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2003

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University Of Central Florida Ir 3-Year Fact Book - Ay 2000-2001 Through Ay 2002-2003, University Of Central Florida Jan 2003

University Of Central Florida Ir 3-Year Fact Book - Ay 2000-2001 Through Ay 2002-2003, University Of Central Florida

Historical Fact Book and Enrollment

Historical fact book and enrollment data for the University of Central Florida.

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Lim Kinase 1 Is Essential For The Invasive Growth Of Prostate Epithelial Cells - Implications In Prostate Cancer, Monica Davila, Andra R. Frost, William E. Grizzle, Ratna Chakrabarti Jan 2003

Lim Kinase 1 Is Essential For The Invasive Growth Of Prostate Epithelial Cells - Implications In Prostate Cancer, Monica Davila, Andra R. Frost, William E. Grizzle, Ratna Chakrabarti

Faculty Bibliography 2000s

Mammalian LIM kinase 1 (LIMK1) is involved in reorganization of actin cytoskeleton through inactivating phosphorylation of the ADF family protein cofilin, which depolymerizes actin filaments. Maintenance of the actin dynamics in an ordered fashion is essential for stabilization of cell shape or promotion of cell motility depending on the cell type. These are the two key phenomena that may become altered during acquisition of the metastatic phenotype by cancer cells. Here we show that LIMK1 is overexpressed in prostate tumors and in prostate cancer cell lines, that the concentration of phosphorylated cofilin is higher in metastatic prostate cancer cells, and …

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Sulfolipid Deficiency Does Not Affect The Virulence Of Mycobacterium Tuberculosis H37rv In Mice And Guinea Pigs, Cécile Rousseau, Oliver C. Turner, Erik Rush, Yann Bordat, Tatiana D. Sirakova, Pappachan E. Kolattukudy, Shannon Ritter, Ian M. Orme, Brigitte Gicquel, Mary Jackson Jan 2003

Sulfolipid Deficiency Does Not Affect The Virulence Of Mycobacterium Tuberculosis H37rv In Mice And Guinea Pigs, Cécile Rousseau, Oliver C. Turner, Erik Rush, Yann Bordat, Tatiana D. Sirakova, Pappachan E. Kolattukudy, Shannon Ritter, Ian M. Orme, Brigitte Gicquel, Mary Jackson

Faculty Bibliography 2000s

Lipids that are found only in the cell envelope of pathogenic mycobacteria, such as those containing multiple methyl-branched fatty acids, have long been thought to play a role in pathogenesis. Among these complex lipids, sulfolipids have been the most extensively studied over the last 50 years. The numerous biological effects exhibited by purified sulfolipids on phagocytic cells led to the idea that these molecules are probably important virulence factors facilitating the intracellular survival of Mycobacterium tuberculosis. However, definitive evidence to support this concept has been lacking. The recent construction of an isogenic sulfolipid-deficient mutant of M. tuberculosis H37Rv (Sirakova et …

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Characterization Of A Novel And Specific Inhibitor For The Pro-Apoptotic Protease Omi/Htra2, Lucia Cilenti, Younghee Lee, Sibylle Hess, Srinivasa Srinivasula, Kwon Moo Parrk, Daniela Junqueira, Hedvika Davis, Joseph V. Bonventre, Emad S. Alnemri, Antonis S. Zervos Jan 2003

Characterization Of A Novel And Specific Inhibitor For The Pro-Apoptotic Protease Omi/Htra2, Lucia Cilenti, Younghee Lee, Sibylle Hess, Srinivasa Srinivasula, Kwon Moo Parrk, Daniela Junqueira, Hedvika Davis, Joseph V. Bonventre, Emad S. Alnemri, Antonis S. Zervos

Faculty Bibliography 2000s

Omi/HtrA2 is a mammalian serine protease with high homology to bacterial HtrA chaperones. Omi/HtrA2 is localized in mitochondria and is released to the cytoplasm in response to apoptotic stimuli. Omi/HtrA2 induces cell death in a caspase-dependent manner by interacting with the inhibitor of apoptosis protein as well as in a caspase-independent manner that relies on its protease activity. We describe the identification and characterization of a novel compound as a specific inhibitor of the proteolytic activity of Omi/HtrA2. This compound (ucf-101) was isolated in a high throughput screening of a combinatorial library using bacterially made Omi-(134-458) protease and fluorescein-casein as …

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Biochemical Function Of Msl5 (Pks8 Plus Pks17) In Mycobacterium Tuberculosis H37rv: Biosynthesis Of Monomethyl Branched Unsaturated Fatty Acids, Vinod S. Dubey, Tatiana D. Sirakova, Michael H. Cynamon, Pappachan E. Kolattukudy Jan 2003

Biochemical Function Of Msl5 (Pks8 Plus Pks17) In Mycobacterium Tuberculosis H37rv: Biosynthesis Of Monomethyl Branched Unsaturated Fatty Acids, Vinod S. Dubey, Tatiana D. Sirakova, Michael H. Cynamon, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

We show that the disruption of one of the mycocerosic acid synthase (mas)-like genes, msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv generates a mutant incapable of producing monomethyl branched unsaturated C-16 to C-20 fatty acids that are minor constituents of acyltrehaloses and sulfolipids. The msl5 mutation did not cause any significant change in the acyl lipid composition and also did not affect growth in culture, in mouse alveolar macrophage cell line MH-S, or in the murine lung.

