Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2007

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 18361 - 18390 of 22017

Full-Text Articles in Entire DC Network

Dna Damage, Homology-Directed Repair, And Dna Methylation, Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Luliano, Alfredo Fusco, Maria R. Santillo, Mark T. Muller, Lorenzo Chiariotti, Max E. Gottesman, Enrico V. Avvedimento Jan 2007

Dna Damage, Homology-Directed Repair, And Dna Methylation, Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Luliano, Alfredo Fusco, Maria R. Santillo, Mark T. Muller, Lorenzo Chiariotti, Max E. Gottesman, Enrico V. Avvedimento

Faculty Bibliography 2000s

To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem repeated green fluorescent protein (GFP) genes (DR-GFP). A total of 2%-4% of the cells generated a functional GFP by homology-directed repair (HR) and gene conversion. However, similar to 50% of these recombinants expressed GFP poorly. Silencing was rapid and associated with HR and DNA methylation of the recombinant gene, since it was prevented in Hela cells by 5-aza-2 …

Go to article

Accd6, A Member Of The Fas Ii Locus, Is A Functional Carboxyltransferase Subunit Of The Acyl-Coenzyme A Carboxylase In Mycobacterium Tuberculosis, Jaiyanth Daniel, Tae-Jin Oh, Chang-Muk Lee, Pappachan E. Kolattukudy Jan 2007

Accd6, A Member Of The Fas Ii Locus, Is A Functional Carboxyltransferase Subunit Of The Acyl-Coenzyme A Carboxylase In Mycobacterium Tuberculosis, Jaiyanth Daniel, Tae-Jin Oh, Chang-Muk Lee, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

The Mycobacterium tuberculosis acyl-coenzyme A (CoA) carboxylases provide the building blocks for de novo fatty acid biosynthesis by fatty acid synthase I (FAS 1) and for the elongation of FAS I end products by the FAS 11 complex to produce meromycolic acids. The M. tuberculosis genome contains three biotin carboxylase subunits (AccA1 to -3) and six carboxyltransferase subunits (AccD1 to -6), with accD6 located in a genetic locus that contains members of the FAS 11 complex. We found by quantitative real-time PCR analysis that the transcripts of accA3, accD4, accD5, and accD6 are expressed at high levels during the exponential …

Go to article

Transgene Containment By Maternal Inheritance: Effective Or Elusive?, Henry Daniell Jan 2007

Transgene Containment By Maternal Inheritance: Effective Or Elusive?, Henry Daniell

Faculty Bibliography 2000s

No abstract provided.

Go to article

Magnetization And Epr Studies Of The Single Molecule Magnet Ni-4 With Integrated Sensors, G. De Loubens, G. D. Chaves-O'Flynn, A. D. Kent, C. Ramsey, E. Del Barco, C. Beedle, D. N. Hendrickson Jan 2007

Magnetization And Epr Studies Of The Single Molecule Magnet Ni-4 With Integrated Sensors, G. De Loubens, G. D. Chaves-O'Flynn, A. D. Kent, C. Ramsey, E. Del Barco, C. Beedle, D. N. Hendrickson

Faculty Bibliography 2000s

Integrated magnetic sensors that allow simultaneous EPR and magnetization measurements have been developed to study single molecule magnets. A high frequency microstrip resonator has been integrated with a micro-Hall effect magnetometer. EPR spectroscopy is used to determine the energy splitting between the low lying spin states of a Ni-4 single crystal, with an S=4 ground state, as a function of applied fields, both longitudinal and transverse to the easy axis at 0.4 K. Concurrent magnetization measurements show changes in spin population associated with microwave absorption. Such studies enable determination of the energy relaxation time of the spin system.

