Digital Commons Network^™

Targeting Inflammatory And Growth Signaling Pathways In Breast Cancer Through Diet, Microbiome, And Metabolite Interactions, Brittany Lorraine Witt

ETDs from 2020-2029

Breast cancer (BC) accounts for 1 in 3 (or 30%) of all new female cancers each year and is the most common malignant cancer in women in the United States. Since the 1990s, there has been a 44% decrease in BC, but there is still a significant gap between certain groups in terms of mortality rates. Black women have a higher mortality rate and risk for triple-negative breast cancer (TNBC). This may be due to social (inadequate access to health care facilities, insurance, or completion of therapy) and biological (genetic mutations, tumor characteristics, or comorbidity) factors between races and other …

The Malaugh Operations And The Quadratic Invariant Gaps Of $\Si_4^C$, Forrest M. Hilton

ETDs from 2020-2029

Connected Julia sets of polynomials generally correspond to laminations, sets of chords of the unit disc that reflect the dynamics of the Julia set. If the circle is measured in revolutions and the polynomials studied are of degree $d$, then the dynamics on the lamination is given by the covering map $\sigma_d(t) := td \pmod 1$ where chords are mapped by their end points. Every lamination has at least one laminational invariant set, which is loosely an invariant complementary component of the lamination. That set has a significant impact on the shape of the Julia set. James Malaugh showed how …

Modeling The Spread Of Competing Narratives In Multimodal Social Media Network, Mayor Inna Gurung

Theses and Dissertations

Social media has fundamentally transformed how narratives are produced, contested, and disseminated, enabling competing interpretations of the same event to spread rapidly across networked populations. Understanding how narratives gain traction over others in these environments is critical for addressing misinformation, supporting informed public discourse, and designing effective counter-messaging strategies. Yet existing research largely treats narrative propagation as a single-process phenomenon and focuses predominantly on textual data, overlooking both the competitive dynamics between opposing narratives and the growing role of visual symbolic communication in shaping how narratives are received. This dissertation addresses these gaps through a multi-platform, multimodal framework applied to …

Sleepfocus – The Attributes And Application, Austin Kim, Erik Keifer, Isaac Amedie

Computer Science and Engineering Senior Theses

Insufficient sleep is a widespread public health concern, yet many consumer sleep tools still emphasize retrospective dashboards over personalized, actionable guidance. Platforms such as Apple Health, Fitbit, Whoop, and Oura collect detailed biometric and sleep data, but users are often left to interpret trends and decide what to change on their own.

SleepFocus was built to address that gap by turning wearable sleep data into clearer feedback, personalized recommendations, and healthier sleep routines. SleepFocus is a native iOS application that integrates with Apple HealthKit to collect sleep-stage data and biometric streams such as heart rate, heart rate variability, respiratory rate, …

Broncosgo: Driving Student Event Participation Via Human-Ai Collaborative Event Curation, Katherine Carter, Ethan Sychangco

Computer Science and Engineering Senior Theses

College campuses rely heavily on email communication for event advertisement. However, due to the sheer number of emails any student may receive, the individual effectiveness of each advertisement decreases. A better alternative for event promotion was needed. How could we introduce students to events they would not usually find on their own, without continuing to fill up their email inbox? And how would information on all of those events be collected and maintained without requiring organizations to jump through extra hoops? Our project, BroncosGo, solves this issue by maintaining a database of campus events which is populated with information provided …

Club Finance Management Application, India Bell, Lydia Martin, Sola Kawahara, Zachariah Wang

Computer Science and Engineering Senior Theses

There are over 160 Registered Student Organizations (RSOs) at SCU as of 2023 [6]. There is currently no centralized system that RSO treasurers use to track and manage club finances. As a result, many organizations rely on fragmented methods such as spreadsheets, shared documents, email chains, and manual record keeping to manage budgets, reimbursements, and financial reports. These disconnected systems often lead to inconsistent organization, communication difficulties, and challenges during leadership transitions between club officers. This project proposes the development of a web-based Club Finance Management Application, Kaikei, designed specifically for Santa Clara University student organizations. The application centralizes financial …

