Digital Commons Network^™

Regulation Of Fungal Morphogenesis, Qiao Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Candida albicans is an opportunistic fungal pathogen in humans. It typically lives as a harmless commensal as part of the human gut and skin flora, but under some conditions it causes mucosal infections. In immunocompromised patients it can also cause lifethreatening systemic infections. C. albicans is a multimorphic organism, and the ability to undergo morphological transition from budding to hyphal growth is associated with its virulence. This morphological switch was reported to be regulated by different signaling pathways. One key pathway is cAMP-PKA signaling pathway. The single adenylyl cyclase in C. albicans is CaCdc35, which was reported to interact with …

Molecules That Target Beta-Amyloid, Cliff I. Stains, Kalyani Mondal, Indraneel Ghosh

Cliff Stains Publications

The devastating effects of Alzheimer’s and related amyloidogenic diseases have inspired the synthesis and evaluation of numerous ligands to understand the molecular mechanism of the aggregation of the beta-amyloid peptide. Our review focuses on the current knowledge in this field with respect to molecules that have been demonstrated to interact with either oligomeric or fibrillar forms of the beta-amyloid peptide. We describe natural proteins, peptides, peptidomimetics, and small molecules that have been found to interfere with beta-amyloid aggregation. We also detail recent efforts in selecting molecules that target beta-amyloid isolated from antibody, protein, and peptide libraries. These new molecules will …

The Role Of The Olfactory System In Mate Recognition And Sexual Discrimination Of Drosophila Melanogaster, Erika Crespo

McNair Scholars Research Journal

No abstract provided.

The Effects Of Lesions To The Insular Cortex On Fear, Anxiety And Pain Processing, Yonathan Tafesse

McNair Scholars Research Journal

No abstract provided.

The Race Gap: Education Of Black Youth In Boston, Alix Cantave Ph.D., Cheryl Holmes Ph.D., Barbara Lewis Ph.D.

William Monroe Trotter Institute Publications

On April 23, 2007, The William Monroe Trotter Institute held a Roundtable convening more than fifty individuals at UMass Boston for a two-hour conversation on the education of black children in Boston. Roundtable attendees represented a balanced mix of professional and lay persons, including educators, advocates, academics, elected officials and policymakers, and donors. Attendees included the Suffolk County Sheriff, the Acting Superintendent of Boston Public Schools (BPS), and the president of the Boston Teacher’s Union.

Beetles For Breakfast: What The Fda Should Be Telling You, Kaycee L. Wolf

Journal of Food Law & Policy

Imagine sitting down to breakfast and eating strawberry yogurt with a glass of grapefruit juice. You think you are eating a healthy meal, but along with vitamins, calcium, and nutrients, you are getting a side of crushed beetles. Cochineal extract and carmine, two color additives derived from the cochineal beetle, color many foods such as strawberry yogurt. When people consume products with color additives, most do not realize that they could be ingesting insects, which can also be potentially dangerous, not to mention possibly unappetizing or upsetting. Imagine that one minute you are sitting down to eat a healthy cup …

Finite Element Modeling Of Soft Tissue Deformation., Hongjian Shi

Electronic Theses and Dissertations

Computer-aided minimally invasive surgery (MIS) has progressed significantly in the last decade and it has great potential in surgical planning and operations. To limit the damage to nearby healthy tissue, accurate modeling is required of the mechanical behavior of a target soft tissue subject to surgical manipulations. Therefore, the study of soft tissue deformations is important for computer-aided (MIS) in surgical planning and operation, or in developing surgical simulation tools or systems. The image acquisition facilities are also important for prediction accuracy. This dissertation addresses partial differential and integral equations (PDIE) based biomechanical modeling of soft tissue deformations incorporating the …

The Changes Of Fructos-2,6-Bisphosphate Level In Transgenic Mice Causing Cardiomyopathy., Jianxun Wang 1969-

