Digital Commons Network^™

Hybrid Lipid-Gold Nanoparticles Designed For Simultaneous Gene Therapy And Photothermal Therapy Against Cancer, Navya Sree Devaguptapu

Theses and Dissertations

Traditional cancer treatments such as chemotherapy and surgery include adverse side effects and acquire resistance. Here, I developed a novel hybrid lipid-gold nanoparticle technology (LGNP) to achieve simultaneous gene regulation and photothermal therapy, specifically targeting pediatric acute myeloid leukemia (AML) and ovarian cancer. This core material consists of slice core/gold nanoshells, which are efficient heat transducers where NIR light activates nanoshells embedded in tumors, generating localized heat for tumor ablation. The ionizable lipid coating facilitates intracellular delivery of nucleic acids, such as mRNA or siRNA, to modulate gene expression effectively. Lipid-gold hybrid nanoparticles (LGNPs) are synthesized via a controlled self-assembly …

Leveraging Oxaziridines In Transition Metal Catalysis And As Reactive Intermediates, Jenna Marie Doran

Theses and Dissertations

Oxaziridines are versatile three-membered nitrogen–oxygen heterocycles that can function both as reactive intermediates and as components of transition-metal catalysts, enabling selective and diverse organic transformations. This work explores the dual role of oxaziridines in facilitating alkene functionalization and amide synthesis. We discovered that vanadooxaziridines catalyze intermolecular allylic amination with high regio- and chemoselectivity, providing a mild route to allylic amines, whereas molybdooxaziridine complexes display an unexpected preference for vinyl sulfonation, revealing a divergent pathway from the typical nitrogen-transfer reactions and offering access to synthetically valuable sulfur-containing motifs. In parallel, oxaziridine intermediates derived from imines mediate efficient formation of amides from …

Clinical Practice Guideline For Evidence-Based Management Of Chronic Prostatitis, Sandra Castro

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project involved the development, expert appraisal, and implementation of an evidence-based Clinical Practice Guideline (CPG) for chronic prostatitis management in adult male patients at a private outpatient clinic. The practice problem was persistent symptom burden from reliance on antibiotic monotherapy without adjunctive therapies, contributing to recurrent symptoms and decreased quality of life. The purpose was to develop and implement a standardized CPG to improve symptom outcomes and support antimicrobial stewardship. The project question was: In adult male patients with chronic prostatitis, how does a standardized CPG incorporating adjunctive ozone therapy and structured symptom monitoring, …

From Classroom To Cell: Examining Protective Factors Against The School-To-Prison Pipeline, Ronald Smith

Walden Dissertations and Doctoral Studies

Truancy and chronic absenteeism among adjudicated youth are significant concerns for educators, school administrators, policymakers, and juvenile justice stakeholders because persistent school disengagement may contribute to pathways associated with the school-to-prison pipeline. Grounded in Hirschi’s social bond theory, the purpose of this quantitative correlational study was to examine the relationship between parental involvement, extracurricular activities, and teacher–student social bonds and truancy/chronic absenteeism among adjudicated youth. Secondary data were obtained from the Pathways to Desistance study, which included 1,070 adjudicated youth ages 14–17 from Maricopa County, Arizona, and Philadelphia County, Pennsylvania. Multiple linear regression was used to examine the relationships among …

Perceptions Of Civilian Faculty In Professional Military Education Regarding Graduate Students’ Development Of Writing Skills, Katherine Zimmerle

Walden Dissertations and Doctoral Studies

The problem that was investigated through this study was the gap in literature about civilian faculty’s perceptions of the writing skills needed and how best to support student success in graduate-level professional military education (PME) university programs. Grounded in schema theory and transfer theory, the purpose of this basic qualitative study was to investigate the perceptions of PME civilian faculty regarding the writing skills needed and recommendations thereof to strengthen the writing skill support in PME university programs. Data were collected through semistructured interviews with eight PME civilian faculty members with at least 3 years of experience. Qualitative content analysis …

Analytic Solutions To Oceanographic Kinematic Property Equations, James Turbett

Theses and Dissertations

With the recent advent of large submesoscale drifter deployments, interpreting the timeseries of kinematic properties (KP) - divergence, vorticity, shear, and normal strain rates observed therein is a pressing issue. The evolution equations for the four KP are derived from the two-dimensional momentum conservation equations. The resulting equations, a nonlinear coupled system of ordinary differential equations, capture the submesoscale motion of drifters along fixed ocean surfaces, with time and space scales on the order of days and kilometers. This thesis builds theory around KP timeseries behavior by solving for the analytic solutions in the particular cases that one KP is …

Ai In Writing And Communication Job Listings, Max Reed

Honors Capstone Projects and Theses

No abstract provided.

