Digital Commons Network^™

Accessibility Of Wvu Websites For Individuals With Vision Impairments, Sarah Jacobin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recently, several major corporations have been sued because their websites are inaccessible to individuals with disabilities. For a website to be accessible, people with disabilities should be able to navigate and interact with the site. Individuals who are blind or have vision impairments have difficulty accessing websites because they commonly use assistive technology to interpret content. This study is the first comprehensive study assessing the accessibility of WVU websites for individuals with disabilities, specifically individuals with visual impairments and comparing those results to those of two comparable universities in other areas of the country. Compliance with specifications of website accessibility …

Application Of The Emotional Intelligence Construct To College Student Binge Drinking, Jeffrey P. Dulko

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although extensive research has been conducted in the area of college binge drinking, relatively little has been done to study differences among alcohol-related consequences. Some initial studies have shown that binge drinking and its consequences are associated with several emotional and interpersonal factors, but there has been no comprehensive examination of these relationships. The theory of emotional intelligence (EI) has been developed recently to study emotional and interpersonal factors as an integrated construct. Research of the relationship between alcohol and EI could provide a valuable base for which to design alcohol prevention programs that target improving emotional and interpersonal deficits …

The Cystic Fibrosis Transmembrane Conductance Regulator: Regulation By Hsp-90, Kevin Marrs

Theses and Dissertations (ETD)

The hypothesis of this project is that a functionally relevant association exists between CFTR and Hsp90. In testing this hypothesis, (a) the association of CFTR and Hsp90 is confirmed via crosslinking and immunoprecipitation of CFTR from stably transfected HEK-293 cells, electrophoretic separation of cross-linked proteins, and protein identification via SDS-PAGE, western blotting, and mass spectrometry. Also, this hypothesis is tested by (b) functionally assessing the effect of Hsp90 on CFTR function via Ussing chamber analysis, two-electrode voltage clamp analysis, preliminary in vivoanimal studies, and protein phosphorylation. The HEK-293 Flag-CFTR cells used in this study allows for a high degree …

Theoretical And Experimental Evaluation Of Spatial Resolution In A Variable Resolution X-Ray Computed Tomography Scanner, Roman Melnyk

Theses and Dissertations (ETD)

A variable resolution x-ray (VRX) computed tomography (CT) scanner can image objects of various sizes with greatly improved spatial resolution. The scanner employs an angulated discrete detector and achieves the resolution boost by matching the detector angulation to the scanner field of view (FOV) determined by the size of an object being imaged. A comprehensive evaluation of spatial resolution in an experimental version of the VRX CT scanner is presented in this dissertation. Two components of this resolution were evaluated – the pre-reconstruction spatial resolution, described by the detector presampling modulation transfer function (MTF), and the post-reconstruction spatial resolution, given …

Dna Binding Specificity Of Mu Transcription Factor C And Crystallization Of C : Dna Complex, Karthik Shanmugantham

Theses and Dissertations (ETD)

The lytic cycle of phage Mu is regulated by a transcriptional cascade consisting of early, middle and late transcription. The Mor protein is an activator of the middle promoter Pm and is encoded by the last gene of the early transcript. The C protein is an activator of the four late promoters Plys, PI, PP, and Pmom and is expressed from the middle transcript. Both Mor and C proteins bind an imperfect dyad-symmetry element just upstream and overlapping the –35 region of Pm and Plys respectively. The main aims of this study was, (1) To understand the binding specificity of …

Synthesis Of Novel Sulfonamide-Based Calpain Inhibitors And Their Potential As Anti-Tumor Agents, Jin Xu

Theses and Dissertations (ETD)

Calpain is a class of intracellular cytoplasmic cysteine proteases.1 The enzyme participates in different intracellular signaling pathways that are mediated by Ca2+.2 The two major isoforms of calpain universally distributed in most mammalian tissues are calpain 1 (µ-calpain) and calpain 2 (m-calpain). The exact in vivo function of the enzyme is not clear, but calpain has been implicated in a variety of physiological and pathological conditions,3 such as cancer, stroke, cardiac ischaemia, muscular dystrophy, cataract and Alzheimer’s disease. Calpain inhibitors are therefore of interest as therapeutic agents and as biomedical tools.

