Digital Commons Network^™

Downregulation Of Rap1gap Contributes To Ras Transformation, Oxana Tsygankova, Gregory V. Prendergast, Kanchan Puttaswamy, Yan Wang, Michael D. Feldman, Hongbin Wang, Marcia S. Brose, Judy L. Meinkoth

Faculty, Staff and Student Publications

Although abundant in well-differentiated rat thyroid cells, Rap1GAP expression was extinguished in a subset of human thyroid tumor-derived cell lines. Intriguingly, Rap1GAP was downregulated selectively in tumor cell lines that had acquired a mesenchymal morphology. Restoring Rap1GAP expression to these cells inhibited cell migration and invasion, effects that were correlated with the inhibition of Rap1 and Rac1 activity. The reexpression of Rap1GAP also inhibited DNA synthesis and anchorage-independent proliferation. Conversely, eliminating Rap1GAP expression in rat thyroid cells induced a transient increase in cell number. Strikingly, Rap1GAP expression was abolished by Ras transformation. The downregulation of Rap1GAP by Ras required the …

Models Of Interdisciplinary Research And Service Learning At Hope College, Aaron A. Best, Matthew Dejongh, Amanda J. Barton, Jeff R. Brown, Christopher C. Barney

Publications

"Children love to explore the world around them. In doing so they are not aware of disciplinary boundaries or even of disciplines. They move freely from watching ants (biology) to building structures (engineering) to counting rocks (mathematics and geology) to seeing what things dissolve in water (chemistry). Only as they go to school do they learn that humans divide up the way we learn about the universe and start to think within disciplinary boundaries. In doing so, those children, who are now us, lose the ability to think broadly and use the insights of various ways of thinking to solve …

Fact Book 2007, Planning, Research, And Policy Analysis

Fact Book (1988-2019)

Fact Book 2007 for Illinois State University

Gender Differences In Acute Cardiac Care: Where It's Not., Marna R. Greenberg Do, Mph, Facep

Department of Emergency Medicine

No abstract provided.

A Standardized Orientation Course On Central Line Placement Leads To Persistent Knowledge Improvement., Andrew C. Miller Do

Department of Emergency Medicine

No abstract provided.

Successful Cessation: Exploring Quit Attempts At Lehigh Valley Hopital's Tabacco Treatment Program., Suzanne L. Smith Bs, Rrt-Nps, Mba, Sharon Kimmel Mha, Phd, Ascepi, Rebecca Johnston Sn, Tas, Dianna Mulhern Ms, Lpc, Judith Sabino

Department of Emergency Medicine

No abstract provided.

Watered Down: The Intersection And Integration Of Tourism Development And Water Resource Management In Marrakech, Morocco, Alison Maassen

Independent Study Project (ISP) Collection

No abstract provided.

Facilitating Consumer Partnerships In State Policy And Program Design, Judith Holt, Darrell L. Jones, Richard E. Petty, Suzanne Crisp, Helen Roth, Sara Galantowicz

Special Education and Rehabilitation Counseling Faculty Publications

No abstract provided.

Implementing Uganda’S National Wetlands Policy: A Case Study Of Kabale District, Sophie Glass

Independent Study Project (ISP) Collection

Uganda’s “National Policy for the Conservation and Management of Wetland Resources” was launched in 1995 to promote the protection of Uganda’s wetlands in order to sustain their ecological and socioeconomic functions. Despite the formal policy, wetlands continue to be drained and converted. This report examines factors that account for the divide between the National Wetlands Policy and reality. Six weeks were spent researching the challenges associated with implementing the National Wetlands Policy. Kabale District was used as a case-study to better understand the issues that institutions and stakeholders face when trying to abide by the precepts of the policy. Rapid …

Permission To Change: The Role Of Culture And Cultural Tourism In Development, Heather Houser

