Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

1999

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 1861 - 1890 of 7528

Full-Text Articles in Entire DC Network

Maritime Pine For Western Australia - Revegetation On Farms Information Kit, David Bicknell, Department Of Conservation And Land Management Aug 1999

Maritime Pine For Western Australia - Revegetation On Farms Information Kit, David Bicknell, Department Of Conservation And Land Management

Natural resources published reports

Revegetation on farms

The Revegetation on Farms Project and the material in this Information Kit is targeted at the agricultural zone of Western Australia with less than 600 mm rainfall. Some of the information is valid outside this range.

All information is provided in good faith, to help make informed revegetation decisions leading to sustainable land use.

TreeNote No 20 - Weed control in eucalypts and pines

TreeNote No 21 - Insect pests of eucalypts and pines

In search of the perfect pine - David Gough (Article)

Farming carbon - Syd Shea (Article)


Smart Decisions, Beatriz Gomez Aug 1999

Smart Decisions, Beatriz Gomez

Theses

It is very often that parents and educators find themselves running out of words when it comes to explaining a sensitive topic to a child. Such topics include but are not limited to sex, abortion, adoption, pregnancy, divorce, drugs, and disease. A computer based game has been designed to help parents and educators address such sensitive topics. This software package consists of a series of two dimensional animations. All of the animations belong to the same story, which as it progress, gives the player the opportunity to make diverse decisions. Each decision leads the player through a different path, hence …


A Note On The Aymptotic Behavior Of The Heights In B-Tries For B Large, Charles Knessl, Wojciech Szpankowski Aug 1999

A Note On The Aymptotic Behavior Of The Heights In B-Tries For B Large, Charles Knessl, Wojciech Szpankowski

Department of Computer Science Technical Reports

No abstract provided.


Data Mining And Probabilistic Network-Based Mechanism For Data Warehousing, Mei-Ling Shyu, R. L. Kashyap Aug 1999

Data Mining And Probabilistic Network-Based Mechanism For Data Warehousing, Mei-Ling Shyu, R. L. Kashyap

Department of Electrical and Computer Engineering Technical Reports

A good multirmedia database managerment systerm (MDBMS) should be able to store, retrieve, and manage rich semantic data in multimedia database syst,ems. Due to the complexity of real-world applications, the number of databases and the volumes of data in databases have increased tremendously. With the explosive growth in the amount and complexity of data, how to effectively manage the network of databases and utilize the large amount of data becomes important. For this purpose, a probabilistic network-based mechanism for constructing a federation of data warehouses and speeding up information retrieval to facilitate the functionality of an MDBMS is proposed. Our …


Graduate Catalog, 1999-2002, New Jersey Institute Of Technology, New Jersey Institute Of Technology Aug 1999

Graduate Catalog, 1999-2002, New Jersey Institute Of Technology, New Jersey Institute Of Technology

Course Catalogs

No abstract provided.


Genetic And Structural Analyses Of Cytoplasmic Filaments Of Wild-Type Treponema Phagedenis And A Flagellar Filament-Deficient Mutant, Jacques Izard, William A. Samsonoff, Mary Beth Kinoshita, Ronald J. Limberger Aug 1999

Genetic And Structural Analyses Of Cytoplasmic Filaments Of Wild-Type Treponema Phagedenis And A Flagellar Filament-Deficient Mutant, Jacques Izard, William A. Samsonoff, Mary Beth Kinoshita, Ronald J. Limberger

Department of Food Science and Technology: Faculty Publications

Unique cytoplasmic filaments are found in the treponeme genus of spirochete bacteria. Their function is unknown, but their location underneath the periplasmic flagellar filaments (PFF) suggests a role in motility and/or cell structure. To better understand these unique structures, the gene coding for the cytoplasmic filaments, cfpA, was identified in various treponemal species. Treponema phagedenis cfpA was 2,037 nucleotides long, and the encoded polypeptide showed 78 to 100% amino acid sequence identity with the partial sequence of CfpA from T. denticola, T. vincentii, and T. pallidum subsp. pertenue. Wild-type T. phagedenis and a …


