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2003

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Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis At The Post-Transcriptional Level, Dennis Peffley, Apurba K. Gayen Jan 2003

Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis At The Post-Transcriptional Level, Dennis Peffley, Apurba K. Gayen

Faculty and Staff Publications

The rate-limiting enzyme for mevalonate and cholesterol synthesis in mammalian cells is 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. Control occurs through both transcriptional and post-transcriptional actions signaled by the end product, cholesterol, and by isoprenoid intermediates. End products of plant mevalonate metabolism, i.e., plant-derived isoprenoids, also suppress mammalian HMG-CoA reductase. Previous studies reported that isoprenoids suppress reductase synthesis at a post-transcriptional level. We tested the hypothesis that plant-derived isoprenoids also regulate mammalian HMG-CoA reductase synthesis at a post-transcriptional level by incubating lovastatin-treated C100 cells with mevalonate or a plant-derived isoprenoid (the monoterpenes, limonene, perillyl alcohol or geraniol) either alone or combined with the …

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Proposed Legislation On Judicial Election Campaign Finance, Roy A. Schotland Jan 2003

Proposed Legislation On Judicial Election Campaign Finance, Roy A. Schotland

Georgetown Law Faculty Publications and Other Works

In light of the recent extraordinary rise in judicial campaign spending, illustrated in Ohio's 2000 judicial elections (and elsewhere, and in Ohio again in 2002), we must consider improving the Model Code of Judicial Conduct. The 1999 amendments to the Code addressed campaign finance, but did not address two major problems. The first one is the absence of limits on aggregate contributions from law firms; only Texas has such limits. This gap allows large contributions from law firms to go to judges presiding in cases in which those firms participate, circumventing the recusal and disqualification triggers. The second problem is …

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Tribute To Harold Jacobson, John H. Jackson Jan 2003

Tribute To Harold Jacobson, John H. Jackson

Georgetown Law Faculty Publications and Other Works

Harold Jacobson was not only a fine scholar and excellent teacher who devoted a career to the University of Michigan, but he was also a very trusted colleague and a close friend. His scholarly work was very well recognized and admired. He was one of my colleagues while I taught at Michigan, to whom I willingly recommended students for a multidisciplinary approach to international relations. He was a theorist of political science and international relations who was willing and able to come to grips with the role of law in those fields.

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Interdisciplinary Collaboration With Jake, Edith Brown Weiss Jan 2003

Interdisciplinary Collaboration With Jake, Edith Brown Weiss

Georgetown Law Faculty Publications and Other Works

Jake and I were professional colleagues and friends for more than twenty years, but it was in the last fifteen years that we worked closely together, bridging the supposed divide between political science and international law. Sometimes we worked together in the American Society of International Law, other times in the Social Science Research Council (SSRC), or in the Human Dimensions of Global Change program. Most often, we worked together as scholars in interdisciplinary research.

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Pushing Drugs: Genomics And Genetics, The Pharmaceutical Industry, And The Law Of Negligence, Heidi Li Feldman Jan 2003

Pushing Drugs: Genomics And Genetics, The Pharmaceutical Industry, And The Law Of Negligence, Heidi Li Feldman

Georgetown Law Faculty Publications and Other Works

This article presents a piece of a larger, ongoing project on the phenomenon of market-driven manufacturing (MDM) and how tort law should address it. In contrast to the larger project, this article provides a relatively brief overview of the general phenomenon of MDM, but zeros in on how pharmaceutical manufacturers specifically practice MDM. MDM is a well-documented, much practiced activity, although American courts do not recognize MDM as a discrete category of conduct. The basic idea of MDM is that marketing considerations should continuously control every aspect and stage of a product's lifecycle. When a company engages in MDM, it …

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Cover And Contents Jan 2003

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Cover And Contents Jan 2003

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Cover And Contents Jan 2003

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Cover And Contents Jan 2003

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Cover And Contents Jan 2003

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Cover And Contents Jan 2003

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Detection Of Ehrlichia Spp. In The Blood Of Wild White-Tailed Deer In Missouri By Pcr Assay And Serologic Analysis, Max Q. Arens, Allison M. Liddell, Gerald Buening, Monique Gaudreault-Keener, John W. Sumner, James A. Comer, Richard S. Buller, Gregory A. Storch Jan 2003

Detection Of Ehrlichia Spp. In The Blood Of Wild White-Tailed Deer In Missouri By Pcr Assay And Serologic Analysis, Max Q. Arens, Allison M. Liddell, Gerald Buening, Monique Gaudreault-Keener, John W. Sumner, James A. Comer, Richard S. Buller, Gregory A. Storch

Open Access Publications

No abstract provided.