Independent Study Project (ISP) Collection

The Batwa are an indigenous people living throughout areas of central equatorial Africa. In Uganda, they constitute a small minority and live in parts of the West and Southwest, primarily in the districts of Bundibugyo, Kabale, Kisoro and Kanungu. This study was conducted in Kisoro District and the data deals primarily with the Batwa that live there. Many of the Batwa’s ancestral homelands were declared national parks in 1991. The Batwa were forced to leave and were given no compensation. As a result, many of them are now squatters and have been forced to beg for a living. Several organizations …

Local And National Health Advancement Using The Power Of Sport In South Africa, Lisa Zook

Independent Study Project (ISP) Collection

South Africa currently suffers greatly from disease and poverty. In particular, the country has a remarkably high prevalence of HIV/AIDS. This study looks at how the popularity of sport is being used to combat these social and health concerns. Many believe the power of sport is one means by which educational messages can be communicated to the public. Over a period of one month, three different sports related non-governmental organizations (NGOs) were examined. Two of the organizations, PeacePlayers International, which uses basketball to teach HIV/AIDS education and personal development, and loveLife Games, which uses sport to attract youth to their …

An Observational Analysis Of Psychosocial Behaviors And Caregiver Responses In The Durban Children’S Home, Sarah Young

Independent Study Project (ISP) Collection

In South Africa, many children find themselves in at risk situations arising from issues like HIV, abuse, and poverty, which highly impact their mental well being by forcing them into unlivable situations. The Durban Children’s Home, located in Glenwood, Durban, works to tackle this problem, providing facilities, meals, and care for 75 homeless, abused, terminally ill, and/or poverty stricken children. Yet in coming from situations where children no longer have support of their primary caregiver or environment, these children require quality psychosocial attention in the Home. However when basic needs of so many children must be met in an institutional …

The Realization Of The Rights To Health, Education And Social Welfare Among Disabled Youth In Ingwavuma And Bhambanana, Kwazulu Natal, Ali Mumford

Independent Study Project (ISP) Collection

This practicum based study was completed in an effort to explore the realization of the rights to health, education and social welfare for disabled children in Ingwavuma and Bhambana, KwaZulu Natal. Very little research has been done on disabled children in South Africa, and estimations of prevalence range from 3.3-6.4%. The absence of accurate data creates a situation where implementation of policy and delivery of services is slow and does not always address the most urgent needs. The new South Africa aimed to bring rights and freedom to all groups of people, but the question which this study attempts to …

The Learning Organization In A Post-Development Era: A Case Study On Orgnizational Development At The Valley Trust, Justin Haruyama

Independent Study Project (ISP) Collection

In the past two decades, the rise of Post-Development theory has witnessed the questioning of the core assumptions of development. Post-Development theorists point to the failures of “development” to create significant decreases in poverty or inequality worldwide. Meanwhile, other theorists call for radical transformations of conventional practice. This paper seeks to grapple with these questions, using the example of The Valley Trust, a development NGO in KwaZulu-Natal, South Africa, as an entry point into the debate. Research was conducted over a four-week period through a mixture of participant observation and formal interviews with staff members of The Valley Trust. An …

You’Ll Never Silence The Voice Of The Voiceless: Critical Voices Of Activists In Post-Apartheid South Africa, Kate Gunby

Independent Study Project (ISP) Collection

The purpose of this research has been to explore how and why former liberation activists have continued to speak out against the government since the African National Congress (ANC) transitioned from a liberation movement to a ruling party. These individuals highlight the importance of having a voice, and making that voice heard by the government. They also provide a plurality of opinions that are just a sampling of the sentiments held by South Africans today. The objective of my research is to better understand what is wrong with the ANC and South Africa, possible causes, and how they can be …

Evaluating The Medicinal Properties Of Mandravasarotra (Cinnamosa Sida) Through Chemical And Pharmacological Screening, Henry J. Bowden Jr.

