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2007

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Effects Of Combined Exposure To Ethanol And Ionizing Radiation On The Antioxidant Status Of In Vitro And In Vivo Models, Joshua Ogony Jan 2007

Effects Of Combined Exposure To Ethanol And Ionizing Radiation On The Antioxidant Status Of In Vitro And In Vivo Models, Joshua Ogony

Doctoral Dissertations

"Ethanol and ionizing radiation exposure are independently known to cause tissue damage through various mechanisms. Non-enzymatic and enzymatic metabolism of ethanol, the latter via the cytochrome P₄₅₀2E1-dependent pathway, produces free radicals which deplete cellular glutathione (GSH). Ionizing radiation exposure has been shown to induce lipid peroxidation, DNA damage, protein oxidation, and GSH depletion, as well. It was postulated that initial exposure to ethanol, followed by ionizing radiation, would result in heightened oxidative stress. The in vitro model used in this investigation was HepG2 cells (human hepatocellular liver carcinoma cell line), while the in vivo model was Cd-1 mice"--Abstract, page iii.

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Advanced Controller Design Using Neural Networks For Nonlinear Dynamic Systems With Application To Micro/Nano Robotics, Qinmin Yang Jan 2007

Advanced Controller Design Using Neural Networks For Nonlinear Dynamic Systems With Application To Micro/Nano Robotics, Qinmin Yang

Doctoral Dissertations

"The dissertation focuses on neural network (NN) control designs for nonlinear systems with application to micro/nano robotic. Critical problems in nano scale including thermal drift are also addressed"--Abstract, page iv.

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Architecting System Of Systems: Artificial Life Analysis Of Financial Market Behavior, Nil Hande Ergin Jan 2007

Architecting System Of Systems: Artificial Life Analysis Of Financial Market Behavior, Nil Hande Ergin

Doctoral Dissertations

"This research study focuses on developing a framework that can be utilized by system architects to understand the emergent behavior of system architectures. The objective is to design a framework that is modular and flexible in providing different ways of modeling sub-systems of System of Systems. At the same time, the framework should capture the adaptive behavior of the system since evolution is one of the key characteristics of System of Systems. Another objective is to design the framework so that humans can be incorporated into the analysis. The framework should help system architects understand the behavior as well as …

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Modeling Network Traffic On A Global Network-Centric System With Artificial Neural Networks, Douglas K. Swift Jan 2007

Modeling Network Traffic On A Global Network-Centric System With Artificial Neural Networks, Douglas K. Swift

Doctoral Dissertations

"This dissertation proposes a new methodology for modeling and predicting network traffic. It features an adaptive architecture based on artificial neural networks and is especially suited for large-scale, global, network-centric systems. Accurate characterization and prediction of network traffic is essential for network resource sizing and real-time network traffic management. As networks continue to increase in size and complexity, the task has become increasingly difficult and current methodology is not sufficiently adaptable or scaleable. Current methods model network traffic with express mathematical equations which are not easily maintained or adjusted. The accuracy of these models is based on detailed characterization of …

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Mechanical Integrity And Behavior Of Thin Films And Their Applications In Mems, Gang Duan Jan 2007

Mechanical Integrity And Behavior Of Thin Films And Their Applications In Mems, Gang Duan

Doctoral Dissertations

"Electric actuated thin films are widely used in micro-electromechanical systems (MEMS) such as radio frequency switches (RF-switches), micro-pumps and valves, and electrostatic actuators. This dissertation will focus on the operation of a MEMS-RF-switch. In a typical MEMS-RF-switch, a mechanically suspended 1-D rectangular or 2-D axisymmetric thin film is pulled by an electrostatic voltage (V₀) applied to an electrode-pad directly underneath. When V₀ exceeds a certain "pull-in" threshold, V₀*, the thin film makes direct contact with the pad so that either an "on" or "off" signal is induced, and when the voltage is removed, the thin film resumes its original undeformed …

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Impacts Of Acid Mine Drainage On Carbon Cycling In Receiving Streams, Ernest W. Fonyuy Jan 2007

Impacts Of Acid Mine Drainage On Carbon Cycling In Receiving Streams, Ernest W. Fonyuy

