Digital Commons Network^™

Engineering A Photo-Control Mechanism For Rna Interference, Richard Andrew Blidner

LSU Doctoral Dissertations

RNA interference (RNAi) is a phenomenon in which RNA molecules elicit potent and sequence-specific post-transcriptional gene silencing. Nucleic acid chemical modifications have been incorporated to improve their pharmacological properties. Despite numerous developments in chemical modifications for increased stability, safety, and efficiency of these therapeutic agents, they still face challenges of spatial and temporal targeting. One potential targeting strategy uses photocaging techniques, which involves the covalent attachment of photolabile compounds to the effector NA species that blocks bioactivity until exposed to near UV-light. This work demonstrates that fully-2’-fluorinated nucleic acids (FNAs) can elicit RNAi and that these effectors are resistant to …

Potential Of A Suite Of Robot/Computer-Assisted Motivating Systems For Personalized, Home-Based, Stroke Rehabilitation, Michelle J. Johnson, Xin Feng, Laura M. Johnson, Jack M. Winters

Electrical and Computer Engineering Faculty Research and Publications

Background

There is a need to improve semi-autonomous stroke therapy in home environments often characterized by low supervision of clinical experts and low extrinsic motivation. Our distributed device approach to this problem consists of an integrated suite of low-cost robotic/computer-assistive technologies driven by a novel universal access software framework called UniTherapy. Our design strategy for personalizing the therapy, providing extrinsic motivation and outcome assessment is presented and evaluated.

Methods

Three studies were conducted to evaluate the potential of the suite. A conventional force-reflecting joystick, a modified joystick therapy platform (TheraJoy), and a steering wheel platform (TheraDrive) were tested separately with …

Predicting Water Quality Effects On Bay Anchovy (Anchoa Mitchilli) Growth And Production In Chesapeake Bay: Linking Water Quality And Individual-Based Fish Models, Aaron Thomas Adamack

LSU Doctoral Dissertations

Water quality in the Chesapeake Bay and the Patuxent River has decreased since the 1950s due to an increase in nutrient loadings. Increased nutrient loads have caused an increase in the extent and duration of hypoxic conditions. Restoration via large-scale reductions in nutrient loadings is now underway. How reducing nutrient loadings will affect water quality is well predicted; however the effect on fish is generally unknown as most water quality models do not include trophic levels higher than zooplankton. I combined two water quality models with bay anchovy models (Anchoa mitchilli) to examine the effects of changes in nutrient loadings …

Effect Of Hole Configurations On Film Cooling From Cylindrical Inclined Holes For The Application To Gas Turbine Blades, Yiping Lu

LSU Doctoral Dissertations

Film cooling is one of the cooling systems investigated for the application to gas turbine blades. Gas turbines use film cooling in addition to turbulated internal cooling to protect the blades outer surface from hot gases. The present study concentrates on the experimental and numerical investigation of film cooling performance for a row of cylindrical holes in a modern turbine blade. The adiabatic film effectiveness and the heat transfer coefficient are determined experimentally on a flat plate downstream of a row of inclined different geometries hole exit by using a single test transient IR thermography technique. The focus of this …

Flow And Distribution Of Water In Fractional Wettability Unsaturated Porous Media, Zaydoun Turkey Abusalem

LSU Doctoral Dissertations

In recent years, interest in fluid flow and transport in the unsaturated zone has gained more attention, due to growing concerns that the quality of the subsurface environment is adversely affected by agricultural, industrial, and municipal activities. The wettability properties (e.g., water repellency) of soil in the unsaturated zone play an important role in determining fluid movement and ultimate distributions. A number of studies have shown that preferential flow and spatially variable moisture content is likely to occur in water repellant soils. Development of appropriate constitutive relations for numerical modeling becomes even more difficult in systems that contain water repellant …

Knowledge-Based Methods For Automatic Extraction Of Domain-Specific Ontologies, Janardhana R. Punuru

LSU Doctoral Dissertations

Semantic web technology aims at developing methodologies for representing large amount of knowledge in web accessible form. The semantics of knowledge should be easy to interpret and understand by computer programs, so that sharing and utilizing knowledge across the Web would be possible. Domain specific ontologies form the basis for knowledge representation in the semantic web. Research on automated development of ontologies from texts has become increasingly important because manual construction of ontologies is labor intensive and costly, and, at the same time, large amount of texts for individual domains is already available in electronic form. However, automatic extraction of …

Computer Model Of Hybrid Compensator Of Fast Varying Loads, Veronica Bohorquez

LSU Doctoral Dissertations

A computer model of the hybrid compensator of fast varying loads was developed in this dissertation. The computer model was implemented in MFC Visual C++ compiler version 6.0. The classification of fast varying loads and effects of their operation in distribution systems were described in this dissertation. The power properties of fast varying loads were expressed in terms of the Currents' Physical Components Theory. Therefore, the Currents' Physical Components Theory was applied to systems with non-periodic voltages and currents. The supply current of the fast varying loads was decomposed into the useful and the useless components using an algorithm based …

