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1999

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Cover And Contents Jan 1999

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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The Use Of Polypeptide Probes Selected Fromartificial Peptide Libraries For The Recognitionand Differentiation Of Dna Sequences, Erol Ömer Atalay, Berri̇n Erdağ, Beyazit Çirakoğlu Jan 1999

The Use Of Polypeptide Probes Selected Fromartificial Peptide Libraries For The Recognitionand Differentiation Of Dna Sequences, Erol Ömer Atalay, Berri̇n Erdağ, Beyazit Çirakoğlu

Turkish Journal of Medical Sciences

In the novel approach suggested here, we examined the use of polypeptide probes selected from artificial peptide libraries for the identification of the differences in dsDNA sequences which are potential targets for the genetic diseases. As a model system two target DNAs which are the polymerase chain reaction (PCR) products of the two hage-display vector multiple cloning sites (MCS) differing at 18 base pair long has been used. In the production of the target sequences biotinylated primers were used in PCR. The polypeptide probes obtained from artificial peptide library by the selection of phage-display techniques. Identified clones bearing the candidate …

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Technical Approach To Generate Polyclonalantibodies Against Bacterially Expressed Gst-Pyk-C: Evaluation Of Cross-Reaction Andrecognition In Some Mammalian And Yeast Celllysates, Ayşegül Ayyildiz Jan 1999

Technical Approach To Generate Polyclonalantibodies Against Bacterially Expressed Gst-Pyk-C: Evaluation Of Cross-Reaction Andrecognition In Some Mammalian And Yeast Celllysates, Ayşegül Ayyildiz

Turkish Journal of Medical Sciences

Pyk-2 is a protein tyrosine kinase, highly expressed in human hippocampus, dentate gyrus and olfactory bulb. In this study, polyclonal antibodies against the C-terminal of pyk-2, starting from Pro-759, were generated by injecting rabbits with the bacterially expressed GST fusion construct, generated by cloning the C-terminal domain of pyk-2 into pGEX-3X vector and affinity purification to increase the specificity of recognition. Anti-pyk-C was shown to recognize a 123 kD band in Western Blots of 293 cells transfected with pyk-2, as well as PC-12, COS and 3T3 cells and not to cross-react with FAK transfected Sf-21 lysates, in spite of high …

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Opioid Modulation Of The Pre-Ovulatory Lh Surge In The Conscious Rat: Involvement Of Indolamines, Bayram Yilmaz, Desmond P. Gilmore Jan 1999

Opioid Modulation Of The Pre-Ovulatory Lh Surge In The Conscious Rat: Involvement Of Indolamines, Bayram Yilmaz, Desmond P. Gilmore

Turkish Journal of Medical Sciences

Endogeonus opioid peptides play an important role in the generation of the pre-ovulatory LH surge. We investigated the interrelationship between the oploid and indolaminergic systems in the regutalion of LH secretion, and the involvement of \mu-and \kappa-opioid subtypes in this process. Concsious female rats bearing cannula in the femoral artery were injected intraperitoneally with \mu-(diamorphine) and \kappa -(U-50488H) opioid agonists either alone or with their respective antagonists, naloxone and MR2266, on pro-oestrus. Blood samples were collected hourly between 15.00 and 19.00 and plasma LH levels were measured by RIA. 5-HT and 5-HIAA concentrations were determined by HPLC-ECD in the MPOA, …

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Effects Of Cyclosporin A On Rat Pancreatic \Beta And Dcells And Glucose Levels (An Immunocytochemicalstudy), Kadri̇ Güven, Fi̇gen Öztürk, Fahretti̇n Keleşti̇mur Jan 1999

Effects Of Cyclosporin A On Rat Pancreatic \Beta And Dcells And Glucose Levels (An Immunocytochemicalstudy), Kadri̇ Güven, Fi̇gen Öztürk, Fahretti̇n Keleşti̇mur

Turkish Journal of Medical Sciences

The effects of cyclosporin A (CsA) on rat pancreatic islet \beta and D cells and plasma glucose levels at doses of 50 mg/kg body weight applied for 20 days were investigated. Fifteen Swiss Albino rats were used as the study group and 5 were the control group. Rat pancreatic islet \beta and D cells were stained immunocytochemically by anti-insulin and anti-somatostation antibodies. \beta and D cells from 15 different islets were evaluated qualitatively and quantitatively. Plasma glucose changes were also compared between the study and the control group. The pancreas morphology was found to be normal in both groups by …

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The Effects Of Hyaluronic Acid On Myringoplasty Inrats, Ahmet Kutluhan, Serdar Uğraş, Emi̇n İnalkaç, Nusret Akpolat Jan 1999

