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Articles 3691 - 3720 of 700245
Full-Text Articles in Entire DC Network
Parkinson’S Disease Phenotype Stratification Using Multiple Correspondence Analysis, Kelly Astudillo
Parkinson’S Disease Phenotype Stratification Using Multiple Correspondence Analysis, Kelly Astudillo
Dissertations, Theses, and Capstone Projects
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, with over 12 million people projected to be affected by 2040 (Dorsey et al., 2018). Deep phenotyping and stratification can provide useful information regarding PD pathogenesis and can aid in the development of disease modifying therapies that aim to delay the progression or prevent the onset of neurodegeneration (Blandini et al., 2019; Smith & Schapira, 2022). Utilizing multivariate methods such as multiple correspondence analysis (MCA) permits for the simultaneous analysis of distinct data modalities. To the best of our knowledge, MCA has not been previously used to explore phenotype patterns …
Gathering Knowledge, Sustaining Science: The Female Forager And American Mushroom Culture, 1880–1930, Madeline S. Dede-Panken
Gathering Knowledge, Sustaining Science: The Female Forager And American Mushroom Culture, 1880–1930, Madeline S. Dede-Panken
Dissertations, Theses, and Capstone Projects
Unearthing origins of modern mycophilia, this dissertation explores the mushroom mania which reverberated through American society at the turn of the twentieth century, empowering Anglo-American women in new ways. America’s largely forgotten first mushroom fad illuminates gendered negotiations of foraging culture and public science. Beginning in the 1880s, a remarkable cohort of women helped turn mushrooms from shunned, mysterious organisms into wholesome delicacies for culinary and intellectual enrichment. Female enthusiasts fostered a vibrant mushroom culture and nationwide network of mycophiles. Culinary applications and poisoning fears legitimized women’s presence in scientific endeavors, positioning mycology as vital female knowledge for public safety …
A Predictive Coding Account Of Spatial Working Memory Following Prophylactic Levetiracetam Administration Prior To Traumatic Brain Injury, Omeima Mutwali
A Predictive Coding Account Of Spatial Working Memory Following Prophylactic Levetiracetam Administration Prior To Traumatic Brain Injury, Omeima Mutwali
Dissertations, Theses, and Capstone Projects
Traumatic brain injury (TBI) symptom prevention and remediation is an important area of research that would benefit vulnerable groups, including active-duty and veteran soldiers. These patients can sustain penetrative forces in fields of combat or in training, which result in focal lesions that trigger inflammatory and degenerative processes in the brain. Both primary and secondary injuries are associated with changes to cognition, behavior and affective state. This disease poses increased risk of epileptogenesis, as well. Given these outcomes, prior research has evaluated levetiracetam (LEV) as a prophylactic treatment for seizures, cognitive deficits and negative emotionality. LEV acts as a presynaptic …
Policing Sex Trafficking: 'They’Re Never Taught, You Know', Anila S. Duro
Policing Sex Trafficking: 'They’Re Never Taught, You Know', Anila S. Duro
Dissertations, Theses, and Capstone Projects
Research shows that victims of sex trafficking are most likely to first come in contact with the police (Baldwin et al, 2011; Twigg, 2017) and at times police have not been able to categorize cases of prostitution as trafficking even when trafficking elements were very clear (Dank et al, 2017; Dempsey, 2017; Farrell & Cronin, 2015). Despite the legal definition of trafficking, the terms prostitution, sex work, and sex trafficking are sometimes used interchangeably by law enforcement, whereas at other times, these words refer to different sets of circumstances and have different criminalization outcomes. Research in this area is limited …
Unfreezing Language: A Decolonial Reframing Of Translanguaging Pedagogies In English As A New Language & Dual Language Bilingual Education Settings, Cristian R. Solorza
Unfreezing Language: A Decolonial Reframing Of Translanguaging Pedagogies In English As A New Language & Dual Language Bilingual Education Settings, Cristian R. Solorza
Dissertations, Theses, and Capstone Projects
