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1997

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Reversal Of Parkinsonian Symptoms In Primates By Antagonism Of Excitatory Amino Acid Transmission: Potential Mechanisms Of Action., I. J. Mitchell, C. B. Carroll Jan 1997

Reversal Of Parkinsonian Symptoms In Primates By Antagonism Of Excitatory Amino Acid Transmission: Potential Mechanisms Of Action., I. J. Mitchell, C. B. Carroll

Peninsula Medical School

Parkinsonism is characterised by overactive glutamatergic transmission in the cortico-striatal and subthalamo-medial pallidal pathways. Local blockade of glutamatergic transmission in these pathways can alleviate parkinsonian symptoms. The effectiveness of the treatment, however, is often limited by the simultaneous appearance of unwanted side-effects. These side-effects, including ataxia and dissociative anaesthesia, are particularly problematic when N-methyl-D-aspartate (NMDA) antagonists are used. In an attempt to overcome these problems we have attempted to manipulate excitatory amino acid (EAA)-mediated neurotransmission indirectly by targeting the NMDA receptor associated modulatory sites. We review evidence which demonstrates that antagonists for both the NMDA associated glycine and polyamine sites …


Growth And Performance Of Small And Medium Sized Enterprises In Rural Peripheral Locations, Matthew John Gorton Jan 1997

Growth And Performance Of Small And Medium Sized Enterprises In Rural Peripheral Locations, Matthew John Gorton

Plymouth Business School Theses

Since the 1970s the number of small firms in the UK has risen, but at temporally and spatially uneven rates. These trends have heightened interest in the role of local economies in shaping small firm growth and performance. This thesis considers the growth and performance of small and medium sized enterprises (SMEs) based in rural peripheral locations in the UK. In measuring this, quantitative survey work was undertaken in rural core as well as rural peripheral localities, with the former acting as a benchmark for comparison. lJtilising returns from standardised postal questiormaires both the performance of the agricultural and non-agricultural …


Junior High School Students' Perception Of The Messages Conveyed Through The Lyrics Of Rock Music, Steven M. Russey Jan 1997

Junior High School Students' Perception Of The Messages Conveyed Through The Lyrics Of Rock Music, Steven M. Russey

University of the Pacific Theses and Dissertations

The purpose of this study was to discover whether or not the accompaniment of a lyric sheet while listening to rock music would aid a student's correct identification of the message conveyed by that song. Participants included one 7th and one 8th grade class of "gifted" students (N = 62). Other elements examined involved students' judgment of the messages as negative or positive, as well as the tonality of each song as pleasant or unpleasant and how these judgments related to correct or incorrect identification of the messages. Results indicated that there was no statistically significant difference regarding correct or …


Video Games, Aggression, And The New Esrb Ratings System, Kelly Stephen Meyers Jan 1997

Video Games, Aggression, And The New Esrb Ratings System, Kelly Stephen Meyers

University of the Pacific Theses and Dissertations

The current study sought to accomplish three goals: (a) examine the short term effects of the current hi-tech aggressive video games on children who play them; (b) improve upon the methodology of previous studies by using a combination of self-report, physiological (heart rate), and behavioral observations (Bobo doll aggression) together in one study; and (c) examine how the new Entertainment Software Rating Board's (ESRB) ratings system relates to aggression in children who have played aggressive and non-aggressive video games. It was hypothesized that (a) playing video games which depict interpersonal aggression would lead to increased aggression in children, and that …