Go to article

Spitzer Transit And Secondary Eclipse Photometry Of Gj 436b, Drake Deming, Joseph Harrington, Gregory Laughlin, Sara Seager, Sarah B. Navarro, William C. Bowman, Karen Horning Jan 2007

Spitzer Transit And Secondary Eclipse Photometry Of Gj 436b, Drake Deming, Joseph Harrington, Gregory Laughlin, Sara Seager, Sarah B. Navarro, William C. Bowman, Karen Horning

Faculty Bibliography 2000s

We report the results of infrared (8 mu m) transit and secondary eclipse photometry of the hot Neptune exoplanet, GJ 436b using Spitzer. The nearly photon-limited precision of these data allows us to measure an improved radius for the planet and to detect the secondary eclipse. The transit (centered at HJD = 2454280.78149 +/- 0.00016) shows the flat-bottomed shape typical of infrared transits, and it precisely defines the planet-to-star 0.00016 radius ratio (), independent of the stellar properties. However, we obtain the planetary radius, 0.0839 +/- 0.0005 as well as the stellar mass and radius, by fitting to the transit …

Go to article

3.8-Mu M Photometry During The Secondary Eclipse Of The Extrasolar Planet Hd 209458b, Drake Deming, L. Jeremy Richardson, Joseph Harrington Jan 2007

3.8-Mu M Photometry During The Secondary Eclipse Of The Extrasolar Planet Hd 209458b, Drake Deming, L. Jeremy Richardson, Joseph Harrington

Faculty Bibliography 2000s

We report infrared photometry of the extrasolar planet HD 209458b during the time of secondary eclipse (planet passing behind the star). Observations were acquired during two secondary eclipses at the NASA Infrared Telescope Facility (IRTF) in 2003 September. We used a circular variable filter (1.5 per cent bandpass) centred at 3.8 mu m to isolate the predicted flux peak of the planet at this wavelength. Residual telluric absorption and instrument variations were removed by offsetting the telescope to nearby bright comparison stars at a high temporal cadence. Our results give a secondary eclipse depth of 0.0013 +/- 0.0011, not yet …

Go to article

Electrode Architecture In Tuning Room Temperature Sensing Kinetics Of Nanomicrointegrated Hydrogen Sensor, Sameer Deshpande, Sudipta Seal, Peng Zhang, Hyoung J. Cho, Nathan Posey Jan 2007

Electrode Architecture In Tuning Room Temperature Sensing Kinetics Of Nanomicrointegrated Hydrogen Sensor, Sameer Deshpande, Sudipta Seal, Peng Zhang, Hyoung J. Cho, Nathan Posey

Faculty Bibliography 2000s

A diffusion model is proposed for elucidating the effect of interelectrode distance modulation on conductance change of a nanomicrointegrated hydrogen sensor at room temperature. Both theoretical and experimental results showed a faster response upon exposure to hydrogen when sensor electrode gap was smaller. Also, a linear increase in the sensor sensitivity from 500 to 80 000 was observed on increasing the electrode spacing from 2 to 20 mu m. The improvement in sensitivity is attributed to the higher reactive sites available for the gaseous species to react on the sensor surface.

Go to article

Anisotropic Optical Phonon Scattering Of Holes In Cubic Semiconductors, M. V. Dolguikh, R. E. Peale Jan 2007

Anisotropic Optical Phonon Scattering Of Holes In Cubic Semiconductors, M. V. Dolguikh, R. E. Peale

Faculty Bibliography 2000s

The formula for the nonpolar optical phonon scattering rate of holes in cubic semiconductors is obtained in the case of strong valence band anisotropy. The deformation potential approximation is used. A three-band, 6x6, k(.)p Luttinger-Kohn representation includes states belonging to the heavy, light, and split-off bands. Mixing with the latter causes strong anisotropy in the transition matrix elements as well as in the density of final states. The derived formula is recommended for silicon, where inter- and intravalence-band scattering rates are much more strongly anisotropic and have significantly different values than those estimated from the usual two-band 4x4, "warped spheres" …

Go to article

Dissociative Recombination Of H-3(+) In The Ground And Excited Vibrational States, Samantha Fonseca Dos Santos, Viatcheslav Kokoouline, Chris H. Greene Jan 2007

Dissociative Recombination Of H-3(+) In The Ground And Excited Vibrational States, Samantha Fonseca Dos Santos, Viatcheslav Kokoouline, Chris H. Greene