Independent Study Project (ISP) Collection

I worked for four weeks at the University of Antananarivo (Ankatso), spending two weeks each in the chemistry and pharmacology laboratories. There I ran a total of eight experiments or “screens” with an alcoholic extract of the medicinal plant Mandravasarotra. This plant is found mainly in northwestern Madagascar, and is often used to stimulate contractions for women having difficulty giving birth. The plant tested positive for three secondary metabolites: tannins, steroids and flavanoids. In the pharmacological tests, the plant exhibited anti-inflammatory properties, and high toxicity in doses exceeding 10ml/kg. Together, conjectures may be made between what is known of the …

Kaya Hip-Hop In Coastal Kenya: The Urban Poetry Of Ukoo Flani, Divinity Lashelle Barkley

Independent Study Project (ISP) Collection

In the global world of the 21st Century, music is one of the few things that has the ability to cross physical as well as cultural borders, which is why my Independent Study Project (ISP) focuses on the role of hip-hop music in the youth culture in Kenya’s largest coastal city, Mombasa. Throughout history, music has proven its artistic power; inspiring people to resist oppression, challenge inequality, and even claim salvation.

This enduring characteristic of music is central to my ISP which explores the emergence of hip-hop in Kenya as well as the evolution of Ukoo Flani, one of the …

An Ancient Practice: Scarification And Tribal Marking In Ghana, Alyssa Irving

Independent Study Project (ISP) Collection

My research on tribal marking and face scarring took place in various parts of the country, but much of the information comes from the residents of Gwollu. By interviewing different people belonging to different regions and ethnic groups throughout the country, I was able to discover the main uses for marking: medical use, decoration, spiritual protection, and tribe or family identification (these marks specifically for ID can be referred to as tribal marks). This paper sweeps over the origins of marking and how it became quite important during slave raiding, but has various uses and implications in modern times. This …

Faith As A Means Of Healing: Traditional Medicine And The Ethiopian Orthodox Church In And Around Lalibela, Lauren Anderson

Independent Study Project (ISP) Collection

This paper examines and explores the relationship between indigenous medical traditions in Ethiopia and the healing rituals of the Ethiopian Orthodox Church. The practices still upheld by the Church today are explored in depth as is the prevalence of debtera, church educated traditional healers in Ethiopia. The relationship between traditional and modern modes of medical treatment in Ethiopia is explored as well as the legitimacy of both church healing and alternative medicine worldwide. Present research into the benefits of complementary and alternative medicine (CAM) including mind/body healing is also examined.

Community Forestry In Oaxaca: An Assessment Of The Level Of Autonomy In Forest Decision-Making And Its Environmental And Economic Importance, Peter Gill

Independent Study Project (ISP) Collection

No abstract provided.

Buscando La Luz: Changes In Partería And The Loss Of Feminine Autonomy In Oaxaca, Mexico, Hannah Ewert-Krocker

Independent Study Project (ISP) Collection

Birth is one of the most fundamental moments of every human being’s life, and women have long been honored in the world’s societies as sacred and vital due to their important roles as life-givers. Because of the importance of birth in the lives and societies of human beings, birth and birthing practices can reveal many values of a culture and of the women within that culture and also demonstrate how and why those values are changing. The choices women make between traditional health care and more “modern” Western models are almost always influenced by the socio-economic and cultural conditions of …

Creating Dreams, Fighting For Rights: A Study With Centro De Cultura Negra Do Maranhão, Brazil, Laura Jenks

Independent Study Project (ISP) Collection

The history of race in Brazil is a long and complicated one which has resulted in a contemporary racial climate fraught with hidden racism and the systematic oppression of the entire black population. Because of this complex history, black movements in Brazil have struggled to gain political power and unified support from the black population. Today, the black movement is made up of many independent organizations, working in their own way to fight racism and inequality within Brazil. This research project looks at the work of one such organization of the Brazilian black movement, the Centro de Cultura Negra in …

The Microcredit Impact: The Evaluation And Effects Of Microloans On Caboclos Communities Of The Tapajós River, Robert Chew