Doctoral Dissertations

"Field and laboratory investigations of acid mine drainage (AMD) contaminated and uncontaminated waters were conducted in order to determine and model processes and reaction mechanisms that control dissolved inorganic carbon (DIC) transformation and shifts in isotope ratio of DIC (Δ¹³CDIC). The results show that AMD caused variable pH changes, overall decreases in Fe²⁺, alkalinity, and DIC, and increases in (Δ¹³CDIC) in receiving streams. AMD caused more than 50 to > 98% seasonal DIC loss in stream water through CO₂ degassing. High DIC losses corresponded to high Fe²⁺ and lower or no HCO₃⁻ in the water samples, because …

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Alphabetic And Phonemic Awareness In Toddlers, Pamela A. Terrell Jan 2007

Alphabetic And Phonemic Awareness In Toddlers, Pamela A. Terrell

LSU Doctoral Dissertations

The ability of 20-24 month-old toddlers to recognize graphemes and phonemes was investigated by reading a Phonic Faces (PF) alphabet picture book. Phonic Faces iconically picture a letter in the mouth of a character producing the sound (the curve of the P looks like the top lip popping the /p/ sound). The book was composed of nine letters and was read individually to experimental subjects three times weekly for six weeks. The control group received no treatment, but engaged in individual play activities for comparable time. Following six-weeks the groups alternated so the former control group now received the alphabet …

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Spatial Econometric Analysis Of Agglomeration Economies Associated With The Geographical Distribution Of The U.S. Biotech Industry, Pramod Reddy Sambidi Jan 2007

Spatial Econometric Analysis Of Agglomeration Economies Associated With The Geographical Distribution Of The U.S. Biotech Industry, Pramod Reddy Sambidi

LSU Doctoral Dissertations

This dissertation analyzed spatial agglomeration economies associated with the geographical distribution of the U.S. biotech industry. Three location issues associated with the biotech industry were addressed in the study. The first study utilized a Bayesian spatial tobit model and examined the overall and regional differences in factors affecting the location of the U.S. biotech industry. The second study examined the inter- and intra-industry spatial association of biotech related research and development (R&D) and testing facilities across all contiguous U.S. counties employing a Spatial Two-Stage Least Squares model. Finally, the interdependence between different subsectors of the U.S. biotech industry was analyzed …

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Chagas In Culture And Place: A Mixed Methods Approach To A New Medical Geography Of Chagas Disease In Los Tuxtlas, Mexico, Frances Heyward Currin Mujica Jan 2007

Chagas In Culture And Place: A Mixed Methods Approach To A New Medical Geography Of Chagas Disease In Los Tuxtlas, Mexico, Frances Heyward Currin Mujica

LSU Doctoral Dissertations

This project is concerned with a new medical geography approach to investigating Chagas disease in Los Tuxtlas, Mexico which focuses on the intersection of disease risk and place. More specifically this work will describe the domestic cycle of Chagas disease and the cultural factors that perpetuate its transmission in six communities in the Los Tuxtlas region, Municipio San Andres, Veracruz State, Mexico. Using several collection techniques, such as interviews and house type surveys, as well as identifying and collecting the vector Triatoma dimidiata (including testing them for the parasite Trypanosoma cruzi), this dissertation describes the characteristics of the Chagas landscape …

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Toward A New Understanding Of Wisdom: The Role Of Communication On Perceptions Of Wisdom, Jon M. Croghan Jan 2007

Toward A New Understanding Of Wisdom: The Role Of Communication On Perceptions Of Wisdom, Jon M. Croghan

LSU Doctoral Dissertations

Wisdom is a multi-faceted, multi-dimensional, multidisciplinary construct which has been discussed and examined since the beginning of recorded history. Many classical and contemporary scholars have sought to define wisdom, but a precise definition has proven elusive. Since wisdom often defies easy categorization, this dissertation examines wisdom using a multi-methodological perspective. Four chapters of this dissertation discuss the historiography of various societal attributions of wisdom using performance studies techniques. Three chapters examine wisdom and the instruments constructed to measure the construct from a social scientific approach. This study seeks to clarify, while simultaneously deconstructing, the definition of wisdom. The four performative …

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Exploring The Binding Of Amine And Sulfonamide Ligands In Rhenium(I) Tricarbonyl And Platinum(Ii) Complexes, Anna Maria Christoforou Jan 2007