This qualitative multi-case study examines how elementary teachers in English as a New Language (ENL) and Dual Language Bilingual Education (DLBE) settings conceptualize, implement, and reflect upon translanguaging pedagogies, with particular attention to translanguaging rings as tools for language differentiation. Grounded in a rearticulation of language as a dynamic, socially, politically, and historically constructed subject and object, this study challenges monoglossic ideologies that position named languages as bounded systems at the center of language education. Instead, it centers students’ lived, embodied, and agentive language practices as foundational to language learning and to their participation as knowledge producers in ENL and …
1d Crust-Magnetosphere Coupling Model For Magnetars, Kennedy M. Jeter
1d Crust-Magnetosphere Coupling Model For Magnetars, Kennedy M. Jeter
Dissertations, Theses, and Capstone Projects
Magnetars are the most extremely magnetized objects in the universe. Their strong magnetic fields generate high-energy magnetic flares with instantaneous luminosity that can outshine their host galaxy. Previous works have explored how Hall drift in the crust affects the dynamics of magnetic field lines in the magnetosphere. This work investigates how a change in the magnetosphere, such as a flare or an outburst, can excite Hall evolution in the crust. We investigate how the twisting and untwisting of magnetic field lines in a magnetar’s magnetosphere launches Hall waves through its crust using a one-dimensional numerical model. We use the Dedalus …
Investigating Individual And Group Level Mediators Of Fear Acquisition, Rachel S. Lese
Investigating Individual And Group Level Mediators Of Fear Acquisition, Rachel S. Lese
Dissertations, Theses, and Capstone Projects
The ability to discriminate between cues predictive of threat vs. safety (fear acquisition) and subsequently update fear responding when contingencies change (fear extinction) is crucial to survival for all organisms. While these processes have been the subject of intense experimental scrutiny for several decades, most human fear learning studies have focused primarily on extinction learning and fear recovery processes, with less focus on fear acquisition itself. Indeed, researchers typically aim to minimize variability during fear acquisition in order to rule out differences in extinction being driven by variability during the initial learning phase. Thus, experimental protocols are often optimized to …
The Influence Of Chief Executive Officer Personality On Mergers And Acquisitions (M&A) Completion, Nikisha Alcindor
The Influence Of Chief Executive Officer Personality On Mergers And Acquisitions (M&A) Completion, Nikisha Alcindor
Dissertations, Theses, and Capstone Projects
In Mergers & Acquisitions (M&A), a deal is completed when it has been announced, a fully executed agreement is in place, and the target's ownership is consolidated with the acquirer. The completion of an M&A deal is vital because it is a labor-intensive process that requires a tremendous number of resources from the firm. Yet even though 39,494 deals were announced in 2025, few studies have examined the variables that influence deal completion. This dissertation examines whether the Chief Executive Officer (CEO)'s personality influences the likelihood of deal completion. CEOs typically initiate the deal and see it through to completion, …
Cooling Deserts For Renters: Heat Equity Inside The Nyc Housing System, Tahreem Ashraf
Cooling Deserts For Renters: Heat Equity Inside The Nyc Housing System, Tahreem Ashraf
Dissertations, Theses, and Capstone Projects
This study introduces the Cooling Desert Index (CDI), a composite spatial measure designed to identify census tracts in New York City where extreme heat vulnerability and structural barriers to adaptive cooling converge. Drawing on five publicly available datasets and a seven phase statistical pipeline, the CDI scores all 2,231 NYC census tracts on a continuous 0 to 100 scale by integrating heat exposure, severe rent burden, household income, racial composition, language access, disability status, and housing crowding. The analysis identifies 557 cooling deserts, defined as tracts where environmental heat risk is high and financial constraints make effective cooling structurally inaccessible, …
Vestigial Choreographies: Climate Consciousness In The Long Nineteenth Century, Alexandra A. Rego
Vestigial Choreographies: Climate Consciousness In The Long Nineteenth Century, Alexandra A. Rego
Dissertations, Theses, and Capstone Projects
