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Articles 7561 - 7590 of 2261889
Full-Text Articles in Entire DC Network
Characteristics Of Intensive Care Unit Registries - Findings From The Global Registry Icu Datasets (Grid) Survey, Luigi Pisani, Paola Lecce, Cornelius Sendagire, Vrindha Pari, Carlo Olivieri, Rabiul Uddin, Diptesh Aryal, Priyantha Athapattu, Sean Bagshaw, Wangari Siika
Characteristics Of Intensive Care Unit Registries - Findings From The Global Registry Icu Datasets (Grid) Survey, Luigi Pisani, Paola Lecce, Cornelius Sendagire, Vrindha Pari, Carlo Olivieri, Rabiul Uddin, Diptesh Aryal, Priyantha Athapattu, Sean Bagshaw, Wangari Siika
Anaesthesiology, East Africa
Background: Intensive care unit registries, which aim to improve the quality of intensive care unit care through benchmarking and quality improvement initiatives, are active worldwide, with considerable dishomogeneity. We aimed to map core datasets, additional variables, and research activities of these registries.
Methods: A cross-sectional survey was disseminated to registry leads between October 2023 and June 2024. The survey was structured into four main topics: registry characteristics and coverage, core dataset features, additional modules, and registry-enabled research.
Results: Leads of 34/42 national registries responded (response rate 81%), covering 3,337 intensive care units, with a larger representation from …
Summer 2026 (202650): May 4, 2026– August 9, 2026
Summer 2026 (202650): May 4, 2026– August 9, 2026
H. Wayne Huizenga College of Business and Entrepreneurship Academic Calendar Archives
No abstract provided.
Spreading Awareness And Advocating For The Shortage Of Special Education Resources In Martin County, Florida, Lynn Potter
Spreading Awareness And Advocating For The Shortage Of Special Education Resources In Martin County, Florida, Lynn Potter
Selected Social Change Portfolios in Prevention, Intervention, and Consultation
Goal Statement:
The goal is to prevent staff shortages of special education and student support professionals in Martin County, FL, and advocate for systemic changes that improve staff retention, raise awareness, and expand special education resources.
Significant Findings:
The shortage of ESE resources in Martin County, Florida, is affecting students’ success outcomes and relationships between parents and educators. With a 42% turnover rate over the past four years, the district needs to drastically improve teacher retention (WPBF 25 News, 2023). The western zone of Indiantown, which has a minority population of Hispanic and Latino students, is critically affected (United States …
Developing Solvent-Based Recycling Methods At Ambient Conditions To Regenerate Bisphenol A Diglycidyl Ether And Recover Metal Oxides From Epoxy Nanocomposites, Heaven Smith
Rose-Hulman Undergraduate Research Publications
No abstract provided.
Highly Confident But Slightly Uncertain: A Long Overdue Reinvention Of The School Scientific Method, Teaching - Volume 4, Stephen Demeo
Highly Confident But Slightly Uncertain: A Long Overdue Reinvention Of The School Scientific Method, Teaching - Volume 4, Stephen Demeo
Publications and Research
In Volume 4, the last book of the series, I continue the argument for greater parity between conceptual knowledge—the "what" of science—and methodological knowledge—the "how" of science—but in the context of teacher instruction. To this end, two literature reviews are presented: One on how students build confidence, specifically regarding the reliability or consistency of measurement or results, and the other on scientific uncertainty. Research studies focusing on student misconceptions are summarized and organized from the elementary to the college level. These literature reviews describe invaluable ways for teachers to improve their instruction, while providing examples of experiments that can be …
Thermal And Mechanical Properties Of Zirconium Carbide Manufactured Via Ceramic On-Demand Extrusion, Clare Sabata, Yue Zhou, Jeremy L. Watts, Gregory E. Hilmas
Thermal And Mechanical Properties Of Zirconium Carbide Manufactured Via Ceramic On-Demand Extrusion, Clare Sabata, Yue Zhou, Jeremy L. Watts, Gregory E. Hilmas
Materials Science and Engineering Faculty Research & Creative Works
Zirconium carbide (ZrC) was fabricated by material extrusion additive manufacturing (AM) followed by pressureless sintering at 2000°C for two hours, achieving a relative density of 90.3 %. SEM analysis revealed grains of 4.6 ± 1.8 μm; XRD confirmed single phase ZrC. A stoichiometry of ZrC0.92 was determined by XPS. Four-point flexure testing exhibited a strength of 331.3 ± 57.1 MPa and Young's modulus of 232.8 ± 13.1 GPa. Vickers hardness was 13.6 ± 1.0 GPa and 11.6 ± 0.5 GPa at 4.91 and 9.81 N, respectively. Indentation fracture resistance was 2.9 ± 0.2 MPa⋅m1/2; Griffith analysis confirmed …
Nh Ece Research Consortium One-Pager, Jess Carson, Evan England
Nh Ece Research Consortium One-Pager, Jess Carson, Evan England
New Hampshire Early Care and Education Research Consortium
The New Hampshire Early Care and Education (NH ECE) Research Consortium is a network of researchers and research users committed to strengthening the state's ECE landscape through the use of data. This one-pager briefly describes what the Consortium does, who is involved, and how to learn more.