Exploring The Binding Of Amine And Sulfonamide Ligands In Rhenium(I) Tricarbonyl And Platinum(Ii) Complexes, Anna Maria Christoforou

LSU Doctoral Dissertations

Platinum is the metal present in various classes of inorganic medicinal agents directed at important diseases such as cancer or viral infections. Several new Pt(II) complexes of polyamine ligands bearing a dansyl moiety linked by a sulfonamide group were prepared; in some cases the sulfonamide nitrogen formed a bond to Pt. The sulfonamido group donates strongly to Pt and places the dansyl group close to a vacant coordination position, allowing it to stack with bound guanine base (G) when G binds. The emission of the fluorophore decreases with decreasing distance to Pt. Metal nuclide radiopharmaceuticals contain a metal core and …

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Sugarcane Tasseling Under Artificial Photoperiod Conditions As Affected By Nitrogen Rate And Temperature, Christopher Michael Laborde Jan 2007

Sugarcane Tasseling Under Artificial Photoperiod Conditions As Affected By Nitrogen Rate And Temperature, Christopher Michael Laborde

LSU Doctoral Dissertations

Optimizing flowering in the LSU AgCenter’s Sugarcane ( Sacchrum spp. hybrids) Breeding Program is an important step in the variety development program. The effect of nitrogen and ambient air temperature in pot cultured sugarcane were examined as a means of improving sugarcane flowering. The experiment was conducted on agronomic and reproductive traits of sugarcane at the Sugar Research Station, St. Gabriel, LA, on sugarcane genotypes subjected to artificial photoperiod regimes. The potting media consisted of equal parts of washed sand, Canadian peat moss, and a Commerce silt loam soil (fine-silty, mixed, nonacid, thermic aeric Fluvaquents). Early nitrogen (22.4-22.4-22.4 kg ha-1) …

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Metabolism And Gene Expression During Diapause In Athropods, Julie Annette Reynolds Jan 2007

Metabolism And Gene Expression During Diapause In Athropods, Julie Annette Reynolds

LSU Doctoral Dissertations

Arthropods may enter diapause to escape environmental insult. Diapause is an endogenously controlled dormant state defined by developmental arrest and species-specific physiological changes (e.g., metabolic depression and upregulation of compounds that protect cell structure and function). Although physiological changes have been documented for a number of species in diapause, biochemical and molecular regulation of diapause remains largely unexplained. Aerobic metabolism in diapause, Artemia franciscana, embryos is reduced up to 92 % compared with post-diapause embryos. Differences in isolated mitochondria are insufficient to account for respiratory depression because mitochondria in diapause embryos are structurally similar to mitochondria in post-diapause embryos. Respiratory …

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Synthesis And Properties Of Isoporphyrins And Related Derivatives For Application In Photodynamic Therapy, Sandra Celinah Mwakwari Jan 2007

Synthesis And Properties Of Isoporphyrins And Related Derivatives For Application In Photodynamic Therapy, Sandra Celinah Mwakwari

LSU Doctoral Dissertations

Isoporphyrins are tautomers of porphyrins with an interrupted macrocyclic conjugation owing to the presence of a sp3 hybridized meso-carbon. Due to their absorption at long wavelengths (~800nm), isoporphyrins are potential candidates as photosensitizers in photodynamic therapy (PDT), a ternary modality of cancer treatment. They are also of biological interest due to their unique redox properties among porphyrin derivatives and could be a new class of near-IR dyes. Isoporphyrins are known to be unstable with respect to transformation back to the fully conjugated porphyrin chromophore except when the meso-carbon is geminally substituted and for this reason a detailed study of this …

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Copper(Ii) Oxide Mediated Formation And Stabilization Of Combustion Generated Persistent Free Radicals, Hieu Truong Jan 2007

Copper(Ii) Oxide Mediated Formation And Stabilization Of Combustion Generated Persistent Free Radicals, Hieu Truong

LSU Doctoral Dissertations

Biologically damaging semiquinone-type radicals have been reported in cigarette smoke, their likely origin being hydroquinone (HQ) and catechol (CT) molecular precursors contained by the tobacco. Since other biomass contains HQ and CT-type species, it is likely that combustion of other biomass will also form semiquinone-type radicals. All hydrocarbon fuels will form phenol and substituted phenol that can form substituted phenoxyl radicals. Because each of these radicals has the potential to be environmentally persistent and biologically active, their formation and stabilization from various molecular precursors was studied with the focus on surface-bound radicals formed in association with combustion-generated fly-ash particles. Comprehensive …

