Digital Commons Network^™

Functionally Active T1-T1 Interfaces Revealed By The Accessibility Of Intracellular Thiolate Groups In Kv4 Channels., Guangyu Wang, Mohammad Shahidullah, Carmen A Rocha, Candace Strang, Paul J Pfaffinger, Manuel Covarrubias

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Gating of voltage-dependent K(+) channels involves movements of membrane-spanning regions that control the opening of the pore. Much less is known, however, about the contributions of large intracellular channel domains to the conformational changes that underlie gating. Here, we investigated the functional role of intracellular regions in Kv4 channels by probing relevant cysteines with thiol-specific reagents. We find that reagent application to the intracellular side of inside-out patches results in time-dependent irreversible inhibition of Kv4.1 and Kv4.3 currents. In the absence or presence of Kv4-specific auxiliary subunits, mutational and electrophysiological analyses showed that none of the 14 intracellular cysteines is …

Book Review: Humanizing Our Global Order: Essays In Honour Ofivan Head, Obiora Chinedu Okafor And Obijiofor Aginam (Eds), Darryl Robinson

Osgoode Hall Law Journal

No abstract provided.

Developmental Systems Theory: A Search For Human Nature, Erin Kenzie

Honors Theses

When trying to identify the driving forces behind the development of traits, 'nature' and 'nurture' are presented as the sole answers to a seemingly inevitable philosophical question. There must be reasons behind why an individual has a certain trait, so the rhetoric goes, and the line of reasoning has to go in one of two directions. Either factors in the individual's environment - such as parental care or life experience - are responsible, or the trait is an immutable characteristic of the individual's biological makeup. Although this dichotomy has permeated the public consciousness, it is dismissed by those who study …

The Presidency And The Meaning Of Citizenship, Malinda L. Seymore

Faculty Scholarship

This Article uses the issue of presidential qualification as a vehicle to examine the meaning of citizenship today, arguing that the Natural-Born Citizen Clause perpetuates a second-class citizenship that is inappropriate and inapposite in modern American society. Upon this premise, this Article proposes that a constitutional amendment may be necessary since the argument that the Fourteenth Amendment serves as an implicit repeal of the Natural-Born Citizen Clause has proved historically insufficient. Part II of this Article examines the origins of the constitutional requirement that the President be a "natural born Citizen" and discusses the unsuccessful attempts to amend this requirement. …

Managing Susceptibility To Hereditary Breast And Ovarian Cancer, Cynthia E. Perry Phd, Msn, Rn

Dissertations

The recent identification of Breast Cancer 1 (BRCA1) and BRCA2 genes offers an opportunity for high-risk individuals to learn whether they may be genetically predisposed to develop breast and/or ovarian cancer. The purpose of this study was to examine how unaffected women, identified as BRCA positive and variant of uncertain significance (VUS) mutation carriers, managed their susceptibility to hereditary breast and ovarian cancer (HBOC). Thirty North American women ranging in age from 22 to 60 years responded to open-ended interviews. These interviews were analyzed using constant comparative method to generate a grounded theory. Managing Susceptibility was identified as the basic …

Notch Signaling From Tumor Cells: A New Mechanism Of Angiogenesis, J-L Li, Al Harris

School of Biomedical Sciences

Notch signaling is an evolutionarily conserved pathway and plays key roles in embryonic vascular development and angiogenesis. Multiple components of the Notch pathway are expressed in vasculature, and mice deficient for a variety of these components display embryonic lethality with vascular remodeling defects. Alteration of Notch signaling in various endothelial cells generates profound effects on angiogenesis in vitro. New evidence shows that Notch signaling from tumor cells is able to activate endothelial cells and trigger tumor angiogenesis in vitro and in a xenograft mouse tumor model. Selective interruption of Notch signaling within tumors may provide an antiangiogenic strategy.