Animal Science Research And Extension Report 2026 (Complete Report), Department Of Animal Science
Animal Science Research And Extension Report 2026 (Complete Report), Department Of Animal Science
Animal Science Research Report 2026
This is the 2026 Animal Science and Extension Report. This highlights the research being generated within the department over the previous year.
Implementing A Professional Wellness Session To Foster Improvement In Oncology Nurse Retention And Well-Being, Connie Tran
Implementing A Professional Wellness Session To Foster Improvement In Oncology Nurse Retention And Well-Being, Connie Tran
Doctor of Nursing Practice Final Project Abstract
Purpose
The purpose of this quality improvement (QI) project was to implement chaplain-led professional wellness sessions to improve the well-being of nurses on an oncology pilot unit. Aims were to increase nurse retention by 5%, decrease staff absenteeism by 3%, and improve Perceived Stress Scale (PSS) scores by 10%, and Professional Quality of Life (ProQOL) scores by 10% from baseline.
Background
The emotionally taxing nature of oncology patient care creates a high-pressure environment, which can lead to turnover. Literature has shown that allowing staff to pray, debrief and engage in peer support groups to discuss work-related stressful encounters reduces stress …
Improving Physiologic Monitoring Adherence During Behavioral Emergencty Sedation In A Prehospital Ems System, Jared Aucoin
Improving Physiologic Monitoring Adherence During Behavioral Emergencty Sedation In A Prehospital Ems System, Jared Aucoin
Doctor of Nursing Practice Final Project Abstract
Abstract
Purpose:
This quality improvement (QI) project evaluated whether provider education and standardized documentation improved adherence to evidence-based physiologic monitoring during behavioral emergency sedation in a prehospital EMS setting.
Background:
Behavioral emergencies are common and often require rapid chemical sedation, with risks of hypoxia, hypercapnia, and cardiovascular instability. At baseline, inconsistent adherence to recommended monitoring and documentation of end-tidal carbon dioxide (EtCO₂) and pulse oximetry (SpO₂) presented an opportunity to improve patient safety.
Methodology:
This QI project educated current adult behavioral emergency protocol in a prehospital EMS setting, re-emphasizing standardized documentation and evidence-based monitoring practices. Utilizing Plan-Do-Study-Act (PDSA) through pre- …
Scroll Control: Reducing The Influence Of Social Media Trends On Adolescent Risk-Taking, Camilla Vitola-Franchi
Scroll Control: Reducing The Influence Of Social Media Trends On Adolescent Risk-Taking, Camilla Vitola-Franchi
Psychology
Adolescents tend to take more risks than other age groups due to a combination of sensitive reward systems, lower impulse control, and stronger susceptibility to peer influences. These days, many adolescents spend a substantial amount of time on social media, which can further influence their decision-making. Although risk-taking plays an important role in adolescent development, social media can increase exposure to unhealthy and potentially dangerous forms of risk. Dangerous online trends and the addictive nature of social media algorithms contribute to the normalization of risky behavior and expose adolescents to social pressures, leading them to be more likely to take …
Birds Of A Tether Flock Together: Examining Centromere Tethering And Chromosome Segregation In Caulobacter Crescentus, Jake Dwyer, Simon Kruczak, Rodrigo Arana-Garrido, Paola Mera
Birds Of A Tether Flock Together: Examining Centromere Tethering And Chromosome Segregation In Caulobacter Crescentus, Jake Dwyer, Simon Kruczak, Rodrigo Arana-Garrido, Paola Mera
MICRO-CCS student projects
Introduction:
Chromosome segregation is essential for all domains of life. Caulobacter crescentus is a key model for studying this process. It divides asymmetrically into two morphologically distinct cells. Proteins can be seen directly with fluorescent tags.
