Digital Commons Network^™

Predictive Natural Language Metrics Of Alzheimer's Disease And Cognitive Decline Trend Analysis, Zerui Ma

Computer Science and Engineering Theses and Dissertations

Inspired by Dr. David Snowden's Nun Study, which linked early-life Propositional Idea Density (PID) to later-life Alzheimer's disease, this thesis investigates two questions: whether fine-tuned Transformer-based large language models (LLM) can detect cognitive decline from patient speech transcripts with meaningful feature attribution, and whether longitudinal PID trends are observable across large-scale internet and academic text corpora. We evaluate dementia prediction on the DementiaBank Pitt Corpus and conduct an exploratory longitudinal PID analysis across seven diverse datasets spanning up to 29 years and over 12.6 million documents. This work suggests that linguistic ability metrics, traditional PID metrics and novel LLM-based analysis, …

Machine Learning And Formal Methods In Quantum Chemistry: Theory And Application, Ishna Satyarth

Computer Science and Engineering Theses and Dissertations

In recent years, the progress in inter-disciplinary application of machine learning and artificial intelligence (ML/AI) have truly transformed various fields, from weather forecasting and drug development to medical diagnostics, energy, and sustainability. Computational chemistry uses computational tools to model, predict, analyze, and explain chemical phenomena, while the Quantum chemistry specifically uses techniques based on quantum mechanics (as opposed to classical mechanics or empirical models). Quantum chemistry or Computational chemistry has also observed a momentum in application of ML techniques over the past decade significantly accelerating results and providing valuable insights into vast datasets, often surpassing traditional methods.

This dissertation explores …

Torá: A Description Of A Dormant Chapacuran Language From Legacy Materials, Akasha Synclair

Linguistics ETDs

Torá, an Amazonian language of the Chapacuran family, went dormant as the Torá people survived colonization. Yet, in the early 1920’s, over 600 Torá words, phrases, and sentences were documented. Despite interest by today’s Torá community in language revitalization, no comprehensive analysis of the data has been undertaken. This project used methods of linguistic reconstitution, cross linguistic comparison, and the creation of an open-access database to produce a phonological and morphosyntactic analysis of Torá. Phonological findings of particular interest include evidence for vowel harmony and variable oralization of nasals. In structure, Torá is very similar to related languages, displaying a …

Three Essays In Applied Gender Economics, Ayus Mitra

Economics Theses and Dissertations

This dissertation contributes to intersection of applied microeconomics and economics of gender. Each chapter attempts to examine how natural experiments as well as endogenous selection processes impact overall outcomes in gender violence, women empowerment as well as mobility and work decisions. It also highlights the role of gender-specific attitudes and norms in shaping outcomes. The first chapter investigates the relationship between the rise in popularity of the Bharatiya Janata Party (BJP) in 2013 and reported crimes against women in India. The analysis utilizes state-panel data from 2009–2016, employing difference-in-differences and event study estimation strategies. The findings indicate that reported incidents …

Bayesian Spatiotemporal Model For Counterfactual Estimation In Socioeconomic Studies, Duwani W. Gonzalez

Statistical Science Theses and Dissertations

Impact evaluations of regional development programs often require estimating counterfactual outcomes for a small number of treated regions using survey-based areal data. In practice, evaluators typically rely on two-group quasi-experimental methods such as propensity score matching (PSM) and Difference-in-Differences (DiD). These approaches perform poorly when only a few regions receive treatment, and when the set of observed covariates is limited or only partially relevant. Moreover, they typically do not explicitly exploit the spatial and temporal dependence present in survey-based areal data such as in ACS (American Community Survey). This dissertation develops a family of Bayesian spatial predictive models for directly …

Characterizing A Potential Cbp/P300 Histone Acetyltransferase Homolog In Tardigrade Germline Specification And Development, Brittney Michelle Hartshorn

Honors Projects

Germline specification is a fundamental process that ensures the proper development of germ cells. Germline specification occurs either through germ cell determinants maternally inherited through the mechanism of preformation or through induction, where cell interaction and epigenetic modifications direct specification. Determining how these mechanisms evolved and diverged remains an important question in developmental biology. Despite research on germline regulation in model organisms such as Caenorhabditis elegans or Drosophila melanogaster, such regulation remains poorly understood in many other animal groups. Tardigrades are an emerging model system for investigating developmental mechanisms due to their phylogenetic placement and experimentally tractable embryos. CBP/P300 is …

Fueling Reactions: Three Empirical Essays On Behavioral Responses, Economic Shocks, And Energy Markets, Euclides Coelho De Medeiros Correia

Economics Theses and Dissertations

This dissertation examines how shocks in energy and commodity markets propagate through local economies and reshape human behavior, spanning three empirical essays that connect energy markets to electoral behavior, commodity price dynamics, and criminal violence.

