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2007

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Acceleration Of The Maturation Of Tissue Engineered Grafts By Dynamic Force Stimulation Or Gene Therapy, Shila Taylor Dec 2007

Acceleration Of The Maturation Of Tissue Engineered Grafts By Dynamic Force Stimulation Or Gene Therapy, Shila Taylor

All Theses

Over 16 million people suffer from osteoarthritis (OA). As the body ages OA and other cartilage diseases create an imbalance of anabolic and catabolic cell activities in cartilage and or over time the cartilage is damaged and wears away which creates lesion that resulting in pain. Most clinical surgeries are either temporary or have not gone through trials to test their success. For a long term solution researchers have been looking at replacing cartilage with a tissue engineered graft. One of the major problems to date has been is the strength of the scaffold.
Natural cartilage needs loading for its …

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Volume 45, Number 18: December 19, 2007, University Of North Dakota Dec 2007

Volume 45, Number 18: December 19, 2007, University Of North Dakota

University Letter Archive

No abstract provided.

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Repeated N-Acetylcysteine Administration Alters Plasticity-Dependent Effects Of Cocaine, Aric Madayag, Doug Lobner, Kristen S. Kau, John R. Mantsch, Omer Abdulhameed, Matthew Hearing, Mark D. Grier, David A. Baker Dec 2007

Repeated N-Acetylcysteine Administration Alters Plasticity-Dependent Effects Of Cocaine, Aric Madayag, Doug Lobner, Kristen S. Kau, John R. Mantsch, Omer Abdulhameed, Matthew Hearing, Mark D. Grier, David A. Baker

Biomedical Sciences Faculty Research and Publications

Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction. System xc− influences glutamate neurotransmission by maintaining basal, extracellular glutamate in the nucleus accumbens, which, in turn, shapes synaptic activity by stimulating group II metabotropic glutamate autoreceptors. In the present study, we tested the hypothesis that a long-term reduction in system xc− activity is part of the plasticity produced by repeated cocaine that results in the establishment of compulsive drug seeking. To test this, the cysteine prodrug N-acetylcysteine …

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Transcript Of Secretary Paulson And Governor Schwarzenegger Roundtable On Trade Long Beach, Calif., Henry M. Paulson Jr., Arnold Schwarzenegger Dec 2007

Transcript Of Secretary Paulson And Governor Schwarzenegger Roundtable On Trade Long Beach, Calif., Henry M. Paulson Jr., Arnold Schwarzenegger

Documents

No abstract provided.

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Identification Of Novel High-Frequency Dna Methylation Changes In Breast Cancer., Jared M. Ordway, Muhammad A. Budiman, Yulia Korshunova, Rebecca K. Maloney, Joseph A. Bedell, Robert W. Citek, Blaire Bacher, Seth Peterson, Tracy Rohlfing, Jacqueline Hall, Robert Brown, Nathan Lakey, Rebecca W. Doerge, Robert A. Martienssen, Jorge Leon, John D. Mcpherson, Jeffrey A. Jeddeloh Dec 2007

Identification Of Novel High-Frequency Dna Methylation Changes In Breast Cancer., Jared M. Ordway, Muhammad A. Budiman, Yulia Korshunova, Rebecca K. Maloney, Joseph A. Bedell, Robert W. Citek, Blaire Bacher, Seth Peterson, Tracy Rohlfing, Jacqueline Hall, Robert Brown, Nathan Lakey, Rebecca W. Doerge, Robert A. Martienssen, Jorge Leon, John D. Mcpherson, Jeffrey A. Jeddeloh

Department of Statistics Faculty Publications

Recent data have revealed that epigenetic alterations, including DNA methylation and chromatin structure changes, are among the earliest molecular abnormalities to occur during tumorigenesis. The inherent thermodynamic stability of cytosine methylation and the apparent high specificity of the alterations for disease may accelerate the development of powerful molecular diagnostics for cancer. We report a genome-wide analysis of DNA methylation alterations in breast cancer. The approach efficiently identified a large collection of novel differentially DNA methylated loci (~200), a subset of which was independently validated across a panel of over 230 clinical samples. The differential cytosine methylation events were independent of …

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Romney Keeps Lead, Mccain Claims Second Slot In Nh 12/19/2007, Unh Survey Center Dec 2007