Time Invariance And Liquid State Machines, Eric Goodman, Dan A. Ventura

Faculty Publications

Time invariant recognition of spatiotemporal patterns is a common task of signal processing. Liquid state machines (LSMs) are a paradigm which robustly handle this type of classification. Using an artificial dataset with target pattern lengths ranging from 0.1 to 1.0 seconds, we train an LSM to find the start of the pattern with a mean absolute error of 0.18 seconds. Also, LSMs can be trained to identify spoken digits, 1-9, with an accuracy of 97.6%, even with scaling by factors ranging from 0.5 to 1.5.

Community Guide: Lawrence Livermove National Laboratory Main Site, Peter Strauss, Tri-Valley Communities Against A Radioactive Environment

Tri-Valley Communities Against a Radioactive Environment (CAREs)

The purpose of this report is to familiarize the community members about the status of the Superfund cleanup and some of the program activities that take place at the Lawrence Livermore National Laboratory (LLNL) Main Site Superfund site.

This research was completed money allocated during Round 5 of the Citizens’ Monitoring and Technical Assessment Fund (MTA Fund). Clark University was named conservator of these works.

If you have any questions or concerns please contact us at [email protected]

The Relationship Of Gender Role Attributes And Perception Of Sexual Issues, Stephanie J. Cunningham

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science and Technology at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science in Psychology by Stephanie J. Cunningham on June 30, 2005.

Clca 2004 Land Conservation Technical Assistance, Dorothy Tripp Taylor

PREP Reports & Publications

The New Hampshire Estuaries Project contracted with the Center for Land Conservation Assistance, a program of the Society for the Protection of New Hampshire Forest, to provide targeted education activities and technical support to increase the capacity of conservation groups in the New Hampshire seacoast area to achieve permanent land conservation. The target audiences were the five land trusts and two county conservation districts serving the NHEP area, municipal conservation commissions and open space committees, municipal and land use attorneys, and real estate professionals. CLCA provided 15 public educational and training events, as well a numerous individual consultations, that reached …

Revision Of The Southern South American Endemic Genus Anomiopsoides Blackwelder, 1944 (Coleoptera: Scarabaeidae: Scarabaeinae: Eucraniini) And Description Of Its Food Relocation Behavior, Federico C. Ocampo

University of Nebraska State Museum: Entomology Papers

Abstract
The South American genus Anomiopsoides Blackwelder is revised and now includes five species: A. aurita (Burmeister), A. biloba (Burmeister), A. catamarcae Martínez, A. cavifrons (Burmeister), and A. heteroclyta (Blanchard). The following species names are new synonyms of A. heteroclyta (Blanchard): A. aberrans Martínez, A. pereirai (Martínez), and A. xerophila Martínez. The following variety is a new synonym of A. biloba (Burmeister): A. biloba var. schaeferi (Martínez). Descriptions, diagnosis illustrations, and distribution maps are provided for all species. A key to species of the genus is provided. The biology and the food relocation behavior of Anomiopsoides species are described. A …

Early-Stage Folding In Proteins (In Silico) Sequence-To-Structure Relation, Michal Brylinski, Leszek Konieczny, Patryk Czerwonko, Wiktor Jurkowski, Irena Roterman

Faculty Publications

A sequence-to-structure library has been created based on the complete PDB database. The tetrapeptide was selected as a unit representing a well-defined structural motif. Seven structural forms were introduced for structure classification. The early-stage folding conformations were used as the objects for structure analysis and classification. The degree of determinability was estimated for the sequence-to-structure and structure-to-sequence relations. Probability calculus and informational entropy were applied for quantitative estimation of the mutual relation between them. The structural motifs representing different forms of loops and bends were found to favor particular sequences in structure-to-sequence analysis. © 2005 Hindawi Publishing Corporation.

Catastrophic Crisis Communication: A Study Of Hospital Crisis Planning Following The September 11, 2001 Terrorist Attacks, Daniel Matthew Lockwood

Theses and Dissertations

The purpose of this study was to determine whether hospitals in southern New Jersey and throughout the United States were prepared to respond to catastrophic crisis situations and find out if hospitals have changed or improved crisis plans since the September 11, 2001 terrorist attacks.

