Digital Commons Network^™

The Fat Cadherin Acts Through The Hippo Tumor-Suppressor Pathway To Regulate Tissue Size, Maria Willecke, Fisun Hamaratoglu, Madhuri Kango-Singh, Ryan Udan, Chiao-Lin Chen, Chunyao Tao, Xinwei Zhang, Georg Halder

Biology Faculty Publications

Background: The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila. Merlin, the Drosophila homolog of the human Neurofibromatosis type-2 (NF2) tumor-suppressor gene, and the related protein Expanded are the most upstream components of the Hippo pathway identified so far. However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified.

Results: Here, we report that the protocadherin Fat acts as an upstream component in the Hippo pathway. Fat is a known tumor-suppressor gene in Drosophila, and fat mutants have severely overgrown imaginal discs. We …

Race, Colorblindness, And Continental Philosophy, Michael Monahan

Philosophy Faculty Research and Publications

The "colorblind" society is often offered as a worthy ideal for individual interaction as well as public policy. The ethos of liberal democracy would seem indeed to demand that we comport ourselves in a manner completely indifferent to race (and class, and gender, and so on). But is this ideal of colorblindness capable of fulfillment? And whether it is or not, is it truly a worthy political goal? In order to address these questions, one must first explore the nature of "race" itself. Is it ultimately real, or merely an illusion? What kind of reality, if any, does it have, …

Research Design In Design Research: A Practical Framework To Develop Theory From Case Studies, S Roworth-Stokes

DRS Biennial Conference Series

Case studies have for a long time been used in design research to provide ‘rich’ insight into successful or unsuccessful new product innovation. As a methodology it has often been cited as useful to derive site specific contexts where phenomena can be observed and reported by respondents in their working environment. Yet, in practice, the primary advantage of the design case study, its ability to reveal insight into ‘real-life’ contemporary phenomena (the here and now), set against a backdrop of critical incidents, happenings or events over time (temporality), often become it’s weakness in achieving valid and credible findings. Essentially it …

Nonlinearity For Design, Jamie Brassett

DRS Biennial Conference Series

No abstract provided.

Use-Inspired Basic Research: Improved Understanding And Innovative Products - A Case Study, D. Steffen

DRS Biennial Conference Series

The paper explores the interplay between disciplinary knowledge creation in basic and applied design research on the one hand and experimental design on the other. As part of my dissertation, several case studies were analysed among them a long-term research project which was conducted at the C_Lab for customization design at the Academy of Art and Design Offenbach, Germany. Subject-matter of this research were the various implications and effects, that digital technology will have on design, on product semantics, the role of the designer and the user as co-designer. It included questions and hypothesis basic for design as well as …

The Wonder Of Change: Where Do New Things Come From And How Do They Get Here?, J Z Langrish

DRS Biennial Conference Series

This paper starts by exploring some answers to questions about the causes and processes of change. These answers range from the ideas of Vitruvius to modern evolutionary accounts using the concept of memes as replicators. The paper then looks at some evidence gathered by the author and his post graduate students over a period of 40 years in studies of technological innovation, design management etc. There are two main conclusions - 1. We need to be much more modest in our beliefs that intentionality, rationality, reason, scientific understanding and so on can lead to better things. 2. We need more …

Lobe And Serrate Are Required For Cell Survival During Early Eye Development In Drosophila, Amit Singh, Xiao Shi, Kwang-Wook Choi

Biology Faculty Publications

Organogenesis involves an initial surge of cell proliferation, leading to differentiation. This is followed by cell death in order to remove extra cells. During early development, there is little or no cell death. However, there is a lack of information concerning the genes required for survival during the early cell-proliferation phase. Here, we show that Lobe (L) and the Notch (N) ligand Serrate (Ser), which are both involved in ventral eye growth, are required for cell survival in the early eye disc. We observed that the loss-of-ventral-eye phenotype in L or Ser mutants is due to …

Child Physical Abuse And Neglect, David K. Dilillo, Andrea R. Perry, Michelle Fortier