Multiscale Optical Imaging: From Single-Molecule Dynamics To Tissue-Scale Mechanics, Weiyan Zhou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Biological systems exhibit hierarchical organization spanning molecular to tissue scales. Molecular orientation and supramolecular packing define nanoscale architecture, while collective organization of these constituents contributes to emergent mechanical and dynamical behavior at the tissue level. Although optical imaging provides access to both regimes, modalities are typically optimized for a single scale and often emphasize qualitative visualization rather than quantitative measurement. Establishing rigorous frameworks for extracting physical parameters from optical signals and articulating conceptual continuity across scales remains a central challenge. This dissertation advances optical imaging as a quantitative measurement technology through the development of complementary approaches at the nanoscale and …

Getting Close, Sadie Laufe Mccarthy

Dissertations and Theses

"Getting Close" is a collection of short pieces, some fiction and some memoir. It's not important which is which.

I'm interested in the barriers we face when it comes to connection, and how aloneness can often be more sensual than togetherness. I'm interested in the places we find respite from the pain of existing within societal pressures.

I'm not interested in acceptability. I write toward a world in which we do not have to be anything other than ourselves.

Pieces Of The Pathway: A Qualitative Exploration Of Social Support For Individuals Navigating Houselessness, Desiree' Jane Duboise

Dissertations and Theses

Houselessness has long been an issue of pressing concern in the United States; and in Multnomah County, Oregon, approximately 10,526 people are experiencing houselessness. Social support has been identified as a critical factor in helping people navigate houselessness and will be explored in the current study. Specifically, the current study examines social support among populations with lived experience of houselessness as they navigate pathways through houselessness. The current study is situated within a broader study examining journeys through houselessness called the Pathways study, and it utilizes a subsample of individuals involved in the Pathways study. The Pathways study and the …

Biologically Informed Negative Samplingfor Antibody Chain Pairing Classification, Ishita Singh

Computer Science Senior Theses

Antibody heavy and light chain (H/L) pairing is fundamental to antigen recognition and stability. While single-cell sequencing preserves native pairing information, widely used bulk repertoire and spatial transcriptomics platforms do not, motivating the need for efficient ML methods to infer H/L pairing. Training a binary classifier for this task faces the methodological challenge of a lack of true biological negatives, since natural selection eliminates B cells with incompatible H/L pairs.

In this thesis, I introduce a biologically informed negative sampling strategy for H/L pairing classification, drawing on known V-gene biases in heavy and light chain pairing. Pseudo-negatives are constructed by …

Mimic: A Multimodal Dataset For Affective Incongruity In Video, Ethan M. Baird

Computer Science Senior Theses

This thesis investigates the computational challenges of constructing a database for affective incongruity, exploring the difficulties in automating the collection of contradictory affective states. Capturing these incongruities is essential for advancing Vision-Language Models (VLMs) and sentiment analysis, which struggle to interpret signals deviating from basic emotional archetypes. Curating non-congruent affect provides the data necessary for models to navigate complex social contexts, which is critical for applications like automated Audio Description (AD) for the visually impaired and nuanced Human-Computer Interaction (HCI). To capture these signals, two distinct methodologies were employed. The first utilized a tripartite decomposition of video data, isolating textual, …

Representing Lean Proofs: Tactics, Trajectories, Search, Elisaveta Samoylov

Computer Science Senior Theses

In neural theorem proving for interactive proof assistants such as Lean, tactic prediction models score proof steps by surface likelihood, missing whether a move actually advances the proof. This thesis proposes representing each step by the symbolic edit it induces on the proof state rather than by its token-level surface form, and shows that this effect-grounded view yields better tactic embeddings, reveals structured geometry in complete proofs, and enables a practical proof search prior.

We introduce Delta Tokens — token-level state edits augmented with structural indicators — and show they outperform surface-only representations on tactic retrieval and operator-analogy benchmarks. Embedding …

Bullying, Early Sexual Debut, And Sexual Health Behaviors Among Adolescents In New York City, Valentina I. Ramirez

Dissertations and Theses

Adolescent sexual and reproductive health remains a critical public health priority in the United States, particularly given the persistent burden of HIV and sexually transmitted infections (STIs) among young people. Adolescents and young adults account for a disproportionate share of STI cases, reflecting ongoing gaps in prevention, early detection, treatment, and equitable access to sexual health care and services. These patterns are shaped not only by individual behaviors but also by broader social, structural, and developmental contexts that influence adolescents’ opportunities to engage in preventive sexual health care.