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Floral Traits, Pollinator Behavior, And Plant Reproduction: Tests Of Natural And Sexual Selection In The Hummingbird-Pollinated Herb Chrysothemis Friedrichsthaliana, Jane Elizabeth Carlson Jan 2007

Floral Traits, Pollinator Behavior, And Plant Reproduction: Tests Of Natural And Sexual Selection In The Hummingbird-Pollinated Herb Chrysothemis Friedrichsthaliana, Jane Elizabeth Carlson

LSU Doctoral Dissertations

Pollinators may promote floral evolution by selectively visiting preferred floral phenotypes. Herbivores may also influence the evolution of floral traits, by reducing the fitness of poorly-defended plants, such as those without protective sepals. In this dissertation, I investigate the reproductive and evolutionary consequences of floral visitors for two floral traits of the Neotropical herb Chrysothemis friedrichsthaliana (Gesneriaceae). I focus on the trait male-biased nectar production, which results from coincident temporal shifts in nectar production rates and sexual function within flowers. First, I review theory relevant to male- and female-biased nectar production, and I generate hypotheses to explain its evolution in …

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The Effects Of Trawling And Habitat Use On Red Snapper And The Associated Community, Robert Joseph David Wells Jan 2007

The Effects Of Trawling And Habitat Use On Red Snapper And The Associated Community, Robert Joseph David Wells

LSU Doctoral Dissertations

The primary impediment to the recovery of Gulf of Mexico (GOM) red snapper is believed to be high levels of bycatch of age 0 and age 1 individuals in shrimp trawls. Thus, conservation of GOM red snapper involves evaluating both habitat-specific function and effects of shrimp trawls on red snapper and the associated benthic ecosystem. The two goals of this study were to evaluate the effects commercial shrimp trawls have on juvenile red snapper life history parameters, on associated fish and invertebrate communities and their habitat, and to identify essential fish habitat (EFH) for red snapper by applying all four …

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Spatial And Temporal Structure Of Typhoid Fever In Washington, D.C., 1895-1909: A Geographic Information Systems Exploration Of Urban Health Concerns, Sarah Elizabeth Hinman Jan 2007

Spatial And Temporal Structure Of Typhoid Fever In Washington, D.C., 1895-1909: A Geographic Information Systems Exploration Of Urban Health Concerns, Sarah Elizabeth Hinman

LSU Doctoral Dissertations

The period between 1880 and 1920 was one of the most dynamic in the history of medicine. Morbidity and mortality rates for infectious diseases dropped quickly. Concurrently, miasmatic theory gave way to germ theory. Many of these dynamic changes occurred in the urban centers of North America, which were also entering into a period of dramatic growth and change. Following the 1905 completion of infrastructure improvements intended to improve public health in Washington, D.C., typhoid fever rates unexpectedly increased. Previously, for mitigation purposes, Dr. George Kober investigated a typhoid epidemic in 1895, and as a result of the 1906 increase …

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A Study Of Auxiliary Be In African American English: A Comparison Of Children With And Without Specific Language Impairment, April W. Garrity Jan 2007

A Study Of Auxiliary Be In African American English: A Comparison Of Children With And Without Specific Language Impairment, April W. Garrity

LSU Doctoral Dissertations

This study’s purpose was to examine the use of auxiliary BE forms in African American English (AAE)-speaking children with and without language impairment. The impetus for this work was a lack of information in the literature about BE use in AAE as a function of form, language status, and tasks, and the relevance of this type of data for testing one theoretical model of childhood language impairment, the Extended Optional Infinitive account (EOI; Rice, Wexler, & Cleave, 1995). Thirty African Americans participated: 10 six-year-olds with specific language impairment (SLI); 10 age controls (AM); and, 10 language controls (LM). All of …

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Cd 610 Moral Development, Chris Kiesling Jan 2007

Cd 610 Moral Development, Chris Kiesling

Syllabi

TEXTBOOKS James C. Wilhoit and John M. Dettoni. Nurture that is Christian: Developmental Perspectives on Christian Education. Wheaton: Victor Books, 1995. James Fowler. Faithful Change: The Personal and Public Challenges of Postmodern Life. Nashville: Abingdon Press, 1996. Jean Piaget, The Moral Judgment of the Child. New York, Free Press, 1965. E Stanley Jones, The Christ of the Mount.

