Digital Commons Network^™

Solution And Solid State Interactions Between Ionic Π-Systems, Jing Chen

University of Kentucky Doctoral Dissertations

Although attractive interactions between π systems (π-π interaction) have been known for many years, understanding of its origin is still incomplete. Quantitative measuring of π-stacking is challenging due to the weak nature of the π-π interaction. This dissertation aims at elucidating a quantitative conformational analysis by NMR ring current anisotropy of an organic compound capable of intramolecular π-stacking in solution and studying charge effects on the stacking of π-systems. This dissertation offers four contributions to the area. (1) A general approach to four-state, conformational analysis based on the magnetic anisotropy of molecules undergoing fast dynamic exchange is described. (2) Study …

Group 13 Chelates In Phosphate Dealkylation, Amitabha Mitra

University of Kentucky Doctoral Dissertations

A series of mononuclear boron halides of the type LBX2 (LH = N-phenyl-3,5-di-tbutylsalicylaldimine,X = Cl (2), Br (3)) and LBX ( LH2 = N-(2-hydroxyphenyl)-3,5-di-tbutylsalicylaldimine,X = Cl (7), Br (8); LH2 = N-(2-hydroxyethyl)-3,5-di-tbutylsalicylaldimine,X = Cl (9), Br (10); LH2= N-(3-hydroxypropyl)-3,5-di-tbutylsalicylaldimine,X = Cl (11), Br (12)) were synthesized from their borate precursorsLB(OMe)2 (1) (LH = N-phenyl-3,5-di-t-butylsalicylaldimine ) and LB(OMe) (LH2 = N-(2-hydroxyphenyl)-3,5-di-t-butylsalicylaldimine (4), N-(2-hydroxyethyl)-3,5-di-tbutylsalicylaldimine(5), N-(3-hydroxypropyl)-3,5-di-t-butylsalicylaldimine (6)). Theborate precursors, 1, 4 - 6, in turn, were prepared by refluxing the corresponding ligandsLH or LH2 with excess B(OMe)3. The boron halide compounds were air- and moisturesensitiveand compound 7 on hydrolysis gave the oxo-bridged compound …

Multifunctional Potential Therapeutics Towards Oxidative Stress Mediated Neurodegenerative Disorders And Models Thereof, Gururaj Joshi

University of Kentucky Doctoral Dissertations

The studies described in this dissertation were performed with the goal of understandingthe function of antioxidant compounds delivered in vivo to rodents and the implication of theresults towards oxidative stress (OS)-related neurodegenerative disorders with particularemphasis on Alzheimer's disease (AD). OS has been implicated in AD and is characterized byextensive oxidative damage to protein, lipids and DNA. A major thrust of this dissertation workwas to gain insight into antioxidant properties of compounds used in the following studies andtheir efficacy as potential therapeutics for treatment of OS-related disorders.D609, a glutathione (GSH) mimetic is known to trap OH. Radicals, scavenge H2O2 andreduce the …

Synthesis And Evaluation Of Pyridinium Derivatives As Central Nervous System Nicotinic Acetylcholine Receptor Ligands, Joshua Thomas Longen Ayers

University of Kentucky Doctoral Dissertations

This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR subtypes. Alkylation of the pyridino nitrogen of the nicotine molecule afforded subtype specific antagonists at a42* nAChR subtypes and nAChR subtypes that mediate nicotine-evoked dopamine release. Using this data, a series of mono-azaaromatic quaternary salts were produced and evaluated in binding and functional assays for a42* and a7* nAChR subtypes and nAChR subtypes that mediate nicotine-evoked dopamine release. Additionally, bis-azaaromatic quaternary salts were synthesized and evaluated in the same assays. Two potent lead compounds were identified. N-n-dodecylnicotinium iodide (NDDNI) was found to be very potent …

The Earned Income Tax Credit: A Study Of Eligible Participants Vs. Non-Participants, Richard K. Caputo

The Journal of Sociology & Social Welfare

Using data from the National Longitudinal Survey of Youth, this study (N = 1,504) showed that about half the EITC eligible tax filers in 2001 did not file EITC tax returns and that differences between EITC tax filers and non-EITC tax filers varied by birth place, Food Stamp program participation, marital status, race, residence, sex, socioeconomic history, and worker classification. Findings suggested that the EITC is well targeted in the sense that economically marginalized groups are likely to participate and that increased outreach efforts are also needed to ensure greater participation among tax filers eligible for the EITC but who …

Professional Hope In Working With Older Adults, Terry Koenig, Richard Spano

The Journal of Sociology & Social Welfare

Writings about hope within gerontological literature assume social workers already possess hope that they can use in their practice. The purpose of this article is to challenge this assumption and to examine ways in which social workers can sustain hope in personal life, in their agencies, and in the reform of larger social structures that impact older adults. The authors examine culture change in nursing homes as an emerging approach that can be more fully developed by applying the strengths perspective to interpersonal work with elders, agency change and broader structural change.