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Antifungal Susceptibility Survey Of 2,000 Bloodstream Candida Isolates In The United States, Luis Ostrosky-Zeichner, John H. Rex, Peter G. Pappas, Richard J. Hamill, Robert A. Larsen, Harold W. Horowitz, William G. Powderly, Newton Hyslop, Carol A. Kauffman, John Cleary, Julie E. Mangino, Jeannette Lee Jan 2003

Antifungal Susceptibility Survey Of 2,000 Bloodstream Candida Isolates In The United States, Luis Ostrosky-Zeichner, John H. Rex, Peter G. Pappas, Richard J. Hamill, Robert A. Larsen, Harold W. Horowitz, William G. Powderly, Newton Hyslop, Carol A. Kauffman, John Cleary, Julie E. Mangino, Jeannette Lee

Open Access Publications

No abstract provided.

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Sensitivity To Changes In Disability After Stroke: A Comparison Of Four Scales Useful In Clinical Trials, Alexander W. Dromerick, Dorothy F. Edwards, Michael N. Diringer Jan 2003

Sensitivity To Changes In Disability After Stroke: A Comparison Of Four Scales Useful In Clinical Trials, Alexander W. Dromerick, Dorothy F. Edwards, Michael N. Diringer

Open Access Publications

No abstract provided.

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Denaturing High-Performance Liquid Chromatography For Detecting And Typing Genital Human Papillomavirus, Jianduan Li, Daniela S. Gerhard, Zhengyan Zhang, Phillis C. Huettner, Jason Wright, Loan Nguyen, Danielle Lu, Janet S. Rader Jan 2003

Denaturing High-Performance Liquid Chromatography For Detecting And Typing Genital Human Papillomavirus, Jianduan Li, Daniela S. Gerhard, Zhengyan Zhang, Phillis C. Huettner, Jason Wright, Loan Nguyen, Danielle Lu, Janet S. Rader

Open Access Publications

No abstract provided.

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Teaching It In A Hybrid Learning Environment: A Case Study, Terry Dennis, Omar F. El-Gayar, Zehai Zhou Jan 2003

Teaching It In A Hybrid Learning Environment: A Case Study, Terry Dennis, Omar F. El-Gayar, Zehai Zhou

Research & Publications

Dakota State University offers a Master’s degree in Information Systems to students using what is referred to as a hybrid learning environment, a simultaneous combination of in-class, remote interactive audio/video connections (DDN), and Internet connections. This paper identifies some of the issues and challenges that have been encountered by faculty and students in this teaching environment.

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Software Project Management: The Role Of Modeling, Omar F. El-Gayar, Sreedhar Thota Jan 2003

Software Project Management: The Role Of Modeling, Omar F. El-Gayar, Sreedhar Thota

Research & Publications

With the ubiquity of software and in the quest towards improving software development activities, the software engineering research community engaged in an active research agenda on modeling software processes. The modeling objectives ranged from process understanding, improvement, and management, to project management. In spite of the significant achievements in the field, few (if any) of the research results are adopted by the industry. This paper presents a brief review and a critical evaluation of the status of software process modeling practices with particular emphasis on their applications to project management from a practitioner's point of view as well as recommendations …

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Behind The Screen. Pubmed Intricacies, Ibrahim Mansoor Jan 2003

Behind The Screen. Pubmed Intricacies, Ibrahim Mansoor

Saudi Medical Journal

No abstract provided.

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Luteal Phase Support In Ovarian Induction Cycles Using Human Chorionic Gonadotropin Or Oral Progestagens, Faheem F. Zayed, Mohammad F. El-Jallad, Haifa A. Al-Chalabi Jan 2003

Luteal Phase Support In Ovarian Induction Cycles Using Human Chorionic Gonadotropin Or Oral Progestagens, Faheem F. Zayed, Mohammad F. El-Jallad, Haifa A. Al-Chalabi

Saudi Medical Journal

OBJECTIVE: To determine the efficacy of luteal phase support with human chorionic gonadotropin (hCG) or oral progesterone during human menopausal gonadotropin (hMG) ovulation induction. METHODS: Between September 1999 and March 2001, a total of 91 couples with infertility were recruited at Al-Hammadi Hospital, Riyadh, Kingdom of Saudi Arabia and Badeea Hospital, Jordan. In this prospective trial 46 couples were allocated to luteal phase support with hCG injections, while 45 couples were allocated to Duphaston (oral progestogens) as luteal support. RESULTS: In the group of hCG luteal support, 46 patients completed 46 cycles of hMG therapy, and 8 pregnancies (5 ongoing …

