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2007

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Role Of Angiotensin Converting Enzymes Ace And Ace2 In Diabetes Induced Cardiovascular Dysfunction, Keerthy Kanakamedala Jan 2007

Role Of Angiotensin Converting Enzymes Ace And Ace2 In Diabetes Induced Cardiovascular Dysfunction, Keerthy Kanakamedala

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Cardiovascular disease is a long term complication of diabetes, which remains a leading cause of mortality and morbidity. There is recent evidence for activation of the Renin angiotensin system (RAS) in diabetic animals and humans. Emerging evidence shows that the vasoconstrictor actions of Ang II may be opposed by formation of the vasodilator, Ang (1-7). There is limited data on blood pressure in murine models of type 2 diabetes. The aim is to study the role of angiotensin converting enzymes ACE and ACE2 in diabetes induced cardiovascular dysfunction using type 2 diabetic murine mouse models (db/db mice). Both db/db mice …

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Modulation Of The 3'Igh Regulatory Region (3'Igh Rr), A Prospective In Vitro Screening Tool For Identifying Potential Immunotoxicants, Rebecca Anne Henseler Jan 2007

Modulation Of The 3'Igh Regulatory Region (3'Igh Rr), A Prospective In Vitro Screening Tool For Identifying Potential Immunotoxicants, Rebecca Anne Henseler

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The immune system is critical to human survival. However, assessing alterations of immune function by potential immunotoxicants is complicated by the diffuse nature of the immune system, which is composed of various effector cells each with differing effector functions. Current immunotoxicity testing is limited to animal studies. We have developed a model, which may provide an in vitro alternative to animal studies in identifying immunotoxicants that specifically target B cell function (i.e., alteration of immunoglobulin (Ig) or expression and antibody secretion). This model consists of a well-characterized B cell line, CH12.LX, which appears to appropriately model primary B cell function. …

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Oral Ld50 Of Botulinum Toxin Serotype A In Guinea Pigs, Christina Marie Wilhelm Jan 2007

Oral Ld50 Of Botulinum Toxin Serotype A In Guinea Pigs, Christina Marie Wilhelm

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As a disease, botulism is a neuroparalytic illness resulting from the action of a potent neurotoxin produced by C. Botulinum. Of the seven distinct C. Botulinum neurotoxin serotypes: A, B, C, D, E, F, and G, only serotypes A, B, E and F cause human disease. The duration of action of the seven toxin serotypes varies with serotype A having the most sustained action (i.e. months vs. days in serotype E). This study was performed due to recently identified critical gaps in our food safety procedures. The goal of this study was to assess whether fresh 2% milk provided protective …

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Discovery Of New Antimicrobial Agents Using Combinatorial Chemistry, William I. Northern Jan 2007

Discovery Of New Antimicrobial Agents Using Combinatorial Chemistry, William I. Northern

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Combinatorial chemistry has become an important aspect of medicinal research due to its flexibility and the ability to produce large numbers of potential therapeutic agents. Once compounds are made, they must be screened to determine if there is any biological activity. This research project focused on developing a screening method for chemical agents produced by a graduate student in the chemistry department at Wright State University. After an acceptable screening method was found, the goal of the project was to determine if compounds produced had either antibacterial activity, antifungal activity, or both. Seven compounds exhibited biological activity. Two of these …

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The Processing Of Β-Endorphin In Morphine Treated Rats Using Seldi-Tof Mass Spectrometry, Jennifer Y. Edwards Jan 2007

The Processing Of Β-Endorphin In Morphine Treated Rats Using Seldi-Tof Mass Spectrometry, Jennifer Y. Edwards

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Endocrine glands secrete peptide hormones that bind to specific receptors, and elicit a response. In the pituitary, prohormone convertases (PC) PC1/3 and PC2 convert inactive prohormones into biologically active peptide hormones. Proopiomelanocortin (POMC) is a precursor molecule that proteolytically cleaves at paired basic residue sites, and produces smaller biologically active peptides, such as adrenocorticotropic hormone (ACTH), α-melanocyte stimulating hormone (α-MSH), and β-endorphin. β-endorphin is an endogenous opioid peptide hormone that plays a vital role in the body's physiological response to stress, fear, and anxiety. Morphine is an exogenous opioid, used for the treatment of moderate to severe pain and competes …

