Digital Commons Network^™

Animal Health Matters, Russ Daly, Jane Hennings

Animal Health MATTERS Newsletter

[Page] 1- New Diagnostic/Research Faculty Bring Talents to SDSU, Dr. Diego Del, Dr. Joy Scaria [Page] 1- More New Hires to Start Soon at VBS Department [Page] 2- Director's Message: “One Health” and the Importance of Training the Next Generation of Scientists [Page] 3- Summary of BVDV-PI Testing at SDSU ADRDL [Page] 4- The Clinical Pathology Section at SDSU’s ADRDL [Page] 5- Governor Daugaard Pays Visit to the ADRDL Through Stethoscope Ceremony [Page] 6- New Hire: Dana Rausch, Molecular Diagnostics [Page] 6- ADRDL Bacteriologist Serves as President [Page] 6- Serology Staff Member Aids Custer State Park Bison Testing Efforts [Page] …

Washington University Record, November 15, 2007

Washington University Record

No abstract provided.

The Register, 2007-11-14, North Carolina Agricutural And Technical State University

NCAT Student Newspapers

No abstract provided.

Leptospira Interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin, Laminin And Regulators Of Complement, Brian Stevenson, Henry A. Choy, Marija Pinne, Matthew L. Rotondi, M. Clarke Miller, Edward Demoll, Peter Kraiczy, Anne E. Cooley, Trevor P. Creamer, Marc A. Suchard, Catherine A. Brissette, Ashutosh Verma, David A. Haake

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues. Infectious leptospires are resistant to killing by their hosts' alternative pathway of complement-mediated killing, and interact with various host extracellular matrix (ECM) components. The LenA outer surface protein (formerly called LfhA and Lsa24) was previously shown to bind the host ECM component laminin and the complement regulators factor H and factor H-related protein-1. We now demonstrate that infectious L. interrogans contain five additional paralogs of lenA, which we designated lenB, lenC, lenD, lenE and lenF …

Central Florida Future, Vol. 39 No. 138, November 14, 2007

Central Florida Future

Nader wants to go green; Food for the student soul; Knights question senators; Group rocks out for the homeless.

The Daily Egyptian, November 12, 2007, Daily Egyptian Staff

November 2007

No abstract provided.

Micro Rna 145 Targets The Insulin Receptor Substrate-1 And Inhibits The Growth Of Colon Cancer Cells, Bin Shi, Laura Sepp-Lorenzino, Marco Prisco, Peter Linsley, Tiziana Deangelis, Renato Baserga

Department of Cancer Biology Faculty Papers

The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti-apoptotic, and anti-differentiation signal. Several micro RNAs (miRs) are suggested by the data base as possible candidates for targeting IRS-1. We show here that one of the miRs predicted by the data base, miR145, whether transfected as a synthetic oligonucleotide or expressed from a plasmid, causes down-regulation of IRS-1 in human colon cancer cells. IRS-1 mRNA is not decreased by miR145, while it is down-regulated by an siRNA targeting IRS-1. Targeting of …

Daily Eastern News: November 9, 2007, Eastern Illinois University

November

No abstract provided.

Florida Red Tides: Public Perceptions Of Risk, Sara E. Allen

USF Tampa Graduate Theses and Dissertations

This research integrates the theoretical implications of risk perception, the social amplification of risk, and the role of place-specific contexts, in order to explore the various perceptions surrounding Florida red tides. Florida red tides are a naturally-occurring event, yet most scientists agree that they are increasing in frequency, duration, and severity. This has profound implication for public health, the local economy, and the biological community. While many of the negative impacts are not easily controllable at this time, some of the secondary impacts can be mitigated through individuals' responses. Unfortunately, public perceptions and consequent reactions to red tides have not …

Central Florida Future, Vol. 39 No. 136, November 7, 2007

Central Florida Future

College of Nursing accredited again; Bowling for nation; Mitt's bus visits UCF; 100 homeless fed every Mon.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University jazz band will perform Nov. 16
• Omicron Delta Kappa induction ceremony set for Nov. 11

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Culture-Negative Prosthetic Joint Infection, Elie F. Berbari, Camelia Marculescu, Irene Sia, Brian D. Lahr, Arlen D. Hanssen, James M. Steckelberg, Rachel Gullerud, Douglas R. Osmon

MUSC Faculty Journal Articles

Background. Culture-negative (CN) prosthetic joint infection (PJI) has not been well studied. We performed a retrospective cohort study to define the demographic characteristics and determine the outcome of patients with CN PJI. Methods. All cases of CN total hip arthroplasty and total knee arthroplasty infections (using a strict case definition) treated at our institution from January 1990 through December 1999 were analyzed. Kaplan-Meier survival methods were used to determine the cumulative probability of success. Results. Of 897 episodes of PJI during the study period, 60 (7%) occurred in patients for whom this was the initial episode of CN PJI. The …