Independent Study Project (ISP) Collection

In 2002, Projeto Saúde e Alegria, an NGO dedicated to improving the health, education and socio-economic situation of rural caboclos communities of the greater Santarém region of Pará, began a microcredit program to facilitate the creation of alternative sources of income and poverty reduction within the communities. Three years later in 2005, the program was cancelled indefinitely due to low repayment rates. The following study attempts to identify and analyze what problems occurred within the microcredit program that led to the project’s eventual failure. Additionally, speculation into whether the program helped certain communities reduce poverty will also be investigated to …

Liberation Theology In The 21st Century: The Catholic Church, The Cpt, And Rural Movements In Southern Pará, Eleanor Sharp

Independent Study Project (ISP) Collection

This study explores the present-day manifestation of liberation theology in the south of Pará, Brazil. Liberation theology has been widely recognized as an important development in theology and Latin American history that helped spark social movements across South and Central America in the 1960s, 70s, and 80s. In the Brazilian Amazon, progressive Church workers (mainly Catholic) have been historically aligned with movements to protect and regain land rights for poor rural workers. Because these movements and organizations are the primary defenders of human rights in this part of Brazil, researching the changing role of religion in their work is important …

Desarrollo Turístico Y Sustentabilidad: Caso Villa Pehuenia Y La Comunidad Mapuche Puel, Sasha Shahidi

Independent Study Project (ISP) Collection

With limited resources and overpopulation on a global level, sustainable development is the only way that human beings will be able to survive on this earth. The problem is that the dominant model of development stresses the importance of economic profits in the short term and far too often exploits natural resources and less powerful cultural groups. This creates dangerous long-term affects as natural resources and indigenous cultures that depend on them continue to disappear with no plan, or possibility, to replace them. Sustainability seeks the least negative impacts possible on the natural environment and indigenous cultures in order to …

Class Of 2010 Incoming Il Law Students, St. Mary's University School Of Law, St. Mary's University School Of Law

Incoming 1L Photos (Facebooks)

Photographs of incoming law students for the St. Mary’s University School of Law, class of 2010

Harmonization Without Consensus: Critical Reflections On Drafting A Substantive Patent Law Treaty, Jerome H. Reichman, Rochelle Cooper Dreyfuss

Duke Law Journal

In this Article, we contend that the World Intellectual Property Organization's proposed Substantive Patent Law Treaty (SPLT) is premature. Developing countries are struggling to adjust to the heightened standards of intellectual property protection required by the TRIPS Agreement of 1994. With TRIPS, at least, these countries obtained side payments (in the form of trade concessions) to offset the rising costs of knowledge products. A free-standing instrument, such as the SPLT, would shrink the remaining flexibilities in the TRIPS Agreement with no side payments and no concessions to the catch-up strategies of developing countries at different stages of technological advancement. More …

Protecting The Least Of These: A New Approach To Child Pornography Pandering Provisions, Stephen T. Fairchild

Duke Law Journal

The pandering of child pornography - selling, distributing, or conveying the impression that one possesses sexually graphic images of children for sale or distribution - facilitates actual harm to children, such as molestation. Yet legislative attempts to curb pandering inevitably implicate concerns about panderers' First Amendment rights. This Note argues that in balancing the vulnerability of children against the power of the First Amendment, the law must shift to focus more on the subject of this grievous harm - children. This approach will appropriately extend protection to a subset of the population that is least able to protect itself.

An Analysis Of Rx For Discovery Reading For Elementary Students Below Average In Reading, Susan Kay Stanley

Doctoral Dissertations and Projects

Rx for Discovery Reading® is an intervention developed by the National Institute for Learning Development to impact the reading abilities of students below grade level in reading. The program was designed to address every area of reading acquisition, but, for this study, the areas of phonological processing, decoding, and fluency were investigated using pre- and post-test scores from the KTEA-II, GORT, and DIBELS. The problem studied was whether Rx for Discovery Reading® would raise the mean standard scores in the three areas at the conclusion of the field test. Using a small-group format, twenty-nine students who were not on grade …

Statement, Fall 2007, Office Of Alumni Relations. Morehead State University

Morehead State Alumni Association Publications

Statement magazine of Morehead State University for Fall of 2007.