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2007

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Sexual Violence And Correlates Among Women In Hiv Discordant Union, Uganda, Donath Emusu Jan 2007

Sexual Violence And Correlates Among Women In Hiv Discordant Union, Uganda, Donath Emusu

All ETDs from UAB

We sought to estimate the prevalence of sexual violence and sexually transmitted diseases (STDs), identify risk factors for sexual violence and STDs among women in Human Immunodeficiency Virus (HIV) discordant unions, and investigate the lived experiences of sexual violence among women in HIV discordant unions attending post-test club services at AIDS Information Centers (AICs) in Uganda. We carried out a prospective cohort study of women in HIV discordant and HIV negative concordant unions after disclosure of their HIV serostatus. We estimated prevalence of STDs in the two study cohorts and compared them for occurrence of risk factors for sexual violence …

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Characterization, Community Structure And Ecological Importance Of Sponge-Associated Bacteria, Patrick M. Erwin Jan 2007

Characterization, Community Structure And Ecological Importance Of Sponge-Associated Bacteria, Patrick M. Erwin

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The study of sponge-bacteria symbioses is emerging as a prominent field in marine biology and biotechnology, with implications ranging from a fundamental understanding of sponge ecology and insight into the evolution of prokaryote-eukaryote symbiotic interactions to natural products prospecting and bioactive metabolite synthesis. The research conducted herein integrates molecular genetic techniques with ecological methodologies to address fundamental issues of sponge-microbe associations. Bacterial communities associated with the marine sponges Hymeniacidon heliophila and Xestospongia sp. were compared to microbial assemblages from ambient seawater and the sympatric tunicate, Didemnum sp, using replicated clone libraries of 16S ribosomal RNA (rRNA) genes and terminal restriction …

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Pneumococcal Choline-Binding Protein A: Its Role In Virulence And Its Utility As A Streptococcus Pneumoniae Vaccine Antigen, David Tawayne Glover Jan 2007

Pneumococcal Choline-Binding Protein A: Its Role In Virulence And Its Utility As A Streptococcus Pneumoniae Vaccine Antigen, David Tawayne Glover

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Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. S. pneumoniae is a leading cause of pneumonia, meningitis, septicemia, and otitis media. Although all age groups can be affected, children and the elderly are espccially susceptible to infection. Currently there is a conjugate vaccine available for use, but this vaccine only contains capsular polysaccahride antigens from the seven most prevelant S. pneumoniae serotypes. The use of the conjugate vaccine has led to serotype shift, with more disease being caused by non-vaccine serotype bacteria. The studies presented in this dissertation identify and characterize a novel S. penumoniae vaccine candidate …

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A Role For P63 In The Regulati On Of Cell Cycle Progression And Cell Death, Eric Scott Helton Jan 2007

A Role For P63 In The Regulati On Of Cell Cycle Progression And Cell Death, Eric Scott Helton

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p63 is a member of the p53 family of transcription factors that is a critical regulator of epithelial development. Studies have shown that p63 does not appear to function as a classical tumor suppressor like p53. Instead, the expression pattern of p63 in cancers suggests that p63 retains the potential to function as either a tumor suppressor or an onco-protein. Here, we provide evidence describing the transcriptional activity of the p63 isoforms and provide mechanisms whereby p63 function is regulated in a context dependent manner. Our data shows that both the ΔNp63 and TAp63 variants retain the potential to regulate …

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Prostate Cancer Chemoprevention With Genistein And Resveratrol In Models Of Spontaneously Developing Prostate Cancer, Curt E. Harper Jan 2007

Prostate Cancer Chemoprevention With Genistein And Resveratrol In Models Of Spontaneously Developing Prostate Cancer, Curt E. Harper