Additive And Synergistic Bactericidal Activity Of Antibodies Directed Against Minor Outer Membrane Proteins Of Neisseria Meningitidis, Vincent E. Weynants, Christiane M. Feron, Karine K. Goraj, Martine P. Bos, Philippe A. Denoeal, Vincent G. Verlant, Jan Tommassen, Ian R. A. Peak, Ralph C. Judd, Michael P. Jennings, Jan T. Poolman

Biological Sciences Faculty Publications

Neisseria meningitidis serogroup B is a major cause of bacterial meningitis in younger populations. The available vaccines are based on outer membrane vesicles obtained from wild-type strains. In children less than 2 years old they confer protection only against strains expressing homologous PorA, a major, variable outer membrane protein (OMP). We genetically modified a strain in order to eliminate PorA and to overproduce one or several minor and conserved OMPs. Using a mouse model mimicking children's PorA-specific bactericidal activity, it was demonstrated that overproduction of more than one minor OMP is required to elicit antibodies able to induce complement-mediated killing …

Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, Rolf Winter, Michael Riscoe

Collected Faculty Scholarship

A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobologram analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive …

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Relative Contributions Of Enterococcus Faecalis Og1rf Sortase-Encoding Genes, Srta And Bps (Srtc), To Biofilm Formation And A Murine Model Of Urinary Tract Infection, Kelvin D Kemp, Kavindra V Singh, Sreedhar R Nallapareddy, Barbara E Murray

Faculty, Staff and Student Publications

Deletion mutants of the two sortase genes of Enterococcus faecalis OG1RF were constructed. srtC (renamed here bps for biofilm and pilus-associated sortase) was previously shown to be necessary for the production of Ebp pili and important for biofilm formation and endocarditis. Here, we report that a srtA deletion mutant showed a small (5%) yet significant (P = 0.037) reduction in biofilm relative to OG1RF, while a DeltasrtA Deltabps double mutant showed a much greater reduction (74% versus OG1RF and 44% versus the Deltabps mutant). In a murine urinary tract infection (UTI), the 50% infective doses of both the DeltasrtA Deltabps …

Washington University Record, November 1, 2007

Washington University Record

No abstract provided.

Comparison Of Real-Time, And Qualitative Polymerase Chain Reaction Assays In Detection Of Cytomegalovirus Dna In Clinical Specimens, Selma Gokahmetoglu, Esma Deniz

Saudi Medical Journal

OBJECTIVE: To compare the real-time (RT), and qualitative (Q) polymerase chain reaction (PCR) assays for detection of Cytomegalovirus (CMV) DNA. METHODS: The study took place in the Department of Microbiology, Erciyes University, Kayseri, and in Iontek Laboratory, Istanbul, Turkey, from August to December 2006. One hundred and seven clinical specimens from 67 patients were included in the study. Cytomegalovirus DNA was investigated using RT-PCR kit (Fluorion Iontek, Turkey) and Q-PCR kit (Fluorion Iontek, Turkey). Deoxyribonucleic acid sequencing was applied to the samples that yielded discrepant results in both assays. MacNemar9s Chi Square test was used for statistical analysis. RESULTS: Of …

Initial Sequence And Comparative Analysis Of The Cat Genome, J. U. Pontius, James C. Mullikin, Douglas R. Smith, Agencourt Bioscience Corporation, Kerstin Lindblad-Toh, Sante Gnerre, Michele Clamp, Jean Chang, R. Stephens, Beena A. Neelam, Natalia Volfovsky, Alejandro A. Schaffer, R. Agarwala, Kristina Narfstrom, William J. Murphy, Urs Giger, Alfred L. Roca, Agostinho Antunes, Marilyn Menotti-Raymond, Naoya Yuhki, Jill Pecon-Slattery, Warren E. Johnson, Guillaume Bourque, Glenn Tesler, Nisc Comparative Sequencing Program, Stephen J. O'Brien

Biology Faculty Articles

The genome sequence (1.9-fold coverage) of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals (human, chimpanzee, mouse, rat, dog, and cow). The results resolved chromosomal positions for 663,480 contigs, 20,285 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs). Additional annotated features include repetitive elements, endogenous retroviral sequences, nuclear mitochondrial (numt) sequences, micro-RNAs, and evolutionary breakpoints that suggest historic balancing of translocation and inversion incidences in distinct mammalian lineages. Large numbers of single nucleotide polymorphisms (SNPs), deletion insertion polymorphisms (DIPs), and …

Physical Properties Of Denture Base Resins Potentially Resistant To Candida Adhesion, Gunjan Dhir, David W. Berzins, Virendra B. Dhuru, Periathamby A. Raj, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Purpose: The addition of anionic charge on denture base resins has been shown to inhibit Candida albicans adhesion and to facilitate adsorption of salivary defense molecules. The aim of this study was to evaluate the physical properties of a modified denture base resin for denture fabrication.