This dissertation examined associations between early sexual debut, experiences of bullying, and …

Designing Cost-Effective Quadrupedal Service Robots For Disability Aid, Kieran Pazmino, Akira Zone, Ryan Toy, Cyrus Wong

Interdisciplinary Design Senior Theses

With aging populations and the increased rate of disability diagnosis in the United States, the economy has taken on an elevated toll, as fewer are able to work, including caretakers. Give the rise in unpaid time put in by the average caretaker, it is necessary to determine ways of reducing this burden, for the caretaker and also for elderly and disabled people. Individuals who service dogs for their daily lives face substantial financial and personal responsibilities, on top of their own medical and living costs. This project proposed a wheeled quadrupedal robotic service dog, designed primarily for mobility assistance. In …

Life Without Oxygen: Cellular Mechanisms Enabling Genome Maintenance And Proliferation In Cells From An Anoxia-Tolerant Vertebrate, Riley Asa Roth-Carter

Dissertations and Theses

When exposed to the complete loss of oxygen (anoxia) most organisms undergo rapid cellular deterioration driven by a range of metabolic dysfunctions associated with the loss of the terminal electron acceptor for aerobic respiration. This loss of ability to create and maintain necessary levels of cellular ATP through oxidative phosphorylation contributes to loss of membrane potentials, increase in the accumulation of acidic by-products of anaerobic metabolism, and a decrease in the ability to support other molecular processes that rely on a steady supply of ATP. While this extreme oxygen stress is lethal to a majority of vertebrate organisms there are …

From Story To Stage: A Journey In Pursuit Of Virtuous Leadership And Artistic Intentionality Through Student Directing A Full Play Production At University Level Theatre, Josephine L. Partridge

Honors Projects

A passionate storyteller and artist, earning her Bachelor of Arts Degree in Honors Liberal Arts and Theatre-Performance, explores her personal potential as the play Director of Little Women, a stage play adaptation based on the 1868 novel by Louisa May Alcott, adapted from the 1912 play by Marian de Forest and Jessie Bonstelle written by Josephine Partridge. Throughout the course of four months, Partridge adapted the script and works as Director and Marketing Director for this production with SPU Theatre Company club. She uses this experience to deepen her understanding and practice of intentionality with artistic vision and virtuous leadership. …

Iajes Website Redesign, Justin Fan, Nicolas Gibson, Isabelle Hu, Anisha Malani

Computer Science and Engineering Senior Theses

The International Association of Jesuit Engineering and Science Schools (IAJES) connects more than sixty Jesuit institutions worldwide to promote collaboration and shared learning in STEM research. Santa Clara University is one of more than sixty member universities whose faculty and staff participate in conferences and task forces to address priority issues identified by the Society of Jesus. IAJES’ existing website, built on a static no-code platform, limited the organization’s ability to manage content, support member interaction, and scale with its growing global network. Users faced unclear navigation options, a basic design, and no effective tools for managing roles, resources, or …

Jesus-Centered Preaching: A Christocentric Approach Based On The Hermeneutical Implications Of The Gospels As Βίοι., Mark Palmer

Dissertations

The purpose of this study was to discover the implied hermeneutic of the Gospels as βίοι and to propose a congruent homiletic. The study addressed the following research questions: What is the genre of the Gospels and the resulting hermeneutic? Does current Christ-centered preaching account for his hermeneutic? Does Christological research account for intrinsic characteristics? What is the intrinsic Christology of Mark’s Gospel? What homiletical process is needed to align with the genre-based hermeneutic of the Gospels? The methodology of this study followed a four-step process: Genre research confirming the Gospels as βίοι, Christological research including the development of an …

Wheelless Snake-Like Robot For Unknown Environment Exploration, Anastasiia Statcenko, Gwyn Anawalt, Eden Steinbeck

Interdisciplinary Design Senior Theses

This project focuses on creating a locomotive device that is capable of movement without relying on active wheels. This kind of system is essential to exploration in rough terrains where wheel-based motion proves to be ineffective. Drawing inspiration from the natural movement of snakes- the animal most successful in traversing difficult and diverse environments- we will develop a modular snake-like robotic prototype. Our modular design will allow for simplified maintenance, easy component replacement, and opportunity for further development and research.