Department of Psychology: Faculty Publications

Although poor and inhumane treatment of children is not a new phenomenon (Doerner & Lab, 1998; Wolfe, 1999), child physical abuse and neglect were not identified as serious social problems until the 1960s, with the publication of Kempe and colleagues’ description of battered-child syndrome (Kempe, Silverman, Steele, Droegemueller, & Silver, 1962). In this influential study, Kempe and colleagues described the clinical manifestation of this syndrome in terms of the deleterious physical consequences maltreated children experienced, ranging from undetected outcomes to those that cause significant physical impairments. Rather than exploring the potential psychological sequelae of maltreated children, Kempe focused on detailing …

The Guardian, November 01, 2006, Wright State University Student Body

The Guardian Student Newspaper

Twenty-eight page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

Preventive Medicine: A "Cure" For The Healthcare Crisis, Janice L. Clarke, Deborah Meiris

College of Population Health Faculty Papers

Introductory Editorial: Few would dispute the premise that prevention, early detection, and early intervention form the first line of defense on the disease management (DM) continuum. That being the case, our national statistics on preventive health should be raising concerns throughout the industry. The US healthcare delivery system continues to fall woefully short of its prevention targets. On the international scene, the United States lags behind countries with less wealth and less technological savvy. Commentaries abound on the problems, but recently I became aware of an organization with an exciting goal and a novel solution for bringing preventive medicine …

2006 November 28 Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 8, November 28, 2006

Carbon Dioxide And Climate Changes, Gregorio Marbán, Ana Arenillas, Ángeles Gómez Borrego, Teresa Valdés-Solís Iglesias, Marta Álvarez Rodríguez, Jesús M. Arrieta López De Uralde, Alexandra Coello Camba, Carlos M. Duarte Quesada, Neus Garcías Bonet, Núria Marbà Bordalba, Aurore Regaudie De Gioux, Sergio Ruiz Halpern, María Sánchez Camacho, Raquel Vaquer Suñer, Roberto Martínez Orio, Isabel Suárez Díaz, Ignacio Cruz Cruz, Diego Martínez Plaza, Fernanda Sánchez Ojanguren

Educational Materials on Latin American Energy

This short guide is divided into four sections. Each one provides an explanation of climate change and how it affects the following: ecosystems; our role as global citizens; our daily habits; the problems associated with the current energy sector; possible clean energy alternatives; and the challenge of transportation.

Reconciling Carbon-Cycle Concepts, Terminology, And Methods, F. S. Chapin Iii, G. M. Woodwell, J. Randerson, E. B. Rastetter, G. M. Lovett, Dennis Baldocchi, D. A. Clark, M. E. Harmon, D. S. Schimel, R. Valentini, C. Wirth, J. D. Aber, J. J. Cole, M. L. Goulden, J. W. Harden, M. Heimann, Robert W. Howarth, P. A. Matson, A. D. Mcguire, Jerry M. Melillo, H. A. Mooney, J. C. Neff, R. A. Houghton, M. L. Pace, M. G. Ryan, Steven W. Running, Osvaldo E. Sala, W. H. Schlesinger, E. D. Schulze

Numerical Terradynamic Simulation Group Publications

Recent projections of climatic change have focused a great deal of scientific and public attention on patterns of carbon (C) cycling as well as its controls, particularly the factors that determine whether an ecosystem is a net source or sink of atmospheric carbon dioxide (CO2). Net ecosystem production (NEP), a central concept in C-cycling research, has been used by scientists to represent two different concepts. We propose that NEP be restricted to just one of its two original definitions-the imbalance between gross primary production (GPP) and ecosystem respiration (ER). We further propose that a new term-net ecosystem carbon balance (NECB)-be …

Judicial Discretion To Find Abuse Under Section 707(B)(3), Eugene R. Wedoff

Missouri Law Review

This article suggests the contrary - that if a section 707(b) motion properly raises the question, a bankruptcy judge has a duty to consider the actual financial situation of a debtor who is not subject to a means test presumption; that the judge should find abuse where the debtor can repay a sufficient amount of unsecured debt; and that the means test serves to guide, rather than foreclose, such determinations of abuse. Part I discusses the language of BAPCPA that requires this result, focusing on the nature of the means test as a presumption. Part II examines (and finds wanting) …