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Prostate cancer is the second leading cause of cancer-related death among men in the United States. The goal of this research was to investigate the potential of three nutriceutical polyphenols, genistein, resveratrol, and epigallocatechin-3-gallate (EGCG), to suppress prostate cancer. Cancer chemoprevention and mechanism of action studies were carried out in transgenic models of prostate cancer. In TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, resveratrol suppressed poorly differentiated tumors by 86%, whereas EGCG suppressed precancerous lesions, but failed to prevent late-stage prostate cancer. Agents that were chemopreventive in the TRAMP model were subsequently evaluated alone, and in combination, in the …

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Teaching Reading Using Informational Texts In Third Grade Classrooms: A Case Study In An Urban School District, Dimple J. Martin Jan 2007

Teaching Reading Using Informational Texts In Third Grade Classrooms: A Case Study In An Urban School District, Dimple J. Martin

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The purpose of these multiple descriptive case studies was to describe and analyze the perspectives of three third grade classroom teachers and two third grade reading coaches regarding the use of informational texts and their influence on reading instruction. The research design involved interviews, and observations using a sample composed of three third grade classroom teachers and two third grade reading coaches in five urban, public elementary schools in the Southeastern United States. The aim of this research was to portray a vivid description of the reading episodes in third grade classrooms. The key findings from the study were that …

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Primer Selection Of E. Coli Trna Lys,3 By Human Immunodeficiency Virus Type-1, Anna Mcculley Jan 2007

Primer Selection Of E. Coli Trna Lys,3 By Human Immunodeficiency Virus Type-1, Anna Mcculley

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Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome (AIDS). HIV replication includes the notable process of reverse transcription, a conversion of RNA to DNA. Reverse transcription is initiated from a primer by a viral enzyme, reverse transcriptase. The primer, tRNALys,3, is selected from the cytoplasm of an infected cell, annealed via the 3’ terminal 18-nucleotides to the viral primer binding site (PBS), and used in a subsequent infection. The mechanism of primer selection has not been determined although numerous studies have been performed. This has been hampered by the challenge of tRNALys,3 manipulation in the cell and …

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Sperm Production And Vitellogenesis As Biomarkers Of Endocrine Disruption In The Male Western Mosquitofish, Gambusia Affinis, Paul D. Melvin Jan 2007

Sperm Production And Vitellogenesis As Biomarkers Of Endocrine Disruption In The Male Western Mosquitofish, Gambusia Affinis, Paul D. Melvin

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Estrogenic compounds of anthropogenic origin enter the environment from several different sources, including domestic wastewater and agricultural runoff. Natural estrogens, synthetic estrogens, and estrogen breakdown products have been identified in wastewater treatment plant (WWTP) effluents. These compounds have direct and indirect effects on the endocrine systems of organisms living in the receiving waters. Male mosquitofish (Gambusia affinis) have been suggested as model bioindicator organisms for endocrine disruption by estrogenic compounds for a variety of reasons, including their hardiness, broad environmental tolerances (including temperature, salinity, and dissolved oxygen), widespread geographical distribution, and ease of use in the laboratory. We examined two …

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Directing Akt And Gsk3ss: Molecular Insights Into Cell Signaling And Survival, Gordon P. Meares Jan 2007

Directing Akt And Gsk3ss: Molecular Insights Into Cell Signaling And Survival, Gordon P. Meares

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Proper regulation of survival signaling is critical for all organisms. One important signaling cascade involved in the coordinated effort to control signals influencing cell fate is the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3β (GSK3β) signaling cascade. Following activation by growth factors the PI3K-Akt pathway promotes cell survival and, cell death is facilitated following inhibition of Akt. Many factors influence the function of the Akt-GSK3β signaling dyad, including phosphorylation, protein complex formation and subcellular localization. Previous work had demonstrated that the 90kDa heat shock protein, HSP90, directly binds and stabilizes Akt. Furthermore, several heat shock proteins including HSP90 and HSP105 can …

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Retinal Pigment Epithelial Cells And The Insulin-Like Growth Factor System In Proliferative Vitreoretinopathy, Sudipto Mukherjee Jan 2007