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Differential Effects Of Mutant Tap63Γ On Transactivation Of P53 And/Or P63 Responsive Genes And Their Effects On Global Gene Expression, Shama Khan Khokhar Jan 2007

Differential Effects Of Mutant Tap63Γ On Transactivation Of P53 And/Or P63 Responsive Genes And Their Effects On Global Gene Expression, Shama Khan Khokhar

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p63, a member of the p53 gene family, known to play a role in development, has more recently also been implicated in cancer progression. Mice lacking p63 exhibit severe developmental defects such as limb truncations, abnormal skin, and absence of hair follicles, teeth, and mammary glands. Germline missense mutations of p63 have been shown to be responsible for several human developmental syndromes including SHFM, EEC and ADULT syndromes and are associated with anomalies in the development of organs of epithelial origin. The contrasting phenotypes associated with the different classes of p63 mutations might be in part due to the differential …

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Functional Interplay Between Subthreshold Ion Channels In Preautonomic Neurons Of The Hypothalamic Paraventricular Nucleus In Health And Disease Conditions, Patrick M. Sonner Jan 2007

Functional Interplay Between Subthreshold Ion Channels In Preautonomic Neurons Of The Hypothalamic Paraventricular Nucleus In Health And Disease Conditions, Patrick M. Sonner

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Under normal conditions, blood pressure is tightly regulated through autonomic tonic and reflex mechanisms. However, when the set-point for blood pressure is chronically elevated, hypertension occurs. Hypertension if untreated can lead to further complications including heart failure, stroke and kidney failure. Elevated sympathetic outflow is known to contribute to the development and/or maintenance of hypertension, and while the hypothalamic paraventricular nucleus (PVN), a preautonomic center, has been implicated in the elevation of sympathetic activity during hypertension, the precise pathophysiological mechanisms underlying sympathoexcitation remain unclear. Subthreshold ion channels, including the A-type K +(I A) and the T-type Ca 2+ …

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Design And Implementation Of Timeline Application For News Documents, Mastan Vali Shaik Jan 2007

Design And Implementation Of Timeline Application For News Documents, Mastan Vali Shaik

Browse all Theses and Dissertations

The growing News document archive emphasizes the need for efficient techniques to retrieve and visualize its content. We present a timeline based graphical interface for this purpose. The timeline is a graph of number of documents supporting association between entity (event, country, person, etc) etc and event (entity, country, person, etc) with respect to dates. The query is formulated based on entity, event, country, and person metadata extracted from the text of the News documents by analyzing the documents using proprietary name-entity recognizers. The timeline also provides a means to index and access relevant documents. Associations inferred on the basis …

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Fabrication And Testing Of Scaffolds For Cell Growth From Ionic Liquid Solubilized Fibroin, Maneesh Kumar Gupta Jan 2007

Fabrication And Testing Of Scaffolds For Cell Growth From Ionic Liquid Solubilized Fibroin, Maneesh Kumar Gupta

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The advent of tissue engineering has spurred research into developing materials to act as scaffolds for tissue growth. These scaffolds require materials capable of mimicking the in vivo conditions so that tissues can be grown effectively in vitro. Silk is an attractive biomaterial for use in tissue engineering applications because of its slow degradation, excellent mechanical properties, and biocompatibility. The major objective of the research in this thesis is to demonstrate a simple method to cast films directly from silk fibroin dissolved in an ionic liquid. The films cast from the silk ionic liquid solution were found to support normal …

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A Hybrid Approach To Retrieving Web Documents And Semantic Web Data, Trivikram Immaneni Jan 2007

A Hybrid Approach To Retrieving Web Documents And Semantic Web Data, Trivikram Immaneni

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The Semantic Web has been evolving into a property-linked web of RDF data, conceptually divorced from (but physically housed in) the World Wide Web of hyperlinked documents. Data Retrieval techniques are typically used to retrieve data from the Semantic Web while Information Retrieval techniques are used to retrieve documents from the Hypertext Web. Conceptually unifying the two webs enables the exploitation of their interconnections resulting in benefits to both data and document retrieval. Towards this end, we present the Unified Web model that integrates the two webs and formalizes the structure and the semantics of their interconnections. We present a …

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Why Do We Ask The Same Questions - The Triple Helix Dilemma Revisited Symposium: Legal Information And The Development Of American Law: Further Thinking About The Thoughts Of Robert C. Berring, Richard Delgado, Jean Stefancic Jan 2007

Why Do We Ask The Same Questions - The Triple Helix Dilemma Revisited Symposium: Legal Information And The Development Of American Law: Further Thinking About The Thoughts Of Robert C. Berring, Richard Delgado, Jean Stefancic

Articles

No abstract provided.

