Digital Commons Network^™

Food Safety, South-North Asymmetries, And The Clash Of Regulatory Regimes, Obijiofor Aginam

Vanderbilt Journal of Transnational Law

This Article explores the globalization of food safety concerns driven by the phenomenon of economic globalization, and the "legalization" of food safety disputes within the rules-based architecture of the World Trade Organization (WTO). Focusing on the interaction between WTO norms and the treaties of other multilateral organizations, the Article discusses the implications of the "clash of food safety regulatory regimes" for South-North asymmetrical relations between the rich and poor countries. The Article also discusses global economic diplomacy and the emerging WTO jurisprudence on the Agreement on Sanitary and Phyto-Sanitary Measures (SPS) disputes. This Article explores both the perceived and actual …

Empathizing With France And Pakistan On Agricultural Subsidy Issues In The Doha Round, Raj Bhala

Vanderbilt Journal of Transnational Law

Among the most contentious issues (if not the most contentious issue) in the Doha Round negotiations are agricultural subsidies. Developed countries stand accused of selfish adherence to domestic support and export subsidies that impoverish farmers in developing countries. Developing countries are blamed for self-inflicted wounds, caused by stubborn adherence to protectionist policies, covering both agricultural and industrial sectors. Agricultural subsidy cuts, as well as increased market access, are politically impossible for developed countries to concede without reciprocal access from developing countries, not only on farm products, but also in non-agricultural markets and service sectors.

There has been, and continues to …

Strafford County 2006 Annual Report Of The Commissioners, Treasurer, Other County Officers And The Strafford County Delegation Strafford County, New Hampshire For The Year Ending December 31, 2006., Stafford County Representatives

Strafford County, NH Annual Reports

This is an annual report containing vital statistics for a county in the state of New Hampshire.

Unenumerated Rights And The Limits Of Analogy: A Critque Of The Right To Medical Self-Defense, O. Carter Snead

Journal Articles

Volokh’s project stands or falls with the claim that the entitlement he proposes is of constitutional dimension. If there is no fundamental right to medical self-defense, the individual must, for better or worse, yield to the regulation of this domain in the name of the values agreed to by the political branches of government. Indeed, the government routinely restricts the instrumentalities of self-help (including self-defense) in the name of avoiding what it takes to be more significant harms. This same rationale accounts for current governmental limitations on access to unapproved drugs and the current ban on organ sales. The FDA …

Crossing Borders: Loving V. Virginia As A Story Of Migration, Victor C. Romero

Faculty Scholarship

The struggle of binational same-gender partners today parallels the struggles of Mildred and Richard Loving during the heyday of the Civil Rights Movement - not only in the obvious parallels between race and sexual orientation as barriers to freedom, but also in the way the law uses these immutable characteristics to limit the freedom of movement. It is this freedom of movement - this migration or immigration - that I want to focus on in this essay. Lest we forget, the Lovings' story is, importantly, a story of migration: It's a story of the great lengths to which an interracial …

Science, Morality, And Universities, Bryan Dowd

Minnesota Journal of Law, Science & Technology

No abstract provided.

Building Intellectual Property Management Capacity In Public Research Institutions In Vietnam: Current Needs And Future Directions, Laurel Kilgour

Minnesota Journal of Law, Science & Technology

No abstract provided.

"Don't Be Evil:" Google Faces The Chinese Internet Market And The Global Online Freedom Act Of 2007, Lindsay Eastwood

Minnesota Journal of Law, Science & Technology

No abstract provided.

In Re Fisher: Denial Of Patents For Ests Signals Deeper Problems In The Utility Prong For Patentability, Lillian Ewing

Minnesota Journal of Law, Science & Technology

No abstract provided.

Genomic Nutritional Profiling: Innovation And Regulation In Nutrigenomics, David Castle

Minnesota Journal of Law, Science & Technology

No abstract provided.