Race Matters In Bankruptcy Reform, A. Mechele Dickerson

Missouri Law Review

On April 20, 2005, the Bankruptcy Abuse Prevention and Consumer Protection Act of ("BAPCPA") was signed into law and became fully effective for cases filed on or after October 17, 2005. 4 After considering bankruptcy reform for almost a decade, Congress ultimately concluded that some debtors were abusing bankruptcy laws by, among other things, discharging debts they had the means to pay. To curb this perceived abuse, Congress decided to radically overhaul the consumer provisions of the Code by generally making it harder for an opportunistic or "Abusive Debtor" to discharge his debts. Given the sweeping nature of these changes, …

Mustang Daily, November 1, 2006

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

On One-Dimensional Self-Assembly Of Surfactant-Coated Nanoparticles, Jee-Ching Wang, Partho Neogi, Daniel Forciniti

Chemical and Biochemical Engineering Faculty Research & Creative Works

Nanometer-sized metal and semiconductor particles possess novel properties. To fully realize their potential, these nanoparticles need to be fabricated into ordered arrays or predesigned structures. A promising nanoparticle fabrication method is coupled surface passivation and self-assembly of surfactant-coated nanoparticles. Due to the empirical procedure and partially satisfactory results, this method still represents a major challenge to date and its refinement can benefit from fundamental understanding. Existing evidences suggest that the self-assembly of surfactant-coated nanoparticles is induced by surfactant-modified interparticle interactions and follows an intrinsic road map such that short one-dimensional (1D) chain arrays of nanoparticles occur first as a stable …

Reform And Empire: The British And American Transnational Search For The Rights Of Black People In The Late Nineteenth And Early Twentieth Centuries, Thomas E. Smith

Department of History: Dissertations, Theses, and Student Research

Late nineteenth century modernity forced reformers in Great Britain and the United States to embrace a new sense of immediacy in their strategies. These new strategies, however, rarely extended to black people who were often subject to violence and discrimination in the period of high imperialism. Instead, when most reformers discussed the problems black people faced all they could offer were traditional promises of religious-based protections or “uplift.” The violence of lynching in the 1890s forced reformers to address the problems of white supremacy in a direct fashion, while promoting an understanding of the connection between the plight of African …

University Reporter - Volume 11, Number 03 - November 2006

1996-2009, University Reporter

This issue of the University Reporter includes articles about funding for the Institute for Community Inclusion's Center for Children with Special Needs, increasing enrollment and diversity at UMass Boston, the efforts of UMass Boston researchers to change the way chemistry is taught in hig schools, the 5th anniversary celebration of the Emerging Leaders Program, actor Danny Glover's involvement with the University's homelessness project, and other news from UMass Boston.

Hidden Overburden Of Female-Headed Households In Guar Bean Production: Zimbabwean Experience, Innocent W. Nyakudya, V. J. Murewa, M. J. Mutenje, M. Moyo, T. J. Chikuvire, R. Foti

Journal of International Women's Studies

The study was done on a guar bean-growing project in Makachi area, Zimbabwe. The study objectives were to determine ownership of resources, time spent on production and access to information by male-headed and female-headed households. Data collection and analysis were based on the FAO Gender Analysis Framework. Results showed that male-headed households had more ownership of resources and spent less time on production; access to information was equal; female-headed households allocated a greater proportion of their land to guar bean production and matched their male counterparts in the mean yield. While inter-household exchanges helped female-headed households access draft power and …

Midwifery Education In Jordan: History, Challenges And Proposed Solutions, Lubna Abushaikha

Journal of International Women's Studies

The purpose of this paper is to provide a historical overview of midwifery education in Jordan during the past fifty years with an emphasis on the first bachelor of midwifery program in Jordan. Nine challenges of midwifery education that include expanding midwifery educational needs, accreditation of programs, recruiting qualified faculty members, clinical training, midwifery preceptorship, exit examinations, continuing midwifery education, recognition of midwifery graduates, and lack of graduate midwifery programs are presented. Proposed solutions for these challenges are discussed.