An Investigation Of Maternal Psychopathology As A Moderator Of Child Response Following Hurricane Katrina, Ann Wingate Spell

LSU Doctoral Dissertations

Previous disaster research has focused on possible risk factors that contribute to child psychological distress following disaster exposure. One of these factors, parental psychopathology, has consistently been indicated as associated with and predictive of child functioning post-disaster. In related areas of violence exposure, researchers have gone beyond correlation and prediction in their attempt to elucidate the relationship between parental psychopathology and child functioning post-trauma. Such researchers have investigated and confirmed parental psychopathology as a moderator variable in the relationship between child violence exposure and child functioning. Thus, in considering the status of research regarding risk factors of child functioning post-disaster …

The Effects Of 3-Dimensional Cadd Modeling Software On The Development Of The Spatial Ability Of Ninth Grade Technology Discovery Students, K. Lynn Basham

LSU Doctoral Dissertations

The purpose of this quantitative study was to determine if there is a difference in the development of spatial abilities of ninth grade Technology Discovery students in Mississippi as measured by the Purdue Visualization of Rotations Test. Students experienced one of three differing instructional methods utilizing Pro/Desktop® 3-D CADD solid modeling software. Participants were students in Mississippi schools operating on a 4 x 4 block schedule during either fall or spring semesters during the 2005-2006 school year, and a control group of students whose schools did not offer CADD. Instructional material designed by the researcher was used for two instructional …

Application-Specific Reliable Data Transfer In Wireless Sensor Networks, Damayanti Datta

LSU Doctoral Dissertations

A wireless sensor network (WSN) is a collection of sensor nodes and base stations connected via wireless medium. It sends data collected from the nodes to the base stations for generating information. The size and low cost of the sensor nodes as well as the WSN's ability to connect without wired links are its key advantages which enable it to be deployed in hostile or inaccessible environments at low cost. However, WSNs suffer from high data loss due to the inherent weaknesses in a wireless transmission medium, transmission problems in hostile environments due to human interference, etc. and node failures …

Oil Bypassing By Water Invasion To Wells: Mechanisms And Remediation, Juan Carlos Hernandez

LSU Doctoral Dissertations

This study addresses oil bypassing caused by water invasion to wells in edge and bottom water-drive oil reservoirs – a significant problem worldwide. It is shown that the amount of by-passed (not recovered) oil is significant and could be predicted analytically and reduced by modifying well’s completion. A large statistical sample from the population of possible reservoir-well systems with edge and bottom-water has been created theoretically using several databases of actual reservoirs properties worldwide. Dimensional analysis allowed converting reservoir properties distributions into dimensionless group distributions. Then, the amount of by-passed oil was correlated with the dimensionless groups using designed experiments …

Laboratory Characterization And Numerical Modeling Of Geogrid Reinforced Bases In Flexible Pavements, Munir Darwish Nazzal

LSU Doctoral Dissertations

This dissertation documents the results of an extensive research study that was conducted to characterize the behavior of geogrid reinforced base course materials. The research was conducted through an experimental testing and numerical modeling programs. The experimental testing program included performing different laboratory tests to evaluate the effect of various factors on the performance geogrid reinforced base course materials. Finite element models were also developed to investigate the benefits of placing geogrids within the base course layer in a flexible pavement structure. The results of the experimental testing demonstrated that the inclusion of the geogrid reinforcement layer(s) improved the compressive …

Micro Injection Fuel/Air Premixer/Combustion, Jian Zhang

LSU Doctoral Dissertations

Lean premixed (LP) combustion has become the dominant industrial approach to reduce NOx emissions. Homogeneous mixing of lean fuel and air mixtures prevents the presence of undesirable localized regions of near-stoichiometric fuel/air mixtures, thereby allowing a reduction in thermal NOx. A new concept, a multi-point micro injection premixer, is presented in this dissertation. The multi-point micro injection premixer is a porous plate that provides a simple but extremely effective method to mix air and fuel. An array of fuel jets is injected in a direction perpendicular to the plane of the premixer plate into an oncoming counterflow stream of air. …

The Relationship Of Image And Form In Poetry, Jeremy T. Bold

Undergraduate Theses and Senior Projects

No abstract provided.

Factors That Influence The Usage Of Online Banking By The University Of North Dakota Students, Melissa Scherf

Undergraduate Theses and Senior Projects

No abstract provided.