Retinal Pigment Epithelial Cells And The Insulin-Like Growth Factor System In Proliferative Vitreoretinopathy, Sudipto Mukherjee

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The goal of this study was to determine the influence, if any, of the insulin-like growth factors (IGFs) on retinal pigment epithelial (RPE) cell tractional force generation and the contributions of vitreous insulin-like growth factor binding proteins (IGFBPs) towards control of IGF activity. Another objective was to evaluate RPE cells as a potential source of all six high-affinity IGFBPs and to determine if IGFBP biosynthesis is modulated in concert with phenotype changes and growth factor stimuli known to be present in disease. RPE generate tractional forces in response to IGF-I and -II with IGF-I being the more potent stimulus. Differential …

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Delayed Childbearing, Pregnancy Spacing And Impact On Subsequent Pregnancy Outcomes: Missouri Resident Mothers 1978-1997, Sarah K. Nabukera Jan 2007

Delayed Childbearing, Pregnancy Spacing And Impact On Subsequent Pregnancy Outcomes: Missouri Resident Mothers 1978-1997, Sarah K. Nabukera

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Introduction The main objective of the study was to examine reproductive health issues among women delaying initiation of childbearing until age 30 or older. Specifically, it examined pregnancy spacing patterns, relationship between pregnancy spacing and subsequent perinatal outcomes as well as racial differences in spacing and adverse perinatal outcomes. Methods A retrospective cohort study was conducted using the Missouri maternally linked live birth, fetal death and infant death files 1978-1997. The study sample was limited to mothers residing in Missouri during the study period, having first pregnancy at age 20-50 years, as well as a subsequent second pregnancy. Final study …

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Association Between The Exposure To Aflatoxin And Micronutrient Status Of Hiv Infected Adults In Ghana, Francis Ayodele Obuseh Jan 2007

Association Between The Exposure To Aflatoxin And Micronutrient Status Of Hiv Infected Adults In Ghana, Francis Ayodele Obuseh

All ETDs from UAB

Aflatoxins, found naturally in some foods are toxic metabolites of some Aspergillus species.They constitute the most potent hepatocarcinogens known and are also mutagenic and hepatotoxic. The preponderance of evidence indicates that aflatoxin is the major cause of hepatocellular cancer. In studies conducted in Africa, food-borne aflatoxin exposure is common (Oyelami et al. 1996; Egal et al. 2005). There is a critical need for additional information on health outcomes associated with exposure to aflatoxin in humans, especially in developing countries with a higher degree of malnutrition and likelihood of HIV infections. We sought to test the hypothesis that aflatoxin B1 and …

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Temperament, Sensation-Seeking, Sleep Patterns, And Alcohol Use During A Competitive Athletic Season: Predicting Injuries In College Athletes, Zachary H. Osborn Jan 2007

Temperament, Sensation-Seeking, Sleep Patterns, And Alcohol Use During A Competitive Athletic Season: Predicting Injuries In College Athletes, Zachary H. Osborn

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Temperament, sensation-seeking, general personality variables, sleep patterns, and alcohol use have all been shown to be related to injuries in both community-based and athlete samples. However, these variables have not been studied in concert with one another to examine how they might interact to predict injuries. One-hundred and seventy-eight athletes (both football and soccer) completed pre-season alcohol use and sleep pattern questionnaires, as well as personality measures. The results indicated that playing football predicted more total injuries. No other personality, sleep, or alcohol use variables were predictive of injuries or injury related variables. Analyses also indicated that football players suffered …

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Regulation Of Vertebrate Gastrulation By Erbb Signaling, Shuyi Nie Jan 2007