Research done on Caulobacter can apply to many different bacteria. The ParABS system is integral to chromosome segregation in Caulobacter.
ParS – DNA sequence on the chromosome
ParB – CTP-binding protein that specifically recognizes parS
ParA – ATP-binding protein that non-specifically binds DNA and provides the force for segregation.
PopZ – Polar tethering protein via interactions with ParB.
TipN - Polar protein that …
Has Plant Domestication Compromised Plant Defensive Chemistry? Aphid Induced Stress In Tomatoes, Nhi Do, Satinderpal Kaur, Minxing Zhu, Esther N. Ngumbi
Has Plant Domestication Compromised Plant Defensive Chemistry? Aphid Induced Stress In Tomatoes, Nhi Do, Satinderpal Kaur, Minxing Zhu, Esther N. Ngumbi
MICRO-CCS student projects
Tomato plants have natural defensive mechanisms.
Direct: Phenolics are secondary metabolites that can protect the plant by intoxicating the herbivores and/or producing strong repulsive odors.
Indirect: VOCs, Volatile Organic Chemicals, are gas phase signals that attract the predators of the attacking herbivore to the plant.
Domestication of plants may chemically alter these defenses by prioritizing fruit production over defensive traits.
We hypothesize that wild/ancient tomato plants would have a greater quantity of volatiles and increased concentration of leaf total phenolics compared to cultivated tomatoes during aphid herbivory.
How Does High-Oil Sorghum Change Potential Extracellular Enzyme Activity Across Soil Depth Profiles Under Drought Conditions?, Krystal Monique Role, Rounak Patra, Wendy Yang
How Does High-Oil Sorghum Change Potential Extracellular Enzyme Activity Across Soil Depth Profiles Under Drought Conditions?, Krystal Monique Role, Rounak Patra, Wendy Yang
MICRO-CCS student projects
Transgenic oil sorghum reallocates photosynthate-carbon (C) into vegetative lipids, accumulating nonstructural lipids in both shoot and root tissues. Altered plant C allocation and root lipid accumulation may shift root exudate chemistry, belowground C inputs, and microbial nutrient demand throughout the soil profile. While aboveground productivity in high-oil sorghum is well-characterized, its belowground impacts on soil microbial enzyme activity and exchangeable cation dynamics, especially across soil horizons under drought stress remain unknown.
Project objective was to find out how transgenic high oil sorghum (Tx-HO1) influences CNP acquiring extracellular enzyme activities and soil exchangeable cation dynamics across soil horizons under drought and …
Investigation Of Biological Denitrification Inhibition By Specific Anthocyanins, Kristin Palazzo, Holly Anderson, Aislinn Geedey, Angela Kent
Investigation Of Biological Denitrification Inhibition By Specific Anthocyanins, Kristin Palazzo, Holly Anderson, Aislinn Geedey, Angela Kent
MICRO-CCS student projects
Nitrogen fertilizers are applied to corn fields to support high crop yields, but some nitrogen is lost through microbial denitrification, producing nitrous oxide (N2O), a potent greenhouse gas. Some plants produce certain flavonoids that can suppress microbial denitrification, a trait known as biological denitrification inhibition (BDI). Maize produces flavonoids in the form of anthocyanins, including cyanidin-3-glucoside (C3G), the major anthocyanin produced by maize.
The goals of this project were to determine whether C3G:
is produced in maize roots
inhibits microbial denitrification
Recovering Plasmid-Id Barcoded Strains Of Sinorhizobium Meliloti From A Native Soil Microbiome, Kenny Sacks, Hannah Murray, Katy Heath
Recovering Plasmid-Id Barcoded Strains Of Sinorhizobium Meliloti From A Native Soil Microbiome, Kenny Sacks, Hannah Murray, Katy Heath
MICRO-CCS student projects
Introduction
Legume-Rhizobia Mutualism: Nitrogen is an essential nutrient for plant growth. Plants can’t produce nitrogenous compounds. Rhizobia fix atmospheric nitrogen gas into bioavailable forms. Rhizobia form a nutrient exchange mutualism with leguminous plants.
Project description
Can our bacteria persist within the rhizosphere and into the nodule when faced with native microbial competitors? The Medicago-Sinorhizobium mutualism is used as a model system. Survival of strains post competition is difficult to measure due to identical 16S rRNA sequences and similar marker genes. Plasmid-ID barcoding sequences may provide a way of testing strains against a community.
