Digital Commons Network^™

Synthetic Seed Production For Germplasm Storage Of Hydrastis Canadensis L. (Goldenseal), Satyaprakash R. Settipalli

Graduate Theses, Dissertations, and Problem Reports (ETD)

Goldenseal (Hydrastis canadensis L.) is an important medicinal plant, native to Canada and Eastern United States, used as an antibiotic, anticonvulsant and in treatments for inflammations and dyspepsia. Over collection of wild population and native habitat destruction has lead the species to be listed as an endangered species in the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), Appendix II. This brought a revived interest in conservation of germplasm.;Calcium alginate solid and hollow bead encapsulation protocols were evaluated. Shoot and callus propagules were encapsulated in calcium alginate solid bead (supplemented with stage II nutrient media) …

The Cystic Fibrosis Transmembrane Conductance Regulator: Regulation By Hsp-90, Kevin Marrs

Theses and Dissertations (ETD)

The hypothesis of this project is that a functionally relevant association exists between CFTR and Hsp90. In testing this hypothesis, (a) the association of CFTR and Hsp90 is confirmed via crosslinking and immunoprecipitation of CFTR from stably transfected HEK-293 cells, electrophoretic separation of cross-linked proteins, and protein identification via SDS-PAGE, western blotting, and mass spectrometry. Also, this hypothesis is tested by (b) functionally assessing the effect of Hsp90 on CFTR function via Ussing chamber analysis, two-electrode voltage clamp analysis, preliminary in vivoanimal studies, and protein phosphorylation. The HEK-293 Flag-CFTR cells used in this study allows for a high degree …

Theoretical And Experimental Evaluation Of Spatial Resolution In A Variable Resolution X-Ray Computed Tomography Scanner, Roman Melnyk

Theses and Dissertations (ETD)

A variable resolution x-ray (VRX) computed tomography (CT) scanner can image objects of various sizes with greatly improved spatial resolution. The scanner employs an angulated discrete detector and achieves the resolution boost by matching the detector angulation to the scanner field of view (FOV) determined by the size of an object being imaged. A comprehensive evaluation of spatial resolution in an experimental version of the VRX CT scanner is presented in this dissertation. Two components of this resolution were evaluated – the pre-reconstruction spatial resolution, described by the detector presampling modulation transfer function (MTF), and the post-reconstruction spatial resolution, given …

Synthesis Of Novel Sulfonamide-Based Calpain Inhibitors And Their Potential As Anti-Tumor Agents, Jin Xu

Theses and Dissertations (ETD)

Calpain is a class of intracellular cytoplasmic cysteine proteases.1 The enzyme participates in different intracellular signaling pathways that are mediated by Ca2+.2 The two major isoforms of calpain universally distributed in most mammalian tissues are calpain 1 (µ-calpain) and calpain 2 (m-calpain). The exact in vivo function of the enzyme is not clear, but calpain has been implicated in a variety of physiological and pathological conditions,3 such as cancer, stroke, cardiac ischaemia, muscular dystrophy, cataract and Alzheimer’s disease. Calpain inhibitors are therefore of interest as therapeutic agents and as biomedical tools.

Several potent calpain inhibitors isolated from natural sources as …

Cardiopulmonary Predicators Of Dysfunctional Ventilator Weaning Response After Coronary Artery Bypass Graft, Annapoorna Mary

Theses and Dissertations (ETD)

Although the majority of coronary artery bypass graft (CABG) surgery patients are extubated within 6 to 8 hours following surgery, 20% to 40% of patients remain intubated 12 hours after surgery due to dysfunctional ventilator weaning response (DVWR). DVWR associated with increased morbidity and mortality (30% to 43%) following CABG surgery. Finding significant antecedence to predict DVWR could help to identify and prevent the complications from DVWR after CABG surgery. Literature review revealed that there is an association between cardiopulmonary indicators (CPI) and DVWR after CABG surgery. Cardiopulmonary indicators are the selected hemodynamic parameters that have an association with DVWR. …