Electronic Theses and Dissertations

Heart failure is recognized as a major cause of death among diabetics. In type I and II diabetes, glucose uptake, glycolysis and pyruvate oxidation are impaired, and fatty acid utilization increases. These alterations in metabolism contribute toward cardiac contractile function. There is a gap in our understanding on how alterations in glycolytic metabolite fructose-2,6-bisphosphate (F-2,6-P 2 ) affects cardiac dysfunction. Two cardiac-specific overexpression of PFK-2 (phosphofructose kinase-2) transgenic models were used to investigate the role of altered metabolism by F-2,6-P 2 in provoking cardiomyopathy. One model is with the PFK-2 kinase active and phosphatase inactive enzyme called MK and another …

Therapeutic Targeting Of Tumor Associated Macrophages., Stephanie Kaye Watkins 1981-

Electronic Theses and Dissertations

Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast, little attention has been given to the potential role of macrophages in the initiation of anti-tumor responses by IL-12 therapy despite reports that macrophages play a major role in promoting tumor growth and metastasis and in suppressing anti-tumor immune responses. Based on the functional adaptivity hypothesis, which is the concept that macrophages functionally adapt, rather than differentiate into specific mature subsets, in response …

Molecular Interactions Between The Wilms' Tumor Transcription Factor And The Aryl Hydrocarbon Receptor During Nephrogenesis And Its Impact On Fetal Programming Of Renal Disease., Adrian Nanez

Electronic Theses and Dissertations

Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in utero that activate or repress the expression of numerous genetic elements resulting in fetal programming of adult diseases. The aryl hydrocarbon receptor (AHR) is an important nuclear transcription factor both during embryogenesis and throughout maturity in multiple organisms. Building upon interesting studies establishing a direct, novel link between AHR and post-transcriptional regulation of the Wilms' tumor suppressor ( WT1 ) gene, the overall goal of the project …

Gene Therapy And Cellular Transplantation : Towards A Combination Strategy For Spinal Cord Injury Repair., Ahmed Abdelzaher Abdellatif

Electronic Theses and Dissertations

The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and feasibility of using such combination has been extensively reviewed in Chapter 1. The study presented in Chapter 2 showed that lentiviral vectors are most suitable in situations where stable long term transgene expression is needed, while adenovirus and retrovirus are more suited for transient gene delivery. Tissue engineering combined with Schwann cell (SC) transplantation is a promising method to enhance regeneration and remyelination of axons following a …

Index Of Volume Xxxiv, Issues 1-4

The Journal of Sociology & Social Welfare

No abstract provided.

Effects Of Direct Atp Delivery To Ischemic Skeletal Muscle., Federico V. Grossi 1974-

Electronic Theses and Dissertations

The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for prolonged periods of time and in preventing in vivo ischemia reperfusion injury in a composite tissue transplantation model. Ischemia and reperfusion injury is a well recognized phenomenon that occurs in situations like organ transplantation, shock, cardiac surgery, etc, where tissues are temporarily deprived of nutrients and oxygen for energy production. When exposed to short periods of ischemia, cells utilize their stored energy to …

André Jeunet : Expanded Educational Opportunities For A Photographic Exhibition., Brian J. Davis 1958-

Electronic Theses and Dissertations

In spring 2006, the Frazier International History Museum, in conjunction with the Ekstrom Library Photographic Archives at the University of Louisville, mounted an exhibit of 47 photographs taken by a young French foot soldier during World War I. The exhibit, titled "André Jeunet: Images of WWI by a Pacifist Soldier," ran from May 19 through September 4, 2006. The main concept behind the exhibit was to show images of World War I that focused less on the horrific aspects of combat and more of the everyday life the of common soldier, and to highlight that although many soldiers fought out …

Soil Phosphate Detection And Archaeology : In-Stride Phosphate Detection And The Elimination Of Arsenate Interference To The Malachite Green Method., Laura A. Deneve