Soil Microbiome Effect On Seedling Diseases And High Throughput Isolate Identification, Annalaysia Smith, Mara Krone, Santiago Mideros
Soil Microbiome Effect On Seedling Diseases And High Throughput Isolate Identification, Annalaysia Smith, Mara Krone, Santiago Mideros
MICRO-CCS student projects
The soil microbiome has a substantial effect on disease suppression. Organic farming is a practice used to create a more diverse microbiome which can create disease suppression. Different agricultural practices such as fertilization and rotation system are known to affect the microbiome (Schlatter et al 2017). Therefore, it is important to study the effects of different microbiomes on disease suppression. Furthermore, methods are necessary for quantifying the effect of disease suppression on specific pathogen populations. To do this, it is important to properly identify the pathogens.
Objectives:
1. Test if different nitrogen treatments cause variations in organic soils disease suppression. …
Effects Of Varying Ph Levels On Prophenoloxidase Activity And Hemocyte Recruitment In Daphnia Dentifera, Yusra Siddiqi, Carla Caceres
Effects Of Varying Ph Levels On Prophenoloxidase Activity And Hemocyte Recruitment In Daphnia Dentifera, Yusra Siddiqi, Carla Caceres
MICRO-CCS student projects
Anthropogenic activities and natural processes are responsible for changing the pH of freshwaters which can impact aquatic life. D. dentifera is a keystone species found in midwestern lakes that is susceptible to a parasitic yeast called Australozyma monospora. A. monospora spores puncture the Daphnia gut into the hemolymph and begin using the host’s resources. Invertebrate immunity is under researched.
Research objective: How will different pH impact prophenoloxidase (proPO) activity and hemocyte recruitment in Daphnia dentifera?
Screening A Random Hile Mutant Library To Characterize Hild Regulation In Salmonella, Danista Kannah, Gracious Donkor, James M. Slauch
Screening A Random Hile Mutant Library To Characterize Hild Regulation In Salmonella, Danista Kannah, Gracious Donkor, James M. Slauch
MICRO-CCS student projects
Salmonella is a leading cause of gastrointestinal diseases globally. It utilizes a type three secretion system (T3SS) encoded on Salmonella Pathogenicity Island 1 (SPI1) to invade host intestinal epithelial cells during infection.
HilE directly regulates HilD via a direct protein-protein interaction. The Slauch lab identified two HilD variants, A141V and A141T, which are blind to HilE. These variants activate hilA expression even in the presence of HilE, indicating that the binding of HilE to these mutants is compromised.
Hypothesis: Performing random mutagenesis of hilE could lead to changes at the protein level which could compensate for the loss of interaction …
Fungal Diversity In Lespedeza Cuneata Roots, Gwendolyn Happ, Sophia Mcdade, Anthony Yannarell
Fungal Diversity In Lespedeza Cuneata Roots, Gwendolyn Happ, Sophia Mcdade, Anthony Yannarell
MICRO-CCS student projects
Background
- Plants form a relationship with fungi that can be beneficial or harmful
- Fungi may grow on the plant surface, within plant tissues, or around roots
- Plants release compounds that invite fungi to their roots and chemicals that can diminish unwanted fungi
Why Lespedeza cuneata?
- Invasive that competes with native plants and damages biodiversity within plant and animal communities
- Alters soil microbiome
- Expansive seed bank and deep root system
- Understanding its microbiome can help in understanding invasive species success and ecology
Efficacy And Evolutionary Dynamics Of 222 Nm Far-Uvc Against Vibrio Cholerae, Kadicha Madakimova, Angus Wu, Nkrumah Grant
Efficacy And Evolutionary Dynamics Of 222 Nm Far-Uvc Against Vibrio Cholerae, Kadicha Madakimova, Angus Wu, Nkrumah Grant
MICRO-CCS student projects
The Far-UVC light at 222 nm wavelength (UV222) is one of the emerging methods of disinfection of bacteria in public spaces such as hospitals and labs.
-
Does not penetrate human skin and does not cause harm to eyes making it a safer alternative to conventional UV systems.
-
Primarily targets proteins preventing regrowth and repair pathways.
However, the potential for bacterial adaptation following sublethal UV222 exposure remains largely unknown.
Central question: How does QS transcriptional state influence the efficacy and resistance profile of V. cholerae to UV222 nm irradiation?
