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Characterization Of The Anti-Angiogenic Properties Of Kdr-Ig4-7 And Its Variants As Potential Anti-Cancer Therapeutics, Jang Pyo Park

All Dissertations

Beginning with the development of an embryo and throughout one's adult life angiogenesis plays an essential role for organ growth and repair. The balancing of pro-angiogenic factors to anti-angiogenic factors is what regulates the process of angiogenesis. When this balance is disrupted in one direction or the other, numerous disorders can occur including ocular and inflammatory diseases and, in particular, tumor growth and metastasis. Therefore, inhibition of angiogenesis has become an effective therapy for arresting the growth of tumors.
A key regulator of angiogenesis involves vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (KDR). The binding of VEGF to …

Phylogeny And Classification Of Hydropsychidae Subfamilies And Genera Of The World (Insecta: Trichoptera), Christy Geraci

All Dissertations

The family Hydropsychidae is nearly ubiquitous in streams and rivers, with over 1600 described species worldwide. Hydropsychidae is ecologically important and its larvae play key roles as indicators of water quality. Conflicting morphological characters have obscured the evolutionary history of the subfamilies, and the wide diversity of phallic morphology among Hydropsyche sensu lato species has created unstable classification systems that have been disputed among authors. My research used five nuclear ribosomal and mitochondrial COI fragments to infer a molecular phylogeny for Hydropsychidae subfamilies and genera, focusing particularly on the Hydropsychinae and the Hydropsyche sensu lato lineage. The monophyly of four …

Board Of Directors Meeting Minutes (December 10, 2007), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on December 10, 2007.

The Role Of Inspiration In Scientific Scholarship And Discovery: Views Of Theistic Scientists, Kari Ann O'Grady

Theses and Dissertations

This qualitative research study examined the ways those who identify themselves as theistic scientists and scholars experience inspiration, as defined as divine guidance or influence, in their scientific scholarship and discovery. It also explored participants' beliefs about how scientists and scholars can seek and prepare to receive inspiration in their work. Open-ended surveys of 450 participants from the behavioral and natural sciences and from a variety of religious backgrounds were analyzed for content themes in the areas of experiences with inspiration, preparing to receive inspiration, and further thoughts on inspiration in science. The themes extracted indicated that these scientists and …

Monitor Newsletter December 10, 2007, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

Porcine Intestinal Epithelial Cell Lines As A New In Vitro Model For Studying Adherence And Pathogenesis Of Enterotoxigenic Escherichia Coli, Seung Y. Koh, Sajan George, Volker Brozel, Rodney A. Moxley, David H. Francis, Radhey Kaushik

School of Veterinary and Biomedical Sciences: Faculty Publications

Enterotoxigenic Escherichia coli (ETEC) infections result in large economic losses in the swine industry worldwide. The organism causes diarrhea by adhering to and colonizing enterocytes in the small intestines. While much progress has been made in understanding the pathogenesis of ETEC, no homologous intestinal epithelial cultures suitable for studying porcine ETEC pathogenesis have been described prior to this report. In the current study, we investigated the adherence of various porcine ETEC strains to two porcine (IPEC-1 and IPEC-J2) and one human (INT-407) small intestinal epithelial cell lines. Each cell line was assessed for its ability to support the adherence of …

Comparison Of Compost Tea And Biological Fungicides For Control Of Early Blight In Organic Heirloom Tomato Production, Richard Kouyoumjian

All Theses

The efficacy of compost tea was evaluated and compared alone and in combination with two biofungicides Serenade Max and Sonata for control of early blight caused by the fungal pathogen Alternaria tomatophila on tomato Solanum lycopersicum (L), heirloom cultivar `Cherokee Purple'. Results of field experiments over two growing seasons indicated that compost tea provided a low level of protection against early blight. The results were variable; most likely due to dry conditions and the presence of bacterial wilt the first year and tomato spotted wilt virus the second year. In both 2006 and 2007 field trials compost tea was not …

Revisioning History: A Rhetorical Redesign Of The Charleston Museum, Brittany Minors

All Theses

The Charleston Museum has the distinction of being the oldest museum in the United States, founded in 1773 and still operating today. It was begun as a branch of the Charleston Library Society and soon grew to be a significant institution in Southern and American scientific discovery and research. Over the 225 years of its existence, it has amassed an impressive collection of natural history specimens, as well as rare artifacts of Lowcountry history and culture. Unfortunately, the exhibits have been neglected since their most recent installment (roughly 20 years ago) and are in need of visual and ideological revision. …