The Effects Of Hyaluronic Acid On Myringoplasty Inrats, Ahmet Kutluhan, Serdar Uğraş, Emi̇n İnalkaç, Nusret Akpolat

Turkish Journal of Medical Sciences

Tympanic membrane perforations arise from a variety of causes. Some of them require myringoplasty. In this study, we used hyaluronic acid, a polysaccharide with high-molecular- weight which may be obtained commercially and affects modulations of cell function. An experimental myringoplasty was performed on rats in which a chronic dry tympanic membrane perforation was formed. While physiological saline was embedded in Gelfoam ® which was supported under and over the graft, in group 1, hyaluronic acid embedded gelfoam was used in group 2. Better epithelization, less calcification and scar tissue were established in group 2 myringoplasties. This study shows that hyaluronic …

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The In Vitro Effects Of The Antimalarial Drug Primaquine, On The Activities Of Some Enzymes In Human Erythrocyte Lyzates, Meltem Müftüoğlu, Nazmi̇ Özer Jan 1999

The In Vitro Effects Of The Antimalarial Drug Primaquine, On The Activities Of Some Enzymes In Human Erythrocyte Lyzates, Meltem Müftüoğlu, Nazmi̇ Özer

Turkish Journal of Medical Sciences

The effect of primaquine on the enzymatic antioxidant defence mechanisms of erythrocytes were determined by measuring the activities of the below enzymes, before and after 30 minutes of incubation of hemolyzates with 1 mM primaquine at 37°C. Among the enzymes studied glucose-6- phosphate dehydrogenase seemed the most sensitive enzyme; 57 % and 78 % inhibition at zero (due to the binding of primaquine to NADP binding site) and 30 minutes of incubation (due to the reactive oxygen species), respectively. Catalase, superoxide dismutase, and glutathione-S-transferase were less sensitive to primaquine-derived reactive oxygen species: 33, 11, and 0 % inhibition at the …

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Estimation Of The Prevalence Of A Disease From Screening Tests, Ergun Karaağaoğlu Jan 1999

Estimation Of The Prevalence Of A Disease From Screening Tests, Ergun Karaağaoğlu

Turkish Journal of Medical Sciences

Since most secreening tests are not 100% accurate, the proportion of subjects screened positive in such a test cannot be used as an estimate of the population prevalence. Methods which take sensitivity and the specificity into consideration should be employed in such circumstances. Estimation of the population prevalence as defined by Gartand Buck may produce results which are outside the range of 0 to 1. A Bayesian approach avoids results of this kind, but requires complicated computations. Lew and Levy proposed an approximation to the Bayesian estimate of the population prevalence. To simplify the computations, I propose a method which …

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Spinal Anesthesia In Children With Rectalpremedication With Midazolam, Ketamine Andatropine, Bi̇nnur Sarihasan, Si̇bel Bariş, Fadi̇me Yeşi̇ltaş, Ayla Tür, Haydar Şahi̇noğlu, Emre Üstün, Fuat Güldoğuş, Deni̇z Karakaya, Zeynep Kayhan Jan 1999

Spinal Anesthesia In Children With Rectalpremedication With Midazolam, Ketamine Andatropine, Bi̇nnur Sarihasan, Si̇bel Bariş, Fadi̇me Yeşi̇ltaş, Ayla Tür, Haydar Şahi̇noğlu, Emre Üstün, Fuat Güldoğuş, Deni̇z Karakaya, Zeynep Kayhan

Turkish Journal of Medical Sciences

This study was designed to investigate the anxiolytic effects as well as acceptance of spinal anesthesia after rectally administered midazolam, ketamine and atropine for postoperative sedation in children. Spinal anesthesia is an easy and safe method in the pediatric age group especially for outpatients. Spinal anesthesia was administered to 20 patients, aged between 2 months and 2 years, premedicated with 0.5 mg/kg midazolam + 5 mg/kg ketamine + 0.02 mg/kg atropine rectally. During vein puncture 14 children were asleep, 5 children were anxious and 1 child was crying and during spinal anesthesia 7 children were asleep, 10 children were anxious …

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The Comparison Of The Efficacy Aerobic Exercisesversus Strengthening, Stretching Andmobilization Exercises In Subacute And Chroniclow Back Pain, Ayşe Karan, Lütfi̇ye Müslümanoğlu, Semi̇h Aki, Mustafa Fi̇li̇z, Emel Özcan Yildiz, Ender Berker Jan 1999

