Digital Commons Network^™

Progestin Stimulation Of The Protooncogene C-̲M̲Y̲C In T47d Human Breast Cancer Cells, Kristy Ann Blankenship

Theses, Dissertations and Capstones

Moore and co-workers have previously demonstrated that progestins stimulate the growth of T47D human breast cancer cells. We now investigate the possibility that progestins might transactivate the protooncogcne c-myc as part of the mechanism for growth stimulation. Treatment of T47D cells with the synthetic progestin R5020 results in a rapid, dose-dependent increase in c-myc mRNA. This stimulation is evident as early as 5 minutes, increases up to 4-fold at 1 hour, and then returns toward basal levels. The optimal concentration of R5020 for induction of c-myc gene expression is 10 nM, which is within the physiologically relevant range of hormone …

The Mechanics And Regulation Of Rat Aortic Smooth Muscle Contraction: Implications Of Cytoskeletal Remodeling, Protein Phosphorylations, And Microtubule-Based Kinase Transport, Alison Summers Battistella-Patterson

Theses, Dissertations and Capstones

The exact nature of the mechanisms and the regulation of vascular smooth muscle contraction is not well understood. To better understand these processes, we examined two systems involved in smooth muscle contraction, the cytoskeleton and the protein kinases. In order to study the role of the cytoskeleton in smooth muscle contraction, we examined the contractile and mechanical effects of cytoskeleton disruption. We found that the relationship between passive tension applied to aortic rings and the resulting increase in tissue length was nearly linear over the range of 1 g to 15 g. However, even with increasing tissue length, within the …

The Role Of Domain I In Laminin Chain Assembly, George D. Kamphaus

Theses, Dissertations and Capstones

Laminin, a major component of basement membrane, is a trimeric glycoprotein comprised of three chains - α, β and γ (Burgeson et al., 1994). An order for trimer assembly has been deduced: first, the β and γ chains bind to form a dimer and subsequently α is added to complete the trimer (I. Hunter et al., 1990 & 1992; Utani et al., 1994 & 1995). The C-terminal portions, found within the protein structural domain I of the p and y chains, are implicated in dimer and trimer formation by biochemical studies performed extracellularly (Utani, et al., 1994 & 1995; Nomizu …

Characterization Of The Promoter And Upstream Activation Sequences Of Sporulation-Specific Genes Spr1 (Ssg1) And Spr2 In Saccharomyces Cerevisiae, Sharmini S. Soosaithasan

Theses, Dissertations and Capstones

Sporulation is a developmental process in which temporally distinct sets of genes regulate the processes of meiosis and ascospore formation. Sporulation-specific genes are classified into early, middle, and late genes based on their peak time of expression during sporulation. Regulation of two late genes, SPR1 and SPR2, was studied. The function of SPR2 is unknown. Its regulatory region contains two Mid Sporulation Elements (MSE) repeated in tandem that are sufficient to confer sporulation-specific regulation to a CYCl-lacZ reporter. These sequences have UAS (upstream activation sequence) properties, as each 14 base pair element is sufficient to confer sporulation-specific regulation …

Molecular Mapping Of The Fatty (F) (Formerly Corpulent) Gene In The La/N Rat Obesity Model, Kenneth G. Butz

Theses, Dissertations and Capstones

The LA/N-corpulent (cp) rat obesity model was a congenic rat strain developed at the National Institutes of Health by C. T. Hansen . The LA/N-cp rat originated from breeding the Koletsky rat, possessing the corpulent gene, with the normotensive LA/N inbred rat. The autosomal recessive single gene mutation, cp, produces obesity with hyperphagia, hyperinsulinemia and elevated activities of liver and skeletal muscle lipogenic enzymes in the LA/N-cp rat model. The Zucker-fatty mutation, which was mapped to rat chromosome , resulted in a comparable, but not identical obesity syndrome. Breeding experiments by Yen et al …

Oral History Interview: Jesse J. Trent, Jesse J. Trent

0064: Marshall University Oral History Collection

This interview is one of series conducted concerning the Oral History of Appalachia. Mr. Trent grew up in the coal camps of Logan County, West Virginia. In this interview, he tells of his life growing up in those camps and how it is different from today. He had nine other siblings. His mother (Allifair Trent) was a housewife and his father (Sampson Trent) was a coal miner. Mr. Trent discusses: his childhood; his family; the mining community; the mining business; his employment history (including mine working and as a bus driver); stories about the mines; how he met his wife …

