Digital Commons Network^™

Elective Genomic Sequencing For Adults In Research, Clinical And Commercial Contexts, Michael D Linderman, Sophia M Adelson, Tala M Berro, Jennifer L Anderson, Scott D Crawford, Tshaka J Cunningham, Edward D Esplin, Altovise T Ewing-Crawford, Daiva E Nielsen, Stacey Pereira, Tara Schmidlen, Heather Andrighetti, Steven B Bleyl, George M Church, Eden V Haverfield, Madhuri Hegde, Lazaridis N Konstantinos, Paul Kruszka, Debra Leonard, Thomas May, Molly Mcginniss, Vaibhav Pandya, Eric E Schadt, Bastian Greshake Tzovaras, Bethany Zettler, Amy L Mcguire, Robert C Green

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Elective genomic sequencing (EGS) returns monogenic disease findings in multiple genes, including potentially novel variants, and may also provide participants with carrier status, pharmacogenomic and other health-related information. The PeopleSeq Study assessed participants' motivations for and concerns about EGS and the associated clinical and psychosocial outcomes across diverse EGS providers.

Methods: We administered a shared questionnaire to participants who chose to undergo EGS via 18 academic, clinical, or commercial EGS platforms.

Results: We enrolled 1575 participants, of whom 1147 (72.8%) completed a questionnaire after receiving their EGS results. A majority (60.3%) of the participants who completed a post-result questionnaire …

Multiplexed Plasmon-Enhanced Lateral Flow Assay For Early Diagnosis Of Acute Kidney Injury, Heng Guo, Yuxiong Liu, Ravi Jada, Ying Liu, Carissa Ng, Aquiles Payte, Jiaying Xu, Connor Malone, Jie Zhao, Kedhareswara Sairam Pasupuleti, Arda Aidan Arikan, Sameer Thadani, Srikanth Singamaneni, Ayse Akcan Arikan, Limei Tian

Faculty, Staff and Students Publications

Early diagnosis of acute kidney injury (AKI) remains a major clinical challenge due to the delayed and insensitive nature of conventional markers such as serum creatinine. Urinary protein biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC), provide earlier and complementary information on kidney injury, but their clinical translation is limited by the lack of rapid, quantitative, and multiplexed point-of-care (POC) diagnostic tests. Here, we report a multiplexed plasmonic-fluor-based lateral flow assay (p-LFA) that enables sensitive, quantitative, and simultaneous detection of NGAL and CysC. By harnessing ultrabright plasmonic-fluor nanolabels and ratiometric fluorescence analysis, the p-LFA achieves picogram-per-milliliter analytical sensitivity …

A Conserved Mechanism For Dimerization And Activation Of Superfamily 1a Uvrd-Family Helicases, Binh Nguyen, Kacey N Mersch, Ankita Chadda, Eric A Galburt, Timothy M Lohman

2020-Current year OA Pubs

DNA helicases are ATP-dependent motor proteins that catalyze duplex DNA unwinding and are involved in DNA repair, recombination, and replication restart. Prominent members of the non-hexameric SF1A UvrD-family helicases are Escherichia coli UvrD, Rep, Bacillus stearothermophilus PcrA, and Mycobacterium tuberculosis (Mtb) UvrD1. SF1A monomers are processive 3'-to-5' single-stranded DNA translocases but need to be activated to become DNA helicases. One mechanism of activation is dimerization. Whereas Rep, UvrD, and PcrA form non-covalent dimers, the Mtb UvrD1 helicase forms a redox-dependent covalent dimer. Dimerization of Mtb UvrD1 occurs between the same regulatory domain (2B) within each subunit stabilized by a disulfide …

A Process For The Preparation Of (S)-3-Amino-3-(4-Chlorophenyl)Propan-1-Ol, Msn Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, Srinivas Reddy Gade, Suresh Challa.

Defensive Publications Series

The present disclosure relates to a process for the preparation of (S)-3-amino-3-(4-chlorophenyl)propan-1-ol of formula-1, which is represented by the following structural formula.

