Digital Commons Network^™

Inhibition Of Hepatic Stellate Cell Collagen Synthesis By N-(Methy1amino)Isobutyric Acid, Thomas L. Freeman, Kusum K. Kharbanda, Dean Tuma, Mark Milliard

United States Public Health Resources

The increased deposition of extracellular matrix by hepatic stellate cells following liver injury, in a process known as activation, is considered a key mechanism for increased collagen content of liver during the development of liver fibrosis. We report that N- (methylamino)isobutyric acid (MeAIB), a specific inhibitor of System A-mediated amino acid uptake, reduces the accumulation of collagen in CFSC-2G hepatic stellate cell cultures and in a rat model of liver injury and fibrosis. Rat CFSC-2G cells were cultured in 0-5 mM MeAIB, and the accumulation and synthesis of collagen were measured by binding to Sirius red F3B and pulse-labeling with …

Effect Of Malondialdehyde-Acetaldehyde-Protein Adducts On The Protein Kinase C-Dependent Secretion Of Urokinase-Type Plasminogen Activator In Hepatic Stellate Cells, Kusum K. Kharbanda, Kris A. Shubert, Todd A. Wyatt, Michael F. Sorrell, Dean J. Tuma

United States Public Health Resources

Previous studies from our laboratory have shown that malondialdehyde-acetaldehyde-protein adducts (MAA adducts) are formed in hepatocytes of ethanol-fed rats and directly influence the hepatic stellate cells (HSCs) to induce their secretion of chemokines and to up-regulate their expression of adhesion molecules. Since protein kinase C (PKC) is known to play a major role in many diverse intracellular signal transduction processes, we investigated whether MAA adducts influence the function of HSCs via a PKC-dependent pathway. HSCs in culture were exposed to MAA adducts, and PKC activity was determined. We observed a time- and concentration-dependent activation of PKC when cultures were exposed …

Ata2-Mediated Amino Acid Uptake Following Partial Hepatectomy Is Regulated By Redistribution To The Plasma Membrane, Thomas L. Freeman, Geoffrey M. Thiele, Dean J. Tuma, Tina K. Machu, Mark E. Mailliard

United States Public Health Resources

System A, the Na⁺-dependent amino acid transport activity, is encoded by the ATA2 gene and up-regulated following partial hepatectomy (PH), and its competitive inhibition interferes with liver regeneration. Rabbit polyclonal antibody was raised against a portion of the ATA2 gene product followed by immunodetection of ATA2 in isolated liver plasma membrane and lysate. The level of ATA2 increased in the plasma membrane following PH, while the relatively high quantity of ATA2 found in liver lysate remained constant. We also have shown that Northern analysis of steady-state ATA2 mRNA revealed no significant change following PH. These data show that …

Family Preservation In Perspective, Anthony N. Maluccio, Edith Fein

Journal of Family Strengths

This essay traces the family preservation movement to its permanency planning roots; discusses the principles and underlying philosophy of the movement, and suggests the appropriate context for considering further development of child welfare services.

Family To Family: Child Welfare For The 21st Century, Jill S. Roberts, Theresa J. Early

Journal of Family Strengths

Child welfare services have undergone many revisions and transformations since their initiation. Some scholars trace the beginning of child welfare in the United States to events such as a 1655 Massachusetts conviction for maltreatment leading to the death of a 12-year-old boy (Watkins, 1990). The predominant philosophy of child welfare has shifted over time from an early emphasis on child saving, to child protection, to family preservation. Building on family preservation, one of the current transformations in child welfare that is taking place in isolated pockets to whole states, is family-centered, neighborhood-based services. One force behind implementation of this transformation …

Pc 655 Clinical Pastoral Education, Tapiwa N. Mucherera

Syllabi

Purpose: The purpose of this course is to provide students the opportunity to experience ministry and to reflect upon that experience. Clinical Pastoral Education is interfaith professional education for ministry. It brings theological students and ministers into supervised encounter with persons in crises. Out of an intensive involvement with persons in need, and the feedback from peers and teachers, students develop new awareness of themselves as persons and of the needs of those to whom they minister. From theological reflection on specific human needs of those to whom they minister. From theological reflection on specific human situations, they gain a …