Hypothesis: Qurom-sensing transcriptional state determines V. cholerae susceptibility to UV222 nm UV …
A Tale Of Two Symbionts: Comparative Cellular Localization Of Two Manipulative Rickettsiella Strains In A Spider, Kaitlyn Costanza, Thea Bliss, Matthew Doremus
A Tale Of Two Symbionts: Comparative Cellular Localization Of Two Manipulative Rickettsiella Strains In A Spider, Kaitlyn Costanza, Thea Bliss, Matthew Doremus
MICRO-CCS student projects
Many arthropods harbor maternally transmitted endosymbionts that manipulate host reproduction to increase their transmission. One such manipulation is cytoplasmic incompatibility (CI), in which embryos produced by infected males and uninfected females fail to develop.
Rickettsiella has recently been discovered to cause CI in Mermessus fradeorum. Two geographically distinct Rickettsiella strains infect this spider: R1 causes strong CI, whereas R2 causes weaker CI.
Hypothesis: H1: Both Rickettsiella strains will localize within or near developing sperm cells in the testes. H2: The stronger R1 strain will exhibit more consistent localization within infected adult reproductive tissues than the weaker R2 strain.
How Important Is Clean Energy To Utahns?, Elizabeth Brunner, Stacia Ryder
How Important Is Clean Energy To Utahns?, Elizabeth Brunner, Stacia Ryder
Utah People and Environment Poll (UPEP)
Utah's energy mix has changed significantly over the past several decades as it has moved to cleaner forms of generation. For example, according to the Energy Information Administration, in 2024, coal fueled about 45% of Utah's total electricity net generation, down from 75% in 2015. As can be seen in the chart below, the state anticipates demand growth, with further reductions in coal alongside a significant increase in solar, storage, and natural gas by 2032. Though not represented in these charts, plans for nuclear power generation have been proposed in Brigham City as well as outside of Green River. Utah …
Evaluating The Accuracy Of Face2gene Phenotyping Tools In South African Children With Neurodevelopmental Disorders, Hendrike Mcdonald, Zandrè Bruwer, Michal Zieff, Emma Eastman, Brigitte Melly, Rizqa Sulaiman-Bardien, Karen Fieggen, Shahida Moosa, Charles Newton, Amina Abubakar
Evaluating The Accuracy Of Face2gene Phenotyping Tools In South African Children With Neurodevelopmental Disorders, Hendrike Mcdonald, Zandrè Bruwer, Michal Zieff, Emma Eastman, Brigitte Melly, Rizqa Sulaiman-Bardien, Karen Fieggen, Shahida Moosa, Charles Newton, Amina Abubakar
Institute for Human Development, East Africa
Objectives Computational phenotyping tools, like Face2Gene, are increasingly used to support genetic diagnosis by analysing facial features. These tools perform well in Global North populations but are less accurate in other groups. This study aimed to assess the performance of Face2Gene’s DeepGestalt, FeatureMatcher, and D-Score in South African children with neurodevelopmental disorders (NDDs) and unaffected controls.
Methods Facial photographs of 301 children from the NeuroDev South Africa study were analysed including 36 children with NDDs with a confirmed molecular diagnosis, 176 with NDDs without a confirmed molecular diagnosis, and 89 controls. Diagnostic accuracy of DeepGestalt and FeatureMatcher was assessed by …
Exploration Of The Vein To Vein Blood Transfusion System In Three Kenyan Counties: A Qualitative Study, Linda Barnes, Jennifer Makin, Jose Paiz, Jana Macleod, Cindy Makanga, Tecla Chelagat, Alejandro Munoz-Valencia, Ejemai Eboreime, Robert Kaburu, Carolyne Njoki
Exploration Of The Vein To Vein Blood Transfusion System In Three Kenyan Counties: A Qualitative Study, Linda Barnes, Jennifer Makin, Jose Paiz, Jana Macleod, Cindy Makanga, Tecla Chelagat, Alejandro Munoz-Valencia, Ejemai Eboreime, Robert Kaburu, Carolyne Njoki
Anaesthesiology, East Africa
Background Severe shortages of blood for transfusion are a persistent global health crisis, with the burden disproportionately concentrated in low-income countries. Diverse stakeholder perspectives on blood availability might inform improvements. We aimed to use a comprehensive approach to identify the challenges, facilitators, and innovations within the blood transfusion continuum (BTC) in three different Kenyan settings.