Katherine Anne Porter's Adaptation Of Joycean Paralysis In The Pale Horse, Pale Rider Collection, Jamie Colwell

All Theses

This thesis is a study of Katherine Anne Porter's Pale Horse, Pale Rider collection in relationship to James Joyce's Dubliners. The main focus of this study is Porter's use of Joycean paralysis in the three stories 'Old Mortality,' 'Noon Wine,' and 'Pale Horse, Pale Rider.' There is evidence in interviews and letters of Porter's admiration of Joyce, and her characters' states of hopelessness reflect a similar paralysis to those found in the following selections of Dubliners: 'The Dead,' 'Grace,' and 'Eveline.' Porter's collection of stories is not an imitation of Joyce's work; her voice and story setting remain distinct. However, …

Figuring The Digital, Molly Morin

All Theses

This body of work is a way of understanding, reflecting on, and contributing to a contemporary dialogue about the impact of digital technology and the Internet on society by looking at the organization of information that lies behind the computer screen, and creating work that is sourced directly from the Internet but becomes a tangible object in the physical world. I use methods of mass production and marketing to create artwork that values individuality over homogenization and complexity over efficiency, co-opting practical digital technology for the purposes of physical beauty. The work should inspire a sense of wonder through its …

Effects Of Season Of Fire On Red-Cockaded Woodpecker (Picoides Borealis) Reproduction And The Breeding Bird Community Of A Longleaf Pine Ecosystem, Sarah Lauerman

All Theses

Fire is the most important management tool in restoring and maintaining the longleaf pine ecosystem but the effects of season of burning on fauna are not fully understood. Of particular concern is the community of birds which breed in the longleaf pine forest, several of which are endangered, threatened or species of concern. This study examined the effects of season of fire on the breeding bird community and a population of red-cockaded woodpeckers (RCW) at Brosnan Forest in Dorchester, South Carolina. Fifty-eight RCW territories received dormant or growing season fire over a five-year period from 2001 to 2005. Prior to …

Multi-Objective Generation Scheduling With Hybrid Energy Resources, Manas Trivedi

All Dissertations

In economic dispatch (ED) of electric power generation, the committed generating units are scheduled to meet the load demand at minimum operating cost with satisfying all unit and system equality and inequality constraints. Generation of electricity from the fossil fuel releases several contaminants into the atmosphere. So the economic dispatch objective can no longer be considered alone due to the environmental concerns that arise from the emissions produced by fossil fueled electric power plants. This research is proposing the concept of environmental/economic generation scheduling with traditional and renewable energy sources. Environmental/economic dispatch (EED) is a multi-objective problem with conflicting objectives …

The Diffusion Of The Reggio Emilia Approach Among Early Childhood Teacher Educators In South Carolina, Julie Hartman

All Dissertations

Growing numbers of U.S. educators are traveling to the northern Italian town of Reggio Emilia to study the innovative, arts-based approach to early education developed in the town's municipal infant-toddler and pre-primary programs now commonly referred to as the Reggio Emilia Approach. And though there is no way of knowing exactly how many educators and early childhood programs across the U.S. are currently making use of the approach, increasing numbers of U.S. colleges and universities are including the approach in both their ECE teacher preparation as well as campus child development programs, suggesting the Reggio Emilia Approach (REA) is diffusing …

A Comparative Fault Diagnosis Methodology Based On Time Series Analysis Of System's Signals, Hany Bassily

All Dissertations

The detection of system anomalies represents an important task in safety critical systems. Over the past two decades, advances in data manipulation techniques and sensor technology have contributed to the widespread application of signal processing concepts for fault diagnosis. However, the majority of these signal processing, or data driven, diagnostics do not possess the redundancy level exhibited in conventional model-based methods. Among signal processing methods, time series analysis is advantageous since it offers insight into the underlying dynamics and forecasts system behavior. Furthermore, the data driven method allows the depiction of system dynamics with an increased level of redundancy. This …

The Molecular Characterization Of The Virus And Virus-Like Agents Present In Ta Tao 5 Germplasm Of Prunus Persica , Diana Marini

All Dissertations

Peach production in the southeastern United States is limited by late spring freezes. Ta Tao 5 germplasm, used either as an interstem or by chip bud inoculation, has been shown to delay bloom and avoid the effects of these late freezes. The growth modification is graft transmissible and the germplasm has been found to be infected with ACLSV, APruV-3, and PLMVd. Using a combination of PCR, cloning, and sequencing techniques, a molecular characterization of the three graft-transmissible agents present in Ta Tao 5 has been completed.