Several potent calpain inhibitors isolated from natural sources as …

Cardiopulmonary Predicators Of Dysfunctional Ventilator Weaning Response After Coronary Artery Bypass Graft, Annapoorna Mary

Theses and Dissertations (ETD)

Although the majority of coronary artery bypass graft (CABG) surgery patients are extubated within 6 to 8 hours following surgery, 20% to 40% of patients remain intubated 12 hours after surgery due to dysfunctional ventilator weaning response (DVWR). DVWR associated with increased morbidity and mortality (30% to 43%) following CABG surgery. Finding significant antecedence to predict DVWR could help to identify and prevent the complications from DVWR after CABG surgery. Literature review revealed that there is an association between cardiopulmonary indicators (CPI) and DVWR after CABG surgery. Cardiopulmonary indicators are the selected hemodynamic parameters that have an association with DVWR. …

The Legal Ethics Of Pediatric Research, Doriane Lambelet Coleman

Duke Law Journal

Since the mid- to late 1990s, the scientific and medical research community has sought to increase its access to healthy children for research protocols that involve harm or a risk of harm. This move reverses longstanding policy within that community generally to exclude healthy children from such protocols on the grounds that the research as to them is non-therapeutic, that they are particularly vulnerable to research-related abuses, and that they are unable themselves to give informed consent to their participation. The research community's new posture has been supported by prominent pediatric bioethicists who have argued that unless healthy children are …

The Long-Term Teratogenic Effect Of Prenatal Alcohol Exposure On The Somatosensory And Motor Cortex Of Rats, Tyson Chappell

Theses and Dissertations (ETD)

The primary goal of this dissertation was to examine the long-term effect of prenatal alcohol exposure (PAE) on the primary somatosensory (SI) and primary motor cortex (MI). For over 30 years, PAE has been shown to produce a triad of symptoms (growth deficits, craniofacial dysmorphologies and central nervous system disruptions) diagnosed as fetal alcohol syndrome (FAS) in children and adults. Since low to moderate levels of prenatal alcohol exposure are less likely to produce FAS symptoms in children, the term “PAE” in this dissertation typically refers to heavy/abusive/chronic levels of prenatal alcohol exposure (in humans this equates to 5+ drinks/per …

Investigating Web-Based Recruitment Sources: Employee Testimonials Vs Word-Of-Mouse, Greet Van Hoye, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Although the internet has dramatically changed recruitment practices, many web-based recruitment sources have not yet been investigated. The present study examines the effects of web-based employee testimonials and web-based word-of-mouth (i.e., 'word-of-mouse') on organizational attraction. The source credibility framework is used to compare these company-dependent and company-independent recruitment sources. In a sample of potential applicants for a head nurse position, word-of-mouse was associated with higher organizational attractiveness than web-based employee testimonials. However, potential applicants were more attracted when testimonials provided information about individual employees than about the organization. Conversely, word-of-mouse was associated with higher organizational attractiveness and more organizational pursuit …

Black Feminist Autobiographical Inquiry Into The Experiences Of A Teen Mom, Advis Dell Wilkerson

College of Graduate Studies: Theses & Dissertations

Using Black feminist thought as the theoretical framework and autobiographical inquiry as methodology, I explored ways in which adversity fostered resiliency of character. Despite difficult circumstances, such as growing up in a poor, single-parent household and becoming pregnant in the 9th grade when continuing one's education after pregnancy or marriage was not permitted in the Deep South, with the help of others, I fought to finish my high school education and succeeded in college. I credit a close bond with a supportive adult and my own development of racial awareness with helping me to turn obstacles into successes. My intent …

Man Behind The Curtain: The 2004 Election From A Historical Perspective, Melissa Michelle Merritt

College of Graduate Studies: Theses & Dissertations

The 2004 election was a very contentious display of modern democracy. It illustrated that political candidates market themselves as though they were products to be bought from a store. By utilizing newspaper articles, autobiographies, and various other sources, this study seeks to show several things. First, it illustrates the evolution of presidential campaigns from the first contested election until the controversial 2000 election. Second, it traces the rise of the Christian Right. It then delves into the Cold War and the War on Terror as a continuation of the former. Finally, the study culminates with an examination of the 2004 …

Design And Real-Time Control Of Shipboard Power System Testbed, Pradeep Pant

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this thesis is to design and test a small scale testbed for the all-electric shipboard power distribution system. Shipboard power system is increasingly becoming more reconfigurable, and multi-agent systems are developed to automate routine operation and emergency reconfiguration. Underlying algorithms of these systems have been verified using software simulation tools. However, these simulators run in soft realtime by using simple mathematical models to represent the physical system. These models do not incorporate every aspect of the physical system. A testbed provides a cost effective physical environment to verify these algorithms and control techniques in the real world. …

University Of San Diego News Print Media Coverage 2007.12, University Of San Diego Office Of Public Relations

Print Media Coverage (1947-2009)

Printed clippings housed in folders with a table of contents arranged by topic.