The aims of this project are twofold: (a) to develop a method of theoretical analysis and (b) to put this method into pointed use. In service of (a), I propose a method of choreographic analysis. This method operates relationally, highlighting the production of movement and stillness among and between bodies, objects, and encounters. Choreographic analysis draws from methods typically sequestered to dance studies. Towards aim (b), this project demonstrates the relevance and breadth of choreographic analysis by connecting it to ecocriticism. Throughout this project, I apply choreographic analysis to a diverse set of case studies. I use choreographic analysis to …
The Desire Of Strict Souls: The Poetry, Criticism, And Letters Of Paul Valéry And Wallace Stevens, Michael Healy
The Desire Of Strict Souls: The Poetry, Criticism, And Letters Of Paul Valéry And Wallace Stevens, Michael Healy
Dissertations, Theses, and Capstone Projects
This dissertation compares the poetic, critical, and epistolary oeuvres of Paul Valéry and Wallace Stevens and the influence of the former on the latter. Valéry famously advocated for the pursuit of “poésie pure” (“pure poetry”) and influenced Stevens especially in this way, though both of them concluded it was not achievable. I establish an approximation of a critical framework based on the work of the following critics and scholars: Wendy Lesser, Wendy Steiner, Anthony Cuda, Michael Clune, Paul Bové, and Liesl Olson. Harold Bloom’s passionate advocacy and deep, sustained engagement with Stevens and his work strongly influenced my choice to …
Roe V. Wade With Audre And Nikki: Their Social And Political Impacts Following The Landmark Decision, Sharon L. Eaddy
Roe V. Wade With Audre And Nikki: Their Social And Political Impacts Following The Landmark Decision, Sharon L. Eaddy
Dissertations, Theses, and Capstone Projects
This thesis analyzes how the 1973 Supreme Court decision Roe v. Wade shaped public understandings of reproductive rights and how those understandings diverged across race, gender, class, and sexuality. Using a qualitative, interdisciplinary design, the study pairs close textual analysis of Nikki Giovanni’s and Audre Lorde’s poems and essays with socio-legal and historical context on constitutional privacy doctrine, the Ninth and Fourteenth Amendments, and the Reconstruction legacy of the Civil Rights Act of 1866. The central research question is: what kinds of reproductive “freedom” become legible through Roe’s rights-based framing, and what forms of constraint remain visible when Black …
Building On Rented Land: An Interpretive Phenomenological Analysis Of Black Women’S Digital Homeplace-Building On Tiktok, Monica Thompson
Building On Rented Land: An Interpretive Phenomenological Analysis Of Black Women’S Digital Homeplace-Building On Tiktok, Monica Thompson
Dissertations, Theses, and Capstone Projects
This interpretative phenomenological analysis (IPA) examined the lived experiences of seven Black women TikTok users, exploring how they describe and make meaning of TikTok as a space of digital expression amid algorithmic constraint and platform precarity. Grounded in Black Cyberfeminism, Critical Race Theory, and hooks’ (1990) homeplace theory, the study asked three questions: how Black women describe their use of TikTok; how they make meaning of the platform as a space of expression; and how they navigate platform instability, political threats, and content restrictions while maintaining authentic expression. Drawing on semi-structured Zoom interviews and analyzed using Smith et al.’s (2009) …
Bureaucracy, Bottlenecks, And Bots: Ai And Migrant Experiences At Germany’S Foreigners’ Authorities, Johanna Brusa
Bureaucracy, Bottlenecks, And Bots: Ai And Migrant Experiences At Germany’S Foreigners’ Authorities, Johanna Brusa
Dissertations, Theses, and Capstone Projects
How can AI provide a meaningful tool in migration management for the German government? Seeking highly-skilled migrants and overburdened by mass migration, the German government is turning to AI to generate solutions to bureaucratic overload in the Ausländerbehörden (ABH, the Foreigners’ Authorities), the Federal Republic's administrative system for managing the processing of migration. AI promises to ease the bureaucratic burden on civil servants, but can it improve migrants' experiences in their interactions with the ABH? And, critically for the German state, could it help convince highly-skilled workers to make Germany their home? Analyzing 530 Google reviews of six different ABH …