Romney Keeps Lead, Mccain Claims Second Slot In Nh 12/19/2007, Unh Survey Center

All UNH Survey Center Polls

Mitt Romney has managed to keep his lead in the New Hampshire Republican primary although John McCain has moved past Rudy Giuliani into the second position. And while Mike Huckabee continues to campaign strongly in Iowa, he has not yet broken through on in New Hampshire. But almost half of Republican voters say they have yet to decide who they will eventually vote for. Election: NH Primary 2008

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Clinton Leads Obama In Nh, On All Issues 12/19/2007, Unh Survey Center Dec 2007

Clinton Leads Obama In Nh, On All Issues 12/19/2007, Unh Survey Center

All UNH Survey Center Polls

Hillary Clinton has expanded her lead over Barack Obama in the New Hampshire primary. Clinton leads her Democratic rivals on all top campaign issues. Election: NH Primary 2008

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Pyridinium Bisretinoids: Synthesis And Photoactivated Cytotoxicity, Junping Gao Dec 2007

Pyridinium Bisretinoids: Synthesis And Photoactivated Cytotoxicity, Junping Gao

Theses and Dissertations

This thesis discusses pyridinium bisretinoid compounds (PBRs), which were prepared for two purposes: 1) to use them as standards for detection of novel fluorophores in human RPE cells, which may be involved in age-related macular degeneration (AMD), and 2) to use them in the development of a targeted and triggered drug delivery system for cancer therapy. We prepared a selection of PBRs using a one-pot biomimetic method; synthesis, mechanisms for formation, and characterization of these compounds is described. We also explored the photoreactivity of three novel PBR compounds and found that these PBRs form oxidation products under blue-light irradiation. The …

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Towards An Understanding Of Salient Neighborhood Boundaries: Adolescent Reports Of An Easy Walking Distance And Convenient Driving Distance, Natalie Colabianchi, Marsha Dowda, Karin A. Pfeiffer, Dwayne E. Porter, Maria João Ca Almeida, Russell R. Pate Dec 2007

Towards An Understanding Of Salient Neighborhood Boundaries: Adolescent Reports Of An Easy Walking Distance And Convenient Driving Distance, Natalie Colabianchi, Marsha Dowda, Karin A. Pfeiffer, Dwayne E. Porter, Maria João Ca Almeida, Russell R. Pate

Faculty Publications

Numerous studies have examined the association between the surrounding neighborhood environment and physical activity levels in adolescents. Many of these studies use a road network buffer or Euclidean distance buffer around an adolescent's home to represent the appropriate geographic area for study (i.e., neighborhood). However, little empirical research has examined the appropriate buffer size to use when defining this area and there is little consistency across published research as to the buffer size used. In this study, 909 12th grade adolescent girls of diverse racial and geographic backgrounds were asked to report their perceptions of an easy walking distance and …

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Results Of The 2007 Indiana Ems Workforce And Training Assessment, George Avery Dec 2007

Results Of The 2007 Indiana Ems Workforce And Training Assessment, George Avery

RCHE Presentations

Project conducted under office of Rural Health, Indiana State Department of Health from december 2006-August 2007.

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Commencement Convocation Program, St. Petersburg Campus, December 18, 2007, University Of South Florida St. Petersburg Dec 2007

Commencement Convocation Program, St. Petersburg Campus, December 18, 2007, University Of South Florida St. Petersburg

USF St. Petersburg Graduations and Commencements

Regional Chancellor's Award for Civic Leadership: Roy Harrell

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Commencement Convocation Program, St. Petersburg Campus, December 18, 2007, University Of South Florida Dec 2007

Commencement Convocation Program, St. Petersburg Campus, December 18, 2007, University Of South Florida

USF Graduation and Convocation Programs

Regional Chancellor's Award for Civic Leadership - Roy Harrell; Outstanding Graduate - Brenda Mettetal

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Students In Dietetics Lead Program For High School Students In Batesville, Jennifer Farish Dec 2007

Students In Dietetics Lead Program For High School Students In Batesville, Jennifer Farish