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Motivating Enforcement: Institutional Culture And The Clean Water Act Fourth Iucn Academy Of Environmental Law Worldwide Colloquium: Implementing Environmental Legislation: The Critical Role Of Enforcement And Compliance, William L. Andreen Jan 2007

Motivating Enforcement: Institutional Culture And The Clean Water Act Fourth Iucn Academy Of Environmental Law Worldwide Colloquium: Implementing Environmental Legislation: The Critical Role Of Enforcement And Compliance, William L. Andreen

Articles

No abstract provided.

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Interpreter Of Maladies: Analyzing Current Young Adult Indo-Caribbean Literature For Inclusion In Today's High School Canon, Reshma Ramkellawan Jan 2007

Interpreter Of Maladies: Analyzing Current Young Adult Indo-Caribbean Literature For Inclusion In Today's High School Canon, Reshma Ramkellawan

HIM 1990-2015

The high school English Language Arts curricula of Central Florida has faced increasing scrutiny during the past decade under often conflicting influences such as a rapidly diversifying student population, activism for and against multicultural curriculum reform, and pressure to streamline curricula and make it conform to state testing standards. Against this social backdrop, the question of how to introduce Inda-Caribbean literature at the secondary level presents unique intellectual and political challenges. On the one hand, first and second generation Inda-Caribbean migrants make up an increasingly significant percentage of Florida's student population. Like other first and second generation Caribbean migrants, Inda-Caribbean …

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Patchwork Culture: Quilt Tactics And Digitextuality, Michelle P. Barrett Ferrier Jan 2007

Patchwork Culture: Quilt Tactics And Digitextuality, Michelle P. Barrett Ferrier

Electronic Theses and Dissertations

Embedded in the quilt top, the fabric patches are relays, time pathways to stories and memories of their former owners. Through the quilts, the voices of the past survive. The stories trace a path of connection between oral traditions, storytelling, the invention of meaning, and the preservation of cultural memory. The theory and method described herein use the quilt patchwork metaphor as the basis for a web interface for designing and modeling knowledge-based graphical, narrative, and multimedia data. More specifically, the method comprises a digital storytelling and knowledge management tool that allows one or more users to create, save, store, …

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Times New Roman, Jason Mckrindey Coates Jan 2007

Times New Roman, Jason Mckrindey Coates

Theses and Dissertations

It is difficult to say that anything will be proven in this thesis of mine. I think of it more as an account of some things that happened in my artwork over the course of graduate school and my earlier development as an artist. Some influences are listed, but certainly not all of them. Likewise, the work that is mentioned in this paper represents a sampling rather than an in-depth survey. I don't have any tables or charts.

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Efficacy Of Removal Of Ccl Viruses Under Enhanced Coagulation Conditions, Morteza Abbaszadegan, Brooke K. Mayer, Hodon Ryu, Nena Nwachuku Jan 2007

Efficacy Of Removal Of Ccl Viruses Under Enhanced Coagulation Conditions, Morteza Abbaszadegan, Brooke K. Mayer, Hodon Ryu, Nena Nwachuku

Civil and Environmental Engineering Faculty Research and Publications

The focus of coagulation as a water treatment process is shifting to accommodate recent regulatory additions that strive to balance the risks between microbial and chemical contamination of drinking water. In this work, enhanced coagulation using increased ferric chloride dose and/or pH adjustment was evaluated for removal efficacy of viruses on the United States Environmental Protection Agency (USEPA) Contaminant Candidate List (CCL), their surrogates, and dissolved organic carbon (DOC). Jar tests demonstrated that optimal DOC removal was achieved using 40 mg/L FeCl3 at a pH between 5 and 6. Under these conditions, bench-scale testing resulted in a maximum removal …

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A Prescriptive Analysis Of The Indiana Coal Transportation Infrastructure, Thomas F. Brady, Chad M. Pfitzer Jan 2007

A Prescriptive Analysis Of The Indiana Coal Transportation Infrastructure, Thomas F. Brady, Chad M. Pfitzer