Geographic Decomposition Of Inequality In Health And Wealth: Evidence From Cambodia, Tomoki Fujii

Research Collection School Of Economics

The small-area estimation developed by Elbers, Lanjouw and Lanjouw (2002, 2003), in which a census and a survey are combined to produce the estimates of welfare measures for small geographic areas, has become a standard tool for poverty analysis in developing countries. The small-area estimates are typically plotted on a map, which are commonly called a poverty map. Poverty maps proved useful for policy analysis and formulation, and have become increasingly popular among policy-makers and researchers. In Cambodia, poverty maps have been used by various international organizations, ministries and non-governmental organizations for analyzing the poverty situations for their operation areas, …

Extensions Of Two-Part Tests To Compare K Independent Populations, Marwan Daoud

Dissertations

We consider two-part models that are mixtures of a point-mass variable with all mass at zero and a continuous random variable. The model may assume a particular distributionh(x) for the continuous part such as a log-normal or a gamma. The response variable is defined as y=(x, d), where d=1 if x > 0 and d=0 if x = 0. The probability distribution function has the following form: fx,d=p ^1-d×1-p ×hx ^d.

Lachenbruch (1976, 2001) proposed several tests to compare means of two populations for this type of data. We proposed a two-part Wald test and …

Audio-Assisted Reading With Digital Audiobooks For Upper Elementary Students With Reading Disabilities, Kelli J. Esteves

Dissertations

Audio-assisted reading has been used as an effective instructional intervention for students with learning disabilities (Carbo, 1978; Gilbert, Williams, & McLaughlin, 1996) and with struggling readers (Chomsky, 1976; Hollingsworth, 1978; Hoskisson & Krohm, 1974; Koskinen, Blum, Bisson, Phillips, Creamer, & Baker, 2000; Rasinski, 1990). The strategy involves reading along while listening to an audio recording of a fluent model (Evans, 1997).

The goal of this study was to compare the efficacy of audio-assisted reading with digital audiobooks against the traditional practice of sustained silent reading in terms of reading fluency rates and reading attitude scores with upper elementary students with …

Treatment Of Co-Morbid Methamphetamine Substance Abuse And Borderline Personality Disorder Features Using Modified Dialectical Behavior Therapy, Jessica R. Schultz Fischer

Dissertations

The study investigated the effectiveness of a time-limited, skills-based treatment in a population of female substance abusers. This project implemented a pilot clinical trial to evaluate the effectiveness of a 12-session modified Dialectical Behavior Therapy (DBT) protocol among a small sample of women, with co-morbid borderline personality disorder features, receiving concurrent outpatient treatment for methamphetamine abuse. A non-concurrent multiple baseline design was used. In addition to on-going assessment conducted during baseline and weekly over the course of treatment, a comprehensive assessment battery was administered pre-, and post-treatment as well as at 1 and 3 months following treatment. Findings suggest that …

Therapists' Handling Of Secrets Between Partners In Couple Therapy, Michael Alan Jansen

Dissertations

This study examines couple therapists' policies, procedures, and perspectives regarding secrets between partners in couple therapy. Handling secrets appropriately is necessary to avoid legal, ethical and therapeutic problems, especially when the secret involves contentious or potentially dangerous material such as infidelity, divorce, paternity, and HIV/AIDS infection. One hundred sixty randomly selected Clinical Members of the AAMFT participated in a 38-question researcher-generated mail survey. Data provided descriptive statistics and allowed for between-groups comparisons to explore for differences between therapists with regard to experience and several specific practices related to handling secrets. The study also examined whether courses in HIV/AIDS confidentiality law …

Creating A Culture Of Safety: The Influence Of Medical Simulation On The Attitudes Of Surgical Team Members, Diane J. Jones

Dissertations

The objective of this study was to determine change in individual and aggregate attitudes of the members of two subspecialty surgery teams (cardiac and vascular) in six domains (teamwork climate, safety climate, job satisfaction, stress recognition, perception of management, and working conditions) following medical team simulation and debriefing exercises. The study was a pre-post partially randomized controlled, quasi-experimental study that took place in a 545-bed hospital with a high-volume cardiovascular surgery program. Participants included interdisciplinary team members caring for cardiac and vascular surgery patients.

Main outcome measures included change in responses to safety attitudes questionnaires (SAQs) administered before, 1 week …

Contexts And Corporate Voluntary Environmental Behaviors: Examining The Epa's Green Lights Voluntary Program, Seong-Gin Moon, Peter Deleon

Peer Reviewed Articles - Public, Nonprofit, and Health Administration

Why do an increasingly large number of firms choose to spend their own money and resources to protect the environment beyond the extant regulatory requirements? This article addresses this question by examining the EPA’s Green Lights (GL) voluntary program in which a firm’s policy makers made an early commitment to limiting greenhouse gases through the installation of energy-efficient lighting technology in its facilities. Two theoretical perspectives—resource-based theory and neo-institutional theory—are adopted to investigate the contexts by which a firm is encouraged to undertake voluntary environmental actions and evaluate environmental strategies associated with them. Accordingly, the authors focus on two major …