Methods In this qualitative study, we interrogated the BTC in Siaya, Nakuru, and Turkana counties as part of the Pathways for Innovation in Blood Transfusion Systems in Kenya (PITS Kenya) mixed methods research study. We used purposive sampling, and through interviews and focus group discussions, …
Communication And Prosocialization: Understanding The Development Of Inclusive Morality, Hannah Smith
Communication And Prosocialization: Understanding The Development Of Inclusive Morality, Hannah Smith
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Relationships between individuals from different social or cultural groups are often impacted by ingroup favoritism, outgroup bias, and structural inequity determined by a person's social and cultural identities. Recognizing this, scholars and practitioners for the last few decades have attempted to address this by creating interventions, workshops, and other applied programs that aim to reduce this intergroup bias and ameliorate the negative consequences. The current dissertation complements this body of applied scholarship by shifting the focus from reducing and minimizing bias to focusing on processes that lead to a more prosocial and inclusive worldview.
The overall aim is to understand …
From Hidden To Display- Building An Exhibition Space From Nothing, Laura Mehaffey, Jessica Cerri, Lawrence Treadwell Iv
From Hidden To Display- Building An Exhibition Space From Nothing, Laura Mehaffey, Jessica Cerri, Lawrence Treadwell Iv
Librarian Presentations
This poster presents the Chesnutt Library at Fayetteville State University’s strategy to identify and transform underutilized space on a limited budget into high impact exhibition and display spaces. This project fostered new opportunities for collaboration between the library, faculty, and other university departments such as programs with the Office of Faculty Development. The result has not only been new partnerships for the library but increased engagement with faculty, students, and alumni while also highlighting the strategic value of the library, its services, and collections.
This Or That- American Library Association 2026, Nicole Mackowiak, Jessica Cerri, Lawrence Treadwell Iv, Danielle Hicks, Morgan Grayson
This Or That- American Library Association 2026, Nicole Mackowiak, Jessica Cerri, Lawrence Treadwell Iv, Danielle Hicks, Morgan Grayson
Librarian Presentations
Gamifying library outreach via analog and digital channels, from simple whiteboard displays to creatively printed Canva posters and Springshare’s LibWizard quizzes, enhances student engagement. The development of these interactive displays leverages library creative space technology and digital engagement tools to boost participation in both on-campus and remote university community members. By combining creative space technology with approachable design tools and simple gamification techniques, this model offers innovative yet replicable methods that can be scaled for academic, public, or school libraries
Gender Differences In The Prevalence Of Anxiety And Post-Traumatic Stress Disorder And Associated Factors Among Adults In Sub-Saharan Africa: A Systematic Review And Meta-Analysis, Basil Masinza, Amina Abubakar, Joy Mukubuyi, Patrick Mwangala
Gender Differences In The Prevalence Of Anxiety And Post-Traumatic Stress Disorder And Associated Factors Among Adults In Sub-Saharan Africa: A Systematic Review And Meta-Analysis, Basil Masinza, Amina Abubakar, Joy Mukubuyi, Patrick Mwangala
Institute for Human Development, East Africa
Background: Sex and gender equity in research has a growing focus, but there are gaps in fully integrating it in mental health research, limiting adoption of sex and gender-sensitive interventions. This review adopted a gendered perspective to synthesize prevalence and associated factors contributing to differences in anxiety and PTSD in SSA.
Methodology: Electronic search was conducted in PubMed, PsycINFO, CINAHL, Scopus, Web of Science databases. Empirical studies conducted in SSA, targeting adults >18 years and having gender-disaggregated anxiety and PTSD prevalence and factors were included. Meta-analysis of proportions stratified by sex was done, and narrative synthesis of the …
Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction In Multiethnic Cohorts, Meri Okorie, Caroline Jonson, Alexis Oddi, Patricia Castruita, Brian Fulton-Howard, Kristine Yaffe, Jennifer Yokoyama, Chinedu Momoh, Shea Andrews
Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction In Multiethnic Cohorts, Meri Okorie, Caroline Jonson, Alexis Oddi, Patricia Castruita, Brian Fulton-Howard, Kristine Yaffe, Jennifer Yokoyama, Chinedu Momoh, Shea Andrews
Brain and Mind Institute
INTRODUCTION Genome-wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer's disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse populations remains low. Here, we evaluated the predictive accuracy of single-, multi-, and cross-ancestry AD-PRS models across multi-ancestral populations.
METHODS We used AD GWAS summary statistics from European, African, Admixed American, and East Asian populations to construct AD-PRS for each target population. Model performance was assessed by estimating odds ratios, R2, and area under the curve.
RESULTS The cross-ancestry Bayesian PRS model demonstrated the highest predictive performance in non-European …