Suburbs As Exit, Suburbs As Entrance, Nicole Stelle Garnett

Journal Articles

Most academics assume that suburbanites are exiters who have abandoned central cities. The exit story is a foundational one in the fields of land-use and local-government law: Exiters' historical, social, and economic connections with their center cities are frequently used to justify both growth controls and regional government. The exit story, however, no longer captures the American suburban experience. For a majority of Americans, suburbs have become points of entrance to, not of exit from, urban life. Most suburbanites are enterers - people who were born in, or migrated directly to, suburbs and who have not spent time living in …

Upstream Of Peril: The Role Of Federal Lands In Addressing The Extinction Crisis: Twelfth Annual Lloyd K. Garrison Lecture On Environmental Law, Karin P. Sheldon

Pace Environmental Law Review

No abstract provided.

The Pardy-Ruhl Dialogue On Ecosystem Management, Part Iv: Narrowing And Sharpening The Questions, J. B. Ruhl

Pace Environmental Law Review

No abstract provided.

The Evolving Role Of Citizens In United States-Canadian International Environmental Law Compliance, Noah D. Hall

Pace Environmental Law Review

No abstract provided.

Alternative Dispute Resolution In Environmental Enforcement Cases: A Call For Enhanced Assessment And Greater Use, Joseph A. Siegel

Pace Environmental Law Review

No abstract provided.

Filling The Void In An Otherwise Occupied Field: Using Federal Common Law To Regulate Carbon Dioxide In The Absence Of A Preemptive Statute , Sarah Olinger

Pace Environmental Law Review

No abstract provided.

Assessing The Universal Declaration On Bioethics And Human Rights: Implications For Human Dignity And The Respect For Human Life, O. Carter Snead

Journal Articles

As advances in biomedical science and biotechnology continue to confer vast new powers to subdue nature for “the relief of man’s estate,” vexed moral and ethical questions inevitably arise about the use of such capacities. To what ends should they be applied? How might they be abused? Are they safe? What is the human meaning of such new powers? Might their use threaten human dignity? What does scientific freedom demand? What does justice require? Who should have access to the fruits of such scientific advances?

In democratic regimes, these questions do not long remain the subject of mere academic reflection …

Survey For Hymenopteran And Dipteran Parasitoids Of The Fall Armyworm (Lepidoptera: Noctuidae) In Chiapas, Mexico, Ramiro E. Ruiz-Najera, Jaime Molina-Ochoa, James E. Carpenter, Jorge A. Espinosa-Moreno, Jose Alfredo Ruiz-Najera, Roberto Lezama-Gutierrez, John E. Foster

Department of Entomology: Faculty Publications

A survey of hymenopteran and dipteran parasitoids of the fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) larvae was conducted to determine their occurrence and parasitism rates in Western Chiapas, Mexico. 1247 FAW larvae were collected from whorl-stage corn cornfields in 21 locations in the region called ‘‘La Frailesca’’ in Chiapas, Mexico during the summer of 2002; 251 larvae produced parasitoids for an overall parasitism rate of 20.1%. Five braconids were recovered from FAW larvae, Rogas vaughani Muesebeck, R. laphygmae Viereck, Chelonus insularis Cresson, C. cautus Cresson, and Glyptapanteles militaris Walsh. Two ichneumonids, Neotheronia sp., and Ophion flavidus Brulle, and one …

Group Rekeying Schemes For Secure Group Communication In Wireless Sensor Networks, Yong Wang, Byrav Ramamurthy

School of Computing: Conference and Workshop Papers

Wireless sensor networks are promising solutions for many applications. However, wireless sensor nodes suffer from many constraints such as low computation capability, small memory, limited energy resources, and so on. Grouping is an important technique to localize computation and reduce communication overhead in wireless sensor networks. In this paper, we use grouping to refer to the process of combining a set of sensor nodes with similar properties. We propose two centralized group rekeying (CGK) schemes for secure group communication in sensor networks. The lifetime of a group is divided into three phases, i.e., group formation, group maintenance, and group dissolution. …

Tgfβ3 Inhibits E-Cadherin Gene Expression In Palate Medial-Edge Epithelial Cells Through A Smad2-Smad4- Lef1 Transcription Complex, Ali Nawshad, Damian Medici, Chang-Chih Liu, Elizabeth D. Hay