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The Recovery Experience For Persons With A Myocardial Infarction And Their Spouses/Partners, Vicki Lynnette Bingham Jan 2007

The Recovery Experience For Persons With A Myocardial Infarction And Their Spouses/Partners, Vicki Lynnette Bingham

All ETDs from UAB

Coronary heart disease, the leading cause of death in Americans today, affects both genders in numerous ethnic populations. This life-threatening event causes both physical and emotional distress for persons with a myocardial infarction (MI), as well as for their spouses or partners and thus possibly forces them on a spiritual journey. The purpose of this study was to increase the understanding of the ways in which spirituality is defined and experienced by both persons with an MI and their spouses/partners during the recovery process. The method utilized in this study was a qualitative approach using interpretative phenomenology from a Heideggerian …

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Localization And Function Of G2e3, William Samuel Brooks Jan 2007

Localization And Function Of G2e3, William Samuel Brooks

All ETDs from UAB

A microarray study was performed which identified G2E3 as a novel, putative ubiquitin ligase that was both G2/M-specific in expression and down regulated at the transcriptional level following DNA damage by γ-irradiation. The initial characterization of this protein is described herein. G2E3 is composed of three PHD/RING (plant homoedomain/really interesting new gene) domains within its amino-terminal half and a carboxy-terminal HECT (homologous to E6AP carboxy-terminus) domain. G2E3 is regulated in part by its subcellular localization. The protein normally resides within the nucleoplasm of cultured cells and distinctly within the nucleolus of HeLa cells. G2E3 is a nucleo-cytoplasmic shuttling protein with …

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Loss Of Pias3 Expression In Glioblastoma Multiforme Tumors:Implications For Stat-3 Activation And Gene Expression, Emily Claire Brantley Jan 2007

Loss Of Pias3 Expression In Glioblastoma Multiforme Tumors:Implications For Stat-3 Activation And Gene Expression, Emily Claire Brantley

All ETDs from UAB

Glioblastoma multiforme (GBM) is the most common form of cancer in the central nervous system in adults. Because of the infiltrative and aggressive nature of GBM, current treatments including surgical resection, radiation and chemotherapy provide little benefit to patients diagnosed with this tumor. Median survival, after treatment, is less than one year. Despite advances in the basic understanding of cancer biology, this poor prognosis has remained virtually unchanged for several decades. Given the continuing difficulty of clinical treatment of GBMs, a molecular appreciation of relevant signaling pathways has grown. Signal Transducers and Activators of Transcription (STATs) function to activate gene …

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Characterization Of A Novel Acetyltransferase Found Only In Pathogenic Strains Of Mycobacterium Tuberculosis, David K. Crossman Jan 2007

Characterization Of A Novel Acetyltransferase Found Only In Pathogenic Strains Of Mycobacterium Tuberculosis, David K. Crossman

All ETDs from UAB

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is still a major threat to the human population. Roughly one third of the world population is asymptomatically infected and two million people die each year of TB. Effective treatments are available as a multi-drug regimen, but there is an ever increasing problem with the rise of multi-drug resistant strains that newer drug targets and a better understanding of how M. tuberculosis affects the host need to be elucidated. The primary target of M. tuberculosis in the human host is the macrophage where M. tuberculosis secretes virulence factors that inhibit various signal …

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A Study Into The Protein/Protein Interactions Involved In Hiv-1 Capsid Assembly, Chanel Catherine Douglas Jan 2007

A Study Into The Protein/Protein Interactions Involved In Hiv-1 Capsid Assembly, Chanel Catherine Douglas

All ETDs from UAB

The aim of this work was to build an understanding of the protein/protein interactions involved in HIV-1 capsid assembly as it relates to the condensation of capsid within the virion. This was undertaken in an attempt to (i) understand how capsid subunits recognize and interact with each other, (ii) gain insight into the protein-protein interactions involved in the process, and (iii) determine if the protein-protein interactions involved in virus cap-sid assembly can be used as a target for viral inhibition. Within this dissertation you will find two approaches to this investigation. The first examines the role of electrostatics in the …