Our approach will integrate electronic circuits, obstacle awareness via live camera feed, and locomotion control programmed via serial protocols on …

Smart Walker, Viet Ha, Harry Ying, Ayden Dauenhauer

Interdisciplinary Design Senior Theses

Traditional walkers provide essential physical support for people recovering from injury, surgery, or reduced mobility, but do not collect objective information about how a person walks. This thesis presents the design, implementation, and evaluation of a SmartWalker system that transforms a standard mobility walker into a portable gait data collection platform. The system integrates Intel RealSense cameras mounted on a walker, NVIDIA Jetson embedded computing units, local storage, and a graphical user interface to record lower-body movement, process video locally, and present clinician-reviewable gait metrics.

The thesis describes the motivation for the monitoring of gait based on walking, the user …

Llzk-Symex: Building A Circuit Verification Framework For The Llzk Zero-Knowledge Intermediate Language, Nicolás Iair Schaievitch

Computer Science Senior Theses

The rising adoption of ZK (Zero-Knowledge) technology has led to a plethora of DSLs (Domain Specific Languages) for facilitating the development of ZK circuits. At the same time, there has also been an increase in the number of compilation targets for these languages, with different cryptographic foundations and performance optimizations. LLZK, by Veridise, aims to unify the ecosystem by providing a single IR (Intermediate Representation) for the different frontend DSLs, that would then also allow choosing between different backends. Given the high stakes (particularly financial) that a lot of ZK circuits are under, together with their high level of complexity, …

Capturing Large Language Model Similarity Through Spectral Analysis, Ishan Verma Prasad

Computer Science Senior Theses

With the rapid development of open-sourced models on Huggingface, there is a strong need for a way to systematically determine the similarity between models. More strongly, for intellectual property and organization, we need a way to determine the "lineage" of models. We borrow principles from Heavy-Tailed Self-Regularization and Random Matrix Theory to provide an inference-free method to accomplish this. We cluster a corpus of several model families by their spectral fingerprints and demonstrate that each model family occupies a distinct region in weight space. This confirms prior ideas of training setups leaving artifacts on model weights and allows us to …

Knockout Tournaments: An Investigation Of Stability, Isabelle Han

Computer Science Senior Theses

Knockout (or single game elimination) tournaments are a competition format widely used to determine a single winner from a pool of participants. However, the seeding, or the initial pairings set by the organizers of the tournament, can dramatically change each participant's probability of winning. This paper introduces stability as a property of tournaments. More specifically, a tournament is stable if no pair of players can be found such that they both wish to swap initial positions. This property is adapted from prior work on stable matchings and is therefore a well-defined structural property.

We investigate three theoretical questions on the …

Reliability-Aware Mixture-Of-Agents For Robust Ai-Generated Image Detection, Jake Jump, Yu-Wing Tai

Computer Science Senior Theses

Detecting AI-generated images requires reasoning across multiple levels of evidence, ranging from low-level statistical artifacts to high-level semantic inconsistencies. Existing approaches typically rely on a single class of signals or emphasize complex multi-agent coordination, which limits robustness under distribution shifts and common image degradations. We propose a reliability-aware Mixture-of-Agents (MoA) framework that treats Vision-Language Model (VLM) agents and computational features as complementary experts and aggregates their predictions based on empirically calibrated reliability. Rather than relying on intricate inter-agent reasoning, our approach centers on structured aggregation: high-precision “anchor” agents drive predictions, while weaker but complementary signals are adaptively incorporated to resolve …

Dancing For The People: A Culturally Grounded Learning-To-Rank Framework For Powwow Dance Evaluation, Avery C. Sutherland