Deliberate Introductions Of Species: Research Needs, John J. Ewel, Dennis J. O'Dowd, Joy Bergelson, Curtis C. Daehler, Carla M. D'Antonio, Luis Diego Gómez, Doria R. Gordon, Richard J. Hobbs, Alan Holt, Keith R. Hopper, Colin E. Hughes, Marcy Lahart, Roger R. B. Leakey, William G. Lee, Lloyd L. Loope, David H. Lorence, Svata M. Louda, Ariel E. Lugo, Peter B. Mcevoy, David M. Richardson, Peter M. Vitousek Aug 1999

Deliberate Introductions Of Species: Research Needs, John J. Ewel, Dennis J. O'Dowd, Joy Bergelson, Curtis C. Daehler, Carla M. D'Antonio, Luis Diego Gómez, Doria R. Gordon, Richard J. Hobbs, Alan Holt, Keith R. Hopper, Colin E. Hughes, Marcy Lahart, Roger R. B. Leakey, William G. Lee, Lloyd L. Loope, David H. Lorence, Svata M. Louda, Ariel E. Lugo, Peter B. Mcevoy, David M. Richardson, Peter M. Vitousek

Svata M. Louda Publications

Research questions about introductions

Several research questions need to be answered to help ensure that proposed introductions are done wisely and safely.

Guarding against risks without sacrificing benefits:
How can the potential benefits and costs of introductions best be evaluated in economic, environmental, and social terms?
Should all introductions be regulated?
How different must organisms or recipient ecosystems be from those assessed previously to warrant independent assessment?
When is it appropriate to assess and regulate taxa other than species?
What are appropriate ecological and political boundaries for regulation?

Alternatives to introductions:
How and when can indigenous organisms be domesticated so …


A Statewide Survey Of Special Education Administrators And School Psychologists Regarding Functional Behavioral Assessment, J. Ron Nelson, Maura L. Roberts, Robert B. Rutherford Jr., Sarup R. Mathur, Lisa A. Aaroe Aug 1999

A Statewide Survey Of Special Education Administrators And School Psychologists Regarding Functional Behavioral Assessment, J. Ron Nelson, Maura L. Roberts, Robert B. Rutherford Jr., Sarup R. Mathur, Lisa A. Aaroe

Department of Special Education and Communication Disorders: Faculty Publications

The 1997 amendments to the Individuals with Disabilities Education Act (IDEA) mandate that schools evaluate, through the process of a functional behavioral assessment, those students with disabilities who are exhibiting significant behavior problems which may lead to suspension and expulsion. We conducted a statewide survey of special education administrators and school psychologists to examine their views of the relative effectiveness, usability, suitability, and practicability of functional behavioral assessment procedures for two types of problem behaviors (i.e., low-level chronic or low frequency unique problem behaviors). The results suggest that special education administrators and school psychologists are generally supportive of the use …


Systematics Of The Eucestoda: Advances Toward A New Phylogenetic Paradigm And Observations On The Early Diversification Of Tapeworms And Vertebrates, Eric P. Hoberg, Scott Lyell Gardner, Ronald A. Campbell Aug 1999

Systematics Of The Eucestoda: Advances Toward A New Phylogenetic Paradigm And Observations On The Early Diversification Of Tapeworms And Vertebrates, Eric P. Hoberg, Scott Lyell Gardner, Ronald A. Campbell

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Evolutionary relationships of the Eucestoda have received intense but sporadic attention over the past century. Since 1996, the landscape has dramatically changed with respect to our knowledge of the phylogenetic relationships among the tapeworms. The 2nd International Workshop for Tapeworm Systematics (IWTS) held in Lincoln, Nebraska in October of that year provided the catalyst for development of novel hypotheses for inter-and intra-ordinal phylogeny. The working-group structure of the 2nd IWTS and results of phylogenetic studies are briefly introduced in the present manuscript. Higher-level phylogenies derived from parsimony analysis of independent data bases representing comparative morphology or molecular sequences were largely …


Modeling Macrophytes Of The Columbia Slough, Oregon, Chris Berger, Scott A. Wells Aug 1999

Modeling Macrophytes Of The Columbia Slough, Oregon, Chris Berger, Scott A. Wells

Civil and Environmental Engineering Faculty Publications and Presentations

The Columbia Slough is a tidally influenced freshwater system of wetlands, channels, and lakes located within the Portland, Oregon metropolitan area at the confluence of the Willamette and Columbia Rivers. It is a eutrophic water body susceptible to algae blooms and crashes and periods of high pH which violate water quality standards. High nutrient loads from groundwater principally controls algae productivity. Past structural changes to the Columbia Slough have included filling of wetlands and lakes and the construction of levees, dikes, culverts and irrigation channels. These changes have altered the natural flow dynamics creating an environment more conducive to eutrophication. …


