Digital Commons Network^™

Enzastaurin, An Inhibitor Of Pkc Beta, Enhances Antiangiogenic Effects And Cytotoxicity Of Radiation Against Endothelial Cells., Aaron C. Spalding, Benjamin David Zeitlin, Kari Wilder-Romans, Mary Ellen Davis, Jacques E. Nör, Theodore S. Lawrence, Edgar Ben-Josef

All Dugoni School of Dentistry Faculty Articles

PURPOSE: Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKC beta) that phosphorylates GSK3 beta to suppress apoptosis and promote endothelial cell proliferation and microvessel formation. We used Enzastaurin (Enz) to test the hypothesis that inhibition of PKC beta results in radiosensitization of endothelial cells in culture and in vivo. MATERIALS/METHODS: We measured PKC beta phosphorylation, VEGF pathway signaling, colony formation, and capillary sprout formation in primary human dermal microvessel endothelial cells (HDMECs) after Enz or radiation (RT) treatment. Microvessel density and tumor …

Characterization Of The Ompl1 Gene Of Pathogenic Leptospira Species In China And Cross-Immunogenicity Of The Ompl1 Protein, Haiyan Dong, Ye Hu, Feng Xue, Dexter Sun, David M. Ojcius, Yafei Mao, Jie Yan

All Dugoni School of Dentistry Faculty Articles

Background: The usefulness of available vaccine and serological tests for leptospirosis is limited by the low cross-reactivity of antigens from numerous serovars of pathogenic Leptospira spp. Identification of genus-specific protein antigens (GP-Ag) of Leptospira would be important for development of universal vaccines and serodiagnostic methods. OmpL1, a transmembrane porin of pathogenic leptospires, was identified as a possible GP-Ag, but its sequence diversity and immune cross-reactivity among different serovars of pathogenic leptospires remains largely unknown.

Results: PCR analysis demonstrated that the ompL1 gene existed in all 15 official Chinese standard strains as well as 163 clinical strains of pathogenic leptospires isolated …

Updated Lessons In Conducting Basics Legal Research By Pro Se Litigants Who Cannot Afford An Attorney., Michael P. Forrest, Mike Martinez Jr., Paul S. Miller

The Scholar: St. Mary's Law Review on Race and Social Justice

Abstract Forthcoming.

Ultra Dynamised And Undynamised Dilutions Of Alloxan At Micro-Doses Influence Selective Pancreatic Beta Cell And Hormonal Profile: An Experimental Approach, Sunil Kumar, C Nayak

Indian Journal of Research in Homoeopathy

Dynamised and Undynamised preparations of Alloxan 6x, 30x, 200x, and 1000x were examined for its anti-diabetic activities in Alloxan induced diabetes mellitus albino rats. Oral administration of dynamised potencies of Alloxan 6x, 30x, 200x, and 1000x at dose level of 50μ1/100 g.b.w. daily for 30 days regularly exhibited slow and steady fall in blood sugar level accompanied with perceptible increase in serum growth hormone (GH) i.e. p < 0.01 (less significant) and p < 0.001 (significant) respectively when compared to dynamised and Undynamised control as well as Undynamised Alloxan fed groups under identical conditions. Histological and histo-morphometric studies also revealed reactivation of Pancreatic β-cells. Dynamised dilutions of Alloxan acts steadily through hypothalamo-hypophysial- pancreatic β-cells axis producing selective reactivation of β-cells at micro-doses, steadily viz 6x < 30x < 200x < 1000x. The drug may indirectly release Releasing factors (RF) from hypothalamic neurons, stimulating the secretion of growth hormone which in turn triggers optimum insulin secretion from β-cells. The therapeutic action of the test drug in dynamised dilutions at micro dose and relatively high dilutions on pancreatic β-cells confirms the phenomenon of "Potentization" & "Similia Similibus Curentur" and lack of acute and sub-acute toxicity at fairly large dosage may open up new prospects in the treatment of diabetes mellitus and throw light in elucidating the mechanism of action at higher dilutions. It was noticed that the dynamised dilutions of alcohol fed control group is more toxic and lethal to animals than the dynamised and Undynamised dilutions of Alloxan and Undynamised alcohol fed control groups. Furthermore, it was also discernible that blood sugar and growth hormone levels were stabilized even after withdrawal of test drug in its 30x, 200x and 1000x potencies.