Regulation Of Vertebrate Gastrulation By Erbb Signaling, Shuyi Nie

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ErbB receptor tyrosine kinases have long been implicated in cancer formation and progression by regulating cell division, migration, and survival. ErbBs are also essential in multiple processes during invertebrate development; however, their activities during vertebrate embryogenesis are not well understood. For functional characterization of ErbB signaling during vertebrate development, frog model Xenopus laevis was used in our studies. The expression pattern and the general activities of ErbB receptors during early frog development were first analyzed and results shown that ErbBs regulate gastrulation, somite organization and head patterning. As gastrulation is the first major morphogenetic event in vertebrate development, I focused …

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Surveying The Chromosomal Supercoiling Levels In Rapidly Growing Wild Type And Gyrase Mutant Strains Of Salmonella Enterica Serovar Typhimurium With Γδ Resolvase-Mediated Recombination Assay, Zhenhua Pang Jan 2007

Surveying The Chromosomal Supercoiling Levels In Rapidly Growing Wild Type And Gyrase Mutant Strains Of Salmonella Enterica Serovar Typhimurium With Γδ Resolvase-Mediated Recombination Assay, Zhenhua Pang

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A gyrase mutant strain (gyrB652) has severe growth defect at 42°C. The survival at high temperature is dependent on DNA repair proteins. The purified mutant gyrase was assayed for supercoiling acitivity and quinolone-induced DNA cleavage activity. The results suggested that the mutant enzyme is not temperature-sensitive, but has slower kinetics than the wild type gyrase. The DNA supercoiling levels at multiple chromosomal loci in exponential phase cells were monitored with γδ resolvase-mediated recombination assay. The wild type cells showed homogenous supercoiling levels throughout most of the chromosome. But the superhelicity at dif locus was significantly lower than the other loci. …

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Insulin Dynamics In African Americans And European Americans: Mechanistic Aspects, And Association With Inflammation, Radhika P. Phadke Jan 2007

Insulin Dynamics In African Americans And European Americans: Mechanistic Aspects, And Association With Inflammation, Radhika P. Phadke

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Identification and characterization of ethnic differences in insulin dynamics, insulin sensitivity (SI), and inflammation may shed light on the greater risk for type 2 diabetes in African Americans (AA), relative to European Americans (EA). Ideally, such studies should take into account the potential confounding roles of adiposity, fat distribution, genetic background, and socioeconomic status (SES). The objectives of this study were, 1) to evaluate ethnic differences in insulin dynamics in AA and EA children and adults using robust measures of insulin secretion and clearance; 2) to identify the contributions of genetic admixture and SES to insulin dynamics; 3) to examine …

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Genetic And Epigenetic Modulation Of Telomerase Activity In Development And Disease, Sharla Marion Ostein Phipps Jan 2007

Genetic And Epigenetic Modulation Of Telomerase Activity In Development And Disease, Sharla Marion Ostein Phipps

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The end replication problem of linear chromosomes leads to the erosion of telomeric DNA with each cell division. A mechanism to counteract telomeric attrition involves the activity of the specialized ribonucleoprotein telomerase. Expression of the catalytic subunit of telomerase, hTERT, is tightly regulated and this regulation is achieved through both genetic and epigenetic mechanisms. Activators such as c- MYC and SP1 and repressors such as MAD1, Menin, and p53 mediate hTERT transcription. Epigenetic control mediated by DNA methylation and histone modifications such as methylation and acetylation can reversibly and potently regulate telomerase activity. Not only is there synergism between the …

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Trafficking Of Hantaviral Nucleocapsid Proteins, Harish N. Ramanathan Jan 2007

Trafficking Of Hantaviral Nucleocapsid Proteins, Harish N. Ramanathan

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Hantaviruses are enveloped, negative-sense RNA viruses belonging to genus Hantavirus, within the family Bunyaviridae. Hantaviruses include many serious human pathogens and are classified as Old and New World based on the geographic distribution of rodent reservoirs and their ability to in induce distinct illnesses in humans. Currently there are no reservoirs known for hantaviruses other than the rodents. Human transmission of hantaviruses occurs via inhalation of aerosolized rodent excreta leading to hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Hantavirus genome consists of small (S), medium (M) and large (L) segments that encode nucleocapsid (N) protein, two …