Signiture Analysis Of Fetal Blood Velocity Waveforms, Ronald Soule Aug 1999

Signiture Analysis Of Fetal Blood Velocity Waveforms, Ronald Soule

Theses

Doppler blood velocity waveform analysis is conducted to affect clinical diagnosis. Current analysis codes developed at RIT posses the capability to assess gross hemodynamic parameters such as heart rate, mean pulse velocity, peak systolic velocity and also the beat to beat variability of these parameters. These computer algorithms have, however, lacked the ability to determine hemodynamic indices such as the pulsatility and resistance index as well as the AB ratio. This latter deficiency stems from an algorithmic need to accurately determine end diastolic velocity in every cardiac cycle. The current thesis specifically augments current algorithms to accurately compute end diastolic …


41st Rocky Mountain Conference On Analytical Chemistry Aug 1999

41st Rocky Mountain Conference On Analytical Chemistry

Rocky Mountain Conference on Magnetic Resonance

Final program, abstracts, and information about the 41st annual meeting of the Rocky Mountain Conference on Analytical Chemistry, co-sponsored by the Colorado Section of the American Chemical Society and the Rocky Mountain Section of the Society for Applied Spectroscopy. Held in Denver, Colorado, August 1-5, 1999.


Evidence Supporting The Recent Origin And Species Status Of The Timberline Sparrow, John Klicka, Robert M. Zink, Jon C. Barlow, W. Bruce Mcgillivray, Terry J. Doyle Aug 1999

Evidence Supporting The Recent Origin And Species Status Of The Timberline Sparrow, John Klicka, Robert M. Zink, Jon C. Barlow, W. Bruce Mcgillivray, Terry J. Doyle

Ornithology Program (HRC)

The Timberline Sparrow (Spizella taverneri), although originally described as a species, is currently classified as a subspecies of the more widespread Brewer's Sparrow (S. breweri). We investigated the taxonomic status and recent evolutionary history of these species by comparison of both morphological and molecular characters. Morphometric comparisons using 6 external and 18 skeletal measurements show that S. taverneri specimens from two widely separated populations (Yukon and southwestern Alberta, Canada) are indistinguishable with respect to size yet are significantly larger (by 3%) than representatives of several breweri populations. Analysis of 1,413 base pairs of mitochondrial DNA (mtDNA) for 10 breweri and …


Experiential Avoidance And Alcohol Dependence Relapse, Darrah Ann Westrup Aug 1999

Experiential Avoidance And Alcohol Dependence Relapse, Darrah Ann Westrup

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project examined whether experiential avoidance differentiated alcohol-dependent relapsers from non-relapsers. Eighty-five subjects receiving inpatient addiction treatment were assessed for degree of experiential avoidance (using a new measure called the AAQ, coping style, alcohol severity, anxiety, and depression. It was hypothesized that the AAQ, along with avoidant coping and negative life events, would differentiate those who subsequently relapsed with those who did not. Three months after discharge, subjects were contacted for follow-up to determine whether or not they had relapsed, and to what degree they had experienced negative and/or positive life events. A series of discriminant function analyses determined that …


Agriculture Western Australia's Centre For Cropping Systems - Northam, Agriculture Western Australia Aug 1999

Agriculture Western Australia's Centre For Cropping Systems - Northam, Agriculture Western Australia

Grain and other field crops published reports

Agriculture Western Australia's Centre for Cropping Systems in York Road, Northam, was established as a centre of excellence for research, development and extension into cropping systems.

Its role is to stimulate the contribution of ideas from individuals, groups and organisations with an interest in research, development, and extension relating to innovative, profitable and sustainable crop-based farming systems.

The Centre for Cropping Systems is part of a regional network with strong links to Agriculture Western Australia's Crop Improvement Institute based at South Perth, the Dryland Research Institute at Merredin and the Avondale Research Fann at Beverley. It also links with universities …


Identifying Structural Differences In Mixed Mesophytic And Northern Hardwood Forests On The Monongahela National Forest Using Remote Sensing Data, John Richard Bender Jr. Aug 1999

Identifying Structural Differences In Mixed Mesophytic And Northern Hardwood Forests On The Monongahela National Forest Using Remote Sensing Data, John Richard Bender Jr.