Faculty Bibliography 2000s

The article presents calculated dissociative recombination (DR) rate coefficients for H-3(+). The previous theoretical work on H-3(+) was performed using the adiabatic hyperspherical approximation to calculate the target ion vibrational states and it considered just a limited number of ionic rotational states. In this study, we use accurate vibrational wave functions and a larger number of possible rotational states of the H-3(+) ground vibrational level. The DR rate coefficient obtained is found to agree better with the experimental data from storage ring experiments than the previous theoretical calculation. We present evidence that excited rotational states could be playing an important …

Go to article

Enhancing The Low Temperature Hydrogen Sensitivity Of Nanocrystalline Sno2 As A Function Of Trivalent Dopants, C. Drake, A. Amalu, J. Bernard, S. Seal Jan 2007

Enhancing The Low Temperature Hydrogen Sensitivity Of Nanocrystalline Sno2 As A Function Of Trivalent Dopants, C. Drake, A. Amalu, J. Bernard, S. Seal

Faculty Bibliography 2000s

The effect of different indium doping concentrations on the room temperature hydrogen sensitivity of nano-SnO2 is investigated. The role of calcination temperature on the surface morphology, phase transformation, and subsequent impact on the gas sensing behavior of nanocrystalline doped SnO2 is presented. Differences in grain growth with varying doping amount give an explanation for enhanced sensing that is not always so obvious. Variation in the charge carrier density for indium doped nanocrystalline SnO2 is calculated as a function of indium concentration in the tin oxide lattice structure. The charge carrier density is correlated to the involved surface species of doped …

Go to article

Band Gap Energy Modifications Observed In Trivalent In Substituted Nanocrystalline Sno2, C. Drake, S. Seal Jan 2007

Band Gap Energy Modifications Observed In Trivalent In Substituted Nanocrystalline Sno2, C. Drake, S. Seal

Faculty Bibliography 2000s

The effect of In doping concentration on the optical band gap of nano-SnO2 is investigated as a function of calcination temperature. Changes in the band gap explain the room temperature H-2 gas sensing of doped nano-SnO2. The band gap was found to be lower than those reported for SnO2 (3.6 eV) from 2.55 to 3.43 eV and may be explained by the presence of nonequilibrium oxygen vacancies in the oxide lattice and band bending effects at the nanoscale.

Go to article

High-Energy Two-Electron Capture With Emission Of A Single Photon, E. G. Drukarev, A. I. Mikhailov, I. A. Mikhailov, W. Scheid Jan 2007

High-Energy Two-Electron Capture With Emission Of A Single Photon, E. G. Drukarev, A. I. Mikhailov, I. A. Mikhailov, W. Scheid

Faculty Bibliography 2000s

We investigate the two-electron capture with emission of a single photon to the ground state in the Coulomb field of a heavy nucleus in its collision with a light atom. Describing electron-electron interactions in the bound state perturbatively, we obtained an analytical formula for the high-energy limit of the cross section. In combination with previous results obtained in the same approach we calculated the cross section in a broad interval of energies of the collision. We show that the amplitude of the process at high energy depends on the behavior of the bound state wave function near the triple coalescence …

Go to article

Microlens Diffusers For Efficient Laser Speckle Generation, Alfred D. Ducharme Jan 2007

Microlens Diffusers For Efficient Laser Speckle Generation, Alfred D. Ducharme

Faculty Bibliography 2000s

Laser Speckle is the optical phenomena resulting from the random interference of coherent light. This phenomenon can be utilized to measure the Modulation Transfer Function (MTF) of detector arrays. Common devices used for speckle generation, such as integrating spheres and ground glass, suffer from low efficiencies less than 20%. Microlens diffusers are shown to be more efficient alternatives for speckle generation. An analysis of the statistical behavior of microlens diffusers is presented with emphasis on their application to MTF testing of detector arrays in the visible spectrum.