The Comparison Of The Efficacy Aerobic Exercisesversus Strengthening, Stretching Andmobilization Exercises In Subacute And Chroniclow Back Pain, Ayşe Karan, Lütfi̇ye Müslümanoğlu, Semi̇h Aki, Mustafa Fi̇li̇z, Emel Özcan Yildiz, Ender Berker

Turkish Journal of Medical Sciences

The aim of this study was to investigate and compare the efficacy of aerobic exercises versus strengthening, stretching and mobilization exercises in patients with subacute or chronic low back pain. Forty patients were recruited for the study and randomly allocated to two groups. All patients were evaluated at admission, mid-treatment and termination of the program by visual analog scale (VAS), face scale, weekly analgesic intake and Million visual analog scale for pain. They were also scored by Roland-Morris scale and Oswestry scale for functional impairment. Beck depression inventory was used to evaluate depression and lumbar range of motion was measured …

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The Evaluation Of Elongated Styloid Process In Panoramic Radiographs In Edentulous Patients, Memduha Gülhal Bozkir, Hasan Boğa, Fahri̇ Dere Jan 1999

The Evaluation Of Elongated Styloid Process In Panoramic Radiographs In Edentulous Patients, Memduha Gülhal Bozkir, Hasan Boğa, Fahri̇ Dere

Turkish Journal of Medical Sciences

It has been estimated that between 2% to 28% of the general adult population has radiographic evidence of elongated styloid process. In adults, the mean radiographic lenght of the styloid process is 20 to 30 mm and its tip is located between the external and internal carotid arteries, just lateral to the tonsillar fossa. Eagle's syndrome occurs when an elongated styloid process or ossified stylohyoid ligament causes recurrent throat pain or foreign body sensation, dysphagia, or facial pain. It may develop inflammatory changes or impinge on the adjacent arteries or sensory nerve endings, leading to the symptoms described. To study …

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Chromosome 2 Fragility- 48, Xxyy Syndrome, Öztürk Özdemi̇r, E. Ferda Perçi̇n, İlhan Sezgi̇n Jan 1999

Chromosome 2 Fragility- 48, Xxyy Syndrome, Öztürk Özdemi̇r, E. Ferda Perçi̇n, İlhan Sezgi̇n

Turkish Journal of Medical Sciences

No abstract provided.

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Cover And Contents Jan 1999

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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Diastolic Dysfunction: Pathogenesis, Therapy Andthe Importance Of Doppler Echocardiography, Fati̇h Yalçin, James Thomas Jan 1999

Diastolic Dysfunction: Pathogenesis, Therapy Andthe Importance Of Doppler Echocardiography, Fati̇h Yalçin, James Thomas

Turkish Journal of Medical Sciences

Diastolic dysfunction is characterized by increased resistance to ventricular filling, inappropriate upward shift of the diastolic pressure-volume relationship and exercise intolerance. Inappropriate tachycardia, decreased diastolic compliance and impaired systolic relaxation lead to diastolic dysfunction. Optimal therapy will depend on the type and pathophysiologic phase of disease. Doppler echocardiography is a valuable tool to diagnose diastolic dysfunction and therapeutic effects of drugs on diastolic function in different groups of patients. Recently a lot of studies have been going on this subject.

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Cloning And Transcriptional Activation Of Thevitamin D Receptor (Amphibians)1, Meral Güzey Jan 1999

Cloning And Transcriptional Activation Of Thevitamin D Receptor (Amphibians)1, Meral Güzey

Turkish Journal of Medical Sciences

The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is an integral part of the body's calcium regulatory system. Mammalian and avian VDR genes were isolated, sequenced and characterized. In this study we cloned the vitamin D receptor from amphibians. We received a cDNA library prepared from amphibian (frog) tissues and prepared a cDNA probe based on the avian VDR. We screened the library and located the positive clones. Complete structure of VDR gene has been compared with other species and concluded that it shares 79%, 73%, 73% and 75% identity at the aminoacid level with the …

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The Effect Of Dietary Calcium Intake On Plasma Renin Activity And Parathormon In Deoxycorticosteron Salt Hypertension, Ali̇ Gözey, Besi̇m Özaykan, Sai̇me Paydaş, Ayşe Doğan Jan 1999

The Effect Of Dietary Calcium Intake On Plasma Renin Activity And Parathormon In Deoxycorticosteron Salt Hypertension, Ali̇ Gözey, Besi̇m Özaykan, Sai̇me Paydaş, Ayşe Doğan