To examine preparedness and improvement of crisis plans since September 11, 2001, the researcher employed qualitative and quantitative studies. The researcher conducted in-depth personal interviews with public relations specialists from four southern New Jersey hospitals and sent email surveys to 40 hospitals throughout the United States to find out if these facilities felt prepared to …

The Connection Between Gender And Literacy In A First Grade Classroom, Jessica V. Feldman

Theses and Dissertations

This study is a qualitative case study that explores the connection between literacy and gender in a first grade classroom environment. The subjects for this study are twenty first grade students in a regular education classroom located in a southern New Jersey elementary school. For this study, students were observed with the attempt to answer three questions: 1) What gender stereotypes have these first graders internalized coming into the classroom? 2) How are these gender beliefs expressed in the language arts classroom? 3) What are teachers doing to foster these biases in their students? Data collected includes student writings, discussions, …

Promoting Voluntary Land Conservation On The Lamprey, Exeter, And Squamscott River Corridors, Brian Hart

PREP Reports & Publications

With the support of the New Hampshire Estuaries Project, the Rockingham Land Trust (RLT) researched the names and addresses of landowners along the Exeter, Squamscott, and Lamprey River corridors and within the target communities. Landowners were invited to participate in one of two free, land conservation and estate planning workshops. RLT followed up with each participant by letter and phone. The goal of the project was to secure the completion of three conservation easements from participants in the workshops. Due to low landowner participation and the significant decision involved in completing a conservation transaction, this goal was determined to be …

Waldo Lake Research In 2004, Mark D. Sytsma, John Rueter, Richard Petersen, Roy Koch, Scott A. Wells, Michelle Wood, Yangdong Pan, Robert Leslie Annear, Aaron Hook, Laura Johnson, Rich Miller, Amanda Murphy, Terry Stoltz

Center for Lakes and Reservoirs Publications and Presentations

The Willamette National Forest has worked with Portland State University, Center for Lakes and Reservoirs (PSU) and the University of Oregon (UO) to investigate ecosystem changes, provide guidance on long-term monitoring methods, assess monitoring data, develop predictive water quality models, and conduct research that will lead to better protection and understanding of the Waldo Lake ecosystem. This report summarizes the second year of collaborative PSU-UO research at Waldo Lake. Research has focused on understanding physical, chemical and biological characteristics of Waldo Lake across a range of spatial and temporal scales. Research tasks that continued from 2003 into 2004 included temperature …

Jefferson Cancer Center Officially Recognized The National Cancer Institute, Jerold A. Glick

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

Sustainable Development And Private Global Governance, Douglas A. Kysar

Cornell Law Faculty Publications

This Article utilizes recent controversy over Coca-Cola's alleged depletion of groundwater resources in India as a vehicle for exploring competing conceptions of global environmental governance and the role of private actors within them. Initially, it uses the Coca-Cola groundwater situation to identify core substantive and procedural meanings that lurk within the otherwise ingeniously ambiguous concept of sustainable development. Through this exercise, it is shown that - when properly understood - the sustainable development paradigm stands in considerable tension with the premises of market liberalism that drive such political and economic trends as global market integration; privatization and commodification of water …

Wmu Board Of Trustees Formal Session June 29, 2005, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Minutes of the WMU Board of Trustees meeting include appendices:

• Personnel Report
• Administrative Appointments
• Resignation

Biotechnology Program Prepares Future Researchers, Lydia E. Mcmorrow, Shirley E. Greening

Population Health Matters (Formerly Health Policy Newsletter)

No abstract available.