College of Dentistry: Faculty Publications

Dissociation of medial-edge epithelium (MEE) during palate development is essential for mediating correct craniofacial morphogenesis. This phenomenon is initiated by TGFβ3 upon adherence of opposing palatal shelves, because loss of E-cadherin causes the MEE seam to break into small epithelial islands. To investigate the molecular mechanisms that cause this E-cadherin loss, we isolated and cultured murine embryonic primary MEE cells from adhered or non-adhered palates. Here, we provide the first evidence that lymphoid enhancer factor 1 (LEF1), when functionally activated by phosphorylated Smad2 (Smad2- P) and Smad4 (rather than β-catenin), binds with the promoter of the E-cadherin gene to repress …

Serum Proteome Profiling Detects Myelodysplastic Syndromes And Identifies Cxc Chemokine Ligands 4 And 7 As Markers For Advanced Disease, Manuel Aivado, Dimitrios Spentzos, Ulrich Germing, Gil Alterovitz, Xiao-Ying Meng, Franck Grall, Aristoteles A. N. Giagounidis, Giannoula Klement, Ulrich Steidl, Hasan H. Otu, Akos Czibere, Wolf C. Prall, Christof Iking-Konert, Michelle Shayne, Marco F. Ramoni, Norbert Gattermann, Rainer Haas, Constantine S. Mitsiades, Eric T. Fung, Towia A. Libermann

Department of Electrical and Computer Engineering: Faculty Publications

Myelodysplastic syndromes (MDS) are among the most frequent hematologic malignancies. Patients have a short survival and often progress to acute myeloid leukemia. The diagnosis of MDS can be difficult; there is a paucity of molecular markers, and the pathophysiology is largely unknown. Therefore, we conducted a multicenter study investigating whether serum proteome profiling may serve as a noninvasive platform to discover novel molecular markers for MDS. We generated serum proteome profiles from 218 individuals by MS and identified a profile that distinguishes MDS from non-MDS cytopenias in a learning sample set. This profile was validated by testing its ability to …

Communicative Predictors Of A Shared Family Identity: Comparison Of Grandchildren’S Perceptions Of Family-Of-Origin Grandparents And Stepgrandparents, Jordan Soliz

Department of Communication Studies: Faculty Publications

From an intergroup perspective on family relationships, the current study investigates family-of-origin grandparents and stepgrandparents to determine similarities and differences in communication and relational dimensions. Participants (N = 88) completed questionnaires on family-of-origin grandparents and stepgrandparent relationships. From the perspective of young adult grandchildren, the research explores the role of supportive communication, reciprocal self-disclosure, nonaccommodative communication, and parental encouragement in predicting a sense of shared family identity with each grandparent type. Results are discussed in terms of implications for intergroup research, grandparent-grandchild communication, and stepfamily relationships.

Identification Of Escherichia Coli O157:H7 Genomic Regions Conserved In Strains With A Genotype Associated With Human Infection, Marina Steele, Kim Ziebell, Yongxiang Zhang, Andrew K. Benson, Paulina Konczy, Roger Johnson, Victor Gannon

Department of Food Science and Technology: Faculty Publications

Beta-glucuronidase-negative, sorbitol-nonfermenting isolates of Shiga toxin-producing Escherichia coli O157 comprise part of a clone complex of related enterohemorrhagic E. coli isolates. High-resolution genotyping shows that the O157 populations have diverged into two different lineages that appear to have different ecologies. To identify genomic regions unique to the most common human-associated genotype, suppression subtractive hybridization was used to identify DNA sequences present in two clinical strains representing the human lineage I O157:H7 strains but absent from two bovine-derived lineage II strains. PCR assays were then used to test for the presence of these regions in 10 lineage I strains and 20 …

Regional Mechanical Properties And Stress Analysis Of The Human Anterior Lens Capsule, Ryan M. Pedrigi, G. David, J. Dziezyc, J. D. Humphrey

Department of Mechanical and Materials Engineering: Faculty Publications

The lens capsule of the eye functions, in part, as a deformable support through which the ciliary body applies tractions that can alter lens curvature and corresponding refractive power during the process of accommodation. Although it has long been recognized that characterization of the mechanical properties of the lens capsule is fundamental to understanding this physiologic process as well as clinical interventions, prior data have been limited by one-dimensional testing of excised specimens despite the existence of multiaxial loading in vivo. In this paper, we employ a novel experimental approach to study in situ the regional, multiaxial mechanical behavior of …