‘And Not Destroyed By The Destruction Of The Body’: Documenting Incarceration: Joya Mitra’S Killing Days, Tutun Mukherjee

Journal of International Women's Studies

This paper discusses an unusual and disturbing narrative of a young student who is incarcerated for four years in Indian jails for participating in an ideological battle with a state government that steadily escalated in violence and brought students like her in direct confrontation with the state machinery. In prison, she is categorized as a ‘political detainee’ and must await her trial which is not allowed to happen until the political dispensation changes. Killing Days is a prison memoir – not of Mitra alone but of all the women she meets and shares pain and anguish with through the period …

Monitor Newsletter Monthly, November/December 2006, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

Panorama November 2006, Southern Adventist University

Panorama Parent Newsletter

This issue of the Panorama parent newsletter contains tips for homesick students as well as information on counseling, testing, and Learning Support services offered at Southern. The newsletter also highlights clubs on campus, including the Wakeboard Club and Southern Striders.

Slam: Sleep-Wake Aware Local Monitoring In Sensor Networks, Issa Khalil, Saurabh Bagchi, Ness B. Shroff

Department of Electrical and Computer Engineering Technical Reports

Sleep-wake protocols are critical in sensor networks to ensure long-lived operation. However, an open problem is how to develop efficient mechanisms that can be incorporated with sleep-wake protocols to ensure both longlived operation and a high degree of security. Our contribution in this paper is to address this problem by using local monitoring, a powerful technique for detecting and mitigating control/data attacks in sensor networks. In local monitoring, a node oversee part of the traffic going in and out of its neighbors to determine if the behavior is suspicious, such as, delay in forwarding a packet. However, a direct application …

Convergence Of Agriculture And Energy: Implications For Research And Policy, Kenneth Cassman, Vernon Eidman, Eugene Simpson, Larry Berger, Robert Loomis, Marie Walsh, Todd A. Peterson, Edward Runge

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Access to an adequate energy supply at reasonable cost is crucial for sustained economic growth. Unfortunately, oil prices and the need to import from politically unstable countries lowers the reliability of the U.S. energy supply and hinders economic development. Although biofuels have been identified as an important component of the national strategy to decrease U.S. dependence on imported oil, the ability to sustain a rapid expansion of biofuel production capacity raises new research and policy issues. This document seeks to identify the most critical of these issues to help inform the policy development process. The goal is to enhance the …

Drinking Game Participation Among College Students: Gender And Ethnic Implications, Eric R. Pedersen, Joseph W. Labrie

Heads Up!

Participation in drinking games by college students has recently sparked research attention. While previous research indicates that women play drinking games at lower frequencies than men, the current study reveals that college women may be playing games at rates similar to college men. In a sample of 105 coed college students, participants completed a 3-month Timeline Followback recording every drinking event and quantity consumed. They then were prompted to identify which drinking events involved drinking games and how much alcohol was consumed during game playing. Both men and women engaged in drinking games at similar rates and consumed more drinks …

Characterization Of Host Cell Death Induced By Chlamydia Trachomatis, Songmin Ying, Silke F. Fischer, Matthew A. Pettengill, Debye Conte, Stefan A. Paschen, David M. Ojcius, Georg Hacker

All Dugoni School of Dentistry Faculty Articles

Chlamydia are obligate intracellular bacteria that modulate apoptosis of the host cell. Strikingly, chlamydial infection has been reported both to inhibit and to induce apoptosis. Although the ability to inhibit apoptosis has been corroborated by the identification of cellular targets, confirmation of cell death induction has been complicated by a mixture of apoptotic features and atypical cell death during infection, as well as by differences in the experimental techniques used to measure cell death. Here we use a panel of well-established approaches in the study of apoptosis to define the form of cell death induced by Chlamydia trachomatis infection. Infected …

Bs News

Building Services Engineering

No abstract provided.

Central Florida Future, Vol. 39 No. 31, November 1, 2006

Central Florida Future

No abstract provided.