The complete nucleotide sequence of the genome of the isolate of ACLSV (ACLSV-Ta Tao …

Ultrahydrophobic Surface Modification Of Polymeric Fibers And Inorganic Substrates, Karthik Ramaratnam

All Dissertations

The wettability of a solid surface is a very important property, and is governed by both the chemical composition and the geometrical microstructure of the surface. Wettability and repellency are important properties of solid surfaces from both fundamental and practical aspects. The wettability of the solid surface is a characteristic property of materials and strongly depends on both the surface energy and the surface roughness. These properties may be approached by mimicking hydrophobic structures created by nature on lotus leaf surface. The lotus effect is based on surface roughness caused by different microstructures together with the hydrophobic properties of the …

Fungal Conversion And Supercritical Carbon Dioxide Processing For Value-Added Canola Oil, Meidui Dong

All Dissertations

There is a growing awareness of health benefits of polyunsaturated fatty acids (PUFAs) e.g. arachidonic acid (ARA, C20:4n6) and eicosapentaenoic acid (EPA, C20:5n3). In general, plant seed oil and animal fat do not contains long-chain PUFAs with more than eighteen carbons. This study investigated the feasibility for addition of ARA and EPA to canola oil through the fermentation of fungi, Mortierella alpina, using canola flake, cake or meal as substrates. Supercritical CO2 extraction was also investigated for lipid extraction. In addition, a supercritical CO2 explosion process was characterized and applied to enhance oil extraction using supercritical CO2 and to potentially …

Nesting And Foraging Characteristics Of The Black Carpenter Ant Camponotus Pennsylvanicus (Degeer) (Hymenoptera: Formicidae), Donald Oswalt

All Dissertations

Potential nesting sites of Camponotus pennsylvanicus (DeGeer) were investigated in South Carolina to determine if nesting sites features could be characterized by habitat features for black carpenter ant nests. Environmental data from forested plots showed large-scale habitat features such as vegetation density and canopy cover were not useful as indicators for the presence or absence of nests. Small-scale individual nest characteristics such as diameter at breast height of trees, log length, tree defect type or tree species were better indicators of occupied nests. In my study, C. pennsylvanicus preferred mature hardwood (Quercus spp.) trees approximately 30 cm in diameter and …

Development Of Novel Prolactin And Growth Hormone Receptor Agonists And Antagonists, John Langenheim

All Dissertations

Potential indications for human prolactin (hPRL) and human growth hormone (hGH) are the support and sustainment of lactation and the enhancement or reconstitution of the immune system when under dysregulation. A prolactin receptor (PRLR) antagonist, hPRL-G129R (G129R), and a PRLR and growth hormone receptor (GHR) antagonist, hGH-G120R (G120R), have been developed which may be useful for the treatment of breast cancer since PRLR is elevated in a majority of human breast tumors and makes cancer cells highly sensitive to the mitogenic and anti-apoptotic activity of hPRL and hGH.

As a single agent, G129R is more cytostatic than cytotoxic to human …

Thermodynaimic Study Of Nucleic Acids Recognition By Aminoglycosides , Hongjuan Xi

All Dissertations

ABSTRACT


Since the origin of first aminoglycosides antibiotics, streptomycin, isolated by Selman Waksman about 60 years ago, a number of aminoglycosides antibiotics were discovered to treat different infections. Neomycin class aminoglycosides were found to originally target the A site 16S rRNA in the 30S subunit of the ribosome within the Gram-negative bacteria. In addition to its antibacterial effect, aminoglycosides were also found to binding to various other viral RNA structures such as TAR and RRE of HIV, Group I introns and hammerhead ribozyme, implying its potential to be used as antiviral reagent.