The Genetic Regulation Of The Response Of Hematopoietic Stem/Progenitor Cells To The Cytostatic Agent Hydroxyurea, Jeffrey Lynn Yates

University of Kentucky Doctoral Dissertations

Cellular proliferation is a key characteristic of hematopoietic stem and progenitor cells (HSC/HPCs) that allows for the production of all blood cell lineages during an individuals lifetime. While this feature of stem cells is strictly regulated during steadystate and stress hematopoiesis, it also contributes to the development of myeloproliferative disorders, such as chronic myelogenous leukemia, essential thrombocythemia, and polycythemia vera. It should come as no surprise then, that common treatments for these diseases often target the proliferative nature of the dysfunctional HSC/HPCs. Thus, the identification of molecular determinants of cell cycle regulation associated with these disorders could serve as targets …

Growth And Population Assessment Of Spotted Bass (Micropterus Punctulatus) In Beaver, Table Rock, And Bull Shoals Lakes, Northern Arkansas-Southern Missouri, Jeremy Troy Risley

Graduate Theses/Dissertations

Little research has been conducted on spotted bass, Micropterus punctulatus, even though it is a popular recreational fish. Most previous research was on young-of-the-year fish and interactions among other species in reservoirs, with little research on adult spotted base in the Ozarks region or other regions of the United States. The objective of this study was to compare the growth and population characteristics of spotted bass within and among Beaver, Bull Shoals and Table Rock Lacks. Growth, abundance, and conditions within and among reservoirs were similar. However, spotted bass in Beaver Lake did not reach as great lengths as those …

Science Education On The U.S./Mexico Border: Field-Based Studies For Future Teachers In Bilingual/Binational Schools, William Robertson, Judith Munter, Claudia Garcia

Departmental Papers (TE)

The University of Texas at El Paso’s field-based program of studies for future teachers provides opportunities for powerful learning through a dialectical union of reflection and action. Methods courses in academic disciplines are linked with seminars and coursework on community partnerships, critical pedagogy and culturally responsive education. This article illustrates the processes of planning, implementation and evaluation of this approach, highlighting the impacts of community service learning. Parents, students and future teachers interact in workshops that center on validating native language literacy, increasing parental involvement and providing conceptually correct science education. The project indicates that two-way dual language programs with …

It's Not About The Money: The Role Of Preferences, Cognitive Biases, And Heuristics Among Professional Athletes, Michael A. Mccann

Brooklyn Law Review

No abstract provided.

Caballes, Place, And Economic Rin-Tin-Tincentives: The Effect Of Canine Sniff Jurisprudence On Demand For And Development Of Search Technology, Michael Bell

Brooklyn Law Review

No abstract provided.

Training Manual On International Environmental Law, Nicholas A. Robinson

Elisabeth Haub School of Law Faculty Publications

Without analyzing each of the hundreds of agreements and instruments in the field, this Training Manual seeks to provide a comprehensive overview of the current body of environmental law. It is aimed at legal stakeholders from all backgrounds including government representatives, judges, university professors and students from both developed and developing countries, to enable them to more effectively participate in the global, regional and national efforts to preserve our Earth for future generations. Specific topics are first presented at the international level and then followed by extracts of national legislation showcasing real life examples of how national law today reflects …

Redevelopment And The Four Dimensions Of Class In Land Use, Audrey Mcfarlane

All Faculty Scholarship

This essay begins with the proposition that the battle over the exercise of eminent domain as a question of the extent to which we accept local economic development as a proper exercise of local governmental authority. In light of the reality that economic development seeks to accomplish redevelopment to meet the social needs and consumption tastes of the affluent, the issue of local governments' autonomy to engage in redevelopment for economic development purposes is suffused with socioeconomic class struggles over land use. Therefore, the changes wrought by redevelopment challenge us to think and talk about class in ways for which …

Trehalose Uptake Through P2x7 Purinergic Channels Provides Dehydration Protection., Gloria Elliott, Jennifer Cusick, Xiang-Hong Liu, Michael Menze, Trudy Witt, Steven Hand, Mehmet Toner

Faculty and Staff Scholarship

The tetra-anionic form of ATP (ATP4-) is known to induce monovalent and divalent ion fluxes in cells that express purinergic P2X7 receptors (Steinberg et al., 1987; Sung et al., 1985), and with sustained application of ATP it has been shown that dyes as large as 831 daltons can permeate the cell membrane (Steinberg et al, 1987). The current study explores the kinetics of loading α,α-trehalose (342 daltons) into ATP stimulated J774.A1 cells, which are known to express the purinergic P2X7 receptor (Steinberg et al., 1987). Cells that were incubated at 37 ̊C in a 50 mM phosphate buffer (pH 7.0) …

The Constitution As Black Box During National Emergencies: Comment On Bruce Ackerman's Before The Next Attack: Preserving Civil Liberties In An Age Of Terrorism, Martha Minow

Fordham Law Review

No abstract provided.