Potential Of Co2 Enhanced Oil Recovery And Sequestration In The Golden Pinnacle Reef Reservoir In The Williston Basin, North Dakota, Charles Gorecki

Undergraduate Theses and Senior Projects

This design project is developed to determine the feasibility of CO2 Enhanced Oil Recovery (EOR) and CO2 sequestration in the Golden Pinnacle Reef Reservoir in the Williston Basin, North Dakota; with a specific analysis of the Shell Golden #34X-34 (SWSE 34 T161N R87 W) well in Renville County, North Dakota, USA. The objectives of this research are to: (1) Characterize the candidate reservoir; (2) Estimate the potential of CO2 EOR and the capacity of CO2 sequestration; and (3) Optimize the operations under different production/injection and economic options. This research is conducted to establish the reservoir parameters and future production possibilities …

Reservoir Characterization Of The Broom Creek Formation For Carbon Dioxide Sequestration, Justin J. Kringstad

Undergraduate Theses and Senior Projects

This engineering design is aimed at providing a thorough investigation on the potential of carbon dioxide (CO2) sequestration in the Williston Basin’s Broom Creek Formation. The objective of the design is to characterize the Broom Creek’s reservoir properties and provide detailed results of CO2 sequestration capacity, plume migration, and safety level. The methodology used to obtain results is an incorporation of geology, reservoir engineering, and injection operations. The reservoir simulation operations were conducted using Schlumberger’s ECLIPSE (Schlumberger, 2006).

Levee Stabilization Design For Flood Control In East Grand Forks, Minnesota, Heather N. Lammers

Undergraduate Theses and Senior Projects

This design investigates stabilization methods for a failing levee system using the method of slices. An assumed failure surface was drawn and divided into vertical slices, where the forces acting on each slice were analyzed. If the forces available to resist movement were greater than the forces driving movement, the slope was considered stable (Rahn 1996). A factor of safety was then calculated by dividing the forces resisting movement by the forces driving movement. A factor of safety of 0.987 was initially obtained, which meant failure at the toe of the embankment was occurring. With the addition of a 4 …

Alternative And Renewable Energy, Emil Opitz

Undergraduate Theses and Senior Projects

The world is going to run out of fossil fuels in the near future. An estimated one to two trillion barrels of oil is believed recoverable using today’s technologies. This amount of oil will last the world no more than 70 years, and perhaps only half that long. A system of alternative and renewable fuels is our only solution to this problem. With proper action and development, a worldwide energy crisis will be avoided.

We have an abundance of renewable and alternative energy sources that are not currently being used, enough to supply almost all of our energy needs. Wind …

In Silico Analysis Of Terpene Synthase Genes In Arabidopsis Thaliana, Sam Zwenger, Chhandak Basu

Biological Sciences Faculty Publications

Terpenes are defense chemicals found in wide groups of plants. Terpenoids play a large role in plant development and stress response. The terpene synthase family comprises a diverse set of genes, all which contribute to production of terpenoids. We have used tools of bioinformatics and performed an in silico analysis of developmental and tissue specific terpene synthase gene expression in Arabidopsis thaliana, as well as those expressed due to biotic and abiotic environmental stimuli. Using software tools from Genevestigator, a powerful microarray analyzer, we used multiple tool sets to better understand terpene synthase expression in Arabidopsis, which will hopefully open …

Optimization Of Porcine Buccal Mucosa For In Vitro Evaluation, Upendra D. Kulkarni

University of the Pacific Theses and Dissertations

Porcine buccal mucosa has been extensively used as in vitro model to study the permeability of drugs and assess their potential to deliver through buccal route. Porcine buccal mucosa is found to be very similar to human oral mucosa in structure and function. However, the in vitro permeation studies across porcine buccal mucosa show high variability which is mostly due to the various experimental and biological variables that are often overlooked while conducting such studies.

The precise nature of the permeability barrier offered by the various tissue layers of buccal mucosa was investigated in this study. It was observed that …

College Students And Voter Mobilization Campaigns : A Grounded Communication Theory For Increasing Political Efficacy And Involvement, Vanessa M. Robinson

University of the Pacific Theses and Dissertations

This study examined which channels, messages, and sources were most effective in increasing political involvement among college students. Political participation among college students has decreased in every election since eighteen year- olds were given the right to vote. Numerous campaigns targeted to increase political participation among college students have been implemented but there is no evidence that these campaigns have been effective.