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Potential Involvement Of Extracellular Signal-Regulated Kinase 1 And 2 In Encystation Of A Primitive Eukaryote, Giardia Lamblia - Stage-Specific Activation And Intracellular Localization, John G. Ellis Iv, Monica Davila, Ratna Chakrabarti Jan 2003

Potential Involvement Of Extracellular Signal-Regulated Kinase 1 And 2 In Encystation Of A Primitive Eukaryote, Giardia Lamblia - Stage-Specific Activation And Intracellular Localization, John G. Ellis Iv, Monica Davila, Ratna Chakrabarti

Faculty Bibliography 2000s

Mitogen-activated protein kinase (MAPK) pathways are major signaling systems by which eukaryotic cells convert environmental cues to intracellular events such as proliferation and differentiation. We have identified Giardia lamblia homologues of two members of the MAPK family ERK1 and ERK2. Functional characterization of giardial ERK1 and ERK2 revealed that both kinases were expressed in trophozoites and encysting cells as 44- and 41-kDa polypeptides, respectively, and were catalytically active. Analysis of the kinetic parameters of the recombinant proteins showed that ERK2 is similar to5 times more efficient than ERK1 in phosphorylating myelin basic protein as a substrate, although the phosphorylating efficiency …

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Body Image Among Older, Rural, African-American Women With Type 2 Diabetes, Leslie Sue Lieberman, Claudia K. Probart, Nancy E. Schoenberg Jan 2003

Body Image Among Older, Rural, African-American Women With Type 2 Diabetes, Leslie Sue Lieberman, Claudia K. Probart, Nancy E. Schoenberg

Faculty Bibliography 2000s

Type 2 diabetes and obesity co-occur in high prevalence among African-American women. The positive value placed on large body size has both historic and contemporary biosocial relevance. The maintenance of weight at medically recommended levels is a cornerstone of both prevention and treatment of Type 2 diabetes. This study of overweight, elderly, rural African-American women with 7 pe 2 diabetes found they generally preferred smaller body sizes compared to previous studies. Normal to slim body images as presented in a photographic array were selected as being more attractive, less likely to have diabetes and hypertension, healthier and to be more …

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Effects Of Environmental Regulations On Manufacturing Plant Births: Evidence From A Propensity Score Matching Estimator, John A. List, Daniel L. Millimet, Per G. Fredriksson, W. Warren Mchone Jan 2003

Effects Of Environmental Regulations On Manufacturing Plant Births: Evidence From A Propensity Score Matching Estimator, John A. List, Daniel L. Millimet, Per G. Fredriksson, W. Warren Mchone

Faculty Bibliography 2000s

This study examines the effects of air quality regulation on economic activity. Anecdotal evidence and some recent empirical studies suggest that an inverse relationship exists between the stringency of environmental regulations and new plant formations. Using a unique county-level data set for New York State from 1980 to 1990, we revisit this conjecture using a seminonparametric method based on propensity score matching. Our empirical estimates suggest that pollution-intensive plants are responding to environmental regulations; more importantly, we find that traditional parametric methods used in previous studies may dramatically understate the impact of more stringent regulations.

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Identification And Initial Characterization Of Three Novel Cyclin-Related Proteins Of The Human Malaria Parasite Plasmodium Falciparum, Anaïs Merckx, Karine Le Roche, Marie-Paule Nivez, Dominique Dorin, Pietro Alano, Gustavo J. Gutierrez, Angel R. Nebreda, Dean Goldring, Christina Whittle, Shelly Patterson, Debopam Chakrabarti, Christian Doerig Jan 2003

Identification And Initial Characterization Of Three Novel Cyclin-Related Proteins Of The Human Malaria Parasite Plasmodium Falciparum, Anaïs Merckx, Karine Le Roche, Marie-Paule Nivez, Dominique Dorin, Pietro Alano, Gustavo J. Gutierrez, Angel R. Nebreda, Dean Goldring, Christina Whittle, Shelly Patterson, Debopam Chakrabarti, Christian Doerig