JTRP Technical Reports

This report presents the findings of a scoping study of Indiana’s coal transportation infrastructure. Throughout the literature search and investigative phases of this project, it was clear that there exists growing awareness of the importance that transportation plays in the domestic coal industry. There is evidence that suggests transportation costs may be higher than the cost of mining coal. Numerous studies suggest that coal transportation can be developed and utilized for significant competitive economic advantage. The Powder River Basin area in Wyoming is a stellar example of how the combination of a large natural resource and careful transportation planning can …

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Effective And Robust Coordination Of Traffic Signals On Arterial Streets, Volume 2, Guidelines Of Design, Wei Li, Andrew P. Tarko Jan 2007

Effective And Robust Coordination Of Traffic Signals On Arterial Streets, Volume 2, Guidelines Of Design, Wei Li, Andrew P. Tarko

JTRP Technical Reports

Many transportation agencies use Synchro and SimTraffic software package to optimize signal coordination. In general, this software package effectively reduces the efforts of traffic systems engineers and improves the quality of the designed coordination. Nevertheless, the initial solutions given by the software packages usually require adjustment, at both the design and implementation stages. The major objective of this research, therefore, is to reduce the time and effort needed in solution tuning and thus to improve the effectiveness and the efficiency of using Synchro/SimTraffic in arterial signal coordination design. The research outcome is expected to help traffic systems engineers reach reasonable …

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Agricultural Producers And Agricultural Cooperatives With Conforming Changes As Of May 1, 2007; Audit And Accounting Guide:, American Institute Of Certified Public Accountants. Agribusiness Special Committee Jan 2007

Agricultural Producers And Agricultural Cooperatives With Conforming Changes As Of May 1, 2007; Audit And Accounting Guide:, American Institute Of Certified Public Accountants. Agribusiness Special Committee

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

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Sos (Safeguard Our Survival): Understanding And Alleviating The Lethat Legacy Of Survival-Threatening Child Abuse, Nancy Wright, Eric Wright Jan 2007

Sos (Safeguard Our Survival): Understanding And Alleviating The Lethat Legacy Of Survival-Threatening Child Abuse, Nancy Wright, Eric Wright

American University Journal of Gender, Social Policy & the Law

No abstract provided.

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Evaluation Of The Nutritional Quality Of Twelve Species Of Grass Tolerant To Salt And Drought In Function To Their Dry Matter Accumulation Curve In The Tamborada Region, Julio César Bustamante Alavi Jan 2007

Evaluation Of The Nutritional Quality Of Twelve Species Of Grass Tolerant To Salt And Drought In Function To Their Dry Matter Accumulation Curve In The Tamborada Region, Julio César Bustamante Alavi

Theses and Dissertations

Currently, livestock production in the Andean highlands of Bolivia is done with low food efficiency due to the free range grazing system. This in turn leads to nutritional deficiencies. Therefore, it is necessary to substitute these grass species for others that fulfill nutritional requirements. Our main objective was to determine the species of grass with the best nutritional quality. Of the 12 species, only 11 were analyzed because the species Didtichlis stricta did not germinate. Five monthly samples were taken after the cut (ddc) at the following intervals: 50, 81, 112, 141, and 176 days. These samples were analyzed in …

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Evaluation Of Vicuñas (Vicugna Vicugna) Fed With Three Types Of Hay In Stables In The Municipality Of Tiahuanaco, Department Of La Paz, José Cartagena Catacora Jan 2007

Evaluation Of Vicuñas (Vicugna Vicugna) Fed With Three Types Of Hay In Stables In The Municipality Of Tiahuanaco, Department Of La Paz, José Cartagena Catacora

Theses and Dissertations

This study was conducted in the Rural Academic Unit of Tiahuanaco, in the Ingavi province, in the department of La Paz. Three juvenile vicunas and three adult vicunas were used. Our objective was to observe the development of vicunas (Vicugna vicugna) fed with three types of hay (Bromus catharicus Phalaris tuberoisum and Medicago sativa) in stables. We obtained the following results: rectal temperature of 38.2ºC in juveniles and 38.6ºC in adults; heart rate of 68 beats/min in juveniles and 67 beats/min in adults; respiratory rate of 18 breaths/min in juveniles and 17 breaths/min in adults; femoral vein pulse of 70 …

