Digital Commons Network^™

Family Environment And Substance Use In Adolescent Males, Emily H. Brechting

University of Kentucky Master's Theses

The purpose of this study was to examine the relationships between several aspects of family environment and adolescent substance use. Participants included 372 (M = 15.45 years, range = 15-17) adolescent males with and without a paternal history of Substance Use Disorder (SUD). Participants completed measures of family functioning, family communication, parentadolescent communication, living arrangement, temperament, and substance use. Results indicated that family functioning and communication predicted a significant reduction in the number of drugs used, frequency of drug use, and problems associated with drug use beyond the effects of demographic covariates. Additionally, temperament and family history of SUD were …

Loline Alkaloid Biosynthesis In Neotyphodium Uncinatum, A Fungal Endophyte Of Lolium Pratense, Jimmy Douglas Blankenship

University of Kentucky Doctoral Dissertations

Some endophytes in mutualistic associations with Festuca, Lolium and other grass species produce insecticidal loline alkaloids (1-aminopyrrolizidines; LA). These loline alkaloids have a saturated pyrrolizidine ring system (two-rings sharing a carbon and nitrogen atom), a 1-amine substituted with methyl, acetyl, or formyl groups, and an oxygen bridge between C-2 and C-7. The development of a reliable system of production of LA in cultures of the Lolium pratense (meadow fescue) endophyte, Neotyphodium uncinatum, facilitated work on the LA biosynthetic pathway. N. uncinatum produced norloline, loline, methylloline, N-acetylnorloline (NANL), N-formylloline (NFL), and N-acetylloline as detected in culture filtrates. The total production …

The Role Of Tombusvirus Replicase Proteins And Rna In Replicase Assembly, Replication And Recombination, Zivile Sliesaraviciute Panaviene

University of Kentucky Doctoral Dissertations

Tombusviruses are single, positive strand RNA viruses of plants, often associated with parasitic defective interfering (DI) RNAs. Two viral- coded gene products, namely p33 and p92, are required for tombusvirus replication. The overlapping domains of p33 and p92 contain an arginine/proline-rich (RPR) RNA binding motif. In this study, the role of RPR motif and viral RNA in tombusvirus replication and recombination, as well as involvement of viral RNA in tombusvirus replicase assembly was examined. Using site-directed mutagenesis I generated a series of RPR mutants of Cucumber necrosis tombusvirus (CNV). Analysis of RPR mutants defined that wild type RPR motif, especially …

Thymoquinone: The Evaluation Of Its Cytotoxic Potential, Effects On P53 Status And The Cell Cycle In Various Cancer Cell Lines, Alison Ann Mokashi

University of Kentucky Master's Theses

Cancer is a group of diseases that are the second leading cause of human mortality in the United States. Discovering new therapies is vital to conquer cancer. Thymoquinone (TQ) is found in the plant Nigella sativa. TQ was found to be cytotoxic to the human ovarian cancer cell lines PA-1, CAOV-3 and SKOV-3, which have varying p53 status. PA-1 cells were the most sensitive, indicating that TQ was effective against cells having wild-type (WT) p53. Western blots indicated an increase in p53 in cell lines having WT p53. TQ when given concurrently with cisplatin resulted in antagonism for PA-1, A172 …

Comparative Mapping: Homology Within The Order Perissodactyla Of Four Genes Located On Equus Caballus Chromosome 20, Christine Marie Mains

University of Kentucky Master's Theses

Since changes in chromosome morphology contribute to the knowledge of evolution as well as to chromosome dynamics, this study looks specifically at one chromosome compared in twelve different species of Perissodactyls: Equus caballus (ECA), E. przewalskii (EPR), Equus africanus somaliensis (EAF), E. asinus (EAS), E. hemionus onager (EHO), E. h. kulan (EHK), E. h. kiang (EKI), E. zebra hartmannae (EZH), E. grevyi (EGR), E. burchelli (EBU), Tapirus indicus (TIN), and Rhinoceros unicornis (RUN). While chromosome morphology studies have been done in some of the extant equids, none have followed the evolution of this chromosome, homologous to Equus caballus chromosome 20 …

Supernatant Protein Factor: Insights Into Its Regulation And Ability To Stimulate Cholesterol Synthesis In Vitro And In Cell Culture, Vishwesh Mokashi

University of Kentucky Doctoral Dissertations

Supernatant protein factor (SPF) is a 46-kDa cytosolic protein that stimulates squalene monooxygenase, which catalyses the second committed step in cholesterol biosynthesis. The mechanism by which SPF stimulates this enzyme is not understood and the goal of these studies was to see if SPF affected cholesterol synthesis in cultured cells. Rat supernatant protein factor-like protein (SPF2) shares 77% sequence identity with human SPF. In my studies SPF2 also stimulated squalene monooxygenase in vitro and incubation of SPF2 with protein kinase A (PKA) and C increased its activity by about 2-fold, as shown earlier with SPF. GTP and GDP prevented the …

