Digital Commons Network^™

From Bench To Bedside: Unraveling The Role Of Sarm1 In Chronic Human Neurodegenerative Disease, Caitlin Dingwall

Arts & Sciences Graduate Student Theses and Dissertations

Axon degeneration (AxD) is an early and often causative event in many neurodegenerative diseases, yet no treatments exist to halt the breakdown of axons. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. NMNAT2 is a highly labile protein produced in the soma and trafficked into the axon. Nerve injury blocks axonal transport and leads to rapid depletion of axonal NMNAT2, causing NMN buildup and NAD+ loss. Recent breakthroughs led to the discovery that SARM1 is activated by an increase in the NMN to NAD+ ratio. While the SARM1 axon degeneration pathway …

Elected Sheriffs’ Election Process And How It Affects Their Behavior, Brian James Ardoin

Walden Dissertations and Doctoral Studies

Scholars have widely examined how electoral pressures influence the behavior of judges and prosecutors; however, less attention has been given to how elections affect law enforcement leaders. This quantitative study examined whether sheriff election cycles in Louisiana were associated with changes in law enforcement behavior. Louisiana parish sheriffs occupy a unique role as both elected officials and chief law enforcement executives, which may create incentives that influence enforcement priorities. Using secondary arrest data from the Federal Bureau of Investigation Uniform Crime Reporting program, this study analyzed parish-level arrest patterns from 2009 through 2019 to determine whether deputies’ arrest behavior differed …

Exploring Marital Resilience Through The Lived Experiences And Perception Of Spousal Support During Events Of Shared Stressors, Prince-James Smith

Walden Dissertations and Doctoral Studies

Marital resilience during shared stressors remains insufficiently understood, particularly when both spouses are simultaneously affected by the same external stressor and must adapt together over time. The purpose of this qualitative phenomenological study was to explore marital resilience through the lived experiences and perceptions of spousal support during shared stressors among individuals who had been legally married for 10 years or more, with specific attention to how participants described the shift from solo coping to dyadic coping over time. Bowlby’s attachment theory provided the theoretical foundation, and Senge’s learning organization theory served as the conceptual framework. Participants included 18 legally …

Performance-Based Budgeting Implementation Strategies For Improving Financial Performance, Waleed Ibrahim Alsyaegh

Walden Dissertations and Doctoral Studies

The lack of effective strategies for allocating organizational financial resources can lead to adverse business outcomes. Business managers are concerned about the ineffective allocation of financial resources, as it can impede financial performance and sustainability.Grounded in stakeholder theory, the purpose of this qualitative single-case study was to explore the performance-based budgeting strategies that business managers use to sustain financial profitability. The participants were 10 business managers who oversee subsidiaries that successfully implemented performance-based budgeting.Data were collected through semistructured interviews and the review of organization documents. Through thematic analysis, four themes were identified: (a) traditional versus contemporary budgeting; (b) importance of …

Exploring Leadership Strategies And Personnel Integration Practices During The Post- Merger Phase Influence The Success Of Mergers And Acquisitions, Rebekah Dumas

Walden Dissertations and Doctoral Studies

Mergers and acquisitions (M&A) have been widely used as a growth strategy; however, many organizations fail to achieve their desired outcomes. This ongoing risk is a major concern for business leaders because ineffective post-merger personnel integration can disrupt workforce stability, reduce productivity, and hinder organizational performance. Grounded in transformational leadership theory, the purpose of this qualitative pragmatic inquiry project was to explore the strategies business leaders used to integrate personnel during post-merger transitions. Data were collected through semistructured interviews with eight business leaders from global corporations who had successfully executed mergers and acquisitions, along with a review of publicly available …

Recall Of Varied Stimuli, Zachary Tyler Cain

Honors Capstone Projects and Theses

No abstract provided.