Materials and Methods: Specimens made from heat polymerizing resin Lucitone 199 were used as the control group. The two experimental groups, E-10 and E-20, had 10% and 20%, respectively, of the monomer substituted with an experimental phosphate-containing monomer. Flexural strength and modulus, water sorption, solubility, and color stability tests were conducted to ensure compliance …

The Activity Of Azithromycin Against Leishmania (Viannia) Braziliensis And Leishmania (Leishmania) Amazonensis In The Golden Hamster Model., Angel Sinagra, Concepción Luna, David Abraham, Maria Del Carmen Iannella, Adelina Riarte, Alejandro J. Krolewiecki

Department of Microbiology and Immunology Faculty Papers

New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated. Different responses among species of Leishmania make species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis was evaluated in golden hamsters infected through footpad injections of metacyclic promastigotes, and compared with untreated controls and animals treated with meglumine antimoniate. Footpad thickness, lesion cultures and dissemination sites were analyzed. Treatment of golden hamsters with oral azithromycin at 450mg/kg had no activity against infections with Leishmania (Leishmania) amazonensis. For infections due to Leishmania (Viannia) braziliensis, …

Rrh Library Newsletter, November 2007, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: Community-Acquired Methicillin-Resistant Staphylococcus aureus

Regional Threats And Security Strategy: The Troubling Case Of Today's Middle East, James A. Russell Mr.

Books, Monographs & Collaborative Studies

The United States needs to undertake a strategic regional net assessment that examines the following issues as it seeks to construct a regional security strategy to protect its interests and mitigate wider threats to international security. That net assessment should include reviewing the role of security guarantees in promoting regional stability, an acknowledgement of the contradictory nature of the inter- and intra state threats and tensions, and the negative impact that the U.S. obsession with force protection is having on its ability to effectively implement strategy on the ground.

Ecthyma Gangrenosum In Saudi Arabia, Obasi E. Obasi, Abimbola O. Osoba, Ali A. Raddadi

Saudi Medical Journal

We report a diagnosis of ecthyma gangrenosum EG in 4 females of mean age 54.8 range 43-64 years, within 10 months. Severe drug reaction treated with high dose systemic corticosteroids in patient one, acute myelocytic leukemia treated with high dose dexamethasone, and multiple broad-spectrum antibiotics in patient 2 preceded the onset of EG. Patients 3 and 4 had vasculitic purpura and hemodialysis. In addition, patient 3 was receiving multiple broad-spectrum antibiotics plus anti-tuberculosis TB drugs for gastric TB, while patient 4 was on melphalan and high dose systemic corticosteroids. Pseudomonas aeruginosa was isolated from blood culture of the first 3 …

Tuberculosis Paradoxical Reaction, Fayaz Hakim, Imad M. Tleyjeh

Saudi Medical Journal

No abstract provided.

The Singapore Academy Of Law Annual Lecture 2007: Australia’S Contribution To The Development Of The Common Law, Delivered By The Honourable Murray Gleeson Ac, Chief Justice Of Australia, Yihan Goh, Nathaniel Khng

Research Collection Yong Pung How School Of Law

No abstract provided.

Introduction To The 2007 Editors’ Symposium: Informational Privacy: Philosophical Foundations And Legal Implications, Larry Alexander

San Diego Law Review

The outstanding collection of articles and comments thereon that follows this Introduction constitutes the 2007 Editors' Symposium of the San Diego Law Review. This year's theme is: "Informational Privacy: Philosophical Foundations and Legal Implications."

The Hilltop 10-29-2007, Hilltop Staff

The Hilltop: 2000 - 2010

No abstract provided.

Elk Use Of Wallows And Potential Chronic Wasting Disease Transmission, Kurt C. Vercauteren, Patrick W. Burke, Gregory W. Phillips, Justin W. Fischer, Nathan W. Seward, Bruce A. Wunder, Michael J. Lavelle

United States Department of Agriculture Wildlife Services: Staff Publications

Deposition of prions into the environment by infected animals may contribute to transmission and spread of chronic wasting disease (CWD) among free-ranging cervids, and identification of such environmental sources may provide an avenue for managing CWD. We evaluated the role that wallow use by elk (Cervus elaphus) may play in CWD transmission by monitoring wallows with animal-activated cameras throughout their period of use. We monitored 39 wallows from 5 August 2005 to 14 October 2005. Elk visited 20 sites; we recorded 22 events when only male elk wallowed and 374 additional events when male and female elk had …