Practitioner Perspectives On End-Of-Life Planning, Katherine M. Krage

Theses and Graduate Projects

It is becoming more common for practitioners to discuss advance directives, thereby affirming each person's right to participate in directing end-of-life care. However, little attention has been paid to models of end-of-life planning. This study, a secondary analysis of research completed in 18 La Crosse area health care organizations, explores the extent to which practitioners engage patients and surrogates in exploring values and goals while educating patients about advance directives. It also explores the communication process, including retrievability of directives. Despite uniform training throughout the community, the extent to which practitioners discuss treatment options with patients, families, and surrogates varies …

Community Capacity Building: How Are Low-Income Families And Communities Of Color Engaged In The Process?, Juanita Judie Cutler

Theses and Graduate Projects

An issue for policy-makers and community organizations across Minnesota is the lack of knowledge about how to engage low-income families and people of color in community decision-making and community capacity building efforts. A culturally diverse research team interviewed forty-nine community leaders who had been identified as change agents, had struggled to become leaders, were perceived as mentors, and/or were viewed as cultural leaders. A major theme of what worked for communities to engage the disenfranchised centered on the development of safe forums for dialogue to create insightful trusting and meaningful relationships and to better understand race, class and culture. A …

Washington University Magazine, Winter 2002

Washington University Magazine

No abstract provided.

Client Satisfaction In A Battered Women's Shelter, Sandra Kathleen Womeldorf

Theses and Graduate Projects

The purpose of this study is to survey and evaluate client satisfaction within a shelter for battered women. This descriptive study was a fuuctional learning tool for the agency, the community as well as for the purpose of the research study, Through an anonymous questionnaire developed by the researcher, participants were asked to complete questions on the five selected areas of focus in an effort to obtain the most recent reflections of women residing in a community shelter for abuse and violence. They were: client satisfaction within access to community resources, staff allocation of time, staff respect and benefit to …

Retaining Volunteers, Nancy A. Hudson

Theses and Graduate Projects

This study investigates what initially motivates a volunteer and if this motivation remains constant over time or if it changes. Using a modified Volunteer Functions Inventory, volunteers in a human service organization were questioned to determine their initial motivation and why they either remain active volunteers or no longer volunteer.

Volunteers have always been a component of the American culture. From the Minutemen of the American Revolution to today's volunteer firemen, volunteers are vital to the success of many organizations and programs. Recruiting volunteers can be as easy as "asking them", but once volunteers are recruited and trained, how does …

Pc 655 Clinical Pastoral Education, Tapiwa N. Mucherera

Syllabi

Purpose: The purpose of this course is to provide students the opportunity to experience ministry and to reflect upon that experience. Clinical Pastoral Education is interfaith professional education for ministry. It brings theological students and ministers into supervised encounter with persons in crises. Out of an intensive involvement with persons in need, and the feedback from peers and teachers, students develop new awareness of themselves as persons and of the needs of those to whom they minister. From theological reflection on specific human needs of those to whom they minister. From theological reflection on specific human situations, they gain a …

Marketplace Handwork Of India: Impacts On Artisan Capabilities, Mary A. Littrell, Marsha A. Dickson

Textile Society of America: Symposium Proceedings

At the 1998 TSA Symposium in New York City, we presented a paper that documented the work of three textile artisan enterprises. All embraced a fair trade approach to their work. Known as Alternative Trade Organizations (ATOs), these enterprises are deeply committed to a mission of sustainable, people-centered development (Littrell and Dickson 1997). More specifically, this fair trade partnership between textile artisans and retailers involves joint commitment to:

• paying fair wages within a local context,

• providing healthy and safe working conditions,

• sustaining the environment,

• promoting capacity building through business and technical training, and

• honoring cultural …

Marketplace Handwork Of India: Impacts On Artisan Capabilities, Mary A. Littrell, Marsha A. Dickson

Textile Society of America: Symposium Proceedings

At the 1998 TSA Symposium in New York City, we presented a paper that documented the work of three textile artisan enterprises. All embraced a fair trade approach to their work. Known as Alternative Trade Organizations (ATOs), these enterprises are deeply committed to a mission of sustainable, people-centered development (Littrell and Dickson 1997). More specifically, this fair trade partnership between textile artisans and retailers involves joint commitment to:

• paying fair wages within a local context,

• providing healthy and safe working conditions,

• sustaining the environment,

• promoting capacity building through business and technical training, and

• honoring cultural …

American Silk From A Marketing Magician: H.R. Mallinson & Co., Madelyn Shaw

Textile Society of America: Symposium Proceedings

Hiram Royal Mallinson, an ambitious and talented son of mid-nineteenth-century immigrants from Poland, entered the silk trade in 1893 as a salesman for the company of Pelgram & Meyer in Paterson, New Jersey. Just two years later Mallinson joined a new firm, Newwitter & Migel, headquartered in New York City, as head of sales. In 1900, Migel and Mallinson bought out Newwitter and renamed the firm M.C. Migel & Co.

Migel and Mallinson consciously targeted the novelty market and the high-end or “class” customer generally conceded to European concerns at the time. The company was regarded as progressive, its output …

Gold & Blue, Fall/Winter 2002, St. Mary's University- San Antonio, Texas

Gold & Blue

This is the Fall/Winter 2002 edition of Gold & Blue which is St. Mary's University's official school publication.

Susceptibility Of Raccoons (Procyon Lotor) To Infection With Mycobacterium Bovis, Mitchell V. Palmer, W. Ray Waters, Diana L. Whipple

Michigan Bovine Tuberculosis Bibliography and Database

Tuberculosis due to Mycobacterium bovis infection is endemic in white-tailed deer (Odocoileus virginianus) in the northeastern portion of the lower Michigan peninsula (USA). Various wild carnivores and omnivores, including raccoons (Procyon lotor), are infected with M. bovis within the endemic area. To investigate the pathogenesis of tuberculosis in raccoons and the likelihood of M. bovis transmission from infected raccoons to other susceptible hosts, we experimentally inoculated raccoons with single oral doses of M. bovis (ranging from 30 to 1.7 x 10⁵ colony forming units [CFU]), five daily oral doses of M. bovis (ranging from 10 …

Milk Containing Mycobacterium Bovis As A Source Of Infection For White-Tailed Deer Fawns (Odocoileus Virginianus), M. V. Palmer, W. R. Waters, D. L. Whipple

Michigan Bovine Tuberculosis Bibliography and Database

Setting:White-tailed deer represent the first wildlife reservoir of Mycobacterium bovis in the United States. The behavior of does with nursing fawns provides several potential mechanisms for disease transmission. Little information exists concerning transmission between doe and fawn, specifically transmammary transmission.

Objective: Determine if fawns can become infected by ingestion of milk replacer containing M. bovis, thus simulating transmission from doe to fawn through contaminated milk.

Design: Seventeen, 21-day-old white-tailed deer fawns were inoculated orally with 2x10⁸ CFU (high dose, n=5), 2.5 x 105 to 2.5 x 106 CFU (medium dose, n=5), and 1x10⁴ CFU (low …

Nebraska's Endangered Species Part 1: Introduction And The Insects, Brett C. Ratcliffe, Steve Spomer

University of Nebraska State Museum: Programs Information

There is now an ongoing, unprecedented loss of species diversity throughout the world as well as a decline in the absolute numbers of organisms from the smallest microorganism to the largest mammal. The current loss of biota has several causes. One is the destruction, conversion, or degradation of entire ecosystems with the consequent loss of entire assemblages of species. Another is the accelerating loss of individual species within communities or ecosystems as a result of habitat disturbance, pollution, and exploitation. Third, and more subtle, is the loss of genetic variability. Selective pressures such as habitat alteration, the presence of chemical …

The National Honors Report, Volume Xxiii, Number 1, Spring 2002

The National Honors Report

THE THREE R’S & MORE

RECRUITING

1. "Selling People on Honors Education" by Lydia Daniel & Joan Digby … l A challenge to honors folks to promote the value of honors education on the local level. With a generic press release that can be adapted to fit particular honors programs' or honors colleges' needs. How to promote honors as well as a specific program or college. How to buy the new third edition of Peterson's Honors Programs and Colleges. From the co-chairs of the NCHC's External Relations Committee.