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The Role Of Complement In Experimental Autoimmune Uveitis, Russell W. Read Jan 2007

The Role Of Complement In Experimental Autoimmune Uveitis, Russell W. Read

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The complement system has been increasingly implicated in the pathophysiology of autoimmune disease. Complement expression in the normal human eye had not been previously completely defined. We performed immunohistochemical studies for membrane complement proteins in normal human retina to provide a baseline for future studies. We found expression of the anaphylatoxin receptors, CD55, and CD59 in the inner retina and CD46 in a polarized fashion on the retinal pigment epithelium. Previous studies in uveitis have shown activated fragments of complement in human eyes with uveitis and animal models have shown an effect on disease by complement depletion with cobra venom …

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Pathogenesis And Therapeutic Potential Of Plasmacytoid Dendritic Cells In Siv/Shiv-Infected Macaques, R Keith Reeves Jan 2007

Pathogenesis And Therapeutic Potential Of Plasmacytoid Dendritic Cells In Siv/Shiv-Infected Macaques, R Keith Reeves

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Plasmacytoid dendritic cells (pDCs) are among the first responders during acute viral infections and are the primary producers of IFN-α, a cytokine known to inhibit viral replication and to activate natural killer (NK) cells. In HIV patients pDCs are decreased in number, are dysfunctional, and can harbor HIV-1 proviruses. However, since the time of transmission is usually unknown, pDC-virus interactions immediately after exposure to HIV remain unclear. Using the SIV/SHIV-macaque model, we showed that an acute and sustained loss of blood pDCs occurred during SIVmac239 infections, and when compared to those from naïve controls, pDCs were also significantly reduced in …

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Factors Influencing The Adoption Of Administrative Innovations, Tom J. Sanders Jan 2007

Factors Influencing The Adoption Of Administrative Innovations, Tom J. Sanders

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The purpose of this dissertation was to investigate the influence of selected environmental and organizational factors on the adoption of administrative innovations in order to better understand strategic adaptation by organizations. General systems theory, various organizational theories, strategic adaptation and management theories, and adoption and diffusion of innovation literature were used to develop a theoretical framework to address four primary and sixteen secondary hypotheses. The administrative innovation used for this study was the magnet hospital concept for enhancing attraction and retention of registered nurses in order to address a persistent workforce shortage in U.S. hospitals. Secondary data related to U.S. …

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Processing, Characterizati On And Modeling Of Carbon Nanofiber Modified Carbo N/Carbon Composites, Francis J. Samalot Rivera Jan 2007

Processing, Characterizati On And Modeling Of Carbon Nanofiber Modified Carbo N/Carbon Composites, Francis J. Samalot Rivera

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Carbon/Carbon (C/C) composites are used in high temperature applications because they exhibit excellent thermomechanical properties. There are several challenges associated with the processing of C/C composites that include long cycle times, formation of closed porosity within fabric woven architecture and carbonization induced cracks that can lead to reduction of mechanical properties. This work addresses various innovative approaches to reduce processing uncertainties and thereby improve thermomechanical properties of C/C by using vapor grown carbon nanofibers (VGCNFs) in conjunction with carbon fabric and precursor phenolic matrix. The different aspects of the proposed research contribute to understanding of the translation of VGCNFs properties …

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The Characterization Of The Subcellular Localization Of Bile Acid Coa: N-Acyltransferase, Nathan Allen Styles Jan 2007

The Characterization Of The Subcellular Localization Of Bile Acid Coa: N-Acyltransferase, Nathan Allen Styles