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Response Of Three Ecotypes Of Maca (Lepidium Meyenii Walp.) To Five Levels Of Ovine Manure In The Community Of Yampupata (Manco Kapac Province - La Paz), Sabina Quispe Paye Jan 2007

Response Of Three Ecotypes Of Maca (Lepidium Meyenii Walp.) To Five Levels Of Ovine Manure In The Community Of Yampupata (Manco Kapac Province - La Paz), Sabina Quispe Paye

Theses and Dissertations

This study was conducted in the community of Yampupata, in the municipality of Copacabana, in the Manco Kapac province, La Paz, to an altitude of 3841 m.a.s.l, agricultural campaign 2003-2004. The purpose of the study was to determine and compare the fenological stages (germination, growth, leafing, and harvesting), hypocotyl yield (dry and fresh), classification of the hypocotyl (diameter, length, etc.), and the economical evaluation as well. The experiment set up was installed in the lower region of the community, dedicated to agriculture, performing all the aforementioned activities together for the period of a year. The experimental design was of Random …

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Foreword: Animal Law: Thinking About The Future, Jeff Welty Jan 2007

Foreword: Animal Law: Thinking About The Future, Jeff Welty

Law and Contemporary Problems

No abstract provided.

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Bred Meat: The Cultural Foundation Of The Factory Farm, David N. Cassuto Jan 2007

Bred Meat: The Cultural Foundation Of The Factory Farm, David N. Cassuto

Law and Contemporary Problems

The care and upkeep of animals raised for human consumption has devolved into an industrial operation focused on maximizing economic return while paying little or no heed to the needs of the "stock." Discussions of the nature of factory farming inevitably include issues of ethical treatment of nonhuman animals and often segue into apologies for or against "animal rights." This article takes a different tack, asking instead how and why the factory-farm industry could grow ascendant in an era when the notion of the human-animal divide has become increasingly blurred.

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Humane Slaughter Laws, Jeff Welty Jan 2007

Humane Slaughter Laws, Jeff Welty

Law and Contemporary Problems

Much recent scholarship has focused on the conditions under which farm animals are raised. This article examines not how such animals are kept, but how they are killed and how such killing is regulated by law.

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Similarity Or Difference As A Basis For Justice: Must Animals Be Like Humans To Be Legally Protected From Humans?, Taimie L. Bryant Jan 2007

Similarity Or Difference As A Basis For Justice: Must Animals Be Like Humans To Be Legally Protected From Humans?, Taimie L. Bryant

Law and Contemporary Problems

Justice may not require that animals be exactly the same as humans or that they have rights exactly coterminous with the rights of humans, but justice would require that animals receive protection in ways that match up with those similarities they share with humans that are characteristics considered essential to the understanding of what it means to be human. Stated generally, the argument is that if animals are similar to humans as to capacities and characteristics of humans that define humans, then animals should receive protections equivalent to the protections of humans because a just society treats like entities alike.

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Broad Exemptions In Animal-Cruelty Statutes Unconstitutionally Deny Equal Protection Of The Law, William A. Reppy Jr. Jan 2007

Broad Exemptions In Animal-Cruelty Statutes Unconstitutionally Deny Equal Protection Of The Law, William A. Reppy Jr.

Law and Contemporary Problems

This article considers the history, interpretation, and constitutionality of statutory exemptions that preclude prosecution either for misdemeanor or felony violation of North Carolina's criminal animal-cruelty statute, section 14-3601 of the General Statutes, in nine situations.

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The Compositional Account Of The Incarnation, Thomas D. Senor Jan 2007

The Compositional Account Of The Incarnation, Thomas D. Senor

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

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The Peahen’S Tale, Or Dressing Our Parts At Work, Julie A. Seaman Jan 2007

The Peahen’S Tale, Or Dressing Our Parts At Work, Julie A. Seaman

Duke Journal of Gender Law & Policy

However, there may ultimately be no logical way to reconcile decisions that prohibit employers from requiring women to wear revealing outfits and others that permit employers to require them to wear makeup,20 or decisions that prohibit penalizing a woman for being insufficiently feminine and others that permit penalizing a man for being insufficiently masculine.21 In addition, the increasing judicial acceptance of the sex stereotyping theory of sex discrimination under Title VII is in substantial tension with recent cases that insist that sex-differentiated dress and grooming requirements that "merely"22 conform to existing social gender norms do not amount to impermissible sex …

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