Pines, C. Plomion, D. Chagné, D. Pot, S. Kumar, P. L. Wilcox, R. D. Burdon, D. Prat, D. G. Peterson, J. Paiva, P. Chaumeil, G. G. Vendramin, F. Sebastiani, C. D. Nelson, C. S. Echt, O. Savolainen, T. L. Kubisiak, M. T. Cervera, N. De María, M. N. Islam-Faridi

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Pinus is the most important genus within the Family Pinaceae and also within the gymnosperms by the number of species (109 species recognized by Farjon 2001) and by its contribution to forest ecosystems. All pine species are evergreen trees or shrubs. They are widely distributed in the northern hemisphere, from tropical areas to northern areas in America and Eurasia. Their natural range reaches the equator only in Southeast Asia. In Africa, natural occurrences are confined to the Mediterranean basin. Pines grow at various elevations from sea level (not usual in tropical areas) to highlands. Two main regions of diversity are …

Protecting Soil And Water In Forest Road Management, J. M. Grace Iii, B. D. Clinton

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The National Forest road system is the network that supports public recreation, which has become the primary use of the public lands. The pattern of use of National Forest roads for recreation has increased dramatically since the late 1940s and is expected to continue to increase beyond the rates observed today. However, research over the past 60 years clearly presents forest roads as a major source of sediment and soil erosion from forest watersheds. Threats to healthy forests have received increased attention in the past decade. In particular, roads, road management, and travel management will likely be critical to addressing …

Giving Voice To Wildlands Visitors: Selecting Indicators To Protect And Sustain Experiences In The Eastern Arctic Of Nunavut, Alan Watson, Brian Glaspell, Neal Christensen, Paul Lachapelle, Vicki Sahanatien, Frances Gertsch

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Many public land management agencies are committed to understanding and protecting recreation visitor experiences. Parks Canada is deeply committed to that objective for visitors to Canada’s National Parks. This 2004 study, informed by a 2003 qualitative study of visitor experiences and influences on those experiences at Auyuittuq National Park in Nunavut, worked to bring 50 potential elements of visitor experiences down to five articulated dimensions of the experience that is currently being received at this remote eastern arctic park. A hypothesized set of 17 influences on experiences, also reduced to just two factors with similar response patterns, and with some …

Structural Definition Of A Conserved Neutralization Epitope On Hiv-1 Gp120, Tongqing Zhou, Ling Xu, Barna Dey, Ann J. Hessell, Donald Van Ryk, Shi-Hua Xiang, Xinzhen Yang, Mei-Yun Zhang, Michael B. Zwick, James Arthos, Dennis R. Burton, Dimiter S. Dimitrov, Joseph Sodroski, Richard Wyatt, Gary J. Nabel, Peter D. Kwong

Nebraska Center for Virology: Faculty Publications

The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3Å resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally …

Structures Of The Ccr5 N Terminus And Of A Tyrosine-Sulfated Antibody With Hiv-1 Gp120 And Cd4, Chih-Chin Huang, Son N. Lam, Priyamvada Acharya, Min Tang, Shi-Hua Xiang, Syed Shahzad-Ul Hussan, Robyn L. Stanfield, James Robinson, Ian A. Wilson, Richard Wyatt, Carole A. Bewley, Peter D. Kwong

Nebraska Center for Virology: Faculty Publications

The CCR5 co-receptor binds to the HIV-l gp120 envelope glycoprotein and facilitates HIV-l entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (α-helix) and 412d (extendedloop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for …

Functional Interplay Between The B-Box 2 And The B30.2(Spry) Domains Of Trim5Α, Xi Ling, Byeongwoon Song, Shi-Hua Xiang, Joseph Sodroski

Nebraska Center for Virology: Faculty Publications

The retroviral restriction factors, TRIM5α and TRIMCyp, consist of RING and B-box 2 domains separated by a coiled coil from carboxy-terminal domains. These carboxy-terminal domains (the B30.2(SPRY) domain in TRIM5α and the cyclophilin A domain in TRIMCyp) recognize the retroviral capsid. Here we show that some B-box 2 changes in TRIM5α, but not in TRIMCyp, resulted in decreased human immunodeficiency virus (HIV-1) capsid binding. The phenotypic effects of these B-box 2 changes on the restriction of retroviral infection depended on the potency of restriction and the affinity of the TRIM5α interaction with the viral capsid, two properties specified by the …