Digital Commons Network^™

Aberrant Ciliogenesis Induced By Enhanced Bmp Signaling Causes Heterotopic Ossification, Hiroyuki Yamaguchi, Jianbo Wang, Fangfang Yan, Jiarui Bi, Radbod Darabi, William R. Lagor, Zhongming Zhao, Aris N. Economides, Yuji Mishina, Yoshihiro Komatsu

Faculty, Staff and Student Publications

Bone morphogenetic protein (BMP) signaling is a principal driver of heterotopic ossification (HO), yet how aberrant BMP activity structurally reprograms cellular signaling machinery to develop HO remains unclear. Here, we identify BMP signaling as a direct upstream regulator of ciliogenesis that coordinates a multi-stage, pro-osteochondrogenic signaling relay during HO. Using a conditional gain-of-function BMP mouse model (Acvr1Q207D/+), we demonstrate that enhanced BMP signaling promotes primary cilium biogenesis and axonemal elongation through canonical Smad1/5/9-dependent transcriptional activation of intraflagellar transport (IFT) Ift20, a core component of the IFT machinery. Rather than operating via a singular downstream cascade, these elongated …

Tranexamic Acid In High-Risk Shoulder Arthroplasty Patients: Safety Across Thromboembolic, Cardiac, Renal, And Neurologic Risk Profiles, Tarishi Parmar, Akin Adio, Asim Handy, Mohammad Daher, Alec Kellish, Adam Khan, Joseph A. Abboud

Rothman Institute Papers

INTRODUCTION: Tranexamic acid (TXA) effectively reduces blood loss and transfusion requirements in shoulder arthroplasty. However, concerns regarding thromboembolic, neurologic, cardiac, and renal complications have limited its use in medically high-risk patients. This study evaluated temporal trends and the safety of TXA in high-risk patients undergoing total shoulder arthroplasty (TSA).

METHODS: A retrospective cohort study was conducted using TriNetX, identifying patients who underwent shoulder arthroplasty (2012-2025). Patients were stratified by preexisting high-risk conditions, including prior thromboembolism, renal failure, atrial fibrillation, seizure disorders, and visual disturbances. Within each subgroup, patients receiving TXA were propensity score-matched to those who did not. Perioperative TXA …

Energy Efficiency Limits And Future Electricity Demand Of Computing Devices, Ricardo Pinto, Tiago Domingos, Paul E. Brockway, Matthew Kuperus Heun, Tânia Sousa

University Faculty Publications and Creative Works

• ICT (information and communication technologies) represented 4% of the world electricity consumption in 2020; 
• Computing devices represented 2% of the world electricity consumption in 2020; 
• In recent scenarios datacentre electricity demand reaches 3% of world electricity in 2030, and more than 4% in 2035

"In My Community, If You're An Addict, People Don't Just Look Down On You For The Drugs, But For Being Black, Too": Black And Latine Methadone Patients' Experiences Around Addiction, Methadone Treatment, And Intersectional Stigma, A.M. Ward, T. Wood, Donny Gerke, Suzan Walters, J. Williams, D. Clement, M. Katandu, D. Ferguson, K. Morrison, Yahya Alnashri, Benjamin Grin, Jessica Jaiswal

Faculty and Staff Publications

Background: Stigma surrounding opioid use disorder (OUD) and medications for opioid use disorder (MOUD), such as methadone, remains a significant barrier to care, despite the effectiveness of MOUD. Intersectional stigma tied to addiction, methadone treatment, structural racism, and classism disproportionately affects minoritized people with OUD, with direct consequences for health and wellbeing. Less is known about how Black and Latine people in methadone treatment think about and experience various dimensions of stigma related to addiction and the social determinants of health.