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis is a study of field data and remotely sensed data to evaluate the structural diversity, texture, spectral and spatial differences between forest stands of three age classes (50--69, 70--89, and >90 years) in the Cheat District on the Monongahela National Forest. The structural diversity was determined with foliage-height profiles for 48 stands ranging from 52 to 148 years old. Structural diversity was highest in the 70--89 and >90 year old stands and lowest in the 50--69 year old stands. The structural characteristics of the 70--89 and >90 year old stands were characterized by greater numbers of larger trees, …


Social And Economic Impacts Of Wild Harvested Products, Brent Bailey Aug 1999

Social And Economic Impacts Of Wild Harvested Products, Brent Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wild harvested products (WHPs) are plants and animals, or parts of them, that are harvested from their native habitats for sale, trade, or personal consumption, by harvesters who are not employed by others to collect them. WHPs embody a range of economic, cultural, and social values held by residents of rural areas. However, the products' significance to harvesters and communities, and their conservation status, have until recently been little studied.;Assessments of social and economic impacts of WHPs on households and communities were conducted in West Virginia and West Africa. Interviews with harvesters, dealers, and resource managers revealed the range of …


Effects Of Gender And Social Support On Cardiovascular Reactivity To A Speech Task, Lynda M. Ciano-Federoff Aug 1999

Effects Of Gender And Social Support On Cardiovascular Reactivity To A Speech Task, Lynda M. Ciano-Federoff

Graduate Theses, Dissertations, and Problem Reports (ETD)

The effects of gender and social support on cardiovascular reactivity to a speech task were examined in this study. Seventeen males and seventeen females performed a speech task, once in the presence of an experimenter with their significant other present offering encouragement and support and once in the presence of the experimenter alone. Both blood pressure (i.e., systolic (SBP) and diastolic (DBP)) and hemodynamic parameters (i.e., heart rate (HR), cardiac output (converted to cardiac index, CI), stroke volume (converted to stroke index, SI), and pre-ejection period (PEP)) were measured during the speech tasks. In addition, total peripheral resistance (TPR) was …


Social Competence And Theory Of Mind Understanding In Elementary School Children With Attention Deficits, Amy Wilson Strange Aug 1999

Social Competence And Theory Of Mind Understanding In Elementary School Children With Attention Deficits, Amy Wilson Strange

Graduate Theses, Dissertations, and Problem Reports (ETD)

The following study explored relations between theory of mind understanding, social competence, and auditory processing in elementary school children with and without Attention Deficit Hyperactivity Disorder. Children in this study were recruited from a local elementary school, as well as two outpatient clinics. Scores on measures of false belief and recursive thinking, social skills (Social Knowledge Interview, Harter, Emotion labels), and auditory processing (Test of Auditory Processing Skills, Revised) were obtained along with teacher ratings of children's self-regulation as measured by Attention and Hyperactivity subscales of the Conners' Teacher Rating Scale - Revised. Language ability was also measured using the …


Alterations Of Vascular Endothelial Nitric Oxide Synthase Activity And Substrate Availability In Chronic Renal Disease, Shen Xiao Aug 1999

Alterations Of Vascular Endothelial Nitric Oxide Synthase Activity And Substrate Availability In Chronic Renal Disease, Shen Xiao

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hypertension and other cardiovascular complications are the major causes of hospitalization and death in patients with chronic renal diseases (CRD). Our laboratory has previously reported that total nitric oxide (NO) production is decreased in CRD. The overall objective in my present series of studies is to investigate the alterations of endothelial NO system and the possible mechanisms in CRD.;In the study on CRD patients who still have residual renal function (∼30% of normal GFR), we found that the plasma from these patients did not affect L-arginine transport into endothelial cells but significantly inhibited endothelial nitric oxide synthase (eNOS) activity from …


Identification And Control Of Dynamical Systems, Eugene Robert Mihaliuk Aug 1999

Identification And Control Of Dynamical Systems, Eugene Robert Mihaliuk

Graduate Theses, Dissertations, and Problem Reports (ETD)