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Uterine Rupture Incidence, Risk Factors, And Outcome, Abdulrahim A. Rouzi, Asmaa A. Hawaswi, Mohammed Aboalazm, Fathia Hassanain, Othman Sindi Jan 2003

Uterine Rupture Incidence, Risk Factors, And Outcome, Abdulrahim A. Rouzi, Asmaa A. Hawaswi, Mohammed Aboalazm, Fathia Hassanain, Othman Sindi

Saudi Medical Journal

OBJECTIVE: To determine the incidence of uterine rupture and to analyze risk factors and outcome in a local hospital in Makkah, Kingdom of Saudi Arabia, (KSA). METHODS: The hospital records of the Maternity and Children9s Hospital (MCH), in Makkah, KSA from April 1999 to December 2000 were retrospectively reviewed to identify women with ruptured uterus. The relevant data relating to the clinical features, risk factors, operative procedures, and maternal and fetal outcomes were assessed. RESULTS: During the study period, there were 23245 deliveries and 23 women were diagnosed to have uterine rupture giving an incidence of one in 1011 deliveries. …

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A Scoring System As A Tool For Antenatal Care Audit In Family Medicine, Rabaa K. Al-Momen, Izzeldin El-Jack, Noura A. Al-Nowaiser, Noura A. Al-Rowais Jan 2003

A Scoring System As A Tool For Antenatal Care Audit In Family Medicine, Rabaa K. Al-Momen, Izzeldin El-Jack, Noura A. Al-Nowaiser, Noura A. Al-Rowais

Saudi Medical Journal

OBJECTIVE: To propose the antenatal assessment score (AAS) as a tool for auditing the process of antenatal care in family medicine, and to highlight its accessibility by applying it at 2 family health care centers. METHODS: A descriptive study of an audit process was conducted in 2 primary health care centers (non commissioned officers9 [NCO] and officers9 health centers [OC]) belonging to the Department of Family Medicine, Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia from February 2001 to June 2002. A systematic random sample of patients registered at the maternal registers of both centers was selected. A score system …

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Prevalence And Correlates Of Nocturnal Enuresis In The United Arab Emirates, Valsamma Eapen, Abdulazim M. Mabrouk Jan 2003

Prevalence And Correlates Of Nocturnal Enuresis In The United Arab Emirates, Valsamma Eapen, Abdulazim M. Mabrouk

Saudi Medical Journal

OBJECTIVE: To determine the prevalence, socio-demographic correlates and associated psychopathology in children with enuresis. METHODS: A community survey of a stratified sample of 400 6-16 year old school children was carried out in the Al-Ain City, United Arab Emirates. Psychiatric disturbance, if any, was ascertained using the Rutter Parent Scale. RESULTS: Thirty-two out of the 400 children (8%) surveyed, reported wetting the bed at least once per week. More boys were affected than girls, and 90% of those with enuresis were aged 6-11 years. Presence of enuresis was found to be associated with psychosocial stress in the family; large family …

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Hearing Screening Of Neonates At Risk, Alwan M. Maisoun, Siraj M. Zakzouk Jan 2003

Hearing Screening Of Neonates At Risk, Alwan M. Maisoun, Siraj M. Zakzouk

Saudi Medical Journal

OBJECTIVE: The aim of this study is to screen infants admitted to the Neonatal Intensive Care Unit (NICU) for hearing loss. METHODS: One hundred and thirty newborns admitted to NICU were screened for hearing loss using otocaustic emission (OAE). Tympanometry was performed using Grason Stadler Incorporation (GSI) 37 and auditory brain response (ABR). RESULTS: Ninety-six of the infants had known risk factors such as prematurely, low birth weight, hyperbilirubinemia, asphyxia and congenital abnormalities. Out of 130 infants 80 passed the OAE test, 50 had to be rescreened, and 19 had ABR. Only 13 were found with moderate to severe hearing …

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Outcome Of Type-1 Tympanoplasty, Fadl A. Fadl Jan 2003