Where Is Home: Finding Belonging In God Through Expressive And Drama Therapy Processes Among Chinese Diaspora International Students, Minmin Pan

Expressive Therapies Theses

Being an international student for 12 years in the United States, this research engages with personal reflection and literature around international student identity formation situated in the current social and political context of increasing visa and employment uncertainty. International students’ ongoing movement across cultural spaces, limited representation of cross-cultural narratives and supportive spaces in academic settings, can contribute to fragmentation in experiences and identity that are shaped by dominant narratives and social positioning, thus further leading to disconnection from self and surroundings.

Relational spirituality literature suggests that one’s relational experience with God can deeply impact their interpretation of experiences, social …

The Effect Of Acute Hypoxia Exposure, With Exercise, On Bone Metabolic Biomarkers, Alyssa Bailly

Health, Exercise, and Sports Sciences ETDs

Hypoxic environments, resulting from decreased atmospheric partial pressure of oxygen, reduce oxygen availability in the blood and tissues, leading to a mismatch between supply and demand. This elicits several physiological adaptations and may influence bone metabolism. Although evidence suggests that hypoxia can modulate bone remodeling through hypoxia-inducible pathways, findings remain mixed, with most data derived from chronic hypoxic exposures in animal and cell culture models. Exercise, an essential stimulus for bone health, may exacerbate hypoxic stress; however, the skeletal response to acute hypoxic exposure combined with exercise remains unclear. We propose that intermittent exercise in hypoxia may increase negative markers …

Empowering Pedagogical Practice Through Autoethnography Within The Context Of Family Literacy Projects, Sarah M. Johnson

Language, Literacy, and Sociocultural Studies ETDs

Family Literacy Projects being used in the high school setting to promote cultural and linguistic identities. The Family Literacy Project is used to bridge the gap between student identities at school and the identities at home. The purpose of this study was for the teacher to reflect in an autoethnographic study of herself in relation to the context of community, pedagogy, and the perceived needs and changes of the project for both students and the school’s culture. Through the autoethnographic study, the focus of the Family Literacy Project is in its importance to the school, community, students, and teachers was …

Benefits Of Advisory & Culturally Responsive Advisory Framework (Craf) Within A Southwestern, Urban, Dual Language Middle School, Mariana Anguelova Castañon

Language, Literacy, and Sociocultural Studies ETDs

In this research report, I examine the benefits of a daily Advisory period at a southwestern, urban, dual-language middle school and explore the impact of the Culturally Responsive Advisory Framework (CRAF), a curriculum I developed as a researcher-practitioner. This work is situated within research on Advisory programs, urban schooling, and dual-language education, while addressing implementation challenges. Grounded in democratic learning theory, CRAF integrates social-emotional learning (SEL), social-cultural learning (SCL), and literacy. To evaluate its impact, I collected qualitative data through anonymous Google Surveys and semi-structured student interviews, supported by quantitative teacher and student surveys. Data were analyzed using open and …

Microtubules In Breast Cancer: Exploring The Α/Β-Tubulin Toggle Switch And Its Implications In Human Breast Cancer, Annemarie Ianos

Student Theses and Dissertations

Microtubules, composed of a/b-tubulin heterodimers, play a central role in breast cancer tumor growth by polymerizing, leading to metastasis and depolymerizing, contributing to proliferation. Human enzymes protein kinase Ca (PKC-a) and cyclin-dependent kinase 1 (Cdk-1) mediate phosphorylation at sites a:Ser165 and b:Ser172, respectively, influencing the growth of microtubules. It is possible that alternating phosphorylation at these sites contribute to an a/b-tubulin “toggle switch” that mediates microtubule instability and tumor growth.