Furthermore, previous studies in our laboratory discovered a …

Water Quality Dynamics Of Lake James In The Catawba River Basin Of North Carolina, Susan Stokes

All Dissertations

Lake James is the uppermost hydropower reservoir in the Catawba River drainage in North Carolina. The Lake James Assessment (LJA) was a descriptive study initiated between Clemson University and Duke Energy Corporation to explore the physical, chemical and biological dynamics of this oligotrophic reservoir from spring 1997 through fall 1999 (Schindler 1997). The goals of this study were to ascertain the primary drivers for the chemical dynamics of Lake James, to assess the quantities of constituents entering and leaving the reservoir, where these chemicals were incorporated within the reservoir basins, and to evaluate the efficacy of the LJA chemical budget …

The Lss Supernodulation Mutant In Medicago Truncatula: Genetics, Characterization And Mapping, Arijit Mukherjee

All Dissertations

The symbiotic association between legumes and nitrogen fixing rhizobia culminates in the formation of root nodules. Legumes control the extent of root nodule formation through a regulatory mechanism in which nodulating roots induce a shoot response that signals back to the roots, inhibiting further nodule initiation. Disruption of genes involved in this regulatory process lead to super or hypernodulation. The lss (like sunn supernodulator) mutant of Medicago truncatula has been identified as a naturally occurring supernodulation mutation in the Jemalong cultivar. The phenotype of lss is practically indistinguishable from the phenotype of the previously isolated sunn mutant with respect to …

Studies In The Biochemistry And Cell Biology Of Trypanosoma Brucei Hexokinases, Jeremy Chambers

All Dissertations

Trypanosoma brucei expresses two hexokinases (TbHK1 and TbHK2) that are 98% identical at the amino acid level. We previously found that recombinant TbHK1 (rTbHK1) has hexokinase activity, while rTbHK2 did not, a finding attributed to differences in the C-termini of the proteins. We found that the C-terminal tails of TbHK contained a novel motif specific for eukaryotic hexokinases found within the final helix of an ATP-binding domain. By altering the residues in the C-terminal tail of TbHK1 to resemble the residues found in TbHK2, we found that D454, F462, M466, and N469 were essential to TbHK1 catalysis. Additionally, we found …

Diversity And Abundance Of Ants At Forest Edges , Eric Paysen

All Dissertations

Fragmented habitats are a common result of human activities that involve the clearing of native vegetation for various land uses. Habitat fragmentation has two primary and inseparable components: habitat loss and insularization. Landscape-level connectivity in fragmented habitats is diminished for many species, and edge characteristics become more important as the edge-to-interior ratio increases. The study of the effects of edges on biodiversity has compelled ecologists to study them for over a century and has influenced the design and management of natural preserves. Invasion of habitats by non-native species is a phenomenon that coincides with the increased human activity typical of …

Influence Of Mercury-Dissolved Organic Matter (Dom) Complexation On Toxicity In Natural Waters, Christina Mcnaughton

All Dissertations

Global industrialization, coupled with a large biogeochemical cycle that moves mercury through the environment, has resulted in higher mercury concentrations being detected in many environmental compartments. Although the presence of mercury in each compartment has the potential to elicit toxicity, mercury found in natural waters provides the greatest risk, due to the various reactions it can undergo, resulting in a plethora of different species.
Due to the fact that mercury contamination in aquatic systems has the potential to bioaccumulate and biomagnify up the food chain and cause toxicity, understanding the behavior of mercury in these systems is imperative in the …

Development Of An In Vitro Test System For Breast Cancer Research, Chih-Chao Yang

All Dissertations

In the United States, breast cancer is the third most common cause of cancer death (after lung cancer and colon cancer). In 2007, breast cancer is expected to cause 40,910 deaths (7% of cancer deaths; almost 2% of all deaths) in the U.S. The long term goal of this project is to develop an in vitro test system that can be used to develop breast cancer vaccine or screen breast cancer chemotherapy. This dissertation was driven by four objectives and it can be thought as a toolbox that provides practical experimental design and lab work for the development of an …

Central Florida Future, Vol. 39 No. 148, December 10, 2007

Central Florida Future

Thanks for the memories; DUI charges follow hit-run; Counseling program addresses suicide; Board allots tuition money.

In The Name Of Educational Research, Shafqat Hussain

Institute for Educational Development, Karachi

No abstract provided.

Commencement Speech - Dec 2007, George C. Wright

President Emeritus George C. Wright Speeches

No abstract provided.

Volume 43 - Issue 10 - Friday, December 7, 2007, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.