Go to article

Group-Index Birefringence And Loss Measurements In Silicon-On-Insulator Photonic Wire Waveguides, David Duchesne, Pavel Cheben, Roberto Morandotti, Boris Lamontagne, Dan-Xia Xu, Siegfried Janz, Demetrios Christodoulides Jan 2007

Group-Index Birefringence And Loss Measurements In Silicon-On-Insulator Photonic Wire Waveguides, David Duchesne, Pavel Cheben, Roberto Morandotti, Boris Lamontagne, Dan-Xia Xu, Siegfried Janz, Demetrios Christodoulides

Faculty Bibliography 2000s

Group-index birefringence in silicon-on-insulator photonic wire waveguides is determined through a polarization beating technique and a Fabry-Perot resonance method. A large group-index birefringence, up to 0.67, is obtained as a result of the structural asymmetry and high field confinement of our waveguides. The group index and linear propagation loss are also determined. In particular, the group index is found to be as large as 4.45 due to the significant change in the effective mode index of the waveguide as a function of the wavelength. The effects of structure size on the measured losses and group indices are analyzed. Our experimental …

Go to article

Analysis Of 81 Genes From 64 Plastid Genomes Resolves Relationships In Angiosperms And Identifies Genome-Scale Evolutionary Patterns, Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. Depamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. Mcneal, Jennifer V. Kuehl, Jeffrey L. Boore Jan 2007

Analysis Of 81 Genes From 64 Plastid Genomes Resolves Relationships In Angiosperms And Identifies Genome-Scale Evolutionary Patterns, Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. Depamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. Mcneal, Jennifer V. Kuehl, Jeffrey L. Boore

Faculty Bibliography 2000s

Angiosperms are the largest and most successful clade of land plants with > 250,000 species distributed in nearly every terrestrial habitat. Many phylogenetic studies have been based on DNA sequences of one to several genes, but, despite decades of intensive efforts, relationships among early diverging lineages and several of the major clades remain either incompletely resolved or weakly supported. We performed phylogenetic analyses of 81 plastid genes in 64 sequenced genomes, including 13 new genomes, to estimate relationships among the major angiosperm clades, and the resulting trees are used to examine the evolution of gene and intron content. Phylogenetic trees from …

Go to article

Comparative Mitochondrial Genomics Of Snakes: Extraordinary Substitution Rate Dynamics And Functionality Of The Duplicate Control Region, Zhi J. Jiang, Todd A. Castoe, Christopher C. Austin, Matthew D. Herron, Frank T. Burbrink, Jimmy A. Mcguire, Christopher L. Parkinson, David D. Pollock Jan 2007

Comparative Mitochondrial Genomics Of Snakes: Extraordinary Substitution Rate Dynamics And Functionality Of The Duplicate Control Region, Zhi J. Jiang, Todd A. Castoe, Christopher C. Austin, Matthew D. Herron, Frank T. Burbrink, Jimmy A. Mcguire, Christopher L. Parkinson, David D. Pollock

Faculty Bibliography 2000s

Background: The mitochondrial genomes of snakes are characterized by an overall evolutionary rate that appears to be one of the most accelerated among vertebrates. They also possess other unusual features, including short tRNAs and other genes, and a duplicated control region that has been stably maintained since it originated more than 70 million years ago. Here, we provide a detailed analysis of evolutionary dynamics in snake mitochondrial genomes to better understand the basis of these extreme characteristics, and to explore the relationship between mitochondrial genome molecular evolution, genome architecture, and molecular function. We sequenced complete mitochondrial genomes from Slowinski's corn …

Go to article

Unusual Double Four-Lobe Textures Generated By The Motion Of Carbon Nanotubes In A Nematic Liquid Crystal, Seok Jin Jeong, Palanivelu Sureshkumar, Kwang-Un Jeong, Anoop K. Srivastava, Seung Hee Lee, Seok Ho Jeong, Young Hee Lee, University Of Central Florida, Shin-Tson Wu Jan 2007

Unusual Double Four-Lobe Textures Generated By The Motion Of Carbon Nanotubes In A Nematic Liquid Crystal, Seok Jin Jeong, Palanivelu Sureshkumar, Kwang-Un Jeong, Anoop K. Srivastava, Seung Hee Lee, Seok Ho Jeong, Young Hee Lee, University Of Central Florida, Shin-Tson Wu

Faculty Bibliography 2000s

Unusual double four-lobe nematic liquid crystal (LC) textures were observed in the carbon nanotube (CNT)-doped nematic LC under electric field. Through the electro-optical studies in a wide range of vertical electric fields in the direction of the long axis of the LC molecules, it was realized that the double four-lobe nematic LC textures were formed in the range of 120 to 160 V-rms at 1 Hz. The formation of these unusual double four-lobe nematic LC textures could originate from the electric field-induced movement of CNTs and the subsequently frustrated reorientation of LCs.