1. A. PRE-COLLEGE PROGRAMS

2. "A Summer of Excellence" by Gerald T. Szymanski …

Scwds Briefs: Volume 17, Number 4 (January 2002)

Southeastern Cooperative Wildlife Disease Study: Publications

• CWD News from Nebraska and Kansas
• Tropical Bont Tick Threat: Amblyomma variegatum
• Avian vacuolar myelinopathy (AVM) was confirmed by SCWDS diagnosticians in two dead bald eagles and is suspected in another four decomposed eagle carcasses recovered since mid-November at Clarks Hill Lake along the Georgia/South Carolina border.
• The Office International des Epipoozties (OIE) agreed to restore the United Kingdom's Foot-and-Mouth Disease (FMD) free status without vaccination for the purposes of international trade.
• Raccoon Roundworms – Public Health Update: Baylisascaris procyonis
• CSF Control Targets Wild Boars: Classical swine fever (CSF), also called hog cholera, is …

Effect Of Motor Vehicle Emissions On Respiratory Health In An Urban Area, David L Buckeridge, Richard Glazier, Bart J Harvey, Michael Escobar, Carl Amrhein, John Frank

Office of the Provost

Motor vehicles emit particulate matter < 2.5 microm in diameter (PM(2.5)), and as a result, PM(2.5) concentrations tend to be elevated near busy streets. Studies of the relationship between motor vehicle emissions and respiratory health are generally limited by difficulties in exposure assessment. We developed a refined exposure model and implemented it using a geographic information system to estimate the average daily census enumeration area (EA) exposure to PM(2.5). Southeast Toronto, the study area, includes 334 EAs and covers 16 km(2) of urban area. We used hospital admission diagnostic codes from 1990 to 1992 to measure respiratory and genitourinary conditions. We assessed the effect of EA exposure on hospital admissions using a Poisson mixed-effects model and examined the spatial distributions of variables. Exposure to PM(2.5) has a significant effect on admission rates for a subset of respiratory diagnoses (asthma, bronchitis, chronic obstructive pulmonary disease, pneumonia, upper respiratory tract infection), with a relative risk of 1.24 (95% confidence interval, 1.05-1.45) for a log(10) increase in exposure. We noted a weaker effect of exposure on hospitalization for all respiratory conditions, and no effect on hospitalization for nonrespiratory conditions.

The Quality And Utilization Of Technical Education Trainers In Kenya, Moses W. Ngware, Fredrick Muyia Nafukho

Journal of STEM Teacher Education

No abstract provided.

Finding Common Ground, Marie C. Hoepfl

Journal of STEM Teacher Education

No abstract provided.

At Issue: Reflective Journal Writing Of Vocational Education Teachers During The Week Of September 11, 2001: Confronting Personal And Professional Demands, Janet Z. Burns, Karen Schaefer

Journal of STEM Teacher Education

No abstract provided.

Gender In School-To-School Transitions: How Students Choose Career Programs In Technical Colleges In Kenya, Isaac Mattemu Kithyo, Stephen Petrina

Journal of STEM Teacher Education

No abstract provided.

Maklumat Semasa, Bil.46 (1), 2002, Library University Of Malaya

Archival Material (2000s)

No abstract provided.

Comparative Epidemiology Of Scrapie Outbreaks In Individual Sheep Focks, C. A. Redman, P. G. Coen, R. M. Lewis, W. S. Dingwall, J. D. Foster, M. E. Chase-Topping, N. Hunter, M. Woolhouse, L. Matthews

Department of Animal Science: Faculty Publications

Data recording the course of scrapie outbreaks in 4 sheep flocks (2 in Cheviot sheep and 2 in Suffolks) are compared. For each outbreak the data on scrapie incidence and sheep demography and pedigrees cover periods of years or decades. A key finding is that the incidence of clinical cases peaks in sheep 2-3 years old, despite very different forces-of infection.This is consistent with age-specific susceptibility of sheep to scrapie, as has beenreported for cattle to bovine spongiform encephalopathy and for humans to variant Creutzfeldt-Jakob disease. Scrapie incidence was higher in ewes than rams and at certain times of years, …

Children's Associational Rights?: Why Less Is More, Emily Buss

Articles

No abstract provided.

Do Liberals And Conservatives Differ In Judicial Activism?, Frank H. Easterbrook

Articles

No abstract provided.