Formula-1

Websites Of Pharmacy Colleges: A Webometric Analysis, Yashwant S. Chaudhari Mr., Hemant S. Bhoye

Library Philosophy and Practice (e-journal)

In the digital era, institutional websites act as the primary gateway for disseminating academic information, services, and research output. Webometric analysis is a quantitative method used to evaluate the performance, visibility, and impact of websites based on web-based indicators such as hyperlinks, web pages, and parts of web pages.  This study examines 17 pharmacy colleges in Nashik district, out of a total of 63 pharmacy colleges affiliated to Savitribai Phule Pune University, Pune. The study examines domain extensions, number of web pages, internal and external links, and availability of library webpages. It also evaluates content features such as academic information, …

Technical Disclosure: The Urban Biosphere Ziggurat (Ubz), Affordable Housing And Urban Planning, Christopher L. Eckes

Defensive Publications Series

Current high-density urban housing models in the United States routinely fail because they optimize strictly for initial cost-per-square-foot, resulting in double-loaded corridor containment layouts that restrict natural light, induce community stagnation, and induce severe benefit "cliff effects" on upwardly mobile residents. The Urban Biosphere Ziggurat (UBZ) framework resolves this systemic crisis by decoupling high-tech, factory-precise structural engineering from regional, artistic architectural cladding. This disclosure outlines a scalable, non-speculative structural chassis integrated into a Community Land Trust (CLT) and Limited-Equity Housing Cooperative (LEHC) [1.5] governance ecosystem, permanently divesting real estate from predatory international speculation. [1]

To maximize municipal feasibility …

Concurrent Presentation And Evaluation Of Multi-Stream Media, Guillaume Vernon Bailey

Defensive Publications Series

Current techniques for displaying vertical videos on landscape displays suffer from inefficient use of lateral screen space and rely on linear navigation that yields limited, dwell-time-based engagement data. The disclosed technology addresses this by replacing single-video presentation with a concurrent multi-stream interface, displaying multiple vertical videos side-by-side in a user interface on a screen of a television. The disclosed technology maintains one media content item in an active playback state while keeping peripheral media content items in a subdued state, such as dimmed or paused. Users navigate horizontally to shift the active focus or vertically to populate a completely new …

In Re: Felicia Smith; Reinard Smith

2026 Decisions

USDC for the District of New Jersey

Pascal Gedeon V. Usa

2026 Decisions

USDC for the Eastern District of Pennsylvania

Cotton/Soybean Insect Newsletter, July 02, 2026, Jeremy K. Greene

Clemson University Cotton/Soybean Insect Newsletter

No abstract provided.

Reframing The "Weekend Effect": From Hospital "Failure" To System-Level Selection, Jonathan Dawson, Aditya Loganathan, Nicholas Melucci, Michael Friedman, Maeve Mclaughlin, Marissa Potenza, Erica Valdovinos, Robert Shesser

URGENT Matters

No abstract provided.

Debtor's Motion To Approve Opt Out Ballot

Catholic Dioceses in Bankruptcy

No abstract provided.

Recommendations For Conducting Ethical Network Research, Francisca Ortiz Ruiz, Paola Tubaro, José Luis Molina, Jennifer Watling Neal, Raffaele Vacca, Jana Diesner, Jimi Adams, Michelle Birkett, Jenny Godley, Juniper Lovato, Michael Schönhuth, Laura Teves, Michael Zimmer

Faculty Publications

Ethical considerations in social network studies are grounded in the general principles of human subjects’ research, including avoidance of harm, promotion of justice, equitable distribution of burdens and benefits, respect for human dignity, and protection of confidentiality. To help navigate these challenges, this article presents recommendations for conducting ethical network research, developed by a multi-disciplinary and multi-national working group. The article is divided in three main sections where there are certain recommendations identified for each one of them: data collections, use, and availability. Discovering how others addressed and solved problems can be a way for all of us to improve …

Health Center Pharmacy Gets New Leader, Maintains Caring Service, James Dowd

University of Mississippi News

OXFORD, Miss. – After a quarter century of leading pharmacy services at the University of Mississippi's V.B. Harrison Health Center, Sandra Bentley has passed the director's torch to teammate Chad Westmoreland.