Materializing The Interface: Personal Data Feeds Generative Art, Erin Livingston
Materializing The Interface: Personal Data Feeds Generative Art, Erin Livingston
Dissertations, Theses, and Capstone Projects
Materializing the Interface: Personal Data Feeds Generative Art is a data-studio capstone project that reconstructs elements of desktop and mobile interfaces as handmade mixed-media artifacts, then digitizes them as an interactive website where generative text and images are fed by personal data flows. Twenty-one paper collage windows — built from cardstock, risograph-printed paper, and mixed media — were photographed, digitized, and activated using code to become the interactive surface of a desktop view driven by browser history. A corresponding mobile view renders a corpus of 500 Instagram advertisement screenshots through a risograph print aesthetic, fed by a hand-tagged emotion and …
Aphrodite In Movement And Miniature: Knidian Statuettes Of The Ancient And Modern, Jacqueline M. Lewis
Aphrodite In Movement And Miniature: Knidian Statuettes Of The Ancient And Modern, Jacqueline M. Lewis
Dissertations, Theses, and Capstone Projects
This thesis examines Hellenistic statuettes of the Knidian Aphrodite as independent works of art with distinct ancient contexts and modern collecting histories. Drawing on archaeological evidence from Delos, archival and public records from the Museum of Fine Arts, Boston, and the Metropolitan Museum of Art, New York, and a comparative framework that places Hellenistic and modern collecting cultures in dialogue, this thesis aims to present the Knidia within the dynamic, interactive history of statuettes. Evaluated on its own terms rather than in relation to a lost original, Knidian Aphrodite statuettes illuminate both the richness of Hellenistic domestic religious life and …
“A Chill Wind Sweeps The High Places”: Audre Lorde’S And June Jordan’S Black Feminist Pedagogies For Remaking Higher Education, Maddie Albanese
“A Chill Wind Sweeps The High Places”: Audre Lorde’S And June Jordan’S Black Feminist Pedagogies For Remaking Higher Education, Maddie Albanese
Dissertations, Theses, and Capstone Projects
In this paper, I center the University as one site for radical pedagogy towards social justice. This paper examines texts written on anti-racist, anti-sexist educational movements within the City University of New York, as well as archival materials from CUNY professors on the topic of radical, social justice-oriented learning. Conor Tomás Reed’s 2023 book New York Liberation School is one recent text on how CUNY activists dismantled the distinction between the University and its surrounding community, inextricably linking academic work with social-political activism. I take his extensive history of CUNY in tandem with various pedagogies developed by CUNY feminist educators …
An Absolute Manner Of Seeing: Flaubert, 1848, And The Development Of Modernist Style, Nicholas Olson
An Absolute Manner Of Seeing: Flaubert, 1848, And The Development Of Modernist Style, Nicholas Olson
Dissertations, Theses, and Capstone Projects
This dissertation examines Gustave Flaubert’s Sentimental Education as a key work in the emergence of literary Modernism from the tradition of Realism. I begin by exploring the intellectual background of Realism in the works of Honoré de Balzac and the ties between this aesthetic theory and the theory of representative government: here I discuss the work of François Guizot, Friedrich Schiller, Friedrich Schlegel, J.W. Goethe, and Walter Scott as well as later thinkers like György Lukács, Pierre Bourdieu, Jürgen Habermas, and Jacques Rancière. From this, I demonstrate a commonly held theory of the social as a discreet totality, which makes …
Whitney Extension Problem For Fractional Sobolev Spaces And Besov Spaces, Han Li
Whitney Extension Problem For Fractional Sobolev Spaces And Besov Spaces, Han Li
Dissertations, Theses, and Capstone Projects
In the dissertation, we go through the development of the Whitney extension problem and prove a type of results for the Whitney extension problem for homogeneous fractional Sobolev spaces and homogeneous Besov spaces.
This dissertation consists of four chapters:
Chapter 1: We recall the history of the Whitney extension problem and talk about some early works which have been done for the Whitney extension problem. We also mention our new results.
Chapter 2: We introduce some basic notations, definitions and preliminary results.