Electronic Theses and Dissertations

Archaeologists use soil analysis to detect chemicals, like phosphate, to indicate areas of anthropogenic activity. Phosphate detection is a multi-step process, which makes standard techniques time consuming. Kinetic studies decreased the analysis time for the malachite green (MG) method of phosphate detection. The 3-minute method allows extraction and analysis to be complete in 15 minutes. Continued studies resulted in two-color spectral monitoring, which provided values instantaneously. Arsenate (As(V)) interfere with the MG method and results in overestimation of phosphate. As(V) must be reduced to non-interfering arsenite. Two As(V) reducing agents--L-Cysteine and thiosulfate--were investigated. The thiosulfate method was suitable for field …

Effects Of Subchronic Dietary Lead Exposure On Dmtp And Dnmtp Performance In Fisher 344 Rats, Joshua D. Vardigan

Masters Theses

Recent attention has focused on the possibility that even low-level Pb exposure can produce subtle neurological impairments in the absence of overt signs of toxicity. Previous behavioral assessments of learning and memory using DMTS procedures have documented learning impairments in monkeys exposed to Pb during early postnatal development, and although a variety of operant behavioral assays have documented detrimental effects of dietary Pb treatment in rats, the DMTS procedure has not been examined in rats following short-term low levels of Pb through dietary exposure. Thus, the objective of this study was to measure the degree of cognitive impairment produced by …

Histopathological Assessment And Comparison Sedimentation And Phosphate Stress On The Staghorn Coral, Acropora Cervicornis, Erin Christine Hodel

HCNSO Student Theses and Dissertations

Traditional coral reef monitoring efforts lack assessment of coral health at tissue and cellular levels. This thesis investigated tissue, cellular, and gross morphological responses of the Caribbean staghorn coral, Acropora cervicornis, to elevated sedimentation and phosphate using state-of-the-art histological techniques. Branch fragments of A. cervicornis were collected offshore Broward County, FL, acclimated for 12 weeks, subjected to a 4-week experimental period, and given a 1-week recovery period in laboratory aquaria. Treatments consisted of high doses (200 mg cm^-2 day^-1) of sedimentation (S), phosphate (4 μM) (P), and a combination of these two (S + P), in …

Gateshead Revisited: Perceptual Simulators And Fields Of Meaning In The Analysis Of Metaphors, L. David Ritchie

Communication Faculty Publications and Presentations

In an extension and partial reformulation of Conceptual Metaphor Theory (Lakoff & Johnson, 1980), Ritchie (2003, 2004, 2006) proposed that the linguistic expressions cited as evidence of complex conceptual metaphors can be parsimoniously interpreted in terms of perceptual simulators (Barsalou, 1999), often within extended fields of meaning, which may be but are not necessarily anchored in underlying conceptual metaphors. Cameron (2003, 2007) added substance and precision to the focal concept of communicative context, and showed how metaphors can be analyzed both as part of an overall pattern of figurative language in a communicative event. In this essay a series of …

Circumventing Daubert In The Gene Pool, Erica Beecher-Monas

Tulsa Law Review

No abstract provided.

Interpreting The Fourteenth Amendment: Two Don'ts And Three Dos, Garrett Epps

William & Mary Bill of Rights Journal

A sophisticated reading of the legislative record of the framing of the Fourteenth Amendment can provide courts and scholars with some general interpretive principles to guide their application of the Amendment to current legal problems. The author argues that two common legal conceptions about the Amendment are, in fact, misconceptions. The first is that the Amendment was chiefly concerned with the immediate situation of freed slaves in the former slave states. Instead, he argues, the legislative record suggests that the framers were broadly concerned with the rights not only of freed slaves but also of foreign-born immigrants in the North …

An Examination Of The Evolution Of Verbal Behavior And The Effects Of Extinction Duration On Accelerated Performance Accuracy, Jose Sanchez

McNair Scholars Research Journal

No abstract provided.

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Eurasian Tree Sparrow—A First Record For Nebraska, Mark A. Brogie

Nebraska Bird Review

On Thursday, 01 February 2007, Scott Raasch of rural Madison County called to say he had what he believed to be a Eurasian Tree Sparrow (Passer montanus) coming to a feeder at his house just east of Enola. The bird had been present for about a week, although he had just identified the species upon purchasing a new field guide. He reported that the bird was very wary and only stayed for a short time at the feeder. The bird was most often observed in the early morning or just before dusk.