Faculty Bibliography 2000s

The molecular mechanisms regulating cell proliferation and development during the life cycle of malaria parasites remain to be elucidated. The peculiarities of the cell cycle organization during Plasmodium falciparum schizogony suggest that the modalities of cell cycle control in this organism may differ from those in other eukaryotes. Indeed, existing data concerning Plasmodium cell cycle regulators such as cyclin-dependent kinases reveal structural and functional properties that are divergent from those of their homologues in other systems. The work presented here lies in the context of the exploitation of the recently available P. falciparum genome sequence toward the characterization of putative …

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Cloning Of Hbsag-Encoded Genes In Different Vectors And Their Expression In Eukaryotic Cells, Shan Qin, Hong Tang, Lian-San Zhao, Fang He, Yong Lin, Li Liu, Xiao-Mei He Jan 2003

Cloning Of Hbsag-Encoded Genes In Different Vectors And Their Expression In Eukaryotic Cells, Shan Qin, Hong Tang, Lian-San Zhao, Fang He, Yong Lin, Li Liu, Xiao-Mei He

Faculty Bibliography 2000s

AIM: To compare the efficiency of different plasmids as DNA vectors by cloning three HBsAg-encoded genes into two eukaryotic expression vectors, pRc/CMV and pSG5UTPL/Flag, and to express HBsAg S, MS, and LS proteins in SP2/0 cells, and to establish monoclone SP2/0 cell strains that are capable of expressing S or S2S proteins stably. METHODS: Segments of S, preS2-S, preS1-preS2-S genes of Hepatitis B virus were amplified by routine PCR and preS1-S fragment was amplified by Over-Lap Extension PCR. The amplified segments were cleaved with restricted endonuclease Hind III/Not I followed by ligation with pRc/CMV, or BamHI/EcoR I followed by ligation …

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Attenuation Of Mycobacterium Tuberculosis By Disruption Of A Mas-Like Gene Or A Chalcone Synthase-Like Gene, Which Causes Deficiency In Dimycocerosyl Phthiocerol Synthesis, Tatiana D. Sirakova, Vinod S. Dubey, Michael H. Cynamon, Pappachan E. Kolattukudy Jan 2003

Attenuation Of Mycobacterium Tuberculosis By Disruption Of A Mas-Like Gene Or A Chalcone Synthase-Like Gene, Which Causes Deficiency In Dimycocerosyl Phthiocerol Synthesis, Tatiana D. Sirakova, Vinod S. Dubey, Michael H. Cynamon, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

Tuberculosis is one of the leading preventable causes of death. Emergence of drug-resistant tuberculosis makes the discovery of new targets for antimyrobacterial drugs critical. The unique mycobacterial cell wall lipids are known to play an important role in pathogenesis, and therefore the genes responsible for their biosynthesis offer potential new targets. To assess the possible role of some of the genes potentially involved in cell wall lipid synthesis, we disrupted a mas-like gene, msl7, and a chalcone synthase-like gene, pks10, with phage-mediated delivery of the disruption construct, in which the target gene was disrupted by replacement of an internal segment …

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The Largest Open Reading Frame (Pks12) In The Mycobacterium Tuberculosis Genome Is Involved In Pathogenesis And Dimycocerosyl Phthiocerol Synthesis, Tatianna D. Sirakova, Vinod S. Dubey, Hwa-Jung Kim, Michael H. Cynamon, Pappachan E. Kolattukudy Jan 2003

The Largest Open Reading Frame (Pks12) In The Mycobacterium Tuberculosis Genome Is Involved In Pathogenesis And Dimycocerosyl Phthiocerol Synthesis, Tatianna D. Sirakova, Vinod S. Dubey, Hwa-Jung Kim, Michael H. Cynamon, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

The cell wall lipids in Mycobacterium tuberculosis are probably involved in pathogenesis. The largest open reading frame in the genome of M. tuberculosis H37Rv, pks12, is unique in that it encodes two sets of domains needed to produce fatty acids. Apks12-disrupted mutant was produced, and disruption was confirmed by both PCR analysis and Southern blotting. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis showed that a 430-kDa protein band present in the wild type was missing in the mutant. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MS) and liquid chromatography (LC)-MS analysis of tryptic peptides showed that 54 peptides distributed …

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Improving Nurse Staffing Measures: Discharge Day Measurement In "Adjusted Patient Days Of Care", Lynn Y. Unruh, Myron D. Fottler, Laura L. Talbott Jan 2003

Improving Nurse Staffing Measures: Discharge Day Measurement In "Adjusted Patient Days Of Care", Lynn Y. Unruh, Myron D. Fottler, Laura L. Talbott

Faculty Bibliography 2000s

Previous research cannot account for the discrepancy between registered nurse (RN) reports of understaffing and studies showing slight improvement. One reason may be that "adjusted patient days of care" (APDC) underestimates patient load. Using data from all Pennsylvania acute care general hospitals for the years 1994 through 1997, we found that APDC is underestimated by two hours. After adjusting APDC, we examined the difference in nurse staffing over the period 1991-2000 before and after the adjustment. We found a significant difference between unadjusted and adjusted measures. However, when applied to the changes in nurse staffing between 1991 and 2000, the …