America The Monstrous: The Birth Of American Horror Fiction In The Long Nineteenth Century, Rachel Kietzman

Dissertations

American gothic works that center the affect of horror explore themes of abjection, inhumanity, and monstrosity that impede a coherent expression of American identity. By approaching these works through the lens of horror rather than only as Gothic works, a picture ofa visceral, embodied becoming takes shape: America is a monstrous birth in the most literal sense of the word, a sign and demonstration that unity and uniformity are not the same, that wholeness does not require conformity, and that political choices are paid for in flesh. In short, American horror fiction is the head of Medusa, an apotropaic sign …

Vibro-Seismic Approach For Remediation Of Near-Wellbore Damage, Mounira Ahmed Abdallah

Theses and Dissertations

The research highlights the importance of vibro-seismic technology in the oil and gas industry. The primary objective of this study is to demonstrate how the vibro-seismic method enhances formation properties which are porosity, and permeability. Ultimately, this will lead to improved productivity and its application to remove the wellbore damage.

The research discusses whether or not the formation properties will be enhanced by the optimized acoustic vibration formation parameters. The thesis details laboratory experiments on core plugs, and four key findings are presented. The experimental work first showed that the use of the proper and optimum parameters enhanced the porosity …

Board Independence And Nonprofit Performance: A Contingency Approach, Ayokunle Abe Amoo

Electronic Theses and Dissertations

Board independence is central to the governance of nonprofit organizations and is widely recommended by regulators and governing bodies to strengthen accountability and performance. However, little is known about its impact on nonprofit organizations and particularly their operational efficiency, an important facet of performance reflected in fundraising and administrative cost ratios, key metrics that donors and other stakeholders rely on to assess whether a nonprofit is a responsible steward of contributed resources. Drawing on agency and institutional theories, this study examines the link between board independence and performance and the extent to which organizations’ broader socioeconomic context moderates this link. …

Strategic Artificial Intelligence Use And Microbusiness Performance: Evidence From U.S. Minority-Owned Business, Doreen Nkenyeh Ayafor

Electronic Theses and Dissertations

Minority-owned microenterprises play a critical role in economic development in underserved communities in the United States, yet persistent disparities in business performance remain. Prior research suggests that Black- and Hispanic-owned microenterprises face lower profitability and revenue relative to their White-owned counterparts, reflecting structural constraints such as limited access to capital, professional networks, and digital resources. As artificial intelligence (AI) becomes increasingly embedded in entrepreneurial decision-making, an important question is whether strategic AI use mitigates or reinforces these disparities. Drawing on the resource-based view (RBV) and critical race theory (CRT), this study examines whether strategic AI use moderates the relationship between …

How Leadership Can Support Inquiry-Based Learning In Myp Mathematics, Paul A. Thompson

Graduate Teacher Education

This literature review examined the research question: “How can instructional leadership prepare IB MYP Mathematics teachers to implement inquiry-based learning (IBL) effectively?” The review defined IBL within the International Baccalaureate Middle Years Program (IB MYP), then explored how inquiry in the MYP was designed to promote better student outcomes in conceptual understandings, interdisciplinary learning, and real-life connections. The role of the MYP Coordinator (MYP), the pedagogical leader of this program, is central to answering the questions that focus on leadership. The literature also examined the benefits and barriers of implementing inquiry-based mathematics instruction. The findings suggested that effective IBL improves …

Spatiotemporal Patterns Of Vaccine Uptake For Measles Outbreaks In Katsina State, Nigeria, Zeenat Kabir Asma'i

Walden Dissertations and Doctoral Studies

Measles remains a public health concern in Nigeria despite the availability of effective vaccines, yet limited research has comprehensively examined spatiotemporal patterns and contextual determinants of vaccination coverage and measles incidence in Katsina State. Guided by the socioecological model, this quantitative ecological study examined spatiotemporal patterns of measles incidence among children aged 9–59 months of age across 183 wards in 34 local government areas of Katsina State, Nigeria, from 2018 to 2022. Confirmed cases (n = 376) were analyzed using negative binomial regression and spatial methods, including Moran’s I, SaTScan, and geographically weighted regression (GWR). Urban wards had higher incidence …