Computer Science Senior Theses

Powwow dance is a form of Indigenous expression that combines movement, storytelling, regalia, and community values. Within competition powwows, dancers are evaluated through a highly subjective judging process that often lacks standardized criteria, creating challenges for consistency, transparency, and fairness. This work investigates whether a learning-to-rank framework can model subjective powwow dance preferences while remaining grounded in the cultural context of the practice. To support this research, a new dataset was constructed consisting of 19 Women's Fancy Shawl dancer profiles and 236 pairwise preference labels collected from experienced members of the powwow community. Each dancer profile combines textual descriptions, images, …

Rscore - A Tool For Learning And Quantifying Software Infrastructure Resiliency, Selena Yujia Zhou

Computer Science Senior Theses

As LLMs take over writing code, infrastructure resilience has become the central challenge of software development, especially for gaming applications, where latency, availability, and scale demands are extreme. However, holistic software infrastructure is difficult to understand for casual developers because of the multiple layers of abstraction that make up an application, and the lack of structured information from proprietary companies. This thesis explores the creation of rscore, a tool that quantifies software infrastructure resiliency and subsequently educates developers about the architecture of any existing gaming application. The tool generates two graphical models of a game’s early versus current infrastructure and …

Blendmo: A Blender Mocap Toolkit, Kelly Lee, Angela Zhou, Dana Steinke

Interdisciplinary Design Senior Theses

Motion capture technology is vital for achieving realistic movement in 3D animation, but industry-standard tracking suits and studios remain expensive and inaccessible for students, independent artists, and amateur filmmakers. Consequently, many creators rely on accessible, marker-less motion capture methods, which frequently yield noisy data, scale mismatches between the actor and the rigged model, and unnatural behaviors like foot sliding. To address these technical barriers, this project introduces a free and accessible extension for Blender designed to streamline the cleanup and integration of marker-less motion capture data. It consists of various solutions for methods of combats to motion-captured complications: the keyframe …

Formation Control Of A Multi-Agent System, Benjamin Banh, Paul Lancaster, Daniel Sims

Interdisciplinary Design Senior Theses

The primary objective of this project is to design and implement a ROS2-based multi-agent robotic prototype capable of demonstrating aggregation and formation-control behavior in a controlled indoor environment. The project explores how multiple mobile robots can coordinate through decentralized interaction rules, peer state information, and namespaced ROS2 communication rather than relying on a single centralized controller.

The project began with theoretical study and MATLAB/Simulink simulation of artificial potential fields, singleintegrator dynamics, aggregation, desired-distance formation control, and obstacle-repulsion concepts. These simulations provided an idealized environment for evaluating the general behavior of the control strategy before physical hardware limitations were introduced.

The …

Wearable Hazard Detection System For The Visually Impaired, Nolan Daly, Sergio Diaz, Brandon Ng

Computer Science and Engineering Senior Theses

This project presents a wearable assistive system designed to help blind or visually impaired people navigate their surroundings more safely. The system uses a Raspberry Pi 5 connected to Camera Module 3 (NoIR Wide) sensors to capture a wide field of view. Real-time object detection is performed using a lightweight YOLOv8 model, and a redundancy-based merging algorithm combines detections across cameras to improve reliability. By requiring agreement between multiple cameras, the system reduces false positives and increases confidence in identifying obstacles.

The device is designed to operate in real time and provide reliable feedback about nearby hazards, helping users make …

Stomp (The Student Organization Management Portal), Lindsey Leong, Madeline Follosco, Noelle Evanich, Irene Chang

Computer Science and Engineering Senior Theses

At Santa Clara University, the Center for Student Involvement (CSI) leads to support hundreds of student-led organizations with different audiences and ambitions, but all aim to bring students together nonetheless. However, such development regarding student organization management proves to be much harder when administrative processes are decentralized and cumbersome, often involving numerous layers of manual work and departmental bottlenecks. Restructuring and optimizing administrative workflows would entail more energy towards the growth of student life at Santa Clara University.

The Student Organization Management Portal, or StOMP, is a web application that aims to centralize and optimize student organization-related processes, as well …