The project investigates the influence of the toggle switch model on microtubule stability by determining the impact of mutants (a:S165D, a:S165N, a:S165S_P, b:S172S_P and a:S165S_P/b:S172S …

Helium Effects In High Entropy Alloys For Fusion Reactor Plasma Facing Components, Shane Evans

Nuclear Engineering ETDs

The plasma facing materials (PFMs) within fusion reactors, such as the divertor, must be able to withstand high temperature (>1000 K) for extended durations of time, in addition to extreme flux from neutrons, helium (He) ash, and neutral species such as deuterium and tritium. These materials must withstand these conditions while maintaining their selected mechanical properties, minimal sputter yield, and low fuel retention. In recent years refractory high entropy alloys (RHEAs) have been investigated due to their improved mechanical and irradiation-resistant properties when compared to pure W, the current material for PFMs. In this work RHEAs have undergone fusion …

Cfd Simulation Analyses Of The Blowdown Phase Of A Depressurized Loss Of Forced Cooling Accident In A Htgr, Keenan Kresl-Hotz

Nuclear Engineering ETDs

This research numerically investigates the helium-air mixing in HTGR containment cavities during the blowdown phase of a simulated DLOFC accident. The results of the performed CFD simulation analyses, using the commercial code STAR-CCM+, are compared with reported measurements from an experiment conducted at CCNY. The analyses investigate the effects of the RANS and LES turbulence models, numerical mesh refinement, time-step size, and flow rate and temperature of the injected hot helium into the scaled reactor cavity. Calculated parameters analyzed include the pressure and spatial distributions of temperature and oxygen concentration in the simulated reactor and steam generator cavities. CFD oxygen …

In-Situ Measurement Of Dynamic Deuterium Retention In Tungsten-Based Alloys Under Plasma Exposure, Ethan Gabriel Rashap

Nuclear Engineering ETDs

Nuclear fusion is a promising pathway for sustainable energy production, but the performance of plasma-facing materials remains a key challenge for reactor operation. In particular, hydrogen isotope retention in tungsten—the leading candidate material for divertor components—affects tritium inventory, fuel recycling, and overall material lifetime. In this work, the temperature-dependent deuterium retention behavior of W–Ti and W–TiTa alloys was experimentally investigated under fusion-relevant ion irradiation conditions between 400 and 700 K. In-situ nuclear reaction analysis (NRA) was used to track retention during plasma exposure and subsequent cooldown, providing depth-resolved insight into deuterium accumulation and release. The results show that deuterium retention …

Shaping Emergent Competitive And Cooperative Behaviors In Multi-Agent General-Sum Games, Ethan F. Erickson

Honors Projects

Reinforcement learning (RL) algorithms can train agents to solve problems in environments using complex behaviors that are not explicitly programmed, known as emergent behaviors. The goal of our research is to investigate how different RL reward values influence the emergence of competitive and cooperative behaviors in games with teams of multiple agents. Specifically, we focus on general-sum games, in which the sum of gains and losses of each team may be non-zero, allowing situations for agents to mutually benefit or mutually fail. Using Unity’s ML-Agents Toolkit to train agents with RL self-play in bounded 2D environments, we identify high-level behaviors …

Efficacy And Equity In Type 2 Diabetes Care: Comparing Glp-1 Therapy And Dietary Interventions Through Clinical, Social, And Ethical Lenses, Makayla Bogle

Honors Projects

Objective: Explores the clinical and sociocultural dimensions regarding type 2 diabetes (T2DM) care, comparing GLP-1 receptor agonist (GLP-1 RA) therapy and dietary interventions for adults with T2DM. Part I consists of a narrative literature review examining clinical outcomes such as glycemic control, insulin sensitivity, and weight management for the two compared treatment methods. Part II conducts a narrative literature review examining the structural and social determinants that influence access to diabetes treatments. The review evaluates how social determinants of health (SDOH) shape the real-world implementation of both GLP-1 RA therapies and dietary interventions. The discussion highlights differences in measurable clinical …

Novel Algorithmic Methods For Random Telegraph Noise Detection And Characterization In Electronic Devices, Victor Darie Pepel