Oral History Interview: Florestine Hopkins Holland, Florestine Hopkins Holland

0064: Marshall University Oral History Collection

This interview is one of series conducted concerning Oral Histories of African-American women who taught in West Virginia public schools. Florestine Hopkins Holland began teaching in Martinsville, Virginia, in an elementary school during 1943. She gives us very detailed information about her family throughout the interview, including family history research she has done (which revealed many white relatives), her children, her son Ronando becoming the first and only black student to be president of the State and Student Council, her mother making costumes and graduation clothes for the children at school, her marriages (including her divorce and her first husband), …

Free Lunch Or Cheap Fix?: The Emissions Trading Idea And The Climate Change Convention, David M. Driesen

College of Law - Faculty Scholarship

Emissions trading has become a key component of U.S. environmental legal regimes. The U.S. has successfully lobbied to make international environmental benefit trading, an expanded form of emissions trading, a part of international efforts to address the threat of global climate change through the Framework Convention on Climate Change and the Kyoto Protocol to that Convention. Legal scholars have lauded emissions trading as a "free lunch" that will encourage innovation, enhance democratic accountability, and reduce the cost of environmental cleanup. This article argues that emissions trading functions as a cheap fix, reducing short-term costs while tending to lessen innovation and …

Current Concepts Review - Corrosion Of Metal Orthopaedic Implants, Joshua J. Jacobs, Jeremy L. Gilbert, Robert M. Urban

Biomedical and Chemical Engineering - All Scholarship

No abstract provided.

Eastside Landmark: A History Of The East Los Angeles Community Union, 1968-1993, John Chávez

eBooks

"Established in 1968 to improve conditions in the barrio of East Los Angeles, the East Los Angeles Community Union has had a pronounced impact on the area, providing social services, helping increase political representation, and, most notably, promoting economic development, particularly through extensive real estate dealings. The history of TELACU is especially significant because it has provided a model for community development in other Mexican-American neighborhoods throughout the Southwest (including Oakland, California; San Antonio, Texas; Embudo, New Mexico; and Phoenix, Arizona).

TELACU and other ethnic community development corporations also offer a successfully tested general model of cooperative economic development for …

Arginine To Glutamine Substitutions In The Fourth Module Of Xenopus Interphotoreceptor Retinoid-Binding Protein, Mark S. Braiman, Claxton A. Baer, Ellen E. Van Niel, Jeffrey W. Cronk, Michael T. Kinter, Nicholas E. Sherman, Federico Gonzalez-Fernandez

Chemistry - All Scholarship

Interphotoreceptor retinoid-binding protein (IRBP) is unusual for a lipid-binding protein in that its gene is expressed uniquely by cells of photoreceptor origin and consists of four homologous repeats, each coding for a module of~300 amino acid residues. All-trans retinol binding domains, which appear to be present in each module, are composed of conserved hydrophobic regions [Baer et al, Exp Eye Res 1998; 66:249-262]. Here we investigate the role of highly conserved arginines contained in these regions.

The Coming Age Of Scarcity : Preventing Mass Death And Genocide In The Twenty-First Century, Michael N. Dobkowski, Isidor Wallimann

Books

The structure of the book is simple. The first part analyzes major forces having an impact on the survivability of civilization as we know it into the twenty-first century. It outlines the challenges we face, including overpopulation, pressure upon the land, migration, ecological damage, and social instability. In part two, we present more detailed discussion of the problem of scarcity and how it relates to conflict. The authors in this section argue that the current level of human activity is unsustain­able. They demonstrate that population growth in particular affects the natural world and can affect the social order and international …

The Key 1998, Bowling Green State University

BGSU Key Yearbooks

Bowling Green State University 1998 Key Yearbook

1998-1999 Bulletin

Graduate Bulletins

Volume 108, Number 1

Scanned from the copy held in the Registrar's Office.

The Swami And The Rorschach: Spiritual Practice, Religious Experience, And Perception, Diane Jonte-Pace

Religious Studies

I propose that the Rorschach test might serve well as such a method for investigating religion, spirituality, psychological structure, and cognition. In addition, it might bring some clarity to the debate between the decontextualists and the constructivists. In this essay I discuss three unique Rorschach studies that, in my view, represent an important step toward such a psychology of religious experience and examine their implications for Forman's decontextualist thesis.