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The liver plays a central role in metabolism. It controls protein metabolism through deamination and transamination of amino acids, removal of ammonia through urea synthesis, synthesis of non-essential amino acids and synthesis of the majority of plasma proteins such as albumin. The liver regulates blood glucose levels through glyconeogenesis and glyconeolysis of glycogen, as well as gluconeogenesis from amino acids. It regulates fat metabolism through oxidation of triglycerides and fatty acids, as well as synthesis of cholesterol, lipoproteins, and phospholipids. Furthermore, the liver is the only site of formation of bile acids and their conjugates, physiologically important compounds that solubilize …

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Bacillus Anthracis Spore-Host Interactions, Melissa K. Swiecki Jan 2007

Bacillus Anthracis Spore-Host Interactions, Melissa K. Swiecki

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The use of Bacillus anthracis as a bioweapon depends on the dispersal of its spores into the environment, entrance into the body, spore uptake by human host cells, germination of the spores in the host and the pathological consequences of the virulence factors produced by the vegetative cells. Prior to 2001, very little was known about the mechanisms of spore entry into the host, including targeting cell types at airway, digestive and skin surfaces, potential spore receptors on these cells and spore encounters with cellular and humoral elements of the innate and adaptive immune systems. To this end, we have …

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Relaxation Rate-Based Magnetic Resonance Imaging Quantification Of Myocardial Infarction, Pal Suranyi Jan 2007

Relaxation Rate-Based Magnetic Resonance Imaging Quantification Of Myocardial Infarction, Pal Suranyi

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Ischemic heart disease is the leading cause of mortality in western societies. Treatment needs to be tailored for each individual, which requires accurate assessment of the underlying pathology. Magnetic Resonance Imaging (MRI) is a relatively young modality in the field of cardiovascular imaging, and boasts with the lack of harmful radiation, excellent soft tissue contrast, and high spatial-temporal resolution. The very foundation of the concept of MRI was the finding that pathology causes changes in the relaxation rates of tissues. Measurement of relaxation rates is more time consuming than generating simple signal intensity images weighted by the longitudinal or transverse …

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A Study Of Perceived Stress, Anxiety, Somatic Symptoms, And Spirituality In Practitioners Of The Martial Art Aikido, Howell E. Tapley Jan 2007

A Study Of Perceived Stress, Anxiety, Somatic Symptoms, And Spirituality In Practitioners Of The Martial Art Aikido, Howell E. Tapley

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The purpose of this study was to examine relationships between physical, mental and spiritual health. An additional purpose was to determine if the practice of aikido was associated with measurable levels of somatic symptoms, perceived stress, anxiety and spirituality. Measurement instruments included Cohen’s 10-item Perceived Stress Scale (PSS), Spielberger’s 20-item Trait Anxiety Inventory (TAI), the Patient Health Questionnaire-15 (PHQ-15), and the 16-item Daily Spiritual Experiences Scale (DSES). A cross-sectional research design was utilized in this study to test the following hypotheses: 1) After controlling for demographic variables, daily spiritual experience will explain variability in perceived stress, anxiety and somatic symptoms, …

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The Study Of Gfap Transcription., Youngjin Lee Jan 2007

The Study Of Gfap Transcription., Youngjin Lee

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No abstract provided.

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The Relationship Of Risk For Unintentional Injury And Externalizing Behavior In Childhood., Elizabeth B. Bowling Jan 2007

The Relationship Of Risk For Unintentional Injury And Externalizing Behavior In Childhood., Elizabeth B. Bowling

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No abstract provided.

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Proteolysis And The Growth Hormone Receptor: Identification And Characterization Of Ghr As A Γ-Secretase Substrate, Jon Walter Cowan Jan 2007

Proteolysis And The Growth Hormone Receptor: Identification And Characterization Of Ghr As A Γ-Secretase Substrate, Jon Walter Cowan

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No abstract provided.

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An Evaluation Of Neighborhood Context And Health Lifestyles: Implications For Obesity Outcomes Among Children, Akilah Dulin Jan 2007

An Evaluation Of Neighborhood Context And Health Lifestyles: Implications For Obesity Outcomes Among Children, Akilah Dulin

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No abstract provided.

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