University of Mississippi News

OXFORD, Miss. -­ Students studying dietetics at the University of Mississippi got hands-on experience and influenced the lives of some high school students in late November thanks to a $7,500 grant from the Mississippi chapter of the March of Dimes. The "New Futures" program, administered at South Panola High School in Batesville, focused on educating students about the dangers of poor nutrition during pregnancy, the risk factors of premature labor and the importance of learning how to set goals to continue their education, said Teresa Carithers, chair of the Department of Family and Consumer Science and principal investigator for the …

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Towards An Understanding Of Salient Neighborhood Boundaries: Adolescent Reports Of An Easy Walking Distance And Convenient Driving Distance, Natalie Colabianchi, Marsha Dowda, Karin A. Pfeiffer, Dwayne E. Porter, Maria João C. A. Almeida, Russell R. Pate Dec 2007

Towards An Understanding Of Salient Neighborhood Boundaries: Adolescent Reports Of An Easy Walking Distance And Convenient Driving Distance, Natalie Colabianchi, Marsha Dowda, Karin A. Pfeiffer, Dwayne E. Porter, Maria João C. A. Almeida, Russell R. Pate

Faculty Publications

Numerous studies have examined the association between the surrounding neighborhood environment and physical activity levels in adolescents. Many of these studies use a road network buffer of Euclidean distance buffer around an adolescent's home to represent the appropriate geographic area for study (i.e., neighborhood). However, little empirical research has examined the appropriate buffer size to use when defining this area and there is little consistency across published research as to the buffer size used. In this study, 909 12th grade adolescent girls of diverse racial and geographic backgrounds were asked to report their perceptions of an easy walking distance …

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The Changing Faces Of New Hampshire: Recent Demographic Trends In The Granite State, Kenneth M. Johnson Dec 2007

The Changing Faces Of New Hampshire: Recent Demographic Trends In The Granite State, Kenneth M. Johnson

Carsey Publications

New Hampshire, with a total population of 1.3 million, gained 79,000 residents between 2000 and 2006. Most of this growth (51,000 residents) came from migration. The migration also brought economic gains: New Hampshire gained at least $1.4 billion in income from migration between 2001 and 2005, and households moving in earned nearly $9,000 more than those leaving.

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Common And Distinct Mechanisms Of Different Redox-Active Carcinogens Involved In The Transformation Of Mouse Jb6p+ Cells, Sun Yang, Bobbye J. Misner, Rita Chiu, Frank L. Meyskens Jr. Dec 2007

Common And Distinct Mechanisms Of Different Redox-Active Carcinogens Involved In The Transformation Of Mouse Jb6p+ Cells, Sun Yang, Bobbye J. Misner, Rita Chiu, Frank L. Meyskens Jr.

Pharmacy Faculty Articles and Research

We transformed JB6P+ cells with prolonged intermittent low-dose UVB radiation or prolonged exposure to low-dose H2O2 or CdCl2. Stable transformation was confirmed by an anchorage-independence assay. The JB6P+ transformants formed more colonies (∼six folds) in soft agar as compared to their JB6P+ parent cells and were associated with increased intracellular reactive oxygen species (ROS) levels. Activating protein-1 (AP-1) is a family of transcription factors that are rapidly activated by elevated intracellular ROS levels, and their composition is important in the process of cellular transformation and/or tumor progression. To investigate if carcinogenesis induced by distinct carcinogens was via similar molecular mechanisms …

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Short-Wavelength Light Sensitivity Of Circadian, Pupillary, And Visual Awareness In Humans Lacking An Outer Retina, Farhan H. Zaidi, Joseph T. Hull, Stuart N. Peirson, Katharina Wulff, Daniel Aeschbach, Joshua J. Gooley, George C. Brainard, Kevin Gregory-Evans, Joseph F. Rizzo Iii, Charles A. Czeisler, Russell G. Foster, Merrick J. Moseley, Steven W. Lockley Dec 2007

Short-Wavelength Light Sensitivity Of Circadian, Pupillary, And Visual Awareness In Humans Lacking An Outer Retina, Farhan H. Zaidi, Joseph T. Hull, Stuart N. Peirson, Katharina Wulff, Daniel Aeschbach, Joshua J. Gooley, George C. Brainard, Kevin Gregory-Evans, Joseph F. Rizzo Iii, Charles A. Czeisler, Russell G. Foster, Merrick J. Moseley, Steven W. Lockley