Practical methods, based upon linear systems theory, are explored for applications to nonlinear phenomena and are extended to a larger class of problems. An algorithm for stabilizing, characterizing, and tracking unstable steady states and periodic orbits in multidimensional dynamical systems is developed and applied to stabilize and characterize an unstable four-cell flame front of the Kuramoto-Sivashinsky equation with six unstable degrees of freedom. A new method is presented for probing chemical reaction mechanisms experimentally with perturbations and measurements of the response. Time series analysis and the methods of linear control theory are used to determine the Jacobian matrix of a …


Inhibition Of The Aminopeptidase From Aeromonas Proteolytica By Aliphatic Alcohols. Characterization Of The Hydrophobic Substrate Recognition Site, Leila Ustynyuk, Brian Bennett, Tanya Edwards, Richard C. Holz Aug 1999

Inhibition Of The Aminopeptidase From Aeromonas Proteolytica By Aliphatic Alcohols. Characterization Of The Hydrophobic Substrate Recognition Site, Leila Ustynyuk, Brian Bennett, Tanya Edwards, Richard C. Holz

Physics Faculty Research and Publications

Seven aliphatic and two aromatic alcohols were tested as reporters of the substrate selectivity of the aminopeptidase from Aeromonas proteolytica (AAP). This series of alcohols was chosen to systematically probe the effect of carbon chain length, steric bulk, and inhibitor shape on the inhibition of AAP. Initially, however, the question of whether AAP is denatured in the presence of aliphatic alcohols was addressed. On the basis of circular dichroism (CD), electronic absorption, and fluorescence spectra, the secondary structure of AAP, with and without added aliphatic alcohols, was unchanged. These data clearly indicate that AAP is not denatured in aliphatic alcohols, …


Perceptions Of Students And Teachers Regarding Agriculture In Leflore County, Mississippi, Ronald L. Howard Aug 1999

Perceptions Of Students And Teachers Regarding Agriculture In Leflore County, Mississippi, Ronald L. Howard

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to assess the perceptions of public high school teachers and students in Leflore County, Mississippi regarding agriculture and provide baseline data regarding the perception of high school students and teachers residing in an agriculturally dependent county with no agricultural education program. A population of 240 high school teachers and students was surveyed for their perceptions regarding agriculture. All three public high schools in Leflore County were represented in this study. Over 65% of the sample resided in the city, while only 3% live on a farm. The major finding of this study was that …


Experiences Of Selected West Virginia Agriculture Teachers Who Have Established Aquaculture Units In Their Schools And Have Taught Aquaculture Classes For Two Years Or More, Paul A. Lovett Aug 1999

Experiences Of Selected West Virginia Agriculture Teachers Who Have Established Aquaculture Units In Their Schools And Have Taught Aquaculture Classes For Two Years Or More, Paul A. Lovett

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study was designed to ascertain and record the experiences of West Virginia agriculture teachers who have established aquaculture units in their schools and have taught aquaculture for two or more years. This study will provide suggestions to those who may yet integrate aquaculture into their curriculum.;A "Focused Interview" was used to gather qualitative data from eight-experienced aquaculture teachers. The respondents answered eight questions that were asked and recorded by the secretary in agricultural and environmental education at WVU to eliminate bias and improve the validity of this study.;The results of this study found that agricultural teachers used aquaculture to …


Effect Of Allopurinol And Hemin On Some Biological Markers Of Aging In Broiler Chickens, Dinesh Singh Rathore Aug 1999

Effect Of Allopurinol And Hemin On Some Biological Markers Of Aging In Broiler Chickens, Dinesh Singh Rathore

Graduate Theses, Dissertations, and Problem Reports (ETD)

Uric acid has been hypothesized as one of the most important antioxidants in limiting the accumulation of advanced glycolated endproducts in broiler breeder hens. This study was designed to quantitatively manipulate the plasma uric acid concentrations using hemin and allopurinol and determine its effect on skin pentosidine, shear force value of Pectoralis major muscle, plasma glucose, body and breast weight, and chemiluminescence induced oxidative stress in broiler chickens. Allopurinol decreased plasma uric acid, ranging from 26% to 74%, with the most pronounced effect at wk 22. Hemin increased plasma uric acid concentrations between 11 and 14%. Skin pentosidine levels increased …


Associations Of Egg Production With The Major Histocompatibility Complex In Broiler Breeder Hens, Becky Jean Tarleton Aug 1999