Design And Implementation Of A Monte Carlo Integrated Graphical User Interface For Rocketpy, An Open Source, Python-Based High-Power Rocketry Library, Elena Maria Dishman

Honors Capstone Projects and Theses

No abstract provided.

Designing Leadership Pipelines For Organizational Health: The Development Of The Civitas Dei Institute, Jeanette Salguero

Doctor of Strategic Leadership (DSL) Capstone Abstracts

Project Type

This project was an applied qualitative case study.

Project Overview

This doctoral capstone project examined leadership formation needs within the National Latino Evangelical Coalition and proposed the design of the Civitas Dei Institute as an auxiliary organizational structure. The study addressed the gap between increasing leadership demands placed on pastors and the lack of structured, scalable, and contextualized systems to support their development. Data was collected through semi-structured interviews, a leadership survey utilizing Likert-scale questions, and document review of existing leadership initiatives. The study focused on a purposive sample of approximately 100 pastors and ministry leaders participating in …

Public Perception Of Equine Rabies And Its Implications For Future Education And Preventative Strategies, Kya Walton

Honors College Theses

This study examined the rabies knowledge, vaccination, and risks of exposures of horse owners/overseers across the state of Kentucky. Research was conducted to determine the need for public health educators and veterinarians to inform the public on rabies. Survey results concluded that respondents' general knowledge of rabies transmission and mortality rate was respectable, but knowledge relating to equine vaccination was comparatively lower. A weak inverse relationship was observed between general rabies knowledge and concern over an individual’s horses contracting rabies. A weak positive correlation was determined when looking into general rabies knowledge and the likelihood of vaccinating an individual’s horses. …

Bptf-Dependent Regulation Of Vaccine-Induced B Cell Responses, Alexandria Sturtz

Arts & Sciences Graduate Student Theses and Dissertations

Vaccination is a method of safely generating highly specific, long-lived immunological memory that can protect a host upon future exposures to a pathogen. Memory B cells (MBCs) and high-affinity plasma cells (PCs) are pivotal populations generated during vaccine-induced immune responses as they provide rapid secondary immune responses upon antigen re-exposure. MBCs and PCs can both be produced by germinal centers (GCs), which are microanatomical structures where B cells undergo iterative rounds of somatic hypermutation and affinity-based selection. Regulation of the GC is complex and the network of factors that controls the identity, function, and magnitude of the GC B cell …

Pepper Spray Exposure And The Effect On Dna Profiling Of Blood, Brandon Schmakel

Honors Projects

Pepper spray is a common self defense tool used in both law enforcement and civilian settings, with the goal of incapacitating the sprayed individual. In real casework where pepper spray was used, a red-brown stain which tested positive presumptively for blood provided no DNA profile after further testing six months later. A previous graduate student, Emma Crawn, attempted to emulate these casework conditions and instead achieved a DNA profile with slight indications of inhibition or degradation. Further analysis of active pepper spray ingredients such as Oleoresin Capsicum (OC) and Chloroacetophenone (CN) reveals that there are observed reactions, such as oxidation, …

Examination Of Celebrity And Influencer Endorsements, Mackenzie Molnar

Honors Projects

This study examines the effects of celebrity and influencer endorsements on consumer attitudes and purchase intentions. A digital survey was distributed through Prolific to 210 U.S. participants ages 18–24. Participants viewed fictional advertisements featuring either a celebrity or an influencer endorsing a product and then rated each endorsement on familiarity, relatability, authenticity, believability, and likelihood of purchase. Results showed that endorsement type alone did not significantly affect believability, indicating that celebrities and influencers can be similarly effective in marketing. However, gender, media usage, and relatability significantly influenced consumer responses. Female participants responded more positively to influencer endorsements, while higher relatability …