Go to article

Advances In Homeland Security Series, Naim Kapucu Jan 2007

Advances In Homeland Security Series, Naim Kapucu

Faculty Bibliography 2000s

This is a book review article for the Advances in Homeland Security Series by Purdue University. The series consist of two volumes. Volume one is entitled The Science of Homeland Security. Volume two is entitled Guiding Future Homeland Security Policy. Amass F. S., Bhunia, A. K, Chaturvedi, A. L., Dolk, D. R., Peeta, S., and Atallah, M. J. Advances in Homeland Security Series: The Science of Homeland Security (Volume 1), West Lafayette, IN: Perdue University Press, 2006 227 pp, introduction, notes, bibliography, index (hardcover). Amass F. S., Chaturvedi, A. L., and Peeta, S. Advances in Homeland Security Series: Guiding Future …

Go to article

Logistics And Staging Areas In Managing Disasters And Emergencies, Naim Kapucu, Wendell C. Lawther, Sommer Pattison Jan 2007

Logistics And Staging Areas In Managing Disasters And Emergencies, Naim Kapucu, Wendell C. Lawther, Sommer Pattison

Faculty Bibliography 2000s

Emergency management is often evaluated and improved after the occurrence of a disaster, especially in the case of preparedness. This paper discusses the importance of logistics planning and operation as it relates to disaster preparedness. The selection of field logistics sites such as staging areas, prior to the occurrence of a natural or man-made disaster, is a crucial step in emergency planning and management. Selection can be aided and kept consistent by pre-identifying state and county-level guidelines for staging areas. This paper reviews state and county criteria for the pre-selection of staging areas and discusses supporting logistical operations in disaster …

Go to article

Filtered Backprojection Inversion Of The Cone Beam Transform For A General Class Of Curves, Alexander Katsevich, Mikhail Kapralov Jan 2007

Filtered Backprojection Inversion Of The Cone Beam Transform For A General Class Of Curves, Alexander Katsevich, Mikhail Kapralov

Faculty Bibliography 2000s

We extend a cone beam transform inversion formula, proposed earlier for helices by one of the authors, to a general class of curves. The inversion formula remains efficient, because filtering is shift-invariant and is performed along a one-parametric family of lines. The conditions that describe the class are very natural. Curves C are smooth, without self-intersections, have positive curvature and torsion, do not bend too much, and do not admit lines which are tangent to C at one point and intersect C at another point. The notions of PI lines and PI segments are generalized, and their properties are studied. …

Go to article

Wide-View Transflective Liquid Crystal Display For Mobile Applications, Hyang Yul Kim, Zhibing Ge, Shin-Tson Wu, Seung Hee Lee Jan 2007

Wide-View Transflective Liquid Crystal Display For Mobile Applications, Hyang Yul Kim, Zhibing Ge, Shin-Tson Wu, Seung Hee Lee

Faculty Bibliography 2000s

A high optical efficiency and wide-view transflective liquid crystal display based on fringe-field switching structure is proposed. The transmissive part has a homogenous liquid crystal (LC) alignment and is driven by a fringe electric field, which exhibits excellent electro-optic characteristics. The reflective part has a hybrid LC alignment with quarter-wave phase retardation and is also driven by a fringe electric field. Consequently, the transmissive and reflective parts have similar gamma curves.

Go to article

Athermal Emission In Yb,Er : Glass, John Koroshetz, Brian Brickeen, Stephan Fahr, Alexandra Rapaport, Michael Bass Jan 2007

Athermal Emission In Yb,Er : Glass, John Koroshetz, Brian Brickeen, Stephan Fahr, Alexandra Rapaport, Michael Bass

Faculty Bibliography 2000s

We report on the temperature dependent spectroscopic properties of Yb3+ and Er3+ co-doped glass gain media in the eye-safe spectral region. Measurements suggest that judicious selection of the operating wavelength can lead to a laser output with minimal dependence on the temperature of the gain medium.