Why Multilevel Selection Matters, Alexander J. Field

Economics

In spite of its checkered intellectual history, and in spite of the myriadproposals of alternative models that claim both to account for the range of humanbehavior and to dispense with the need for selection above the organism level, a mul-tilevel selection framework allowing for biological as well as cultural group selectionremains the only coherent means of accounting for the persistence and spread ofbehavioral inclinations which, at least upon first appearance at low frequency, wouldhave been biologically altruistic. This argument is advanced on three tracks: througha r eview of experimental and observational evidence inconsistent with a narrow ver-sion of rational choice …

Dimond, Not Daubert: Reviving The Discretionary Standard Of Expert Admission In Alaska, Gregory R. Henrikson

Alaska Law Review

No abstract provided.

Louisiana State Museum Edward Douglass White Historic Site Report & Analysis, Diana Buckley

Arts Administration Master's Reports (1984-2016)

The following analysis serves as an invitation to the reader interested in house museums and museum development, as well as a study of the internal operations of the Louisiana State Museum's Edward Douglass White Historic Site. The Louisiana State Museum is a relatively large system of 12 museum sites spread throughout the state. A brief history of the LSM is provided in chapter one, which precedes the reports primary substance expressed in chapter three, where day-to-day operations of the LSM-Edward Douglass White Historic Site house museum are analyzed via a SWOT analysis. Every part of research went hand in hand …

Vol 53 #3, Judy Zelenski

MPLA Newsletter

No abstract provided.

Full Issue 3.3

Genocide Studies and Prevention: An International Journal

No abstract provided.

Rape As A Weapon Of Genocide, Alllison Ruby Reid-Cunningham

Genocide Studies and Prevention: An International Journal

Sexual violence against women during war and genocide is a pressing problem. Rape is used as a tactic of war and genocide because of its physical and psychosocial consequences for individuals, families, and communities. The physical and emotional sequelae of individual assaults are magnified when rape is committed on a mass scale, as in Bosnia-Herzegovina (1992–1996), Rwanda (1994), and Darfur, Sudan (2003–present). The victimization of raped women affects the community through the collective responses of survivors and their families, friends, and neighbors. Forced intercourse and impregnation represent a symbolic conquest of the woman by the rapist. This conquest becomes generalized …

Tempo Magazine, Fall 2008, Office Of Student Life

Tempo Magazine

Tempo Magazine is Coastal Carolina University's student-produced feature magazine. TEMPO #20. Editor: Lauren Formalarie. Faculty advisor: Melissa Paschuck and Paul Olsen.

Streptococcus Pyogenes: A Versatile Human Pathogen, Maria E. Cevallos

Mako: NSU Undergraduate Student Journal

Streptococcus pyogenes is one of the most medically relevant genera of Gram positive bacteria. S. pyogenes belongs to Group A streptococcus (GAS), the most pathogenic streptococci. S. pyogenes is exclusively a human pathogen that is known for its ability to cause a wide array of infections ranging from superficial pharyngitis and impetigo to invasive life threatening conditions including septicemia, necrotizing fasciitis, and streptococcal toxic shock syndrome. The dissemination of S. pyogenes within a human host is dependent upon virulence factors aimed at host immune system evasion leading to infection. More specifically, S. pyogenes’ virulence factors are required for bacterial …

Yersiniae Virulence Factors: Type Iii Secretion System, Jessica Blanco

Mako: NSU Undergraduate Student Journal

Several Gram-negative pathogenic bacteria have evolved a complex protein secretion system termed the Type Three Secretion System (TTSS) to deliver bacterial effector proteins into host-cells that then modulate host-cellular functions. These bacterial devices are evolutionarily related to the flagellar apparatus. Although the TTSSs are substantially conserved among different species, the effector molecules they deliver are species-unique. There exist three human pathogenic Yersiniae. Yersinia enterocolitica and Yersinia pseudotuberculosis cause self-limiting gastro-enteric diseases and infect mesenteric lymph nodes, while Yersinia pestis is transmitted by fleas and can be aerosolized, causing the lethal disease known as plague (also known as Black Death). The …

Characterization Of Dna Sequences That Confer Complement Resistance In Leishmania Chagasi, Rebecca R. Dahlin-Laborde, Eric J. Scolaro, Nathan M. Romine, Amanda Ramer-Tait, Soi Meng Lei, Jeffrey K. Beetham