The Legal Ethics Of Pediatric Research, Doriane Lambelet Coleman

Duke Law Journal

Since the mid- to late 1990s, the scientific and medical research community has sought to increase its access to healthy children for research protocols that involve harm or a risk of harm. This move reverses longstanding policy within that community generally to exclude healthy children from such protocols on the grounds that the research as to them is non-therapeutic, that they are particularly vulnerable to research-related abuses, and that they are unable themselves to give informed consent to their participation. The research community's new posture has been supported by prominent pediatric bioethicists who have argued that unless healthy children are …

The Long-Term Teratogenic Effect Of Prenatal Alcohol Exposure On The Somatosensory And Motor Cortex Of Rats, Tyson Chappell

Theses and Dissertations (ETD)

The primary goal of this dissertation was to examine the long-term effect of prenatal alcohol exposure (PAE) on the primary somatosensory (SI) and primary motor cortex (MI). For over 30 years, PAE has been shown to produce a triad of symptoms (growth deficits, craniofacial dysmorphologies and central nervous system disruptions) diagnosed as fetal alcohol syndrome (FAS) in children and adults. Since low to moderate levels of prenatal alcohol exposure are less likely to produce FAS symptoms in children, the term “PAE” in this dissertation typically refers to heavy/abusive/chronic levels of prenatal alcohol exposure (in humans this equates to 5+ drinks/per …

Delta-Like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, And Promotes Tumor Growth In Vivo, J-L Li, Rca Sainson, W Shi, R Leek, Et Al

School of Biomedical Sciences

The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often ineffective, suggesting that other factors/pathways are also important in tumor angiogenesis. We have previously shown that the Notch ligand Delta-like 4 (DLL4) is up-regulated in tumor vasculature. Here, we show that DLL4, when expressed in tumor cells, functions as a negative regulator of tumor angiogenesis by reducing the number of blood vessels in all five types of xenografts, but acts as a positive driver for tumor growth in two of them (human glioblastoma and prostate cancer). The growth …

When Using Intensive Grazing Practices, Does It Matter How Often You Move Cattle To A New Paddock On Improved, Irrigated Pastures In Utah?, R. D. Weidmeier

All Current Publications

This publication includes results from a study that answers the question of how often to move cattle to a new paddock when using intensive grazing practices.

Global Analysis Of An Expectations Augmented Evolutionary Dynamics, Angelo Antoci, Antonio Gay, Massimiliano Landi, Pier Luigi Sacco

Research Collection School Of Economics

We consider a deterministic evolutionary model where players form expectations about future play. Players are not fully rational and have expectations that change over time in response to current payoffs and feedback from the past. We provide a complete characterization of the qualitative dynamics so induced for a two strategies population game, and relate our findings to standard evolutionary dynamics and equilibrium selection when agents have rational forward looking expectations.

Parker Mountain Adaptive Resource Management Group 2007 Annual Report, Michael Guttery, David Dahlgren, Michael Monsen, Terry Messmer

All Current Publications

No abstract provided.

Seasonal Changes In Thermal Conductance Of Bat Pelage: A Comparison Of The Eastern Red Bat (Lasiurus Borealis) And Big Brown Bat (Eptesicus Fuscus), Daniel Justin Judy

All-Inclusive List of Electronic Theses and Dissertations

Two species with different ecologies and natural histories use different morphological characteristics and thermoregulatory strategies to survive seasonal environmental changes. The purpose of this project was to investigate two such species, the eastern red bat (Lasiurus borealis) and big brown bat (Eptesicus fuscus). Red bats roost in the foliage of trees and occasionally leaf litter and have dense fur, as well as a furred interfemoral membrane. These two species differ in their morphology and roosting ecology in that big brown bats are generally larger with less dense fur, no fur on the interfemoral membrane, and are less exposed to environmental …