Electrical and Computer Engineering ETDs

Random telegraph noise (RTN) produces discrete stochastic fluctuations in nanoscale semiconductor devices and increasingly limits performance and reliability as dimensions scale. This dissertation introduces three algorithmic contributions enabling automated and accurate RTN characterization across diverse devices and operating conditions. First, a computationally efficient histogram-based detection algorithm enables rapid identification of RTN in large focal plane array datasets for statistically robust defect analysis. Second, a frequency decomposition framework separates slow and fast RTN components, extending the range of extractable time constants and reducing estimation error in multi-trap signals obscured by background noise. Third, to address the lack of standardized RTN metrics, …

Applications And Comparisons Of Machine Learning Methods In Ultra-Fast Laser Control, Aasma Aslam

Electrical and Computer Engineering ETDs

This dissertation demonstrates the applications and comparative analyses of machine learning methods in ultrafast laser control. By learning the relationship between the system’s input parameters and output pulse characteristics, the performance of a laser can be significantly improved. In this work, the results are presented in two stages by utilizing data from the femtosecond laser system. The first stage concerns two neural networks, named NN1 (fitrnet) and NN2 (feedforwardnet). The second stage, which extended with five different models, namely the linear regression (fitlm), the support vector machine (SVM), the Gaussian process regression (GPR), the boosted tree (fitrensemble), and LASSO (fitrlinear), …

Ab Initio Method Development For Electronic Structure Response And Symmetry Quantification, Duc Anh Lai

Chemistry Theses and Dissertations

Electronic structure provides a fundamental framework for understanding molecular properties and reactivity, as it encodes the spatial distribution of electrons and their response to external and internal perturbations. This dissertation develops theoretical and computational frameworks to characterize and manipulate electronic structure through two complementary directions: the response to oriented external electric fields and the quantification of symmetry regulation in electron density.

First, a rigorous theoretical and computational framework is established for treating electric fields with arbitrary orientations relative to molecular structure. The concept of the rotational potential energy surface is introduced to characterize the dependence of molecular energy on field …

Beyond Brain Drain: H-1b Visas, Innovation, And Human Flourishing, Joel Wong

Honors Projects

High-skilled migration has become one of the defining features of the modern global economy, especially in technology, engineering, and research-intensive industries. While public debate surrounding the H-1B visa program often centers on its effects within the United States, less attention has been given to how these migration flows affect the countries from which workers originate. This question is important because many sending countries invest heavily in the education and development of highly skilled workers while also seeking long-term economic growth and innovation. This study examines whether increases in H-1B visa migration are associated with changes in innovation outcomes in major …

Fluid Identities: Using Seattle's Diverse Water Narratives To Shape Cultural Values And Adaptive Conservation Strategies, Brooke J. Vanden Berg

Honors Projects

This paper explores human interactions with the environment in and around Seattle, Washington, following its trajectory from the Vashon glacial episode to its present standing as a city on the frontier of future urban climate resilience. By examining the shift from indigenous stewardship to a twentieth-century settler-led industrial “taming” paradigm, ecological vulnerabilities are considered through the lens of ill-advised hydraulic regrading and the centralization and privatization of water infrastructure and rights. This history is contextualized in the 21st century as climate projections indicate that Seattle's reliance on mountain snowpack, increasing thermal extremes, sea-level rise, and hydraulic instability caused by climate …

Musical Expression: How Do We As Composers And Performers Use The Tools Of Music In Such A Way To Realize Our Creative Endeavors And Communicate Them To Others?, Max Vance

Honors Projects

Why do we create things? This project delves into the deep, intentional processes of composition and cello performance. This paper discusses how the process is vital to the final outcome, outlines the necessary steps for composition and performance, and provides examples of work that has emerged from these processes.

Improving Health Literacy And Self-Management In Adults With Heart Failure: A Nurse-Led Virtual Intervention In Outpatient Support Groups, Vivian Efosa Osunde

Doctoral Projects

Heart failure is a leading cause of morbidity and hospital readmissions, with limited health literacy contributing to poor self‑management and adherence challenges. The purpose of this Doctor of Nursing Practice project was to evaluate the feasibility and preliminary outcomes of a nurse‑led, virtual education-intervention designed to improve health literacy, self‑care behaviors, and medication adherence among adults with chronic heart failure who participate in an outpatient support group. A quality improvement design was used. Convenience sampling yielded nine adult participants with a documented diagnosis of chronic heart failure who attended at least one virtual support group session. The intervention consisted of …

Whiny Women: How Medical Gaslighting Becomes Medical Trauma, Neena Marcus

Honors Projects

Background: The idea of “medical gaslighting” has been present since 1969, but it has increased in popularity in the recent century. Women in particular are at increased risk of being dismissed by their healthcare providers, as throughout history they have been deemed “hysterical” or untrustworthy when recounting their symptoms.