Department of Food Science and Technology: Faculty Publications

Serial passage of axenically cultured Leishmania chagasi promastigotes results in a progressive diminution in resistance to complement-mediated lysis (CML), whereas high CML resistance is seen in infectious metacyclic promastigotes from the sandfly vector as well as metacyclic-like promastigotes within low-passage cultures at stationary growth phase. As we previously reported, in a screen seeking to identify novel genes involved in CML resistance: (1) a genomic cosmid library derived from DNA of CML-resistant L. chagasi promastigotes was transfected into highpassage (constitutively CML-sensitive) L. chagasi promastigotes; (2) transformants were screened for acquisition of CML-resistance; (3) multiple cosmid-transfectants exhibited partial CML resistance; and (4) …

The Human Immunodeficiency Virus Type 1 Envelope Confers Higher Rates Of Replicative Fitness To Perinatally Transmitted Viruses Than To Nontransmitted Viruses, Xiaohong Kong, John T. West, Hong Zhang, Danielle Shea, Tendai J. M'Soka, Charles Wood

Nebraska Center for Virology: Faculty Publications

Selection of a minor viral genotype during perinatal transmission of human Immunodeficiency virus type 1 (HIV-1) has been observed, but there is a lack of information on the correlation of the restrictive transmission with biological properties of the virus, such as replicative fitness. Recombinant viruses expressing the enhanced green fluorescent protein or the Discosoma sp. red fluorescent (DsRed2) protein carrying the V1 to V5 regions of env from seven mother-infant pairs (MIPs) infected by subtype C HIV-1 were constructed, and competition assays were carried out to compare the fitness between the transmitted and nontransmitted viruses. Flow cytometry was used to …

Shaping The Cross Timbers With Fire And Grazing, John A. Guretzky

Department of Agronomy and Horticulture: Faculty Publications

Recently, our agricultural research team has been asked to provide talks during tours of our Oswalt Road Ranch. The Oswalt Road Ranch is a 4,992-acre property in Love County, Okla., willed to us by D. Joyce Coffey. The Noble Foundation took full control of the property in 2000. The ranch is a valuable piece of property because of its unique natural beauty and potential to support livestock production and wildlife habitat. On the tours, we have been showing off our new state-of-the art livestock handling facilities and providing information about results from recent research on by-product feeds, the Noble Foundation …

Monitoring Tissue Engineering Using Magnetic Resonance Imaging, Huihui Xu, Shadi F. Othman, Richard L. Magin

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Assessment of tissue regeneration is essential to optimize the stages of tissue engineering (cell proliferation, tissue development and implantation). Optical and X-ray imaging have been used in tissue engineering to provide useful information, but each has limitations: for example, poor depth penetration and radiation damage. Magnetic resonance imaging (MRI) largely overcomes these restrictions, exhibits high resolution (approximately 100 μm) and can be applied both in vitro and in vivo. Recently, MRI has been used in tissue engineering to generate spatial maps of tissue relaxation times (T₁, T₂), water diffusion coefficients, and the stiffness (shear moduli) of …

Quantitative Rrna-Targeted Solution-Based Hybridization Assay Using Peptide Nucleic Acid Molecular Beacons, Xu Li, Eberhard Morgenroth, Lutgarde Raskin

Department of Civil and Environmental Engineering: Faculty Publications

The potential of a solution-based hybridization assay using peptide nucleic acid (PNA) molecular beacon (MB) probes to quantify 16S rRNA of specific populations in RNA extracts of environmental samples was evaluated by designing PNA MB probes for the genera Dechloromonas and Dechlorosoma. In a kinetic study with 16S rRNA from pure cultures, the hybridization of PNA MB to target 16S rRNA exhibited a higher final hybridization signal and a lower apparent rate constant than the hybridizations to nontarget 16S rRNAs. A concentration of 10 mM NaCl in the hybridization buffer was found to be optimal for maximizing the difference between …

In Vitro Testing Of Daptomycin Plus Rifampin Against Methicillin-Resistant Staphylococcus Aureus Resistant To Rifampin, Faisal A. Khasawneh, Deborah S. Ashcraft, George A. Pankey

