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2003

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Transcriptional Inhibition Of Type I Collagen Gene Expression In Scleroderma Fibroblasts By The Antineoplastic Drug Ecteinascidin 743., Natalia Louneva, Biagio Saitta, David J Herrick, Sergio A. Jimenez Oct 2003

Transcriptional Inhibition Of Type I Collagen Gene Expression In Scleroderma Fibroblasts By The Antineoplastic Drug Ecteinascidin 743., Natalia Louneva, Biagio Saitta, David J Herrick, Sergio A. Jimenez

Department of Medicine Faculty Papers

We previously showed that COL1A1 expression is up-regulated at the transcriptional level in systemic sclerosis (SSc) fibroblasts and that the CCAAT-binding factor (CBF) is involved in this increased expression. Ecteinascidin 743 (ET-743) is a chemotherapeutic agent that binds with sequence specificity to the minor groove of DNA and inhibits CBF-mediated transcriptional activation of numerous genes. Therefore, we examined the effects of ET-743 on the increased COL1A1 expression in SSc fibroblasts. The drug caused a potent and dose-dependent inhibition of type I collagen biosynthesis, which reached 70-90% at 700 pM without affecting cell viability. The same drug concentration caused 60-80% reduction …


The Hilltop 10-10-2003, Hilltop Staff Oct 2003

The Hilltop 10-10-2003, Hilltop Staff

The Hilltop: 2000 - 2010

No abstract provided.


Washington University Record, October 10, 2003 Oct 2003

Washington University Record, October 10, 2003

Washington University Record

No abstract provided.


Crusader, October, 10, 2003, College Of The Holy Cross Oct 2003

Crusader, October, 10, 2003, College Of The Holy Cross

Student Newspapers

The student newspaper for the College of the Holy Cross in Worcester, Massachusetts. Articles include coverage of campus events and issues, sports, editorials and special features.


Montana Kaimin, October 10, 2003, Students Of The University Of Montana, Missoula Oct 2003

Montana Kaimin, October 10, 2003, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.


The Daily Egyptian, October 09, 2003, Daily Egyptian Staff Oct 2003

The Daily Egyptian, October 09, 2003, Daily Egyptian Staff

October 2003

No abstract provided.


October 9, 2003, James Madison University Oct 2003

October 9, 2003, James Madison University

The Breeze, 2000-2009

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.


The Murray State News, October 9, 2003, The Murray State News Oct 2003

The Murray State News, October 9, 2003, The Murray State News

Murray State University Collection

No abstract provided.


The Antelope, University Of Nebraska At Kearney Oct 2003

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.


The Comment, October 9, 2003, Bridgewater State College Oct 2003

The Comment, October 9, 2003, Bridgewater State College

The Comment

No abstract provided.


Central Florida Future, Vol. 36 No. 14, October 9, 2003 Oct 2003

Central Florida Future, Vol. 36 No. 14, October 9, 2003

Central Florida Future

Vandals rip flags from classrooms; Traffic accidents on rise near UCF; A vote for Wonder Woman won't work; It's back to class for adults who want to teach.


Commonwealth Times 2003-10-09 Oct 2003

Commonwealth Times 2003-10-09

Commonwealth Times, 1969-

No abstract provided.


Daily Eastern News: October 09, 2003, Eastern Illinois University Oct 2003

Daily Eastern News: October 09, 2003, Eastern Illinois University

October

No abstract provided.


Spectator 2003-10-09, Editors Of The Spectator Oct 2003

Spectator 2003-10-09, Editors Of The Spectator

The Spectator

No abstract provided.


The Pacifican October 9, 2003, University Of The Pacific Oct 2003

The Pacifican October 9, 2003, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.


The Cowl - Vol 67 - No. 8 - Oct 9, 2003 Oct 2003

The Cowl - Vol 67 - No. 8 - Oct 9, 2003

The Cowl

The Cowl - student newspaper of Providence College. Vol 67 - No. 8 - October 9, 2003. 24 pages.


Vista: October 09, 2003, University Of San Diego Oct 2003

Vista: October 09, 2003, University Of San Diego

USD Vista (1965-)

No abstract provided.


Montana Kaimin, October 9, 2003, Students Of The University Of Montana, Missoula Oct 2003

Montana Kaimin, October 9, 2003, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.


Spectrum, Volume 22, Issue 5, Sacred Heart University Oct 2003

Spectrum, Volume 22, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Public Safety Holds "Rape Aggression Defense" -- Saving the Horseshoe Crab -- SHU Throws it All Away -- Columbus Day, the Disappearing Holiday -- Students Question Sports Page Safety -- A University on the Rise -- Study Abroad Goes Down Under -- "Queer Eye" Not For Every Guy -- Everything I Wanted: Meeting Vertical Horizon -- One Man Band Rocks Sacred Heart Financial Assistance -- Bars and Restaurants Snuff Out Smoking -- SHU Student Reflects on Walk for Cancer -- Maria Trades Sesame Street For Park Avenue -- Is There Any "Real" Left In Reality TV? -- Mike …


The Cord Weekly (October 8, 2003) Oct 2003

The Cord Weekly (October 8, 2003)

The Cord

No abstract provided.


Mustang Daily, October 8, 2003 Oct 2003

Mustang Daily, October 8, 2003

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.


The Winonan, Winona State University Oct 2003

The Winonan, Winona State University

The Winonan - 2000s

No abstract provided.


Prospectus, October 8, 2003, Rachel White-Domain, Patrick Yeagle, Tara Gray, Jordan Holmes, Mark Gillie, Leah Nordness, Jarrod Finn, Peter Gabriel Oct 2003

Prospectus, October 8, 2003, Rachel White-Domain, Patrick Yeagle, Tara Gray, Jordan Holmes, Mark Gillie, Leah Nordness, Jarrod Finn, Peter Gabriel

Prospectus 2003

No abstract provided.


Banner News, Laura Griffin, Darin Longman, April Walker, James Joy, Pam Snow, Lacey Dierks, Holly Losh, Wendy Goering, Laura Anderson, Josh Hutt Oct 2003

Banner News, Laura Griffin, Darin Longman, April Walker, James Joy, Pam Snow, Lacey Dierks, Holly Losh, Wendy Goering, Laura Anderson, Josh Hutt

Banner News

No abstract provided.


The Lumberjack, October 08, 2003 Oct 2003

The Lumberjack, October 08, 2003

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.


Panther- October 2003 - Vol. Lxxxi, No.6, Prairie View A&M University Oct 2003

Panther- October 2003 - Vol. Lxxxi, No.6, Prairie View A&M University

PV Panther Newspapers

No abstract provided.


Daily Eastern News: October 08, 2003, Eastern Illinois University Oct 2003

Daily Eastern News: October 08, 2003, Eastern Illinois University

October

No abstract provided.


Montana Kaimin, October 8, 2003, Students Of The University Of Montana, Missoula Oct 2003

Montana Kaimin, October 8, 2003, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.


The George-Anne, Georgia Southern University Oct 2003

The George-Anne, Georgia Southern University

The George-Anne

  • Off-Campus Vendors Charging Service Fee for EAGLEXPRESS Use
  • News Briefs
  • Campus Calendar
  • Only in America
  • Opinions
  • Sports
  • Classifieds, Comics, Etc
  • News


The Advocate (Vol. 1, Issue 2) Oct 2003

The Advocate (Vol. 1, Issue 2)

Student Newspaper (Amicus, Advocate...)

No abstract provided.