Chapter 3: We show the existence of a bounded linear extension operator for homogeneous fractional Sobolev space L …
Supramolecular Assembly In Short Peptide Systems For Selective Metabolite Recognition And Drug Nanoencapsulation, Maithreyi Ramakrishnan
Supramolecular Assembly In Short Peptide Systems For Selective Metabolite Recognition And Drug Nanoencapsulation, Maithreyi Ramakrishnan
Dissertations, Theses, and Capstone Projects
Short peptides can form adaptive supramolecular assemblies, and understanding how minimal sequences organize around neurometabolites or hydrophobic cancer drugs enables the rational design of functional materials. This thesis combines molecular dynamics with experimental validation to establish design rules linking peptide sequence to emergent structure and function. Chapter 1 outlines the molecular determinants governing peptide assembly. Chapter 2 reviews computational workflows that reveal sequence-dependent conformations and supramolecular organization. Chapter 3 applies these principles to Dynamic Peptide Libraries which identify tetrapeptides that selectively interact with neurometabolites. Chapter 4 extends the same interaction-driven framework to design tryptophan-rich pentapeptides that co-assemble with kinase inhibitors …
Le Féminin-Fantastique: Entre Construction Symbolique Et Figuration De L’Altérité. Étude Des Figures Féminines Surnaturelles Dans La Littérature Fantastique Française Du Xixe Siècle, Ivana Prelevic
Dissertations, Theses, and Capstone Projects
This dissertation examines the féminin-fantastique in nineteenth-century French literature, arguing that supernatural female figures—vampires, animated objects, and revenantes—form a symbolic system through which the century negotiates anxieties surrounding sexuality, materiality, subjectivity, capitalism, mortality, and historical memory. Drawing on theoretical frameworks including Julia Kristeva’s concept of abjection, Barbara Creed’s monstrous-feminine, Marxist analyses of commodity fetishism, Freudian mourning, Derridean hauntology, and Georges Bataille’s theory of eroticism, the study analyzes works by Gautier, Féval, Mérimée, Maupassant, Villiers de l’Isle-Adam, and Nodier. Through three thematic axes—the female vampire, the animation of feminine objects, and the female revenant—the dissertation demonstrates how the supernatural feminine destabilizes …
Reimagining Puerto Rican Sonic Identity: Musical Style And Creation After Hurricane María., Gabriel E. Bouche Caro
Reimagining Puerto Rican Sonic Identity: Musical Style And Creation After Hurricane María., Gabriel E. Bouche Caro
Dissertations, Theses, and Capstone Projects
This dissertation examines the manifestation of Puertorriqueñidad (Puerto Rican identity) in concert music composed after Hurricane María (2017), a catastrophe that catalyzed a profound shift in Puerto Rico's cultural consciousness. Focusing on four composers whose early careers were shaped by this period—Johanny Navarro, John Rivera Pico, Iván E. Rodríguez, and Christian Quiñones—the study combines close readings of scores and recordings with extensive original interviews to understand how musical identity is constructed in the wake of collective trauma. The analysis reveals that while the composers share a generational bond, their aesthetic practices are strikingly diverse: Navarro preserves Afro-Caribbean rhythmic structures, Rivera …
Que Tus Ojos No Se Cansen De Brillar, Gabriel E. Bouche Caro
Que Tus Ojos No Se Cansen De Brillar, Gabriel E. Bouche Caro
Dissertations, Theses, and Capstone Projects
Que tus ojos no se cansen de brillar is a nine-song song cycle for soprano, saxophone, clarinet, percussion, electric guitar, violin, viola, and cello. Setting texts by Giannina Braschi alongside selected poems by Ángela María Dávila, Julia de Burgos, and Pedro Pietri, the work explores Puertorriqueñidad through musical hybridity. Drawing on Puerto Rican musical traditions and the island’s diasporic experience as core structural elements, the cycle constantly shifts styles, weaving together lyrical, experimental, and vernacular elements to reflect the resilience, fragmentation, and diversity of Puerto Rican identity across its literary, musical and experiential voices.
Contesting The Sacred: Ideology And Church Music Reform In Spain, 1850–1900, Francisco J. Legasa
Contesting The Sacred: Ideology And Church Music Reform In Spain, 1850–1900, Francisco J. Legasa
Dissertations, Theses, and Capstone Projects
This dissertation argues that sacred-music reform in Spain between 1850 and 1900 was not a unified movement culminating in the 1903 Motu proprio, but a contest between two distinct and contemporaneous programs. The first, associated with Hilarión Eslava, affirmed musical expression and artistic progress, embraced stylistic eclecticism, and sought to rebuild musical institutions, modernize pedagogy, and forge alliances with civic life. It drew on Romantic thought that attributed to music a distinctive capacity to mediate religious experience. The second, aligned with Roman ultramontanism, held that Gregorian chant and Renaissance polyphony were the only legitimate models for sacred music and that …
Quiver Of Affine Monoid Of A Vector Space Over Finite Field, James Junie Chen Cleary