Saudi Medical Journal

OBJECTIVE: To test for synergy between daptomycin (DAP) and rifampin (RIF) against RIF-resistant methicillin-resistant Staphylococcus aureus (MRSA) isolates. METHODS: Synergy testing using time-kill assay (TKA) was performed on 6 clinically, and genetically unique RIF-resistant MRSA isolates. The isolates were identified out of 489 (1.2%) samples collected during April 2003 to August 2006, from patients at the Ochsner Medical Center in New Orleans, Louisiana, United States of America. RESULTS: Synergy testing of DAP plus RIF by TKA showed that 5 isolates were indifferent, but one isolate was antagonistic. CONCLUSION: Our in vitro study failed to demonstrate synergy between DAP plus RIF, …

Low-Dose Chemotherapy For Extra-Abdominal Desmoid Tumor, Mohammed L. Al-Otaibi, Robert E. Turcotte, Ingrid Hings, Julie Beaudet, Marc Isler, Ayoub Nahal, Cindy Wong

Saudi Medical Journal

OBJECTIVE: To assess the outcome of patients with extra-abdominal desmoid tumor treated with low dose chemotherapy (methotrexate and vinblastine) both for tumor response and treatment related toxicity. METHODS: We retrospectively reviewed the outcome of 12 patients who underwent low dose chemotherapy for extra abdominal desmoid of different locations. The study took place in the McGill University Health Center, Montreal, Canada between 1996 and 2003. We evaluated the patients for their compliance, tumor response, complications of treatment, and impact of treatment on symptoms. There were 7 females and 5 males with a mean age of 46 years. RESULTS: Disease related morbidity …

Oxidative Stress And Antioxidant Status In Neonatal Hyperbilirubinemia, Mehmet Davutoglu, Ekrem Guler, Seref Olgar, Ergul B. Kurutas, Hamza Karabiber, Mesut Garipardic, Hasan C. Ekerbicer

Saudi Medical Journal

OBJECTIVE: To investigate the possible relationships between plasma bilirubin levels and concentrations of nitric oxide (NO), malondialdehyde (MDA), and erythrocyte antioxidant enzyme activities in newborn infants with hyperbilirubinemia. METHODS: Thirty term (gestational age >/= 37 weeks) newborn infants with indirect hyperbilirubinemia aged less than 10 days were prospectively recruited in the Kahramanmaras Sutcu Imam University Neonatal Unit, Kahramanmaras, Turkey, between January and July 2007. Thirty randomly selected healthy newborns who had similar age and without clinical jaundice comprised the control group. Erythrocyte catalase, superoxide dismutase, glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase, and plasma MDA and NO concentrations were measured. RESULTS: Both …

25-Hydoxyvitamin D Levels Among Healthy Saudi Arabian Women, Haifa A. Al-Turki, Mir Sadat-Ali, Abdulmohsen H. Al-Elq, Fathma A. Al-Mulhim, Amein K. Al-Ali

Saudi Medical Journal

OBJECTIVE: To assess the serum level of 25 hydroxyvitamin D 25OHD among healthy Saudi Arabian women living in the eastern province. METHODS: A cross-sectional randomized study was conducted between February 1st 2008 and May 31st 2008 at the King Fahd University Hospital, Al-Khobar, Kingdom of Saudi Arabia in 200 Saudi women between 25-35 years group 1 and women of >/=50 years group 2. Clinical examination, laboratory tests, a complete blood picture, serum calcium, phosphorous, alkaline phosphatase, parathormone, and the serum levels of 25OHD levels were carried out. Data on lifestyle, dietary, and demographic questionnaires were collected. Vitamin D was defined …

Determination Of Free Catecholamines In Urine By Tandem Affinity/Ion-Pair Chromatography And Flow Injection Analysis, David H. Thomas, Jay D. Taylor, Omar S. Barnaby, David S. Hage

David Hage Publications

Background—A system was developed for the simultaneous measurement in urine of free catecholamines (i.e., dopamine, norepinephrine, epinephrine) and creatinine (i.e., an indicator of urine output and volume). This method was based on the use of tandem affinity/ion-pair HPLC and flow injection analysis.