Performance, Catherine M. Bell

Religious Studies

Scholars use many terms to talk about religious activity, most basically, liturgy, worship, ritual, and recently performance. Although these terms reflect different perspectives and assumptions, they share the supposition that ceremonial actions characterized by a self-conscious formality and traditionalism are a primary aspect of religion and an important focus in any project to understand religion. Nonetheless, most theories of religion since the Enlightenment have tended to emphasize the more cognitive aspects of religion no matter how rooted these were thought to be in emotional, doctrinal, or communal experience. In the last several decades, however, religious studies has become (as have …

Winter 1998 Law Letter, Georgia State University College Of Law

The Law Letter

No abstract provided.

Symposia

Journal of the Minnesota Academy of Science

Abstracts from the Symposia Papers given at the 66^th Annual Meeting for the Journal of the Minnesota Academy of Science.

Winchell Papers

Journal of the Minnesota Academy of Science

Abstracts from the Winchell Papers given at the 66^th Annual Meeting for the Journal of the Minnesota Academy of Science.

Back Matter

Journal of the Minnesota Academy of Science

No abstract provided.

Front Matter

Journal of the Minnesota Academy of Science

No abstract provided.

Regenerative Biology: New Tissues For Old, David L. Stocum

Journal of the Minnesota Academy of Science

Throughout the human life cycle, tissues are regenerated either continuously to maintain tissue integrity in the face of normal cell turnover or in response to acute or chronic damage due to trauma or disease states. Blood, epithelia of skin and tubular organs, hair and nails, and bone marrow are examples of human tissues which regenerate continuously as well as in response to damage. Bone, muscle, adrenal cortex and kidney epithelium also regenerate in response to damage, and bone is continually remodeled in response to stress vectors.

The response of many other vital tissues to damage, however, is not regeneration but …

Perspectives On Liver Regeneration, Janeen H. Trembley, Clifford J. Steer

Journal of the Minnesota Academy of Science

No abstract provided.

Tissue Engineering: At The Interface Between Engineering, Biology And Medicine, Brenda Ogle, Priti Gairola, Jodi Balik, Daniel L. Mooradian

Journal of the Minnesota Academy of Science

No abstract provided.

Umm Telephone Extensions 1998-99, University Of Minnesota, Morris

UMN Morris Directories

No abstract provided.

Bacterial Analysis Of Refrigerated Human Milk Following Infant Feeding, Rachel Renee Brusseau

CUP Undergraduate Research

The number of infants who are breastfed is on the rise, as is the number of women in the workforce. Many women who choose breastfeeding after returning to work, express milk during the day and store this milk for a future feeding. When infants do not finish a bottle of expressed breastmilk, doctors recommend unfinished portions be thrown away. This study examined bacterial levels in expressed, partially consumed breastmilk that was stored for 48 hours at 4-6° C. A portion of unconsumed milk was examined as a control. Samples were taken every 12 hours for bacterial analysis. Tests were performed …

1998 Scholar's Day Schedule, State University Of New York At Cortland

Transformations

Scholars' Day was established in 1997 and is a day-long conference devoted to showcasing the wide array of scholarship, research and creative activities occurring on campus. In 2012, a new emphasis on student research lead to a name change to Transformations: A Student Research and Creativity Conference. This event focuses on student research, which is defined as an original investigation or creative activity through the primary efforts of a student or group of students. The work should show problem-solving skills and demonstrate new conceptual outcomes.

1998 Scholar's Day Abstracts, State University Of New York At Cortland

Transformations

Scholars' Day was established in 1997 and is a day-long conference devoted to showcasing the wide array of scholarship, research and creative activities occurring on campus. In 2012, a new emphasis on student research lead to a name change to Transformations: A Student Research and Creativity Conference. This event focuses on student research, which is defined as an original investigation or creative activity through the primary efforts of a student or group of students. The work should show problem-solving skills and demonstrate new conceptual outcomes.

The Effects Of Intestinal Microbes On Nestling Tree Swallow (Tachycineta Bicolor) Growth And Development, Natasha Brock

McNair Scholars Journal

Subclinical doses of broad-spectrum antibiotics (BactrimTM and ClavamoxTM) were given to half of the nestlings in tree swallow broods as the other half received a placebo. There were no differences in the microbial communities between the treated and untreated birds onND5or on ND19. Physical measures on ND19 showed that treated nestlings had significantly smaller tarsi and larger mass.

Managing The Iatrogenic Risks Of Risk Management, Jonathan Baert Wiener

RISK: Health, Safety & Environment (1990-2002)

Analogizing to concerns that led the practice of medicine to shift from a specialist to a team-based approach, Dr. Wiener suggests that public and environmental health objectives would be better served if, e.g., regulatory jurisdiction were less atomized.