Department of Neurology Faculty Papers

As the ear has dual functions for audition and balance, the eye has a dual role in detecting light for a wide range of behavioral and physiological functions separate from sight. These responses are driven primarily by stimulation of photosensitive retinal ganglion cells (pRGCs) that are most sensitive to short-wavelength ( approximately 480 nm) blue light and remain functional in the absence of rods and cones. We examined the spectral sensitivity of non-image-forming responses in two profoundly blind subjects lacking functional rods and cones (one male, 56 yr old; one female, 87 yr old). In the male subject, we found …

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Nursing Faculty Member Awarded Fellowship, Rachel Hatch Dec 2007

Nursing Faculty Member Awarded Fellowship, Rachel Hatch

News and Events (Discontinued Series)

No abstract provided.

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Stevenson Center Compass, Vol. 1, Iss. 1, December 18, 2007, Illinois State University, Stevenson Center For Community And Economic Development Dec 2007

Stevenson Center Compass, Vol. 1, Iss. 1, December 18, 2007, Illinois State University, Stevenson Center For Community And Economic Development

Stevenson Center Compass

Newsletter for the Stevenson Center for Community and Economic Development

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Evidence-B(I)Ased Medicine: Limitations And Non-Superstition-Based Alternatives, Joshua S. Green M.D., Ph.D. (Pgy4) Dec 2007

Evidence-B(I)Ased Medicine: Limitations And Non-Superstition-Based Alternatives, Joshua S. Green M.D., Ph.D. (Pgy4)

Jefferson Journal of Psychiatry

The Evidence-Based Medicine (EBM) movement crystallized in the early 1990's at McMaster University in Canada. The movement originally challenged practitioners to validate their treatments based on reasoning and clinical studies rather than personal authority. In this essay, I will argue that, contrary to this wholesome intention, EBM is authoritarian in spirit and actually constricts discourse about how to make clinical decisions.

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Diphenhydramine-Dependence Resulting From Self-Medication Of Antipsychotic- Induced Extrapyramidal Symptoms, Faisal S. Shaikh M.B.B.S., Ann M. Mortimer M.D. Dec 2007

Diphenhydramine-Dependence Resulting From Self-Medication Of Antipsychotic- Induced Extrapyramidal Symptoms, Faisal S. Shaikh M.B.B.S., Ann M. Mortimer M.D.

Jefferson Journal of Psychiatry

Antipsychotic-induced extrapyramidal symptoms should be recognised and adequately treated. We report an unusual complication of not doing so: a patient’s self-medicating to control these symptoms, which produced diphenhydramine-dependence.

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Dissociative-Like Spells In A Child With Neurofibromatosis (Type 1), Gregory M. Singleton M.D. (Pgy2), Ann M. Lagges Ph.D., Karen G. Meighen M.D. Dec 2007

Dissociative-Like Spells In A Child With Neurofibromatosis (Type 1), Gregory M. Singleton M.D. (Pgy2), Ann M. Lagges Ph.D., Karen G. Meighen M.D.

Jefferson Journal of Psychiatry

Neurofibromatosis, type 1, (NF1) is a common neurocutaneous disorder of childhood. Little is known about the psychiatric aspects of the condition. We present the case of a 10-year-old male with NF1 and complex spells. For two years he had been experiencing self-limited paroxysms of auditory and visual hallucination, assaultiveness, excited undressing, and amnesia. The spells have been refractory to multiple treatments, including antipsychotic medication. The question remains whether this episodic amnestic disorder is comorbid with NF1 or is caused by it.

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A Major Event Of Self-Mutilation In A Patient With Fetal Alcohol Syndrome, Joel P. Johnson M.D. (Pgy4), Steven Sugden M.D., James A. Bourgeois O.D., M.D. Dec 2007

A Major Event Of Self-Mutilation In A Patient With Fetal Alcohol Syndrome, Joel P. Johnson M.D. (Pgy4), Steven Sugden M.D., James A. Bourgeois O.D., M.D.