Turkish Journal of Medical Sciences

The effects of diets containing 2% and 4% calcium (Ca) on deoxycorticosteron (DOC) salt hypertension were studied in 29 male rats weighting 210-260 g. Rats were categorized into four groups: Group I: control rats (6), group II: DOC hypertensive group (n=8), group III: DOC-low Ca diet (2% CaCl 2 ) (8) and group IV: DOC-high Ca diet (4% CaCl_2 ) (n=7). During the six weeks follow up period, indirect systolic blood pressure (SBP) was highest in group II while it was found to be less increased in group III and IV. Weight increase was lowest in group IV (P

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The Therapeutic Effect Of Nifedipine As A Ca+2entry Blocker On Experimental Transientischemic Retina, Murat Kaya, Cemal Gündoğdu Jan 1999

The Therapeutic Effect Of Nifedipine As A Ca+2entry Blocker On Experimental Transientischemic Retina, Murat Kaya, Cemal Gündoğdu

Turkish Journal of Medical Sciences

We evaluated the effect of nifedip-ine, an L-type voltage sensitive Ca+2 channel (VSCC) blocker, on the onset of neuronal damage induced by transient ischemia of guinea pig retinas in vivo. The animals were divided into two groups. In the first group 2 mg/kg Nifedipine was administered intraperi-toneally, while only 2 cc/kg NaCl 0.9% solution was given to the second group thirty minutes before the ischemic insult. Seven days after the temporary ligation of bilateral common carotid arteries for 45 minutes, the animals were dispatched and the eyes were enucleated for histopathologic analysis. It was observed that in the Nifedipine treated …

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Teratogenic Effects Of Electromagnetic Fields Onthe Skeletal Systems Of Rat Fetuses, Hi̇kmet Hassa, Ömer T. Yalçin, Ni̇lgün Basmak, Hamza Esen, Duygu Koyuncu, Nevi̇n Kurtdere, Reşat N. Aşti Jan 1999

Teratogenic Effects Of Electromagnetic Fields Onthe Skeletal Systems Of Rat Fetuses, Hi̇kmet Hassa, Ömer T. Yalçin, Ni̇lgün Basmak, Hamza Esen, Duygu Koyuncu, Nevi̇n Kurtdere, Reşat N. Aşti

Turkish Journal of Medical Sciences

OBJECTIVE: To evaluate the potential teratogenic effects of electromagnetic fields on the skeletal systems of rat fetuses. MATERIAL AND METHODS: Twenty-five pregnant rats, which had been exposed to electromagnetic fields with frequencies of vertical 50 Hz and horizontal 20 kHz and a total maximum intensity of 10 milligauss, during their pregnancies, were the study group, while 15 pregnant rats were the control group. One hunderd eighty-nine and 125 fetuses obtained from the study and the control group respectively, were evaluated for abnormalities and variations in the skeletal system. The chi-square test was used for the statistical analysis. RESULTS: Major abnormality, …

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The Prevalance Of Diseases With Diarrhoeaamong Children Under Five Years Old In Differentsocio-Economical Levels, Ali̇ İhsan Bozkurt, Servet Özgür, Bi̇rgül Özçirpici Jan 1999

The Prevalance Of Diseases With Diarrhoeaamong Children Under Five Years Old In Differentsocio-Economical Levels, Ali̇ İhsan Bozkurt, Servet Özgür, Bi̇rgül Özçirpici

Turkish Journal of Medical Sciences

This study was carried out on a representative sample consisting of 429 households in Gaziantep. The prevalance of diseases with diarrhoea was found to be 22.9% among children under five years old in the two weeks preceding the survey. It was observed that 51.3% of children with diarrhoea were taken to a medical facility, the mean duration of the diarrhoea was 4.5±3.8 days, and the rate of children with diarrhoea during the preceding 24 hours was 11.8%. It was also determined that the rate of children with diarrhoea whose intake of fluids was increased was 65.1%, the ratio of children …

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Treatment Of Cervical Spondylosis By Anteriorsubtotal Vertebrectomy And Iliac Bone Fusion, Mehmet Yaşar Kaynar, Pami̇r Erdi̇nçler, Ali̇ Kafadar, Murat Hanci, Emi̇n Özyurt, Ali̇ Çeti̇n Sarioğlu Jan 1999

Treatment Of Cervical Spondylosis By Anteriorsubtotal Vertebrectomy And Iliac Bone Fusion, Mehmet Yaşar Kaynar, Pami̇r Erdi̇nçler, Ali̇ Kafadar, Murat Hanci, Emi̇n Özyurt, Ali̇ Çeti̇n Sarioğlu