Dave Heidt and I arrived the …

Fall Field Report, August-November 2007, W. Ross Silcock

Nebraska Bird Review

This was essentially a normal fall season in Nebraska, with no major weather events or significant shifts in breeding or migration ranges, although a possible exception is a first record of Lesser Goldfinch breeding in the state. One observer made the point, though, that the hard freeze in the spring affected seed and fruit crops for fall, most conspicuously resulting in fewer large American Robin flocks. Excellent water conditions in the Rainwater Basin were welcome, but few herons and egrets were present, and no unusual breeding events were reported there.

As winter approached, however, increased numbers of a few finch …

Nebraska Bird Review (December 2007) 75(4), Whole Issue

Nebraska Bird Review

Fall Field Report, August-November 2007 by W. Ross Silcock ... 98

Eurasian Tree Sparrow—A First Record for Nebraska by Mark A. Brogie ... 118

NOU Fall Field Days at Halsey, September 28-30, 2007 ... 121

Index to Volume 75 ... 125

Subscription and Organization Information ... 135

Subscription And Organization Information [December 2007]

Nebraska Bird Review

The Nebraska Bird Review is published quarterly by the Nebraska Ornithologists' Union, Inc., as its official journal, and is sent to members not in arrears of dues. Annual subscription rates (on a calendar-year basis only): $15 in the United States, $18 in Canada and $30 in all other countries, payable in advance. Single copies are $4 each, postpaid, in the United States, $5 in Canada, and $8 elsewhere. Send orders for back issues to Mary Lou Pritchard, NOU Librarian, c/o University of Nebraska State Museum, W-436 Nebraska Hall, Lincoln, NE 68588-0514.

Memberships in the NOU (on a calendar-year basis only): …

Index To Volume 75

Nebraska Bird Review

Accipiter species 22-23

Ahlering, M. A. 60

Alexander, Irene 19

Allen, Sue 19

Allwine Prairie Preserve 15

American Ornithologists' Union 93

Ames CBC 17-30

Amiotte, Sue 61

Anderson, Chris 19

Anderson, T. R. 120

Ani, Groove-billed 88

Aubushon, Kathy 18

Avocet, American 41, 76, 106, 122

Halsey Fall Field Days

Nebraska Bird Review

The 2007 NOU Fall Field Days were held at the 4-H Camp in the Nebraska National Forest near Halsey on September 28-30, 2007. Among the approximately 45 in attendance were two first time attendees: Juanita Rice of Fairmont and Tim Hajda of Broken Bow.

Wayne Mollhoff spoke on Friday night about the progress on the new breeding bird atlas: "A Funny Thing Happened on the Way to the Atlas," and on Saturday night, Bob Rooney did a multimedia presentation entitled "A Sandhills Odyssey."

Field trips to Cherry, Logan, and Brown Counties were led by Clem Klaphake, Mark Brogie, and Dave …

Choreographing Race: An Analysis Of Black Performance And White Audience, Katrina Dyonne Thompson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

[to be added]

Detection Of Polychlorinated Biphenyls In The Rio Grande Basin Above Cochiti Dam: Sources & Significance, Anthony D. Edwards

Water Resources Professional Project Reports

Polychlorinated biphenyls (PCBs) have been detected with increasing frequency in water and fish tissue samples in the Rio Grande Basin above Cochiti Dam (RGBACD), which correlates with the use of improved analytical methods for quantifying PCBs. Levels of PCBs identified in some fish have exceeded levels considered safe for human consumption, resulting in a Fish Consumption Advisory' for Abiquiu and Cochiti Reservoirs and the Rio Grande from Pojoaque Creek to Frijoles Canyon (Bandelier National Monument). In June of 2007, the New Mexico Environment Department (NMED) listed seven water bodies in the RGBACD as impaired due to elevated concentrations of PCBs …