The Transport And Modulation Of Hiv Protease Inhibitors Into The Rat Central Nervous System And Milk, Jeffrey Earl Edwards

University of Kentucky Doctoral Dissertations

The objective of this dissertation is to study the mechanism by which HIV protease inhibitors enter into the central nervous system (CNS) and breast milk of rats, and what effects MDR modulators have on the distribution and metabolism of HIV protease inhibitors. The transporter P-glycoprotein (P-gp) has been shown to limit the distribution of HIV protease inhibitors into the CNS of rodents. This thesis examined the effects of GF120918, an MDR modulator, on the CNS distribution of amprenavir, an HIV protease inhibitor, in rats. GF120918 significantly increased the unbound CNS concentrations of amprenavir without altering the unbound blood concentrations of …

Regulation Of Concentrated Animal Feeding Operations: An Application Of Economic Theory To Firm Decision Making And Applications For Public Policy, Benjamin Gramig

University of Kentucky Master's Theses

The livestock industry in the United States has experienced significant concentration and vertical integration in recent years. This change has resulted in greater observed levels of pollution attributed to concentrated animal feeding operations (CAFO) and society has attempted to use regulation to remedy these problems. Despite regulation at the federal and local level no documented improvement in water quality has been observed to date. This thesis is concerned with the response of profit-maximizing economic agents to the form of environmental regulation adopted at the federal level. A theoretical model of firm profit is proposed and analyzed using comparative statics to …

Breeding For Fusarium Head Blight Resistance In Soft Red Winter Wheat, Virginia Laura Verges

University of Kentucky Master's Theses

Fusarium graminearum, the causative agent of Fusarium head blight, is an economically important pathogen of wheat (Triticum aestivum). Breeding Fusarium head blight (FHB) resistant wheat requires knowledge of the underlying genetic control of FHB resistance. Genetic parameters for FHB resistance and five related traits were estimated in three populations at two locations and in two years. Moderate broad sense heritabilities for FHB severity and Fusarium damaged kernels (FDK) were observed. Incidence of FHB and the toxin deoxynivalenol (DON) accumulation had low to moderate broad sense heritabilities. Correlations between FDK and severity and FDK and DON were moderate to high in …

Line Associative Registers, Krishna Melarkode

University of Kentucky Master's Theses

As technological advances have improved processor speed, main memory speed has lagged behind. Even with advanced RAM technologies, it has not been possible to close the gap in speeds. Ideally, a CPU can deliver good performance when the right data is made available to it at the right time. Caches and Registers solved the problem to an extent. This thesis takes the approach of trying to create a new memory access model that is more efficient and simple instead of using various add on mechanisms to mask high memory latency. The Line Associative Registers have the functionality of a cache, …

Pressurized Solvents In Whole-Cell Bioprocessing: Metabolic And Structural Perturbations, Geoffrey D. Bothun

University of Kentucky Doctoral Dissertations

Compressed and supercritical fluids, such as pressurized CO2, ethane, orpropane, provide a versatile and environmentally acceptable alternative to conventionalliquid organic solvents in bioprocessing applications – specifically in the areas ofproduct extraction, protein purification, microbial sterilization, and enzymatic and wholecellbiocatalysis. While their advantages have been well demonstrated, the effects ofcompressed and supercritical fluids on whole cells are largely unknown.Metabolic and structural perturbations of whole cells by compressed andsupercritical fluid solvents were examined. These perturbations exist as cell metabolismand membrane structure are influenced by pressure and the presence of a solventphase. Continuous cultures of Clostridium thermocellum (a model ethanol-producingthermophilic bacterium) were conducted …

Characterization And Applications Of Multiwalled Carbon Nanotubes, Jenny Marie Hilding

University of Kentucky Doctoral Dissertations

Multiwalled carbon nanotubes (MWNTs) have attracted great interest during thelast decade due to their possession of a unique set of properties. In addition totheir strength, MWNTs have well defined morphologies, with large aspect ratiosand pores in the meso range, and intriguing transport properties, such as highelectrical and thermal conductivity.We are interested in how variations in the MWNT morphology affect areas ofpossible engineering applications. We have identified morphology as a criticalelement for the performance of MWNTs in engineering applications. Specificareas studied and reported here spans from surface adsorption and capillarycondensation, to dispersion and dispersion processes, and transport propertiesin relation to MWNT …

The Social Life Of Poetry: Pluralism And Appalachia, 1937-1946, Christopher Allen Green