Foraging Behavior And Habitat Use By The Carolina Chickadee (Poecile Carolinensis) In West-Central Indiana, Ihan Chen

All-Inclusive List of Electronic Theses and Dissertations

I studied the effect of environmental conditions on the foraging behavior of Carolina chickadees (Poecile carolinensis) in Kiewig woods, property of Indiana State University, in West Terre Haute in west-central Indiana. My study method uses Optimal Foraging Theory (Brown 1988) to measure the giving up density (GUD) of Chickadees under different environmental conditions ( different resource abundances, different habitat types, different resource types and different seasons). For my experiment, I set up 24 feeding stations in three kinds of habitats ( open area, secondary growth woods and mature woods) within 4 sites and paired trays in each habitat X site. …

Most Caenorhabditis Elegans Micrornas Are Individually Not Essential For Development Or Viability, Eric A. Miska, Ezequiel Alvarez-Saavedra, Allison L. Abbott, Nelson C. Lau, Andrew B. Hellman, Shannon M. Mcgonagle, David P. Bartel, Victor R. Ambros, H. Robert Horvitz

Biological Sciences Faculty Research and Publications

MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or development of C. elegans, and mutations in most miRNA genes do not result in grossly abnormal phenotypes. These observations are consistent with the hypothesis that there is significant functional redundancy among miRNAs …

Mustang Daily, November 30, 2007

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

The Docket (November 30, 2007), William & Mary Law School

The Docket

No abstract provided.

Flyer News, Vol. 55, No. 18 (Nov. 30, 2007), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton

Volume Cxxv, Number 9, November 30, 2007, Lawrence University

The Lawrentian

No abstract provided.

The Daily Egyptian, November 30, 2007, Daily Egyptian Staff

November 2007

No abstract provided.

Hawks' Herald -- November 30, 2007, Roger Williams University

Hawk's Herald

No abstract provided.

The Wooster Voice (Wooster, Oh), 2007-11-30, Wooster Voice Editors

The Voice: 2001-2011

This edition of the College of Wooster's student run newspaper--the Wooster Voice--was published on November 30, and it is eight pages long. The men's basketball team was defeated by Lake Erie College last Sunday. Wooster will be hosting the annual Midwest Regional Tournament this Friday and Saturday. Anatole Ayissi, senior political advisor of the United Nations Secretary General Special Representative in West Africa, spoke on Tuesday on the tensions in Darfur, Sudan. Marty Schneider and Katie Foulds debate the pros and cons of vegetarianism. The four Christian groups on campus will be participating in a 24 hour fast beginning at …

The Bg News November 30, 2007, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 30, 2007. Volume 98-Issue 68.

Education In The Environment: A Strategy For Continued Interagency Outdoor Education Programming: Quarterly Progress Report, Period Ending November 30, 2007, Environmental Education Strategy For Nevada

Reports (PLI Education)

During the past three months, the focus of the university’s efforts has included the following highlights:

• Progress was made on three projects to meet SNAP strategic messaging needs: an anti-litter exhibit; a volunteer restoration program with educational components; and activity stations to tell the story of Lee Meadows restoration efforts.
• Interpretive planning is underway for Mountain’s Edge Explorer’s Interpretive Trail.
• A Spanish class tailored to meet the communication needs of environmental educators and interpreters will be offered January 2008.
• Forever Earth was scheduled for 15 days and benefited 411 individuals.
• Eight Discover Mojave Outdoor World events were conducted for 102 …

The Inkwell, Armstrong Atlantic State University

The Inkwell

No abstract provided.

November 30, 2007, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Mustang Daily, November 29, 2007

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

The Daily Egyptian, November 29, 2007, Daily Egyptian Staff

November 2007

No abstract provided.

Vol.35 N.28 November 29th 2007, Brown Publishing Company

Black Voice News

No abstract provided.

The Pacifican November 29, 2007, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

Chanticleer | Vol 56, Issue 13, Jacksonville State University

Chanticleer

No abstract provided.