Methods: Semi-structured interviews were conducted with Black and Latine patients from two Newark, NJ, United States, methadone clinics (n …

Climate-Responsive Design For Sustainable Construction: Passive Strategies In Domestic Architecture Supporting Sustainability, Nahed Chakouf

All Works

This study explores climate-responsive design in domestic architecture, focusing on the application and effectiveness of passive strategies across various climatic regions, including the UK, hot-arid, tropical, and cold climates. A qualitative comparative case study method was used to explore different passive design strategies, integration of sustainability, procurement, the coordination of stakeholders, and compliance with regulations in residential architectural projects under varying climate conditions. Drawing from a combination of historical case studies and original architectural projects, the research evaluates how spatial configuration, material selection, solar orientation, shading, ventilation, and insulation are optimized to achieve thermal comfort and energy efficiency. In temperate …

Childhood Development Podcast Assignment, Masha Komolova

Open Educational Resources

The assignment asks students to analyze how a particular aspect of their childhood has shaped them into a person they are today. Students will use literature review, interview with a caregiver, and their own reflection to analyze their childhood development and its effects on them. The assignment will be in the form of a podcast.

Ai-Resistant And Ai-Resilient Assessment In Higher Education: A Systematic Review Of Validity-Grounded Strategies, Institutional Frameworks, And Equity Implications, Asrat Genet Amnie

Publications and Research

The emergence of large language models has precipitated a fun damental disruption to higher education assessment. Conventional instruments are susceptible to AI-assisted completion, threatening construct validity across disciplines and institutional contexts. When submitted work reflects AI capability rather than student competency, the inferential chain from performance to qualifica tion is invalidated – a problem of design rather than detection. This systematic review makes two contributions. First, it theorises and grounds the distinction between AI-resistant assessment, which seeks to prevent or impede AI access through containment, and AI-resilient assessment, which assesses genuine human cogni tive performance of intrinsic educational value regardless …

Advancing Bioinformatics With Language Models: Components, Applications, And Perspectives, Jiajia Liu, Mengyuan Yang, Yankai Yu, Haixia Xu, Tiangang Wang, Kang Li, Xiaobo Zhou

Faculty, Staff and Student Publications

Large language models (LLMs) are deep learning-based artificial intelligence models that have achieved remarkable success in natural language processing. Typically composed of neural networks with billions of parameters, they are trained on massive unlabeled datasets using self-supervised or semi-supervised learning. Beyond language, LLMs hold immense potential for addressing complex bioinformatics challenges. This review provides a comprehensive overview of transformer-based model applications in genomics, transcriptomics, proteomics, drug discovery, and single-cell analysis. We discuss critical components, including tokenization strategies for diverse biological data, transformer architectures, attention mechanisms, and pretraining approaches. We also survey currently available foundation models and their downstream applications across …

“I Never Really Thought That Would Be Something To Talk About With My Doctor”: Developing A Theory-Led Decision Aid For College Students’ Substance Use Disclosure In Healthcare, Hayley Stahl

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

College students who use drugs face compounding barriers to disclosing substance use to healthcare providers, including uncertainty about health consequences and stigma-driven identity concerns. Existing disclosure tools address neither barrier in an integrated fashion. This explanatory sequential mixed-methods study examined how constructs from the Theory of Motivated Information Management (TMIM; Afifi & Weiner, 2004) and Stigma Management Communication (SMC; Meisenbach, 2010) theory suggest factors influencing substance use disclosure among college students and shape their lived disclosure experiences. In Study 1, simultaneous-entry multiple regression analyses revealed that communication efficacy was associated with information seeking, perceived benefits of disclosure were linked to …

The Role Of Cross-Cultural Connections In Leadership Identity Development: From Entry To Embodiment, Jennifer Okoliko

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Leadership identity development has received considerable attention in the literature, but most of what we know comes from studies focused on students in formal leadership programs or on the mentee’s side of mentoring relationships. Less understood is the mentor's leadership identity development journey and the role of culture in that process.

This study explores how mentors from low power distance cultural backgrounds who engaged with mentees from high power distance cultural backgrounds interpreted the impact of those experiences on their leadership identity development.