Jefferson Journal of Psychiatry

We describe a young adult male with fetal alcohol syndrome (FAS) who presented with a non-repetitive, major, genital self-mutilation necessitating urological intervention. On formal psychiatric evaluation, he did not have psychosis or suicidality. Most commonly, self-injury in developmental disability is less severe and more stereotypic; major-class self-mutilation is confined, generally, to psychosis. It is this discrepancy that is the unusual feature of our case.

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Autocastration And Autoamputation Of The Penis In A Patient With Delusions Of Sexual Guilt, Craig B. Franke M.D. (Pgy4), James A. Rush M.D. (Pgy3) Dec 2007

Autocastration And Autoamputation Of The Penis In A Patient With Delusions Of Sexual Guilt, Craig B. Franke M.D. (Pgy4), James A. Rush M.D. (Pgy3)

Jefferson Journal of Psychiatry

Genital self-mutilation (GSM) is a rare event that is commonly associated with psychotic disorders; we report an occurrence in the context of psychosis and drug use. We also review the etiologies of this phenomenon and how these etiologies differ across gender.

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Clozapine, Fluoxetine, And Benztropine- Associated Ileus: Case Report, Pegah Pajouhi M.D. (Pgy1), James A. Bourgeois O.D., M.D. Dec 2007

Clozapine, Fluoxetine, And Benztropine- Associated Ileus: Case Report, Pegah Pajouhi M.D. (Pgy1), James A. Bourgeois O.D., M.D.

Jefferson Journal of Psychiatry

Gastrointestinal complications of anticholinergic medications are prevalent, potentially life-threatening, and could be more actively prevented. We present a case report of an ileus that required surgical intervention and developed in the context of clozapine, benztropine, and fluoxetine use. The case exemplifies the potential anticholinergic toxicities of clozapine and benztropine as well as possible pharmacokinetic interactions between fluoxetine, clozapine, and benztropine. We discuss ways to minimize the likelihood of anticholinergic complications with these medications.

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Cognitive Functioning, Immune Functioning, And Disease Progression In Perinatally Infected Hiv+ School-Aged Children On Highly Active Anti Retroviral Therapy, Erin Theresa O'Callaghan Dec 2007

Cognitive Functioning, Immune Functioning, And Disease Progression In Perinatally Infected Hiv+ School-Aged Children On Highly Active Anti Retroviral Therapy, Erin Theresa O'Callaghan

Open Access Dissertations

This study is one of the only investigations to examine the complex inter-relationships between immune status, cognitive functioning, and disease progression in school-aged, perinatally infected, HIV+ children on HAART over time and is the first to conduct long-term follow-up assessments beyond one year after initiating HAART. Previous research has shown that HIV+ children on HAART show stability in cognitive functioning for up to one year. The current study investigated cognitive functioning, as measured by the Wechsler Intelligence Scale for Children -III, as a function of immune functioning and disease progression over time in this sample. Overall, results showed that PIQ …

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The Dose-Response Of Maternal Exercise Volume On Newborn And Placental Outcomes, Melisa A. Mena Dec 2007

The Dose-Response Of Maternal Exercise Volume On Newborn And Placental Outcomes, Melisa A. Mena

Open Access Dissertations

Current ACOG guidelines recommend exercise during a low-risk pregnancy for 30 minutes on most, if not all days of the week. However, little is known about how the volume of exercise performed during pregnancy affects fetoplacental size. In addition, the confounding effects of maternal nutrient intake and weight gain, and how they interact with exercise volume to influence fetoplacental size have not been appropriately addressed. Therefore, the purpose of this study was to examine the effects of varying maternal exercise volumes on neonatal birthweight and placental volume, while addressing the influence of maternal nutrient intake and weight gain. Subjects evaluated …

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Pistor V. Secretary Hhs Dec 2007

Pistor V. Secretary Hhs

2007 Decisions

USDC for the District of New Jersey

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Commencement Convocation Program, Lakeland Campus, December 17, 2007, University Of South Florida Dec 2007

Commencement Convocation Program, Lakeland Campus, December 17, 2007, University Of South Florida

USF Graduation and Convocation Programs

Outstanding Senior - Tara Crum; Distinguished Service Award - Commissioner Jack Myers

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Uab Announces Health System Interim Leadership, Staff Dec 2007

Uab Announces Health System Interim Leadership, Staff

Browse All News

No abstract provided.

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