University of Kentucky Doctoral Dissertations

This dissertation demonstrates how poetry about Appalachia expanded American considerations of democracy, ethnicity, and cultural values. I argue that poetry is profoundly communal in its construction and investigate how the value of poetry changes based upon its transfer through varying networks of production, circulation, and reception. Informed by theories of cultural capital and rhetoric, the chapters trace three books of poetry from their composition and publication to their reception and influence, noting how central political and social institutions and individuals shaped that process. The dissertation establishes how the poets crafted their writing to sway specific interpretive communities attitudes on pluralism. …

Rethinking Copyright Misuse, Kathryn Judge

Faculty Scholarship

Over the last few decades, copyright has evolved in dramatic and unprecedented ways. At the heart of this evolution lies a series of changes in the statutory scheme that have substantially expanded copyright's scope. There has also been a rise in private ordering as copyright holders increasingly use licenses to govern use of their copyrighted material and thereby supplant the default terms prescribed by the Copyright Act. Mediating and contributing to this evolution has been the judiciary. The judiciary has long played an active role in protecting copyright policy, and the dynamism of the last thirty years has only accentuated …

The Rise Of State Bankruptcy-Directed Legislation, Ronald J. Mann

Faculty Scholarship

The papers at this conference generally focus on the rise of securitization and the possibility that statutes designed to remedy abuses of securitization will wreak undue havoc on our capital markets. I take my starting point from the relatively intractable policy questions that those problems raise. It seems well accepted that securitization provides financing at lower cost to the large companies that use those transactions. If so, rules fostering securitization could enhance the overall performance of our economy. At the same time, there are legitimate concerns that the rise of securitization makes it less likely that large companies in financial …

Credit Card Policy In A Globalized World, Ronald J. Mann

Faculty Scholarship

This paper relies on data from countries around the world to present a comprehensive analysis of policy issues related to credit cards. The first part discusses the rise of credit cards and debit cards and how their uses differ from country to country. It closes with a framework for explaining why cards are more and less successful in different countries, focusing in large part on the ready availability of detailed consumer credit information. The second part considers the relation between credit card use and bankruptcy. Relying on a time series of data from the United States, Canada, Great Britain and …

Judicial Campaign Codes After Republican Party Of Minnesota V. White, Richard Briffault

Faculty Scholarship

The vast majority of judicial offices in the United States are subject to election. The votes of the people select or retain at least some judges in thirty-nine states, and all judges are elected in twenty-one states. By one count, 87% of the state and local judges in the United States have to face the voters at some point if they want to win or remain in office. Judicial elections, however, differ from elections for legislative or executive offices in a number of significant ways. In nineteen states, most judges are initially appointed but must later go before the voters …

Be Careful What You Wish For: Legal Sanctions And Public Safety Among Adolescent Offenders In Juvenile And Criminal Court, Jeffrey Fagan, Aaron Kupchik, Akiva Liberman

Faculty Scholarship

Three decades of legislative activism have resulted in a broad expansion of states' authority to transfer adolescent offenders from juvenile to criminal (adult) courts. At the same time that legislatures have broadened the range of statutes and lowered the age thresholds for eligibility for transfer, states also have reallocated discretion away from judges and instituted simplified procedures that permit prosecutors to elect whether adolescents are prosecuted and sentenced in juvenile or criminal court. These developments reflect popular and political concerns that relatively lenient or attenuated punishment in juvenile court violates proportionality principles for serious crimes committed by adolescents, and is …

Sexual Tensions Of Post-Empire, Katherine M. Franke

Faculty Scholarship

In this essay Katherine Franke examines two contemporary cites in which state efforts to eradicate the traces of empire and to resurrect an authentic post-colonial nation have produced sexual subjects that serve as a kind of existential residue and reminder of a demonized colonial past and absence. Looking first at post-colonial Zimbabwe, Franke argues that President Mugabe's aggressively homophobic policies have played a key role in fortifying his leadership as authentically African and post-colonial.

Franke then turns to current efforts by the Mubarak government in Egypt to publically prosecute men for having sex with men. The Mubarak government has used …

The Broadband Debate, A User's Guide, Tim Wu

Faculty Scholarship

Back in the 1990s, Internet communications policy was easier. It was easy to agree that the network's growth ought not be impended by excessive government regulation. It was easy to hope that the Internet would solve all of its own problems. Yet it turned out that the success of the network was hiding strong differences of opinion. Today, the euphoria is gone, and the divide in Internet communications policy has become clear and unmistakable. It most clearly a divide between two distinct groups: the self-proclaimed "Openists" and "Deregulationists."