Most Caenorhabditis Elegans Micrornas Are Individually Not Essential For Development Or Viability, Eric A. Miska, Ezequiel Alvarez-Saavedra, Allison L. Abbott, Nelson C. Lau, Andrew B. Hellman, Shannon M. Mcgonagle, David P. Bartel, Victor R. Ambros, H. Robert Horvitz

Biological Sciences Faculty Research and Publications

MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or development of C. elegans, and mutations in most miRNA genes do not result in grossly abnormal phenotypes. These observations are consistent with the hypothesis that there is significant functional redundancy among miRNAs …

Police In Peril: Determining The Work-Induced Stressors Affecting Officers And The Subsequent Use Of Individualized Coping Strategies, Ami Möller

All-Inclusive List of Electronic Theses and Dissertations

Identifying what stressors affect an officer and how he or she copes is essential in maintaining psychologically healthy officers. Studies have found that police officers consider the organizationally based aspects of the job to greatly influence their level of stress. The present research used the Police Stress Survey and COPE Inventory to identify common stressors and coping strategies among forty-five officers in the state of Indiana. The study attempted to determine whether or not a chronic overall stress -produced by frequent organizational stressors existed, and if this stress led to an increased use of maladaptive coping strategies. Results indicated a …

Using Science, Engineering, And Education To Address Water Supply Challenges In The Highlands Of Guatemala, Andrew Curtis Elmore, William Fahrenholtz

Materials Science and Engineering Faculty Research & Creative Works

The Guatemalan Highlands is a Popular Destination for Non-Government Organizations Interested in Performing Relief Projects. U.S.-Based Organizations Such as Rotary International, Engineers Without Borders, and Various Religious Organizations Travel to Guatemala to Conduct Humanitarian Activities Which May Be Effective for the Short Term, But It is Not Clear that the Efforts Have a Systematic Impact. Students and Faculty at the University of Missouri-Rolla Have Systematically Studied Water Supply Issues Including Undergraduate and Graduate Research Projects and Undergraduate Engineering Courses Such as International Capstone Design. Materials Engineers Have Been Involved in the Study of Ceramic-Based Water Treatment Devices. These Microfilters Have …

How To Prevent Perioperative Myocardial Injury: The Conundrum Continues, Jian-Zhong Sun, David Maguire

Department of Anesthesiology Faculty Papers

BACKGROUND: Perioperative myocardial injury (PMI) remains a major cause of perioperative morbidity and mortality but clinical strategies to prevent PMI are still uncertain.

METHODS AND RESULTS: We comprehensively searched PubMed for major research articles concerning clinical strategies to prevent PMI. The key findings are as follows: (1) the American College of Cardiology/American Heart Association guideline update for perioperative cardiovascular evaluation for noncardiac surgery is very useful to stratify cardiac risk preoperatively; (2) cardiac troponin has emerged as a biomarker to diagnose postoperative PMI and to predict clinical outcomes; (3) coronary revascularization before noncardiac surgery probably would provide cardiac protection in …

God's Design And Phonemic Awareness: What Is Phonemic Awareness, What Is Phonics, And What Does God Have To Do With It?, Jill A. Jones, Connie Mcdonald

Christian Perspectives in Education

Phonemic awareness is the foundation for a child’s literacy development. God’s initial interaction with man after creation, through the spoken word, bestows authority on oral language. Manipulation of language begins in infancy and continues throughout one’s life. Teachers need to understand what phonemic awareness entails in order to develop and assess a child’s development in this area.

Preparing Tomorrow's Classroom Leaders: Challenges For Christian Higher Education, James E. Watson, Ph.D., Joel T. Uecker, M.A.

Christian Perspectives in Education

Christian college teacher education program faculties face the challenge of employing a Christian epistemology that includes a pedagogy that embraces today’s learners. The authors seek to communicate the foundations of modernism and postmodernism and their impact on the epistemology and pedagogies employed in university classrooms. How the postmodern thinking claims have influenced the lives of Christian students will also be examined. The paper concludes with a discussion of the challenges for Christian teacher education faculties.

A Case Study Of The Impact Of Musical Pattern Rehearsal On The Acquisition Of Oral And Written Language Skills In A Young Child With Learning Differences, Rebecca F. Carwile

Christian Perspectives in Education

The study explores the relationship between learning musical patterns and learning language patterns. A case study of a male diagnosed with learning differences in generative writing and graphic processing indicates a positive relationship between the neurological patterning of rehearsed musical patterns and the acquisition of oral and written language skills. The anecdotal study tracks the development of literacy from the initial identification of dysfunctional patterns of performance at age three through the acquisition of oral language and the mastery of basic reading skills in the primary years. Analysis of the case study supports the need for musical training in the …

Mustang Daily, November 30, 2007

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Volume 43 - Issue 09 - Friday, November 30, 2007, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.