Turkish Journal of Medical Sciences

There is no ideal surgical technique for cervical spondylosis. The choice of surgical procedure remains controversial. A series of 25 patients who had undergone subtotal vertebrectomy and iliac bone fusion between 1985 and 1995 were reviewed. There were 19 men and 6 women with an average age of 55.6 years. All of the patients had cervical myelopathy and /or radiculopathy due to multi-level spondylosis and 7 with associated ossification of the posterior longitudinal ligament. In 6 patients 1 vertebral body, in 10 patients 2 vertebral bodies, and in 9 patients 3 vertebral bodies were resected. After a mean 15-month follow-up …

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Some Variations In The Formation Of The Brachialplexus In Infants*, Ahmet Uzun, Sai̇t Bi̇lgi̇ç Jan 1999

Some Variations In The Formation Of The Brachialplexus In Infants*, Ahmet Uzun, Sai̇t Bi̇lgi̇ç

Turkish Journal of Medical Sciences

The anatomical variations of the brachial plexus in human have clinical significance to surgeons, radiologists and anatomists. We studied some variations in the formation of 130 brachial plexuses in sixty-five infant cadavers (34 males, 31 females; aged 1-7 days). The brachial plexus consisted of the 5 th , 6 th , 7 th , and 8 th cervical spinal nerves and 1 st thoracic spinal nerve (69.23%). We found that among the 130 plexuses, 30.77% also received a contribution from C4 (Fig.1, A ) . The variations in the formation of brachial plexuses were classified into three groups. Group 1 …

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The Federal Volunteer Protection Act: Does Congress Want To Play Ball?, Kenneth W. Biedzynski Jan 1999

The Federal Volunteer Protection Act: Does Congress Want To Play Ball?, Kenneth W. Biedzynski

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

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In-Situ Measurement Of Denitrification In The Elk Valley Aquifer, Allen Schlag Jan 1999

In-Situ Measurement Of Denitrification In The Elk Valley Aquifer, Allen Schlag

Theses and Dissertations

Groundwater serves more than half of North Dakota's population as a drinking water source. Nitrate (NO₃¯) is a common groundwater contaminant associated with fertilizers, septic systems and livestock waste in shallow unconfined aquifers. As a suspected carcinogen and cause of potentially lethal methemoglobinemia in infants, the natural attenuation of NO₃¯ by denitrification can be an important process in keeping groundwater as a reliable source of clean drinking water for North Dakota. Organic carbon is often considered the most important electron donor for the chemical reduction of NO₃¯ into harmless nitrogen gas. However, several studies have shown that inorganic electron donors …

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Timing Isn't Everything: The Supreme Court Decides That A Presidential Cancellation Does Indeed "Walk, Swim, And Quack" Like A Line-Item Veto, Thomas C. Weisert Jan 1999

Timing Isn't Everything: The Supreme Court Decides That A Presidential Cancellation Does Indeed "Walk, Swim, And Quack" Like A Line-Item Veto, Thomas C. Weisert

Seton Hall Law Review

No abstract provided.

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J Am Coll Dent 1999 66 2 Jan 1999

J Am Coll Dent 1999 66 2

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

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J Am Coll Dent 1999 66 1 Jan 1999

J Am Coll Dent 1999 66 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

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The Forbes Decision: Has The Court Closed The Public Forum On Candidate Speech?, Monica Mardikian Jan 1999

The Forbes Decision: Has The Court Closed The Public Forum On Candidate Speech?, Monica Mardikian

Seton Hall Law Review

No abstract provided.

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The Housing Crisis Facing Low Income Families, César E. Torres Jan 1999

The Housing Crisis Facing Low Income Families, César E. Torres

Seton Hall Law Review

No abstract provided.

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Electronic Stacks: Using Web Sources In Reference Service, Di Su Jan 1999

Electronic Stacks: Using Web Sources In Reference Service, Di Su

Publications and Research

The awareness of Web sources in reference service has risen in recent years, as many reference librarians have become more Internet-minded. During the reference process, we often ask ourselves: can this question be answered by using the Web? The use of Web sources is expanding the amount of available reference information, enhancing individual libraries’ collection, and hence, providing better user service. There are many benefits in using the Web sources in reference service. There are also some drawbacks. Some useful Web sources are reviewed. The Web, when used properly, provides reference librarians with a valuable resource option to help improve …

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Clearing The Air: Four Propositions About Property Rights And Environmental Protection, Daniel H. Cole Jan 1999

Clearing The Air: Four Propositions About Property Rights And Environmental Protection, Daniel H. Cole

Articles by Maurer Faculty

No abstract provided.

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