Methods: Articles were compiled from CINAHL Complete, Google Scholar, and the University of Washington library. A total of 33 articles were chosen and reviewed.

Results: Medical gaslighting results in lasting medical trauma, a decreased quality of life and detachment from standard healthcare. Six themes were recurrent in the papers utilized: sexism, …

Shelter From The Storm: Public Library Value And Community Adaptive Capacities, Margo Gustina

Economics ETDs

This dissertation contributes to theoretical framing within the discipline of library science, while building out empirical methods for quantitatively valuing broadly loved public libraries. Chapter 1 lays the foundation for understanding how analysis public libraries must always be set within regional contexts. Chapter 2 demonstrates that positive voter valuation of public libraries is driven by proximity to a library building by using data from public funding referendum events. Chapter 3 estimates a reduction of 0.75 percentage point (p=0.002) in graduation rates where public libraries were closed (but school instruction was in-person) from COVID closures. Chapter 4 builds on the previous …

Perception, Payment, And Pollution- Examining The Effects Of Air Quality On Health And Healthcare, Colin Sleeper

Economics ETDs

Abstract

This dissertation examines how air quality and public attention to environmental shock affect perceived health status and healthcare utilization. The first chapter uses publicly available survey data from BRFSS and a triple difference framework to analyze the effects of the 2018 wildfire season in Oregon on self-reported mental and physical health. Findings indicate that those in Oregon in 2018, during the period of heightened attention to wildfire smoke, experienced approximately 1.4 additional poor mental health days, on average. The second chapter includes Merative MarketScan commercial insurance claims data to test whether these changes translate into a behavioral response. Results …

Agricultural Water Management, Farmer Decision-Making And Climate Adaptation In Dryland Agriculture: A Case Of The Middle Rio Grande Basin, Oluwatosin A. Olofinsao

Economics ETDs

Agriculture in dryland regions faces mounting pressure from climate change, water scarcity, and shifting land-use demands. The Middle Rio Grande Basin (MRGB) of central New Mexico exemplifies these challenges, where irrigated agriculture relies on increasingly variable surface water supplies. This dissertation examines agricultural water use, farmer decision-making, and adaptation strategies across farm types and climate conditions in the MRGB. The first study presents a spatial descriptive analysis of farm size, crop patterns, groundwater access, evapotranspiration (ET), and effective ET, revealing a landscape numerically dominated by smallholder farms that account for a substantial share of irrigation water use. The second study …

Marine Geophysical Studies Of Coupled Tectonic And Sedimentary Processes At Active Plate Boundaries, Sarah R. Rysanek

Earth and Planetary Sciences ETDs

Deep-sea and convergent margin sedimentary systems preserve critical records of tectonic and climatic processes that shape Earth’s surface. This dissertation investigates source-to-sink sediment routing and forearc deformation to better constrain the interplay between sedimentary and tectonic processes, through investigations of a deep-sea fan system, and the forearc geomorphology offshore Nicaragua. In the Gulf of Alaska, we integrate ultra-long-offset and regional multi-channel seismic reflection data, multi-resolution bathymetry, and plate reconstructions to remap the Baranof Fan system. Results show that the fan is larger than previously recognized and constructed by two primary depocenters linked to distinct glacial sediment pathways, with accommodation space …

Self-Supervised Spoofing Detection, David S. Choi

Electrical and Computer Engineering ETDs

Global Navigation Satellite Systems (GNSS) are vulnerable to spoofing attacks that can mislead receivers with counterfeit signals. Traditional detection techniques, such as antenna-based, encryption based, and signal processing approaches, often face limitations in adaptability, computational cost, or reliance on predefined thresholds. Supervised machine learning models, while powerful, require large labeled datasets and struggle to generalize to unseen spoofing scenarios. In this work, we propose a self-supervised spoofing detection framework based on Adaptive Sparse Gaussian Processes (ASGP). The method predicts incoming GNSS features using past observations and identifies spoofing as anomalous deviations in the prediction residuals. Unlike supervised approaches, ASGP adapts …