Outcome Of Type-1 Tympanoplasty, Fadl A. Fadl

Saudi Medical Journal

OBJECTIVE: The outcome of 97 patients who underwent tympanoplasty type-1 surgery by different ear, nose and throat surgeons was evaluated. METHODS: This retrospective study was carried out from the records pertaining to all patients who had tympanoplasty type-1 at King Fahd Specialist Hospital, Buraidah, Al-Qassim, Kingdom of Saudi Arabia, during the years April 1995 through to April 2000. Specific criterias were setup for selecting all the patients involved and excluding others. Thus 97 ears were selected in this study. The factors presumed to influence the outcome included age, sex, nationality, affected ear, middle ear status at surgery, perforation size and …

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Otolaryngologic Manifestation Of Gastroesophageal Reflux In Children, Ahmed Y. Al-Ammar Jan 2003

Otolaryngologic Manifestation Of Gastroesophageal Reflux In Children, Ahmed Y. Al-Ammar

Saudi Medical Journal

OBJECTIVE: This study was performed to assess the role of gastroesophageal reflux (GER) in varieties of otolaryngologic dysfunction. METHODS: This study was carried out over a one year period, between January 1995 and January 1996, at Sainte-Justine Hospital, Montreal, Canada. Thirty-seven charts were examined for different variables including, symptoms, signs, dysfunction, investigations, treatment and outcome. RESULTS: In children with otolaryngologic manifestation of GER, apnea and regurgitation were common presenting symptoms. Gastroesophageal reflux was also found to be more commonly associated with ear infection, adenoid hypertrophy, bronchial asthma and recurrent pneumonia. CONCLUSION: Gastroesophageal reflux has complicated manifestations in otolaryngology that are …

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Congenital Acinar Dysplasia. Familial Cause Of A Fatal Respiratory Failure In A Neonate, Kefah A. Al-Senan, Abdulhakiem K. Kattan, Fouad H. Al-Dayel Jan 2003

Congenital Acinar Dysplasia. Familial Cause Of A Fatal Respiratory Failure In A Neonate, Kefah A. Al-Senan, Abdulhakiem K. Kattan, Fouad H. Al-Dayel

Saudi Medical Journal

Pulmonary hypoplasia is a rare cause of pulmonary insufficiency, and has a significant rate of morbidity and mortality among affected infants. In most cases, pulmonary hypoplasia is secondary to underlying abnormalities. These may include space occupying lesions, as in infants with congenital diaphragmatic hernia; malformation of chest wall resulting in a small thoracic cavity; severe and prolonged oligohydramnios; and neuromuscular disorders, which prevent normal fetal chest expansion. All lead to poor lung development. Primary pulmonary hypoplasia as a result of congenital acinar dysplasia is exceedingly rare and is diagnosed by exclusion of all known etiologies of secondary pulmonary hypoplasia.

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Silicosis In A Housewife, Wassef F. Safa, Jose L. Machado Jan 2003

Silicosis In A Housewife, Wassef F. Safa, Jose L. Machado

Saudi Medical Journal

Silicosis is an occupational respiratory disease caused by inhaling respirable crystalline silica dust. We report the case of silicosis in a 50-year-old woman that presented with pulmonary fibrosis and later developed pulmonary tuberculosis. Her condition is believed to be due to inhalation of dust produced by scrubbing a silica rich surface during usual daily housework.

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Paradoxical Response In Tuberculosis And Reversal Reaction In Leprosy. Different Terminology For Same Immunology?, Sarosh Khan, Abdulrahman Bhat, Latif A. Khan Jan 2003

Paradoxical Response In Tuberculosis And Reversal Reaction In Leprosy. Different Terminology For Same Immunology?, Sarosh Khan, Abdulrahman Bhat, Latif A. Khan

Saudi Medical Journal

No abstract provided.

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Malaria Parasitemia During Delivery, Abdulmageed M. Imam Jan 2003

Malaria Parasitemia During Delivery, Abdulmageed M. Imam

Saudi Medical Journal

No abstract provided.

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Shareholder Value And Auditor Independence, William Wilson Bratton Jan 2003

Shareholder Value And Auditor Independence, William Wilson Bratton

Articles

This Article questions the practice of framing problems concerning auditors' professional responsibility inside a principal-agent paradigm. If professional independence is to be achieved, auditors cannot be enmeshed in agency relationships with the shareholders of their audit clients. As agents, the auditors by definition become subject to the principal's control and cannot act independently. For the same reason, auditors' duties should be neither articulated in the framework of corporate law fiduciary duty, nor conceived relationally at all. These assertions follow from an inquiry into the operative notion of the shareholder-beneficiary. The Article unpacks the notion of the shareholder and tells a …

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