How Pollinator Populations Can Impact Chronic Disease Risk, Kylee Cubbison

Honors Projects

This project investigates how pollinator populations can impact chronic disease risk. Pollinator populations are declining, which can have serious implications for human health. Declining pollinator populations can limit healthy food production and affordability. Poor nutrition is a major risk factor for most chronic diseases. Less healthy food available for people to consume can negatively impact diets and increase the risk of developing chronic diseases. This project aims to address a potential gap in research existing on this specific topic regarding pollinator populations and human chronic disease risk. A brochure targeted towards educating the general public on this topic was created …

Politics, Profit, And Programming: Examining The Distinct Effects Of Artificial Intelligence In The Corporate And Political World, Grant Lotts

Honors Projects

How has AI diffusion impacted the power and success of existing countries and corporations? This paper analyzes how these entities have invested their resources into expanding their AI presence, and how it has affected their role in their established spheres. For countries, it is examined how the amount of AI publications they create affects their means of using power, along with how efficient their governments have become. For corporations, it is examined how their capital expenditures (of which AI is becoming increasingly tied to) affects their stock price and annual revenue. Conflicting results are found. Countries tend to exhibit behavior …

Narrative Traditions In Francophone Africa And The Caribbean, Elizabeth Kill

Honors Projects

This research paper explores the cultural significance and the roles of folktales in francophone countries in Africa and the Caribbean. By analyzing recurring themes and character types in folktales, this study argues the importance of storytelling and traditional folklore in the shaping of a culture. Through close reading of a selection of folktales from a variety of francophone countries in Africa and the Caribbean, the research highlights themes of wisdom, greed, and explanations of the natural world, among others. Additionally, this paper touches on the historical importance of storytelling in cultures around the world. The research draws on information from …

Establishment Of A Hek293t Cell Model System To Investigate Direct Intracellular Interactions Between Amyloid-Β (Aβ) And The Nlrp3 Inflammasome, Cristina Sinobas Pereira

Dissertations

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. While Amyloid-β (Aβ) aggregation is a defining pathological feature, increasing evidence highlights chronic neuroinflammation as a critical contributor to disease progression. Soluble Aβ assemblies can act as damage associated molecular patterns (DAMPs) including activation of the NLRP3 inflammasome, which links amyloid pathology to sustained inflammatory responses in the brain (Heneka et al., 2015; Nakanishi et al., 2018). However, the molecular mechanisms by which specific Aβ conformations influence inflammasome assembly remain incompletely understood.This study aimed to investigate whether distinct aggregation states of amyloid β42 (Aβ42) are …

College Students, Immigration, And The News: Navigating What Is Reliable News, Alexis Pineda-Bautista

Departmental Honors & Graduate Capstone Projects

People treat mainstream media as a trustworthy source, but mainstream media has recently come into question. Mainstream media’s ability to quickly deliver accurate information has been called into doubt and there has been an increase in partisan reporting (Bennett and Livingston, 2018 as cited in Besalú and Pont-Sorribes, 2021; Besalú and Pont-Sorribes 2021). This research aims to demonstrate how the public views the mainstream media’s ability to deliver reliable information, why some participants are turning towards social media as a news source, and how people use their personal experience to verify the validity of media claims.

In semi-structured interviews, 13 …

Beyond The Numbers: Supporting Young Adults With Diabetes In The Transition To Adulthood, Alexis Salkovick

Honors Projects

This project focuses on the transition to adulthood for young people with diabetes, a chronic medical condition. Both Type 1 and Type 2 diabetes are included. The main research focus is two-part: first examining this transition including barriers to health care, changes in lifestyle, and mental health, and then creating a new, innovative tool to support young adults with diabetes. An independent literature review was conducted to investigate diabetes management, barriers to health care, how transitioning to adulthood impacts diabetes care, and the importance of patient support systems. Then, a board game was developed with the dual purpose of educating …

Analyzing 24-Hour Diet Recalls To Assess Dietary Changes Among Children Who Complete Oral Food Challenges (Ofcs), Hannah Plank, Wan Shen, Heesoon Lee