Using Interpretive Phenomenological Analysis (IPA), I conducted two semi-structured interviews with ten participants recruited from different formal …

Sales Innovativeness Climate And B2b Salesperson Performance: The Roles Of Persistence, Entrepreneurial Self-Efficacy And Creative Selling, John Charles Peter Edwards, Steven Peter D'Alessandro, Morgan Miles

Research outputs 2022 to 2026

Purpose: Persistence is widely viewed as essential for success in business to business (B2B) selling, yet it remains unclear how persistence translates into higher sales performance when selling requires experimentation and novel customer solutions. This study examines whether a perceived sales innovativeness climate enables persistence and entrepreneurial self-efficacy (ESE) and, in turn, creative selling, driving B2B sales performance.

Design/methodology/approach: An online survey of 346 US-based B2B salespeople was analyzed using partial least squares structural equation modelling (PLS-SEM).

Findings: The perceived sales-innovativeness climate is positively associated with ESE, persistence, and sales performance. Persistence is positively related to sales performance and ESE, …

Transformative Phygital Service Research (Tpsr): An Agenda For Future Research, Saadia Shabnam, Sanjit K. Roy, Yonathan Silvain Roten, Gaganpreet Singh, Taewon Suh, Hairong Li

Research outputs 2022 to 2026

Purpose – This paper aims to develop a transformative phygital service research (TPSR) framework to explain how hybrid physical-digital service systems shape consumer well-being, autonomy, dignity and inclusion. While prior phygital service research (PSR) advances understanding of hybrid experiences and human-centred ecosystems, key ambiguities persist around agency, governance and interpretive labour in algorithmically mediated interactions. Existing frameworks address value co-creation but lack clarity on how digitally enforced rules and redistributed labour drive transformation. TPSR addresses this gap by theorising contradiction-driven processes through which human–AI arrangements and socio-technical dynamics produce both empowering and erosive outcomes in phygital service environments. Design/methodology/approach – …

Patients, Not Lab Values: Ethical Reflections On The Limits Of Reductionist Biology, Kody Park, Tai Metzger, Sung-Ki Lee, Abdullah Jalal, Christine Lin, Jasmanet Chahal, Kacie Park

Student Publications

No abstract provided.

Multiplexed Plasmon-Enhanced Lateral Flow Assay For Early Diagnosis Of Acute Kidney Injury, Heng Guo, Yuxiong Liu, Ravi Jada, Ying Liu, Carissa Ng, Aquiles Payte, Jiaying Xu, Connor Malone, Jie Zhao, Kedhareswara Sairam Pasupuleti, Arda Aidan Arikan, Sameer Thadani, Srikanth Singamaneni, Ayse Akcan Arikan, Limei Tian

Faculty, Staff and Students Publications

Early diagnosis of acute kidney injury (AKI) remains a major clinical challenge due to the delayed and insensitive nature of conventional markers such as serum creatinine. Urinary protein biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC), provide earlier and complementary information on kidney injury, but their clinical translation is limited by the lack of rapid, quantitative, and multiplexed point-of-care (POC) diagnostic tests. Here, we report a multiplexed plasmonic-fluor-based lateral flow assay (p-LFA) that enables sensitive, quantitative, and simultaneous detection of NGAL and CysC. By harnessing ultrabright plasmonic-fluor nanolabels and ratiometric fluorescence analysis, the p-LFA achieves picogram-per-milliliter analytical sensitivity …

Elective Genomic Sequencing For Adults In Research, Clinical And Commercial Contexts, Michael D Linderman, Sophia M Adelson, Tala M Berro, Jennifer L Anderson, Scott D Crawford, Tshaka J Cunningham, Edward D Esplin, Altovise T Ewing-Crawford, Daiva E Nielsen, Stacey Pereira, Tara Schmidlen, Heather Andrighetti, Steven B Bleyl, George M Church, Eden V Haverfield, Madhuri Hegde, Lazaridis N Konstantinos, Paul Kruszka, Debra Leonard, Thomas May, Molly Mcginniss, Vaibhav Pandya, Eric E Schadt, Bastian Greshake Tzovaras, Bethany Zettler, Amy L Mcguire, Robert C Green

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Elective genomic sequencing (EGS) returns monogenic disease findings in multiple genes, including potentially novel variants, and may also provide participants with carrier status, pharmacogenomic and other health-related information. The PeopleSeq Study assessed participants' motivations for and concerns about EGS and the associated clinical and psychosocial outcomes across diverse EGS providers.