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A Renewal Of The Sacred Heart University Library: A New Role For The Sacred Heart University Library, Dennis C. Benamati Jan 2003

A Renewal Of The Sacred Heart University Library: A New Role For The Sacred Heart University Library, Dennis C. Benamati

Librarian Publications

It is a pleasure to present this prospectus for renewal of University’s Library to the students, faculty, administration, alumni and friends of Sacred Heart University. This first part of a two-part plan is intended to provide a statement of how we will proceed toward transforming the Library into a center of learning. But this is only the starting point for a larger and more exciting plan. Part II will outline a new role for the Library—one befitting a 21st century university—that we believe will distinguish Sacred Heart University among its peers. One that, we hope, will contribute to the University’s …

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H. Wayne Huizenga School Of Business And Entrepreneurship 2003-2004 Catalog, Nova Southeastern University Jan 2003

H. Wayne Huizenga School Of Business And Entrepreneurship 2003-2004 Catalog, Nova Southeastern University

Huizenga Postgraduate Course Catalogs

No abstract provided.

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Selected Dhs Data On 10–14-Year-Olds: Ghana, Population Council Jan 2003

Selected Dhs Data On 10–14-Year-Olds: Ghana, Population Council

Poverty, Gender, and Youth

Annex to "Facts about adolescents from the Demographic and Health Survey—Statistical tables for program planning"

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Mba 660.01: Marketing Management, Jakki J. Mohr Jan 2003

Mba 660.01: Marketing Management, Jakki J. Mohr

University of Montana Course Syllabi

No abstract provided.

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Psyc 649.01: Attachment And Attachment Disorders, Paul S. Silverman Jan 2003

Psyc 649.01: Attachment And Attachment Disorders, Paul S. Silverman

University of Montana Course Syllabi

No abstract provided.

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Psyc 536.01: Advanced Child And Adolescent Psychological Disorders, Paul S. Silverman Jan 2003

Psyc 536.01: Advanced Child And Adolescent Psychological Disorders, Paul S. Silverman

University of Montana Course Syllabi

No abstract provided.

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Hfd 414.01: Community Service Delivery I - Case Management, Susie Morrison Jan 2003

Hfd 414.01: Community Service Delivery I - Case Management, Susie Morrison

University of Montana Course Syllabi

No abstract provided.

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Psyc 336.02: Child And Adolescent Psychological Disorders, D. Balfour Jeffrey Jan 2003

Psyc 336.02: Child And Adolescent Psychological Disorders, D. Balfour Jeffrey

University of Montana Course Syllabi

No abstract provided.

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Psyc 330.02: Abnormal Psychology, Gyda Swaney Jan 2003

Psyc 330.02: Abnormal Psychology, Gyda Swaney

University of Montana Course Syllabi

No abstract provided.

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Psyc 330.01: Abnormal Psychology, Jennifer D. Gottlieb Jan 2003

Psyc 330.01: Abnormal Psychology, Jennifer D. Gottlieb

University of Montana Course Syllabi

No abstract provided.

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Psyc 265.01: Cognition, Wendy Sheilds Jan 2003

Psyc 265.01: Cognition, Wendy Sheilds

University of Montana Course Syllabi

No abstract provided.

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Pt 576.01: Synthesis Of Clinical Evaluation And Intervention, Steve Fehrer Jan 2003

Pt 576.01: Synthesis Of Clinical Evaluation And Intervention, Steve Fehrer

University of Montana Course Syllabi

No abstract provided.

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Pt 572.01: Practice And Administration, David L. Levison Jan 2003

Pt 572.01: Practice And Administration, David L. Levison

University of Montana Course Syllabi

No abstract provided.

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Pt 568.01: Neurorehabilitation Ii, Steve Fehrer Jan 2003

Pt 568.01: Neurorehabilitation Ii, Steve Fehrer

University of Montana Course Syllabi

No abstract provided.

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Pt 567.01: Principles Of Adult Neurological Rehabilitation, Charles T. Leonard Jan 2003

Pt 567.01: Principles Of Adult Neurological Rehabilitation, Charles T. Leonard

University of Montana Course Syllabi

No abstract provided.

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Pt 536.01: Neuroscience, Charles T. Leonard Jan 2003

Pt 536.01: Neuroscience, Charles T. Leonard

University of Montana Course Syllabi

No abstract provided.

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Pt 528.01: Therapeutic Interventions Ii, James J. Laskin, Ann K. Williams Jan 2003

Pt 528.01: Therapeutic Interventions Ii, James J. Laskin, Ann K. Williams

University of Montana Course Syllabi

No abstract provided.

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