Quiver Of Affine Monoid Of A Vector Space Over Finite Field, James Junie Chen Cleary
Dissertations, Theses, and Capstone Projects
In this paper, we study the quiver of the complex monoid algebra CAFF(n, q). There are n + 1 maximal subgroups of AFF(n, q), each isomorphic to AGL(k, q) for some 0 ≤ k ≤ n. Every irreducible representation of CAFF(n, q) arises from a character of CAGL(k, q) for a suitable k. Thus, we study two different approaches to classifying the characters of CAGL(k, q). Next, we compute the full quiver Q(CAFF(n, q)). Finally, we show that this quiver is a disjoint union of straight-line paths and that its basic algebra has radical square zero. Hence, it has finite …
Alive And Thriving: Ancestral Wisdom Usage Among Us Based Latine Clinical Social Workers In Psychotherapy Practice, Yaneth Lombana
Alive And Thriving: Ancestral Wisdom Usage Among Us Based Latine Clinical Social Workers In Psychotherapy Practice, Yaneth Lombana
Dissertations, Theses, and Capstone Projects
At a time when the United States is rolling back protections to vulnerable communities, this dissertation investigates experiences of Latine clinical social workers in New York and New Jersey as it relates to the intersection of ancestral wisdom and their profession. It addresses how Latine clinical social workers, who incorporate ancestral wisdom in their practice determine when, with which clients and with which methods to do so. This work advances current scholarship on how clinical social workers can combat racism and white supremacy. It highlights resistance practices that have been critical in keeping people indigenous to colonized lands alive and …
Who Is Invited To The National Family? A Brazilian Autoethnography Of Being A Woman Under The U.S. O-3 Visa, Bruna Lauermann
Who Is Invited To The National Family? A Brazilian Autoethnography Of Being A Woman Under The U.S. O-3 Visa, Bruna Lauermann
Dissertations, Theses, and Capstone Projects
This thesis lives in the borderlands between Brazil and the United States, during the nine years of my immigration to the United States. Using autoethnography, I analyze the O-3 visa as a tool that controls and alienates foreign women and devalues knowledge produced outside U.S. borders. This visa, for spouse or children of O-1 holders, which are people considered to have extraordinary abilities to work in the U.S. showcases the reasons why one is invited to be part of the national family and under what obligations and circumstances. A decision that is shaped far more by the interests of the …
Elite Manipulation Of Accountability Institutions: A Comparative Analysis Of Cicig And Maccih, Kevin E. Contreras
Elite Manipulation Of Accountability Institutions: A Comparative Analysis Of Cicig And Maccih, Kevin E. Contreras
Dissertations, Theses, and Capstone Projects
Strong accountability institutions are expected to limit elite manipulation. Yet elites continue to manipulate them. This paper shows that strong accountability institutions are insufficient to prevent elite manipulation. A comparative analysis of Honduras (MACCIH) and Guatemala (CICIG) traces the relationship between institutional strength and elite manipulation. The findings indicate that this relationship is contingent on context. Preventing manipulation would require accountability institutions to sustain greater mobilization and institutional leverage than elites. Accountability institutions alone are insufficient to achieve this condition.
Exploring The Influence Of Ear-Level Devices On Adult Perceptions Across Professional, Social, And Educational Settings, Lucia R. Berry
Exploring The Influence Of Ear-Level Devices On Adult Perceptions Across Professional, Social, And Educational Settings, Lucia R. Berry
Dissertations, Theses, and Capstone Projects
Background: The hearing aid market is continuously advancing to address the increasing prevalence of hearing loss and the barriers to obtaining hearing aids. The Food and Drug Administration (FDA) approved Apple AirPods Pro 2 devices to function as over-the-counter (OTC) hearing aids. This is an alternative option to manage hearing difficulties; however, it presents secondary complications related to headphone use and stigma.
Objective: Limited research is available regarding attitudes towards individuals wearing Apple AirPods Pro 2 as OTC hearing aids. This study intended to analyze if people’s pre-established perceptions of Apple AirPods shift once they learn they are being used …
Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel
Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel
Dissertations, Theses, and Capstone Projects
Nucleosome core particles (NCP) are the building blocks that form a highly organized and compact chromatin structure. Nucleosomes package DNA in the nucleus of eukaryotic cells. The NCP consists of about 147 base pairs of DNA wrapped around the histone octamer, with 1.65 superhelical turns in a left-handed manner. The histone octamer is composed of two copies of H3, H4, H2A, and H2B. Together with histone H1 and linker DNA, they further assemble into a higher-order chromatin structure. The nucleosome complex is stabilized by electrostatic interactions between positively charged histone residues and the negatively charged DNA backbone. To effectively access …