Methods: We administered a shared questionnaire to participants who chose to undergo EGS via 18 academic, clinical, or commercial EGS platforms.

Results: We enrolled 1575 participants, of whom 1147 (72.8%) completed a questionnaire after receiving their EGS results. A majority (60.3%) of the participants who completed a post-result questionnaire …

Rapid Recovery Of Peripheral Oxygen Saturation In Hypoxic Covid-19 Patients With Ivermectin/Doxycycline/Zinc Multidrug Therapy, Sabine Hazan, Adriana C. Vidal, Eleftherios Gkioulekas, Anoja W. Gunaratne, Sibaish Dolai, Robert L. Clancy, Peter A. Mccullough, Thomas J. Borody

School of Mathematical & Statistical Sciences Faculty Publications

Several combination therapies for the early outpatient treatment of COVID-19 were proposed by independent research groups at the onset of the pandemic during 2020 and 2021. In this observational study, we report on the outcomes of an off-label triple combination therapy, consisting of ivermectin, doxycycline, and zinc, with adjunct vitamin C and D3 supplementation, which was used on high-risk COVID-19 patients. These patients refused an initial recommendation to seek inpatient care, despite a high-risk presentation compounded with one or more comorbidities and/or severe hypoxia. Telemedicine was used to administer personalized treatment to patients at home, who did not have access …

A Core Outcome Measurement Set For Hyperemesis Gravidarum Research: A Consensus Study, Kate Maslin

School of Nursing and Midwifery

BackgroundOutcome reporting in hyperemesis gravidarum (HG) research lacks standardization, which hampers the aggregation of data. A core outcome set (COS) for HG research has been developed to increase standardization. While a COS represents which key outcomes should be measured, it does not describe how and when they should be measured. Our aim was to develop a consensus-based core outcome measurement set for HG complementing the existing COS for HG.MethodThis study included multiple phases: (1) systematic review to identify all existing outcome measurement instrument (OMI)s in HG research; (2) a consensus meeting with the steering committee of this study to vote …

Understanding The Role Of Entropy In Designing High-Performance Thermoelectrics, Subrata Ghosh, Soongyu Kwon, Wenjie Li, Dipika Mandal, Amin Nozariasbmarz, Marcia Ahn, Sumanta K. Karan, Allison M. Beese, Yi Xia, Shashank Priya, Bed Poudel

Mechanical and Materials Engineering Faculty Publications and Presentations

The design of high-entropy alloys is effective in lowering thermal conductivity but often reduces carrier mobility, thereby limiting electrical transport properties. Understanding the relationship among configurational entropy, thermal conductivity, and carrier mobility in high-entropy alloys is critical for enhancing thermoelectric performance. We demonstrate that a systematic and substantial increase in configurational entropy in half-Heusler alloys leads to an asymptotic reduction of lattice thermal conductivity. The reduced phonon group velocity and enhanced phonon scattering induced by atomic-scale chemical disorder result in a low lattice thermal conductivity of 2 watts per meter per kelvin at room temperature, with an achievable minimum of …

A Conserved Mechanism For Dimerization And Activation Of Superfamily 1a Uvrd-Family Helicases, Binh Nguyen, Kacey N Mersch, Ankita Chadda, Eric A Galburt, Timothy M Lohman

2020-Current year OA Pubs

DNA helicases are ATP-dependent motor proteins that catalyze duplex DNA unwinding and are involved in DNA repair, recombination, and replication restart. Prominent members of the non-hexameric SF1A UvrD-family helicases are Escherichia coli UvrD, Rep, Bacillus stearothermophilus PcrA, and Mycobacterium tuberculosis (Mtb) UvrD1. SF1A monomers are processive 3'-to-5' single-stranded DNA translocases but need to be activated to become DNA helicases. One mechanism of activation is dimerization. Whereas Rep, UvrD, and PcrA form non-covalent dimers, the Mtb UvrD1 helicase forms a redox-dependent covalent dimer. Dimerization of Mtb UvrD1 occurs between the same regulatory domain (2B) within each subunit stabilized by a disulfide …

A Process For The Preparation Of (S)-3-Amino-3-(4-Chlorophenyl)Propan-1-Ol, Msn Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, Srinivas Reddy Gade, Suresh Challa.