Honors Projects

Pediatric food allergies are a growing public health concern in America due to their potential association with long-term nutritional impacts and reduced quality of life in those affected. Oral food challenges (OFCs) are considered the gold standard for clinical food allergy diagnosis, but few studies have examined if passing or failing an OFC affects overall diet quality in infants. This clinical observational study examined differences in diet quality, measured by the Healthy Eating Index (HEI), among 39 children aged 0–6 years who participated in OFCs at ProMedica Allergy and Immunology Clinic in Perrysburg, Ohio. Parents and caregivers reported daily dietary …

Recognizing Metaphorical References To Sexual Assault Resistance And Represented Rape Myths In Coraline (2009), Braden Slater

Theses and Dissertations

Is there any value in children’s horror literature and film? Literary theorists have shown that children’s horror is uniquely positioned to be not only captivating and accessible, but also educational and hopeful for some young audience members. Like most fictional monsters, those presented in children’s horror can be read as metaphors for the fears and experiences people face in real life. Scholars have argued that engaging with this type of frightening media may help people confront challenging ideas and feelings from a place of safety. Building on this theoretical foundation, I perform a close reading of the 2009 film Coraline, …

“As Though You Could Never Sink”: Gender Euphoria Through Aquatic Embodiment In The Sun Also Rises, Devan Edwards

Honors Theses

Recent scholarship in disability studies and queer theory (2007-2024) reveals that Jake Barnes's war wound in Hemingway's The Sun Also Rises functions as something more complex than tragic loss. This paper argues that Jake's swimming and fishing scenes constitute moments of gender euphoria, a term borrowed from contemporary transgender studies, enabled specifically by aquatic embodiment. In these scenes, water functions as the physical and symbolic medium through which Jake's war-wounded body transcends the performative demands of 1920s heteronormative masculinity. Building on Michael Anesko's provocative reading of Jake as "accidentally transgendered" (Literature and Medicine, 2015) and Martina Kübler's argument that impotence …

Modulating Acute Stress Reactivity: Behavioral Interventions And Caffeine-Linked Stress Physiology In College Students, Kaitlyn Smith

Honors Theses

College students frequently rely on caffeine to manage academic demands, yet its physiological and psychological effects on acute stress remain poorly understood. Although caffeine is known to increase cardiovascular arousal and self‑reported anxiety, little research has compared different caffeine sources within the same individuals or examined whether brief behavioral interventions can buffer these effects. Self‑affirmation, a short writing exercise centered on personal values, has been shown to reduce stress reactivity, but its interaction with caffeine‑induced arousal has not been tested. This within‑subjects study examines how coffee, energy drinks, and a no‑caffeine control influence acute cardiovascular and self‑reported stress responses, and …

Hazardous Devices Disruptor Field Data Application, Matthew David Abrams

Honors Capstone Projects and Theses

No abstract provided.

Experimental Investigation Of Mode-Ii Interlaminar Fatigue Damage In Stitched And Unstitched End-Notched Flexure Carbon Fiber Composites, Madelyn Sloan Berry

Honors Theses

Composite materials are increasingly used in aerospace structures due to their high strength-to-weight ratio, but their susceptibility to interlaminar fatigue damage remains a critical concern, particularly under mode-II shear loading. This study investigates the fatigue behavior of stitched and unstitched quasi-isotropic carbon fiber composite specimens made of SAERTEX Class-75 non-crimp fabrics and Hexcel 1078-1 epoxy via vacuum assisted resin transfer molding. Global fatigue behavior was analyzed using displacement and crack length cycle relationships derived from compliance calibration methods (CCM), while local behavior was examined using digital image correlation (DIC). Unstitched specimens exhibited a single rapid crack growth associated with unstable …

Rationale Behind Subtitle Usage In Non-Deaf Individuals Across Various Platforms, Jenna E. Kasselman