This divide will do much to inform the reform of the Telecommunications …

Zach's News, Georgia Southern University

Library Publications (1999-2023)

• New Catalog Feature Allows Users to Save and Repeat Searches
• Online Catalog Offers Links to Electronic Resources
• GALILEO Gains Two New Databases from EBSCOhost
• Henderson to Order Three Wilson Databases Eliminated From GALILEO
• Library Uses Positive Reinforcement to Reduce Overdues
• Library Circulation Declines, Prompts Librarian's Research
• Recent Additions to ICPSR Database

Generation Of The Transient Electrical And Spontaneous Magnetic Fields By Solid State Combustion, Karen S. Martirosyan, J. R. Claycomb, J. H. Miller Jr., D. Luss

Physics & Astronomy Faculty Publications

Experiments revealed that transient electric field intensities up to 2.5 V/cm were generated during the initial period of combustion synthesis of the ferromagnetic products before the maximum temperature was reached. This occurred when the iron particles were partially oxidized and the reaction product was mainly magnetite sFe3O4d. The electromagnetic field caused spontaneous magnetization of the product in the postcombustion zone. Magnetic field values up to 4 µT formed after the sample temperature fell below the Curie temperature and the initial reactants were completely converted to the ferromagnetic phase PbFe12O19. Increasing the volume of the samples increases the absolute residual magnetic …

An Empirical Investigation Of Liquidation Choices Of Failed High Tech Firms, Ronald J. Mann

Faculty Scholarship

Perhaps it is merely a reflection of my interests, but to my mind, empirical research requires a certain risk-preferent boldness. I like projects that explore how and why particular businesses make important decisions. After I identify a topic, I typically try to gather as much qualitative and quantitative information about it as I can, with the expectation that when I have learned a great deal about the topic something interesting will emerge that relates in some important way to an ongoing academic debate. Those projects usually do not begin with a specific hypothesis to prove or disprove-often either answer will …

What Caused Enron? A Capsule Social And Economic History Of The 1990s, John C. Coffee Jr.

Faculty Scholarship

The sudden explosion of corporate accounting scandals and related financial irregularities that burst over the financial markets between late 2001 and the first half of 2002 – Enron, WorldCom, Tyco, Adelphia and others – raises an obvious question: Why now? What explains the concentration of financial scandals at this moment in time? Much commentary has rounded up the usual suspects and placed the blame on a decline in business morality, an increase in "infectious greed," or other similarly subjective trends that cannot be reliably measured. Although none of these possibilities can be dismissed out of hand, approaches that simply reason …

New Frontiers In Collection Development Preparing To Meet New Standards, Gary R. Shook

The Christian Librarian

This article describes the general policies which may be included in a comprehensive collection development policy, attempting to follow national guidelines. It also describes one approach to analyzing how well the library collection supports the various parts of the curriculum, and presents a technique to compare a library collection with peer libraries by subject majors. Finally, the "Collection Development Plan" section provides a format for stating an action plan to develop the collection based upon all of the information gathered.

Resource Reviews, Phyllis Fox

The Christian Librarian

No abstract provided.

Beyond The Book: Promoting Effective Research, Jana M. Borchardt

The Christian Librarian

In the past library professionals have primarily collected and provided access to materials; however, this paper will argue that we must now go beyond access or "Beyond the Book. " One way to do this is to learn about the information search process and then assume a new and more assertive role as a "research advisor. " We need to change our patrons 'expectations so that they see us as knowledgeable about sources, yes, but also as experts on effective research as a process of discovery. Three relevant information search process models are covered, as well as the way people …

Ministry Resource Center: Access Through A Database-Driven Website, Greg Sennema

The Christian Librarian

The new Ministry Resource Center (MRC) of Calvin College and Calvin Theological Seminary is a premiere collection of practical resources for all aspects of congregational ministry. To help MRC patrons locate appropriate resources, the College and Seminary s Hekman Library has created a website that combines information from manually created static webpages and bibliographic data imported from the Library s online catalog. The result is one website that gathers together, and provides access to, the entire MRC collection.

Resource Reviews, Phyllis Fox

The Christian Librarian

No abstract provided.

Training Levels And Methodologies For Glass Cockpit Training In Collegiate Aviation, Richard O. Fanjoy, John P. Young

Journal of Aviation/Aerospace Education & Research

Modern commercial aircraft use extremely complex and sophisticated flight instrumentation systems that present training concerns for the aviation industry and collegiate aviation programs. The authors sampled 42 four-year collegiate flight-training programs to determine their current program emphasis on "glass cockpit" training and plans for curriculum enhancements in that area. Although nearly fifty percent of sampled program administrators believe instruction in flight automation is critical to the success of their graduates, most cite cost of materials and competing curriculum priorities as reasons to defer such instruction to future employers. The authors suggest that program enhancements are within the reach of modern …