Juvenile Probation Officers’ And Therapists’ Perceptions Of Challenges In Rehabilitating Juvenile Sex Offenders And Reducing Recidivism In The Northern Region Of Texas, Raven L. Miles-Henderson

Walden Dissertations and Doctoral Studies

Juvenile probation officers (JPOs) and therapists play a critical role in supervising and rehabilitating juvenile sex offenders (JSOs) while balancing community safety and continuity of care. However, limited community-based services, variations in professional training, and challenges related to family engagement may create barriers to successful rehabilitation and recidivism reduction. The purpose of this qualitative grounded theory study was to explore how JPOs and therapists describe the obstacles they encounter when ensuring continuity of care for JSOs in the northern region of Texas. The study was guided by Bronfenbrenner’s social-ecological model to examine systemic and relational influences on supervision practices. Data …

Impact Of Wet Vs. Dry Hair And Varying Hair Changes On Surface Dose And Setup Consistency In Whole Brain Radiation Therapy, Dyanira Salinas

Masters Projects

Purpose: The purpose of this research was to quantify how varying hair conditions—dry hair versus wet hair, complete hair loss, and the use of hair extensions—influence surface dose during WBRT. The study evaluated mask fit differences between the varying hair parameters and the potential implications for immobilization accuracy.

Methods: Four CT scans were acquired with a water phantom and varying hair parameters. A whole brain radiation therapy (WBRT) plan was created on a dry wig human hair scan using 6MV photos. Thermoluminescent dosimeters (TLDs) were used to measure surface dose for each hair condition. Gap between the water phantom and …

Musical Objects, Territories, And Otherness, Andrew Farrar

LSU Doctoral Dissertations

As the materials that composers work with have become increasingly focused on elements outside traditional pitch relations such as timbre or register, so have their approaches to form. One such stream in modern composition, starting from electronic composers such as Pierre Schaeffer, is the use of ”sound” or ”musical” objects. These materials are marked by their wholistic nature, where qualities such as timbre, density, and con- tour are as important to their identity as pitch relationships. Composers such as Schaeffer, James Tenney, and Denis Smalley have all discussed these sound objects in their writings, though they refer to them under …

Teachers’ Experiences In Teaching Foundational Reading Skills In The General Education English Language Arts Classroom In Grades 9-12, Jodi Leigh Mckenzie

Walden Dissertations and Doctoral Studies

No abstract provided.

A Regression Tree Framework For Denoising And Monitoring Of Image Data, Subhasish Basak

Doctoral Theses

The proliferation of advanced image acquisition technologies has led to the routine collection of large-scale image data across numerous scientific domains. This widespread reliance on image data accentuates the imperative to develop robust and efficient imaging techniques, which are essential for supporting modern applications across various scientific and industrial domains. This dissertation focuses on the development and analysis of methods for image denoising and image monitoring, two fundamental tasks in modern image analysis. A wide array of image denoising techniques exists in the literature, each tailored to handle specific types of noise or structural characteristics. However, no single method proves …

Effective Strategies For Retaining Millennial Employees In Small Southern Retail Businesses, Justin Nathaniel Moore

Walden Dissertations and Doctoral Studies

Small retail businesses in the Southern United States continue to experience costly millennial employee turnover, threatening workforce stability and long-term business sustainability. This issue is important to small Southern retail business owners because turnover increases staffing costs, disrupts customer service, and weakens organizational performance. The purpose of this qualitative pragmatic inquiry was to explore strategies some small Southern U.S. retail business owners use to improve millennial employee retention. The job demands–resources model grounded the research project. Participants were six owner-operators in Virginia, Alabama, and Tennessee with at least 5 years of leadership experience managing millennial employees. Data were collected through …

Measuring The Economic Effectiveness Of Climate Smart Agriculture In U.S. Rice Production Systems, Adriana Dimas

LSU Doctoral Dissertations

This dissertation evaluates the economic performance and adoption potential of climate-smart irrigation practices in Louisiana rice production systems, with particular emphasis on Alternate Wetting and Drying (AWD). Rice producers in the U.S. Mid-South face increasing challenges associated with rising input costs, water management constraints, and climate variability, creating interest in production practices that improve resilience and resource-use efficiency.