Honors Theses

Subtitles have a long history with the medium of audiovisual communication. Options for viewing media with added text have only increased with technology, and in the age of the internet, more accessible material is available than ever before. While numerous studies have been conducted on the beneficial effects of subtitles for both the deaf and the hearing, little academic publication has been done on the rates of subtitle usage, reasons for usage, and how that usage differs based on what media is being viewed. The current study examines subtitle usage, frequency of subtitle usage, and reasoning for that usage divided …

Quantification Of Mouse Tracheal Epithelial Cell Differentiation With Cilia Defects, Olivia V. Allen

Honors Thesis

Primary Ciliary Dyskinesia (PCD) is an autosomal recessive disorder that affects 1 in every 7,500 live births. PCD results from motile cilia defects, impairing mucociliary clearance and causing chronic respiratory infections. Our lab studies include three PCD mouse lines — bgh (Spef2), nm1054 (Cfap221), and Cfap54^gt/gt (Cfap54). Prior transcriptomic data led us to hypothesize that PCD mutant mouse tracheal epithelial cells (MTECs) exhibit reduced differentiation into ciliated cells. MTECs from the trachea of the Wild Type (WT) and the PCD mutant mouse lines were cultured at an Air Liquid Interface (ALI) to start …

Liminality And Space In The Iliad And The Heike Monogatari, Jade Simmons

Theses and Dissertations

Both the Iliad and the Heike monogatari have received scholarly attention throughout the years, though rarely in comparison with one another. A few scholars, such as Tyler Creer and Naoko Yamagata, have attempted to examine the two side by side, but very little work has been done beyond their respective analyses. This is unsurprising as a cursory glance at the two texts suggests that they are too separated by time and space to warrant closer examination. I argue, however, that there is great value in analyzing the two side by side. Indeed, a closer look at these texts reveals that …

Gratitude And The Second Language Writer: The Effects Of Gratitude Journaling In The English Language Writing Classroom, Lauren Smith

Theses and Dissertations

Gratitude journaling interventions have repeatedly been shown to enhance wellbeing when conducted in participants’ first language (Emmons & McCullough, 2003; Sansone & Sansone, 2010), yet no studies to date have examined these practices in second language (L2) contexts. This mixed-methods quasi-experimental study investigated the effects of a six-week gratitude journaling intervention on adult L2 English writers enrolled in an intensive English program. Eleven writing classes (N = 183) were randomly assigned to either a gratitude journaling group or a neutral-events control group, with 123 participants completing all four stages of data collection. Trait gratitude and subjective wellbeing were measured pre-intervention, …

Weighted, I Drown Peacefully, Clarke P. Hamilton, Masaru Suzuki

Honors Thesis

weighted, i drown peacefully is a call-and-response to my ancestral history and heritage as African American, and my physical experience at the door of no return on Goree Island off the coast of Dakar, Senegal.

Through ceramic face pots invoking the face jugs recovered from Edgefield, South Carolina, visual metaphors of the calla lily and cowrie shell, wood iris petals holding water, and a watercolor painting with Adinkra symbols Adwo & Sankofa, I mark the Atlantic Ocean as a resting place of my ancestors.

This piece is for those who have transitioned from this plane to the next. I carry …

The Necessity Of Adaptive Sports: Addressing Financial Barriers To Participation In Children With Spinal Cord Injuries, Megan G. Wells

Student Capstone Papers

 Children with spinal cord injuries (SCIs) experience numerous barriers to participation in adaptive sports despite the well-established physical, psychosocial, and developmental benefits of physical activity. Financial constraints, limited awareness of funding opportunities, and the complexity of grant application processes often prevent families from accessing adaptive sports programs and specialized equipment. The purpose of this doctoral capstone project was to develop a comprehensive financial guidebook for families of children with SCIs to address financial barriers to adaptive sports participation, promote physical activity, and improve overall quality of life. Guided by the Person-Environment-Occupation-Performance (PEOP) model, this doctoral capstone project addressed financial accessibility …