given speeches and run television advertisements on the issue and (after a slow start) are being asked questions by the national press about where they stand on climate change and energy.

This article compares the actions and positions of the two candidates on environmental, energy, and resources issues. It begins by looking at their voting records, presents their endorsements and campaign contributions, and then discusses their positions as shown in their campaign …

Climate Change And The Environmental Impact Review Process, Michael B. Gerrard

Faculty Scholarship

In the explosion of modern environmental law that occurred in the 1970s, the first major statute was the National Environmental Policy Act (NEPA), 42 U.S.C. §§ 4321-4347, signed into law by President Richard M. Nixon on January 1, 1970. It spawned "little NEPAs" in about twenty-five states and eighty countries. Council on Environmental Quality, The National Environmental Quality Act: A Study of Its Effectiveness After Twenty-Five Years (1997). All of these laws were designed to require governments to consider environmental issues in their decisions. The chief mechanism of NEPA and its state equivalents is the preparation of environmental impact statements …

Design For Manufacturing For Friction Stir Welding, Harish Bagaitkar

Masters Theses

"This thesis is divided in two parts. In the first part, technical feasibility of implementing Friction Stir Welding (FSW) for automobile chassis fabrication is discussed using a case study. In the case study, Design for Manufacturing (DFM) principles are applied to manufacture an aluminum automobile chassis. Various DFM issues such as Tool Accessibility Issue, Joint Configuration Issue, and Fixture Support Issue along with relevant guidelines such as component geometry change and component elimination are discussed in the first section. Results show that more than 50% of the chassis joints can be welded using FSW technique. The second part of the …

A Laboratory Study Of Struvite Precipitation For Phosphorus Removal From Concentrated Animal Feeding Operation Wastewater, Sushmita Dhakal

Masters Theses

"Struvite precipitation occurs spontaneously in many wastewater treatment facilities as a nuisance. However, struvite precipitation is now being studied as a method to concurrently treat high phosphorus wastewaters and generate a valuable product. Many factors influence the precipitation of struvite such as component -ion molar ratios, pH, aeration, solubility, solids and mixing energy. In the present work, struvite precipitation in the actual swine wastewater was studied by strategically controlling aeration, pH, and mixing"--Abstract, page iv.