A Socio-Legal Methodology For The Internal/External Distinction: Jurisprudential Implications, Brian Z. Tamanaha

Fordham Law Review

No abstract provided.

Some Essential Differences Between Consciousness And Attention, Perception, And Working Memory, B. Baars

CCRG Papers

No abstract provided.

The Lida Architecture: Adding New Modes Of Learning To An Intelligent, Autonomous, Software Agent, S. Franklin, F. Patterson

CCRG Papers

No abstract provided.

An Ontology For Comparative Cognition: A Functional Approach, S. Franklin, M. Ferkin

CCRG Papers

No abstract provided.

Counseling Patients Exposed To Ionizing Radiation During Pregnancy, Robert L. Brent

The Selected Works of Robert Brent

Health physicists and knowledgeable clinicians have the responsibility to counsel women of reproductive age about the reproductive risks of ionizing radiation exposure before conception or during pregnancy. It is important to realize that lay individuals have many misconceptions about the reproductive risks of ionizing radiation. Many patients who have already had or will undergo some type of radiological test are apprehensive about the reproductive and developmental risks of diagnostic radiological procedures. Epidemiological studies and animal studies indicate that high exposures of ionizing radiation can cause miscarriage, congenital malformations, growth retardation, stillbirth, and cancer. With the exception of cancer, there are …

Department Of Radiology-Annual Executive Summary Report-July 1, 2005 To June 30, 2006, Vijay M. Rao M.D.

Department of Radiology Administrative Documents and Reports

98 page Department of Radiology Annual Executive Summary Report, July 1, 2005 to June 30, 2006, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Physiological And Behavioral Responses Of Eurycea Sosorum To Variation In Levels Of Conductivity, H. Arthur Woods, Mary F. Poteet

KIP Data Sets and Technical Reports

"This report summarizes our findings on the response of adult salamanders to conductivity and covers a portion of our work between February 21 and August 23, 2006. We also include our results on salamander activity levels in response to dissolved oxygen (DO) in order to justify the oxygen levels we are currently testing in the 28 day oxygen toxicity experiment. Our next report will provide a detailed discussion of the effects of DO on salamander behavior, physiology and mortality. In this report, we cover all aspects of adult salamander response to conductivity, but we do not address the response of …

2005-2006 Annual Report

Annual Report Archive

No abstract provided.

Effects Associated With Dredging For Beach Renourishments On Reef Fish Communities Offshore Of Miami-Dade County, Florida:, Christian L. Avila

HCNSO Student Theses and Dissertations

Beach erosion is an ongoing problem in South Florida. Beach replenishment has been the primary means of maintaining these economically important beaches, and dredging offshore sand deposits, adjacent to reef tracts, has been the pervasive method since the 1970's. Over the past ten years, greater attention has been paid to potential impacts dredging can have on adjacent reef communities, which has led to increased monitoring efforts. With the increase in monitoring efforts, scope has expanded from a strict focus on the benthic community to include the fish communities. This study evaluates the effects of dredging on reef fish communities associated …

Performance Efficacy Using A Comparison Of Commerical And In-House Y-Str Multiplex Systems For Operational Use, Kathleen Mayntz-Press

Electronic Theses and Dissertations

It is routine for the forensic scientist to obtain a genetic profile of an individual from DNA recovered from a biological stain deposited at a crime scene. In contrast, only a limited number of laboratories in the United States have the capability of performing Y-STR analysis in casework. In order to aid in facilitating the transfer of Y-STR technology to the crime laboratory community for operational use, a comparison between commercial products from three main vendors (Applied Biosystems AmpFLSTR Yfiler PCR Amplification Kit, Promega PowerPlex - Y System, Reliagene Y-PLEX 12) and two in-house Y-STR multiplexes (MPI and MPB) commenced. …

Bo34-6-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

Bo34-2-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

A Case-Control Study Of Farming And Prostate Cancer In African-American And Caucasian Men, Tamra E. Meyer, Ann L. Coker, Maureen Sanderson, Elaine Symanski

CRVAW Faculty Journal Articles

Objective: To determine the risk of prostate cancer associated with farming by duration, recency and specific activities among African-Americans and Caucasians.

Methods: This population-based case–control study had information on farming-related activities for 405 incident prostate cancer cases and 392 controls matched for age, race and region in South Carolina, USA, from 1999 to 2001. Cases with histologically confirmed, primary invasive prostate cancer who were aged between 65 and 79 years were ascertained through the South Carolina Central Cancer Registry. Appropriately matched controls were identified from the Health Care Financing Administration Medicare Beneficiary File. Data were collected using computer-assisted telephone interviewing, …

Summary Of Meetings 2004-2005, Alison Ellicott

Delaware Ornithologist

No abstract provided.

Volume 2 No. 3 January 2006, Nova Southeastern University

The Beacon: The Quarterly Newsletter of the Center for Teaching and Learning

No abstract provided.