The Cell Cycle–Regulated Genes Of Schizosaccharomyces Pombe, Anna Oliva, Adan Rosebrock, Francisco Ferrezuelo, Haiying Chen, Saumyadipta Pyne, Steve Skiena, Bruce Futcher, Janet Leatherwood

Department of Molecular Genetics and Microbiology Faculty Publications

Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mechanisms, we have used microarrays to measure gene expression through the cell cycle of Schizosaccharomyces pombe (fission yeast). The 750 genes with the most significant oscillations were identified and analyzed. There were two broad waves of cell cycle transcription, one in early/mid G2 phase, and the other near the G2/M transition. The early/mid G2 …

Cross-Validated Bagged Learning, Mark J. Van Der Laan, Sandra E. Sinisi, Maya L. Petersen

U.C. Berkeley Division of Biostatistics Working Paper Series

Many applications aim to learn a high dimensional parameter of a data generating distribution based on a sample of independent and identically distributed observations. For example, the goal might be to estimate the conditional mean of an outcome given a list of input variables. In this prediction context, Breiman (1996a) introduced bootstrap aggregating (bagging) as a method to reduce the variance of a given estimator at little cost to bias. Bagging involves applying the estimator to multiple bootstrap samples, and averaging the result across bootstrap samples. In order to deal with the curse of dimensionality, typical practice has been to …

Ua3/9/5 Sygen Announcement, Wku President's Office

WKU Administration Documents

Program and talking points used by WKU president Gary Ransdell when announcing $2.5 million gift from Sygen and the creation of the Sygen Chair in Biotechnology.

Spatio-Temporal Point Processes: Methods And Applications, Peter J. Diggle

Johns Hopkins University, Dept. of Biostatistics Working Papers

No abstract provided.

Introduction To Taxonomy, Larry A. Sagers, Gretchen Campbell

All Archived Publications

No abstract provided.

The Murray Ledger And Times, June 27, 2005, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

June 27 2005 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Phylogeny And Biogeography Of Ice Crawlers (Insecta: Grylloblattodea): Evidence From Six Molecular Loci, Karl J. Jarvis

Theses and Dissertations

Ice crawlers (Insecta: Grylloblattodea) are rarely encountered insects that consist of five genera representing 26 species from North America and Asia. Asian grylloblattids are the most diverse, but North American ice crawlers (genus Grylloblatta) are known for their adaptation to cold conditions. Phylogenetic relationships among grylloblattid species and genera are not known. Late Pleistocene glaciations had a major effect on the current Grylloblatta distribution, because their specific habitat requirements restrict them to small geographical areas. Six genes were sampled in 37 individuals for 18S rRNA, 28S rRNA, histone 3, 12S rRNA, 16S rRNA, and cytochrome oxidase II (COII) from 27 …

Oral History Interview With Dr. Patricia Lancaster, Patricia Lancaster, Wenxian Zhang

Oral Histories

Patricia Anne Lancaster joined the faculty of Rollins College in 1970 as a professor of French and humanities. For thirty-five years, Lancaster has not only worked for Rollins College as a teacher, but also as an able administrator.

Lancaster was born in Spartanburg, South Carolina. She studied French at Coker College and Emory University. She received her A.B. in 1963 from Coker, her M.A. in 1970 and her Ph.D. in 1971 from Emory.

Beginning her career as a professor, Lancaster joined the ranks of administrators in 1983 as the Associate Dean of Faculty for four years. She then served as …

Gravin Targets Pka Rii To Subcellular Sites In Cultured Cells, Xiaohong Yan

Theses and Dissertations

Gravin, an A Kinase Anchoring Protein, has been shown through biochemical studies to bind to the regulatory subunit of type II PKA and to PKCα. Preliminary studies also show that gravin localizes to the cell periphery but redistributes to an intracellular vesicular compartment in response to PKC activation using PMA. Although the intracellular targeting mechanisms of some AKAPs have been explored, the targeting domains and possible targeting mechanisms of gravin remain unknown. In addition, the capacity for gravin to affect the subcellular distribution of PKA has not been investigated in vivo. To identify the domains critical in determining the subcellular …