Go to article

Custom-Designed Orthopedic Implants Evaluated Using Finite Element Analysis Of Patient-Specific Computed Tomography Data: Femoral-Component Case Study, Ola La Harrysson, Yasser A. Hosni, Jamal F. Nayfeh Jan 2007

Custom-Designed Orthopedic Implants Evaluated Using Finite Element Analysis Of Patient-Specific Computed Tomography Data: Femoral-Component Case Study, Ola La Harrysson, Yasser A. Hosni, Jamal F. Nayfeh

Faculty Bibliography 2000s

Background: Conventional knee and hip implant systems have been in use for many years with good success. However, the custom design of implant components based on patient-specific anatomy has been attempted to overcome existing shortcomings of current designs. The longevity of cementless implant components is highly dependent on the initial fit between the bone surface and the implant. The bone-implant interface design has historically been limited by the surgical tools and cutting guides available; and the cost of fabricating custom-designed implant components has been prohibitive. Methods: This paper describes an approach where the custom design is based on a Computed …

Go to article

An Initial Evaluation Of Mathpad(2): A Tool For Creating Dynamic Mathematical Illustrations, Joseph J. Laviola Jr. Jan 2007

An Initial Evaluation Of Mathpad(2): A Tool For Creating Dynamic Mathematical Illustrations, Joseph J. Laviola Jr.

Faculty Bibliography 2000s

MathPad(2) is a pen-based application prototype for creating mathematical sketches. Using a modeless gestural interface, it lets users make dynamic illustrations by associating handwritten mathematics with free-form drawings and provides a set of tools for graphing and evaluating mathematical expressions and solving equations. In this paper, we present the results of an initial evaluation of the MathPad(2) prototype, examining the user interface's intuitiveness and the application's perceived usefulness. Our evaluations are based on both performance and questionnaire results including first attempt gesture performance, interface recall tests, and surveys of user interface satisfaction and perceived usefulness. The results of our evaluation …

Go to article

Electro-Optic Properties Of A Homeotropic Liquid Crystal Cell With 90 Degrees Surface Rubbings And A Reverse-Handed Chiral Dopant, Ju-Hyun Lee, Zhibing Ge, Shin-Tson Wu Jan 2007

Electro-Optic Properties Of A Homeotropic Liquid Crystal Cell With 90 Degrees Surface Rubbings And A Reverse-Handed Chiral Dopant, Ju-Hyun Lee, Zhibing Ge, Shin-Tson Wu

Faculty Bibliography 2000s

The electro-optic properties of a 90 degrees twisted-homeotropic liquid crystal (LC) cell with a chiral dopant whose handedness is opposite to the LC twist are studied. In the voltage-off state, the LC directors exhibit a homeotropic alignment. However, in the intermediate voltage state, the bulk LC directors behave like a homogeneous alignment due to the balanced torques between the electric field, surface anchoring, and reversed chiral dopant. Potential applications of this mode for liquid crystal displays, especially for dual-cell-gap transflective liquid crystal displays, are emphasized.

Go to article

A Structure Theorem For The Gromov-Witten Invariants Of Kahler Surfaces, Junho Lee, Thomas H. Parker Jan 2007

A Structure Theorem For The Gromov-Witten Invariants Of Kahler Surfaces, Junho Lee, Thomas H. Parker

Faculty Bibliography 2000s

We prove a structure theorem for the Gromov-Witten invariants of compact Kahler surfaces with geometric genus p(g) > 0. Under the technical assumption that there is a canonical divisor that is a disjoint union of smooth components, the theorem shows that the GW invariants are universal functions determined by the genus of this canonical divisor components and the holomorphic Euler characteristic of the surface. We compute special cases of these universal functions.