Defensive Publications Series

The present disclosure relates to a process for the preparation of (S)-3-amino-3-(4-chlorophenyl)propan-1-ol of formula-1, which is represented by the following structural formula.

Formula-1

Websites Of Pharmacy Colleges: A Webometric Analysis, Yashwant S. Chaudhari Mr., Hemant S. Bhoye

Library Philosophy and Practice (e-journal)

In the digital era, institutional websites act as the primary gateway for disseminating academic information, services, and research output. Webometric analysis is a quantitative method used to evaluate the performance, visibility, and impact of websites based on web-based indicators such as hyperlinks, web pages, and parts of web pages.  This study examines 17 pharmacy colleges in Nashik district, out of a total of 63 pharmacy colleges affiliated to Savitribai Phule Pune University, Pune. The study examines domain extensions, number of web pages, internal and external links, and availability of library webpages. It also evaluates content features such as academic information, …

Technical Disclosure: The Urban Biosphere Ziggurat (Ubz), Affordable Housing And Urban Planning, Christopher L. Eckes

Defensive Publications Series

Current high-density urban housing models in the United States routinely fail because they optimize strictly for initial cost-per-square-foot, resulting in double-loaded corridor containment layouts that restrict natural light, induce community stagnation, and induce severe benefit "cliff effects" on upwardly mobile residents. The Urban Biosphere Ziggurat (UBZ) framework resolves this systemic crisis by decoupling high-tech, factory-precise structural engineering from regional, artistic architectural cladding. This disclosure outlines a scalable, non-speculative structural chassis integrated into a Community Land Trust (CLT) and Limited-Equity Housing Cooperative (LEHC) [1.5] governance ecosystem, permanently divesting real estate from predatory international speculation. [1]

To maximize municipal feasibility …

Concurrent Presentation And Evaluation Of Multi-Stream Media, Guillaume Vernon Bailey

Defensive Publications Series

Current techniques for displaying vertical videos on landscape displays suffer from inefficient use of lateral screen space and rely on linear navigation that yields limited, dwell-time-based engagement data. The disclosed technology addresses this by replacing single-video presentation with a concurrent multi-stream interface, displaying multiple vertical videos side-by-side in a user interface on a screen of a television. The disclosed technology maintains one media content item in an active playback state while keeping peripheral media content items in a subdued state, such as dimmed or paused. Users navigate horizontally to shift the active focus or vertically to populate a completely new …

A Scholarship, A Calling, And A Bright Future, July 02, 2026, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

In Re: Felicia Smith; Reinard Smith

2026 Decisions

USDC for the District of New Jersey

Pascal Gedeon V. Usa

2026 Decisions

USDC for the Eastern District of Pennsylvania

Daniel Lewis V. Superintendent Phoenix Sci

2026 Decisions

USDC for the Eastern District of Pennsylvania

Cotton/Soybean Insect Newsletter, July 02, 2026, Jeremy K. Greene

Clemson University Cotton/Soybean Insect Newsletter

No abstract provided.

Reframing The "Weekend Effect": From Hospital "Failure" To System-Level Selection, Jonathan Dawson, Aditya Loganathan, Nicholas Melucci, Michael Friedman, Maeve Mclaughlin, Marissa Potenza, Erica Valdovinos, Robert Shesser

URGENT Matters

No abstract provided.

Debtor's Motion To Approve Opt Out Ballot

Catholic Dioceses in Bankruptcy

No abstract provided.