Methods—The free catecholamines were extracted directly from urine by using an on-line phenylboronic acid affinity column. The extracted solutes were then separated and measured by ionpair chromatography followed by amperometric detection. Creatinine was measured by an on-line flow injection analysis system based on the Jaffe reaction, which analyzed creatinine as it eluted nonretained from the phenylboronic …

How Does A Riverine Setting Affect The Lifestyle Of Shellmound Builders In Brazil?, Sabine Eggers, C. C. Petronilho, K. Brandt, C. Jericó-Daminello, J. Filippini, Karl Reinhard

Karl Reinhard Publications

The contact of inland and coastal prehistoric groups in Brazil is believed to have been restricted to regions with no geographical barrier, as is the case in the Ribeira de Iguape valley. The inland osteological collection from the riverine shellmound Moraes (5800–4500 BP) represents a unique opportunity to test this assumption for this region. Despite cultural similarities between riverine and coastal shellmounds, important ecological and site distribution differences are expected to impact on lifestyle. The purpose of this study is thus to document and interpret health and lifestyle indicators in Moraes in comparison to coastal shellmound groups. Specifically we test …

Presentation Of The 2008 Asp Distinguished Service Award To William C. Campbell, Robin M. Overstreet

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Presentation of the 2008 American Society of Parasitologists Distinguished Service Award to William C. Campbell, Dana Fellow for scientists emeriti at Drew University.

The Effect Of The Amide Substituent On The Biodistribution And Tolerance Of Lanthanide(Iii) Dota-Tetraamide Derivatives, Mark Woods, Peter Caravan, Carlos F.G.C. Geraldes, Matthew T. Greenfield, Garry Kiefer, Mai Lin, Kenneth Mcmillan, M. Isabel M. Prata, Ana C. Santos, Xiankai Sun, Jufeng Wang, Shanrong Zhang, Piyu Zhao, A. Dean Sherry

Chemistry Faculty Publications and Presentations

Objectives—Recent advances in the design of MRI contrast agents have rendered the lanthanide complexes of DOTA-tetraamide ligands of considerable interest, both as responsive MR agents and paramagnetic chemical exchange saturation transfer agents. The potential utility of these complexes for in vivo applications is contingent upon them being well tolerated by the body. The purpose of this study was to examine how the nature of the amide substituent, and in particular its charge, affected the fate of these chelates postinjection.

Materials and Methods—Complexes of 6 DOTA-tetraamide ligands were prepared in which the nature of the amide substituent was systematically …

Protecting Critical Infrastructure With Games Technology, Adrian Boeing, Martin Masek, Bill Bailey

Australian Information Warfare and Security Conference

It is widely recognised that there is a considerable gap in the protection of the national infrastructure. Trying to identify what is in fact ‘critical’ is proving to be very difficult as threats constantly evolve. An interactive prototyping tool is useful in playing out scenarios and simulating the effect of change, however existing simulators in the critical infrastructure area are typically limited in the visual representation and interactivity. To remedy this we propose the use of games technology. Through its use, critical infrastructure scenarios can be rapidly constructed, tested, and refined. In this paper, we highlight the features of games …

Are Delay Discounting, Probability Discounting, Time Perception, And Time Perspective Related? A Cross-Cultural Study Among Latino And White American Students, Ana Amelia L. Baumann Neves

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The present study aimed to evaluate (a) the extent to which different impulsivity measures would be related to each other and to a risk taking measure, (b) the extent to which impulsivity, risk taking, time perception and time perspective are related to each other, and (c) the extent to which these processes differ in Latino and White American students. Experiment I was conducted at Utah State University. One hundred and forty-three participants were exposed to the delay discounting, probability discounting and temporal bisection procedures, and answered the Barratt Impulsiveness Scale (BIS-11) and the Zimbardo Time Perspective Inventory (ZTPI). Results showed …

Measuring And Modeling Of Plant Root Uptake Of Organic Chemicals, Erik Dettenmaier

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Determining the root uptake of xenobiotic organic chemicals into plants is critical for assessing the human and ecological health risks associated with the consumption of plants growing in contaminated environments. Root uptake of xenobiotic organics occurs passively in conjunction with transpiration and the transport from root to shoot is ultimately controlled by passage through one or more lipid root membranes. The transpiration stream concentration factor (TSCF), the ratio between the concentration of a chemical in the xylem to that in the solution used by the roots, is used to describe the relative ability of an organic chemical to be passively …

Design Guidelines For The Historic Downtown Of The City Of St. George, Utah, Bronson Ron Tatton

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This document proposes historic preservation guidelines for the downtown area of the City of St. George, Utah. It grew from a summer internship with the city where I took inventory of the streetscape in the Historic Downtown and prepared recommendations in the form of a PowerPoint Presentation that was given to the city council. This paper summarizes the summer internship and introduces a more appropriate approach based on reflection of the internship. The new approach involves a thorough inventory of the historic character, in-depth research of the historic elements that contribute to the historic character, development of design guidelines and …