Go to article

Coherent Pulse Detection And Multi-Channel Coherent Detection Based On A Single Balanced Homodyne Receiver, Wangkuen Lee, Hoss Izadpanah, Peter J. Delfyett, Ron Menendez, Shahab Etemad Jan 2007

Coherent Pulse Detection And Multi-Channel Coherent Detection Based On A Single Balanced Homodyne Receiver, Wangkuen Lee, Hoss Izadpanah, Peter J. Delfyett, Ron Menendez, Shahab Etemad

Faculty Bibliography 2000s

The performance of coherent pulse detection (CPD) and multichannel coherent detection (MCCD) based on a single dual-balanced homodyne receiver was experimentally demonstrated using a grating-coupled hybridly mode-locked semiconductor laser. Compared with direct detection, a high coherent gain of over 10 dB, as well as an SNR improvement of over 5 dB, was obtained in both detection schemes. Our experimental results have confirmed that the coherent detection processes in CPD and MCCD are nearly the same based on a square-root LO power dependence. Nevertheless, the MCCD scheme has shown an advantage in a path-length error over the CPD scheme, revealing 2 …

Go to article

Role Of Crkii In Fc Gamma Receptor-Mediated Phagocytosis, Warren L. Lee, Gabriela Cosio, Keith Ireton, Sergio Grinstein Jan 2007

Role Of Crkii In Fc Gamma Receptor-Mediated Phagocytosis, Warren L. Lee, Gabriela Cosio, Keith Ireton, Sergio Grinstein

Faculty Bibliography 2000s

Phagocytosis of IgG-opsonized pathogens by Fc gamma receptors requires extensive remodeling of the actin cytoskeleton, a process regulated by the small GTPase Rac. Vav was thought to be the guanine nucleotide exchange factor responsible for the activation of Rac, but recent evidence indicates that Fc gamma receptor-mediated phagocytosis is unaffected in macrophages lacking all three isoforms of Vav. We therefore tested whether another GEF, DOCK180, participates in Fc gamma receptor-initiated phagocytosis. DOCK180 associates with the adaptor protein Crk, which mediates recruitment of the GEF to sites of tyrosine phosphorylation. CrkII and DOCK180 were found to accumulate at the phagocytic cup. …

Go to article

Specific Grb2-Mediated Interactions Regulate Clathrin-Dependent Endocytosis Of The Cmet-Tyrosine Kinase, Ning Li, Marta Lorinczi, Keith Ireton, Lisa A. Elferink Jan 2007

Specific Grb2-Mediated Interactions Regulate Clathrin-Dependent Endocytosis Of The Cmet-Tyrosine Kinase, Ning Li, Marta Lorinczi, Keith Ireton, Lisa A. Elferink

Faculty Bibliography 2000s

Lysosomal degradation of the receptor-tyrosine kinase cMet requires receptor ubiquitination by the E3 ubiquitin ligase Cbl followed by clathrin-dependent internalization. A role for Cbl as an adaptor for cMet internalization has been previously reported. However, the requirement for Cbl ubiquitin ligase activity in this process and its mode of recruitment to cMet has yet to be determined. Cbl can directly bind cMet at phosphotyrosine 1003 or indirectly via Grb2 to phosphotyrosine 1356 in the multisubstrate binding domain of cMet. The direct binding of Cbl with cMet is critical for receptor degradation and not receptor internalization. Here we show a strict …

Go to article

Role Of Enpp1 On Adipocyte Maturation, Jian Liang, Mingui Fu, Ester Ciociola, Manisha Chandalia, Nicola Abate Jan 2007

Role Of Enpp1 On Adipocyte Maturation, Jian Liang, Mingui Fu, Ester Ciociola, Manisha Chandalia, Nicola Abate

Faculty Bibliography 2000s

Background. It is recognized that the ability of adipose tissue to expand in response to energy excess, i.e. adipocyte maturation, is important in determining systemic abnormalities in glucose and lipid metabolism. Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1, also known as PC-1) has been recently reported to be involved in the pathogenesis of insulin resistance and related diseases. However, its role on adipose tissue physiology as a mechanism of systemic insulin resistance is not understood. This study was performed to evaluate whether ENPP1 is regulated during adipogenesis and whether over-expression in adipocytes can affect adipocyte maturation, a potential novel mechanism of ENPP1-related …

Go to article

First Prev Next Last