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The Molecular Biology Of Temperature-Dependent Sex Determination In Reptiles, Keela Dodd Jan 2007

The Molecular Biology Of Temperature-Dependent Sex Determination In Reptiles, Keela Dodd

All ETDs from UAB

Temperature-dependent sex determination (TSD) is a type of environmental sex determination in which the egg’s incubation temperature determines the sex of the embryo. The exact physiology of TSD is not yet understood. Hormones and temperaturetriggered genes have been hypothesized to play a role. This study evaluates putative male and female factors that may play a role in TSD. Regarding female factors, this study evaluates clutch sensitivity to estradiol-17β and an aromatase inhibitor, and estradiol- 17β’s potential role in müllerian duct differentiation. Regarding male factors, this study also quantifies SOX9 mRNA during TSD in untreated and estradiol-17β treated embryos. In the …

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Factors Associated With Sexual Debut And Depression Among Adolescents In Rural Jamaica, Olaniyi J. Ekundayo Jan 2007

Factors Associated With Sexual Debut And Depression Among Adolescents In Rural Jamaica, Olaniyi J. Ekundayo

All ETDs from UAB

Individual and family factors have been hypothesized to influence adolescent sexual behavior and depression, but the extent to which this is true for adolescents in Jamaica as a whole and for those in rural areas in particular, has not been well studied. The objective of this dissertation was to identify individual and family factors associated with sexual debut and depression among rural Jamaican adolescents. To elucidate these factors and to provide information to guide future interventions, we analyzed data on 748 adolescents attending public high schools in the rural parish of Hanover, Jamaica. Multivariate logistic regression was used to predict …

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Sexual Violence And Correlates Among Women In Hiv Discordant Union, Uganda, Donath Emusu Jan 2007

Sexual Violence And Correlates Among Women In Hiv Discordant Union, Uganda, Donath Emusu

All ETDs from UAB

We sought to estimate the prevalence of sexual violence and sexually transmitted diseases (STDs), identify risk factors for sexual violence and STDs among women in Human Immunodeficiency Virus (HIV) discordant unions, and investigate the lived experiences of sexual violence among women in HIV discordant unions attending post-test club services at AIDS Information Centers (AICs) in Uganda. We carried out a prospective cohort study of women in HIV discordant and HIV negative concordant unions after disclosure of their HIV serostatus. We estimated prevalence of STDs in the two study cohorts and compared them for occurrence of risk factors for sexual violence …

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Characterization, Community Structure And Ecological Importance Of Sponge-Associated Bacteria, Patrick M. Erwin Jan 2007

Characterization, Community Structure And Ecological Importance Of Sponge-Associated Bacteria, Patrick M. Erwin

All ETDs from UAB

The study of sponge-bacteria symbioses is emerging as a prominent field in marine biology and biotechnology, with implications ranging from a fundamental understanding of sponge ecology and insight into the evolution of prokaryote-eukaryote symbiotic interactions to natural products prospecting and bioactive metabolite synthesis. The research conducted herein integrates molecular genetic techniques with ecological methodologies to address fundamental issues of sponge-microbe associations. Bacterial communities associated with the marine sponges Hymeniacidon heliophila and Xestospongia sp. were compared to microbial assemblages from ambient seawater and the sympatric tunicate, Didemnum sp, using replicated clone libraries of 16S ribosomal RNA (rRNA) genes and terminal restriction …

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Pneumococcal Choline-Binding Protein A: Its Role In Virulence And Its Utility As A Streptococcus Pneumoniae Vaccine Antigen, David Tawayne Glover Jan 2007

Pneumococcal Choline-Binding Protein A: Its Role In Virulence And Its Utility As A Streptococcus Pneumoniae Vaccine Antigen, David Tawayne Glover

All ETDs from UAB

Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. S. pneumoniae is a leading cause of pneumonia, meningitis, septicemia, and otitis media. Although all age groups can be affected, children and the elderly are espccially susceptible to infection. Currently there is a conjugate vaccine available for use, but this vaccine only contains capsular polysaccahride antigens from the seven most prevelant S. pneumoniae serotypes. The use of the conjugate vaccine has led to serotype shift, with more disease being caused by non-vaccine serotype bacteria. The studies presented in this dissertation identify and characterize a novel S. penumoniae vaccine candidate …

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