The first component of this study analyzes the profitability and risk efficiency of alternative irrigation systems using stochastic simulation and Stochastic Efficiency with Respect to a Function (SERF). Results indicate that Hybrid AWD systems in Morehouse Parish consistently generated the highest risk-adjusted …

Implications Of Weather Variability On Corn Yield In The U.S., Gideon Ayettey

LSU Master's Theses

Climate variability is a major source of risk to U.S. crop production, disrupting planting schedules and threatening yields. While prior research has explored the implications of weather shocks on crop yields, this study investigates the indirect channel via which weather variability impacts corn yield through planting delays in the U.S. Previous research has shown that U.S. corn production is highly vulnerable to short-term climate variability (Hu & Buyanovsky, 2003). We use county-level data from 2015 to 2024 for the top five corn-producing states and use a 2-stage least squares method to measure the effect. However, in our specification, planting day …

Assessing Integrated Pest Management Protocols For The Invasive Aquatic Weed Giant Salvinia (Salvinia Molesta), Samantha Lee Prinsloo

LSU Doctoral Dissertations

Giant salvinia (Salvinia molesta) is free-floating aquatic fern that originates from South America. Through human introduction, giant salvinia has escaped its native range and is listed as an invasive species across multiple continents causing negative socio-economic and environmental impacts. This research aimed to expand our understanding of integrated pest management for controlling giant salvinia by combining chemical and biological control. The objectives were to assess the effects of rainfastness, carrier volume, and growth stage on herbicide efficacy, assess augmented biological control and optimal weevil release densities, assess weevil populations in the field, determine herbicide and surfactant toxicity to …

The Role Of The Student-Teacher Relationship In The Behavioral And Academic Outcomes Of Students With Emotional And Behavioral Disorders, Samantha Warren

Graduate Teacher Education

For students with or at risk of Emotional and Behavioral Disorders (EBD), achieving success in school is challenged by a continuous cycle of behavioral and academic challenges. This literature review examined the role of student-teacher relationships in influencing both behavioral and academic outcomes for this student population. This review synthesized the findings of 15 peer-reviewed, original research studies that utilized qualitative, quantitative, and mixed-methods approaches to capture behavioral metrics and participant perspectives. The studies highlighted how distinct relational dynamics served as either a primary catalyst or a significant barrier to student improvement through day-to-day classroom interactions. Targeted praise-to-reprimand ratios and …

Interference Between Speaking And Computer Tasks In Senior Adults, Tyla K. Flake

Undergraduate Honors Theses

Multitasking is common in daily life. Previous studies have often relied on contrived tasks and utterances to explore divided attention and speech. The focus of the present study was on older adults performing everyday computer tasks while speaking naturally. Thirty participants aged 55 - 82 participated in speech-only, computer-only, and simultaneous speech and computer tasks to measure dual-task interference of the two activities. The speech task consisted of 60-second speech samples based on a list of procedural discourse prompts. Three computer tasks were completed with and without concurrent speech, one requiring data-entry and sorting and a text formatting task with …

The Relationship Between Emotional Intelligence And Leadership Styles Among African American Female Law Enforcement Supervisors, Hudson Cutno, Jr.

Walden Dissertations and Doctoral Studies

No abstract provided.

Black Entrepreneurs’ Strategies For Sustainability, Barbara Davis

Walden Dissertations and Doctoral Studies

No abstract provided.

Elementary Teachers’ Experiences Providing Feedback During 1:1 Writing Conferences, Trina Gould Williams

Walden Dissertations and Doctoral Studies

No abstract provided.

Reducing Turnover At The Frontline: Hotel Leadership Strategies, Tamica Hales

Walden Dissertations and Doctoral Studies

No abstract provided.

Organizational Demands, Worker Adaptation, And The Relational Ripple Effect In Child Welfare Case Planning, Mackenzie Alexia Leach

Walden Dissertations and Doctoral Studies

No abstract provided.

Mandatory Arrest Laws: Breaking The Cycle Of Violence In Colorado And Nebraska, Ryann Lavata Livingstone

Walden Dissertations and Doctoral Studies

No abstract provided.