This study developed a grounded theory for increasing political participation among college students l;!ased on several focus group interactions. Students were asked to report on which channels, messages and sources they currently received political information from and were …

Novel Concepts For Enhanced Nuclear Thermal Propulsion Using Flow Area Tailoring And A Grooved-Ring Core Design, Julien Michel Apeloig

Theses and Dissertations

The most likely candidate for human missions to Mars and beyond will be spacecraft using Nuclear Thermal Propulsion (NTP). NTP provides for high thrust-to-weight ratio and significantly improved specific impulse over even the best chemical rockets. The improved specific impulse reduces required trip times, thereby minimizing the exposure time of the crew to space radiation. Using the PHOEBUS 2A 5 GW reactor, developed in the 1960’s with a thrust of 1,113 N and a specific impulse of 820 s, as a basis for comparison this thesis focuses on efforts to improve the specific impulse and reactor longevity. Hydrogen is the …

Taking Shareholder Rights Seriously, Julian Velasco

Journal Articles

The great corporate scandals of the recent past and the resulting push for legal reform have revived the role of the shareholder in the corporation as a subject of great debate. Those who favor an expanded role for shareholders in corporate governance tend to focus on developing new legal rights for shareholders, and their critics respond with reasons why such rights are unnecessary and inappropriate. While these issues certainly are worthy of consideration, issues concerning existing shareholder rights are more fundamental. If existing rights are adequate or could be improved, then new rights may not be necessary; but if existing …

Abstraction, Technology, And Power, John Wilkinson

Theses and Dissertations (Comprehensive)

The work's central question is how technological designs affect the political power of individuals. This discussion supplements claims that more democratic control over the design and deployment of technology is necessary; it does so by showing how the general tendency toward parametric designs creates technological delegates: artifacts to which we inadvertently delegate our political powers. "Delegation" in this sense is the central theme. It is developed in the context of recent philosophy and sociology of technology, as well as ecofeminism and the existentialism of Gabriel Marcel and Martin Heidegger. A distinction is made between live and dead abstractions (chapter two); …

Non-Pecuniary Interests And The Injudicious Limits Of Appellate Standing In Bankruptcy, S. Todd Brown

Journal Articles

Standing to appeal bankruptcy court orders today is limited to those with a pecuniary interest. This prudential limitation is based on the person aggrieved requirement of Section 39(c) of the Bankruptcy Act of 1898 - a requirement that was not included in the Bankruptcy Code. This article examines the extensive differences between the Act and the Code, the potential justifications for extending the pecuniary interest test in spite of the omission of the person aggrieved requirement, and the potential ramifications for parties and the integrity of the bankruptcy process. This analysis suggests that standing to appeal bankruptcy orders should be …

Análisis De Deslizamientos En La Ciudad Capital Utilizando Sistemas De Información Geográfica, Pedro Pablo Conlledo, Ronaldo Luna

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

En Guatemala, los daños ocasionados por deslizamientos de tierra son innumerables, y sin embargos son pocos los esfuezos que se han hecho a nivel nacional por estudiarlos. El principal objetivo de este trabajo fue utilizar Sistemas de lnformacion Geografica (SlG) para estudiar sistematicamente la ocurrencia de deslizamientos en el Departamento de Guatemala con la informacion disponible.

Rodmrp - Resilient On Demand Multicast Routing Protocol, Dhammika Pathirana

Theses

ODMRP (On-Demand Multicast Routing Protocol) [6] [8] [2] is a popular multicast protocol for wireless ad hoc networks. The strengths of ODMRP are simplicity, high packet delivery ratio, and non-dependency on a specific unicast protocol. ODMRP floods a route request over the entire network to select a set of forwarding nodes for packet delivery. However, a single forwarding path is vulnerable to node failures, which are common due to the dynamic nature of mobile ad hoc networks. Furthermore, a set of misbehaving or malicious nodes can create network partitions and mount Denial-of-Service (DoS) attacks. This thesis proposes a ODMRP-based wireless …

Enron And The Special Purpose Entities - Use Or Abuse - The Real Problem - The Real Focus, Neal Newman

Faculty Scholarship

On the heels of Enron's debacle came the Sarbanes-Oxley Act of 2002, the far reaching legislative reform that was designed to shore-up the accounting and corporate governance shortfalls that the legislature and the investing public believed allowed Enron to do what it did unabated. Supplementing the reforms set forth in the Sarbanes-Oxley Act are a number of accounting rules, guidelines, and interpretations that are designed to curtail the type of accounting fraud Enron perpetrated through its use (or more accurately abuse) of what are referred to as special purpose entities (SPEs). Although much has been written chronicling and analyzing the …

Formation Of In- (2×1) And In Islands On Si (100) - (2×1) By Femtosecond Pulsed Laser Deposition, M. A. Hafez, H. E. Elsayed-Ali

Electrical & Computer Engineering Faculty Publications

The growth of indium on a vicinal Si (100) - (2×1) surface at room temperature by femtosecond pulsed laser deposition (fsPLD) was investigated by in situ reflection high-energy electron diffraction (RHEED). Recovery of the RHEED intensity was observed between laser pulses and when the growth was terminated. The surface diffusion coefficient of deposited In on initial two-dimensional (2D) In- (2×1) layer was determined. As growth proceeds, three-dimensional In islands grew on the 2D In- (2×1) layer. The RHEED specular profile was analyzed during film growth, while the grown In islands were examined by ex situ atomic force microscopy. The full …