Associations Of Egg Production With The Major Histocompatibility Complex In Broiler Breeder Hens, Becky Jean Tarleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study documents effects of the major histocompatibility complex (MHC) on reproductive traits in a flock of Cobb X Cobb broiler breeder hens. The objective was to determine if the MHC affects reproduction of non-congenic broiler breeder hens. Genomic DNA was isolated from 35 hens. Restriction fragment length polymorphism (RFLP) analysis was performed on each sample, using a chicken class II MHC probe (Xu et al. 1989). Restriction endonuclease digestion using PvuII resulted in polymorphisms in all birds. Five polymorphic bands were identified. The largest bands, 7.5 kb and 5.4 kb, were present in one and four hens respectively. The …


Influence Of Selection For Breast Muscle Mass On Ph And Metabolism Of Supracoracoideus Muscle From Male And Female Turkey, John Kenneth Yost Aug 1999

Influence Of Selection For Breast Muscle Mass On Ph And Metabolism Of Supracoracoideus Muscle From Male And Female Turkey, John Kenneth Yost

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this study was to determine if selection for increased breast muscle mass has affected the supracoracoideus muscle's ability to regulate pH during physical activity in turkeys. The lightweight male line (LM) had the greatest breast muscle mass as a percent of body weight (p < 0.0001), a lower average pH (6.68; p < 0.0001), and greater Lactate Dehydrogenase (293 mmol NADH min-1mug-1 ; p < 0.0001) and Glyceraldehyde Phosphate Dehydrogenase (0.4452 mmol NADH min-1mug-1; p < 0.05) activities than the HM and FL lines. The LM line had the highest ratio (2.33:1) (p < 0.05) of adult to neonatal myosin. Hens had greater breast muscle mass as a percent of body weight than males (p < 0.0001), and a lower average pH (6.62; p < 0.05). This study showed that genetic selection for breast muscle mass resulted in an increased ratio of adult to neonatal myosin and an increased anaerobic capacity, which may predispose birds to a lower ultimate pH during physical activity.


Verbal Aggression In Sibling Relationships, Shannon Marie Brogan Aug 1999

Verbal Aggression In Sibling Relationships, Shannon Marie Brogan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The major focus of this study was to further investigate the area of sibling verbal aggression. In order to research this area, students at West Virginia University and their siblings were asked to complete a questionnaire about verbal aggression. The results showed that self-reports of verbal aggression were consistent with other reports. Results also showed that male same sexed siblings were more likely to display more verbal aggression than all other combinations. Results revealed that males self-reports of verbal aggression were higher than females. Results also indicated that males are reported by their siblings to be more verbally aggressive than …


Thanatos-Eros, Being-Non Being: Psychoanalytic - Existential Connection, Ryan D. Miller Aug 1999

Thanatos-Eros, Being-Non Being: Psychoanalytic - Existential Connection, Ryan D. Miller

Student Work

This Thesis examines and shows the relationship between Sigmund Freud's Death Instinct and Life Instinct Theories and their relation to the Existential concepts of Being and Non- Being. These intertheoretical concepts were interpreted in order for practitioners of Psychotherapy to be better acquainted with both concepts; so they may be better used in the mental health professions. A discussion of the two concepts as seen in Existential Psychotherapy and Freudian Psychoanalytic thought was presented and expanded upon and the relationship between the two was explained.


Global Cns Gene Transfer For A Childhood Neurogenetic Enzyme Deficiency: Canavan Disease., Paola Leone, Christopher G Janson, Scott J Mcphee, Matthew J During Aug 1999

Global Cns Gene Transfer For A Childhood Neurogenetic Enzyme Deficiency: Canavan Disease., Paola Leone, Christopher G Janson, Scott J Mcphee, Matthew J During

Department of Neurosurgery Faculty Papers

The neurogenetic prototypic disease on which we chose to test our gene therapy strategy is Canavan disease (CD). CD is an autosomal recessive leukodystrophy associated with spongiform degeneration of the brain. At present the disease is uniformly fatal in affected probands. CD is characterized by mutations in the aspartoacylase (ASPA) gene, resulting in loss of enzyme activity. In this review, recent evidence is summarized on the etiology and possible treatments for CD. In particular, we discuss two gene delivery systems representing recent advances in both viral and liposome technology: a novel cationic liposome-polymer-DNA (LPD) complex, DCChol/DOPE-protamine, as well as recombinant …