Hypoglossal Nerve Stimulation For Obstructive Sleep Apnea: A Systematic Review And Meta-Analysis On Responder-Based Outcomes And Between-Study Heterogeneity, Clemens Heiser, Marcel Braun, Colin Huntley, Michael Hutz, Thomas Michael Kaffenberger, Maurits Boon

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Background: Hypoglossal nerve stimulation (HNS) is an established surgical therapy for adults with moderate-to-severe obstructive sleep apnea (OSA) who are intolerant to positive airway pressure. Although aggregate response rates of ~70–80% have been reported, substantial variability across clinical settings remains poorly understood. Prior meta-analyses have largely emphasized pooled continuous outcomes, limiting interpretation of responder-based endpoints and drivers of between-study heterogeneity. Methods: A PRISMA-compliant systematic review and meta-analysis was performed. MEDLINE, Embase, and Cochrane CENTRAL were searched from inception through 31 December 2025. Eligible studies enrolled adults with OSA treated with implantable HNS, reported Sher-defined response (≥50% AHI reduction and residual …

Zoom In And Zoom Out: (Re)Telling Our Cultural Literacy Practices Through Engaged Learning, Isela Almaguer

Bilingual and Literacy Studies Faculty Publications

Empowering bilingual learners to engage in the Zoom In and Zoom Out approach is a way to enrich and validate students' cultural identity and support students' linguistic and academic development while fostering rich writing opportunities for students. Teachers will discover a genuine way that empowers students to explore vocabulary, build comprehension, and acquire a love for writing. This effective multifaceted strategy approaches writing by leveraging students' cultural background and literacy practices. Students will capitalize on their funds of knowledge and use their experiences to further propel their writing efforts. By starting from within, diverse learners make stronger connections with the …

P-Value Visualizer, Manish Rami

Software

An interactive tool demonstrating what a user set p-value indicates with regards to probability.

Effect Size & Distributional Overlap Visualizer, Manish Rami

Software

An interactive tool comparing a control group and a treatment group, both with standard scores (M = 100, SD = 15). Cohen's d is expressed in standard deviation units. The three shaded regions show what each group's distribution looks like and how much they overlap. You can either use the preset buttons for effect sizes (SLP benchmarks) or the slider to change the values of Cohen's d to examine the distributions.

Ucf Pegasus Plan - Kindergarten - Time, Continuity, And Change, Enrique M. Perez Hernandez, Taya L. Green, Mia J. Derham, Anna V. Ly, Dyana Soto

Pegasus Plans: Social Studies Unit Plans for Florida Teachers

During this Tiny Time Travelers unit, students will explore and compare life from the past to life in the present consistently making real world connections. They will record their understanding of each lesson through a pre-made unit long journal.

Comprehensive Study On Explainable Artificial Intelligence For Enhanced Decision-Making, Eman Taher, Wessam H. El-Behaidy, Doaa S. Elzanfaly

Computer Science

Artificial Intelligence (AI) models are often criticized for their black-box nature, particularly in high-stakes domains such as finance, healthcare, and business decision-making, where transparency, accountability, and trust are essential. As machine learning advances with more complex architectures, including deep neural networks and ensemble models, the need for explainability becomes increasingly critical. This study focuses on Explainable Artificial Intelligence (XAI) as a key approach to enhance interpretability in classification, regression, and clustering tasks that serve as the foundation of data-driven analytical systems. XAI methods such as SHAP (SHapley Additive exPlanations), LIME (Local Interpretable Model-agnostic Explanations), and Integrated Gradients provide a means …

Michael Salawu V. District Director United States Citizenship And Im

2026 Decisions

USDC for the Western District of Pennsylvania

Oregon State Rank Assessment For Mt. Hood Bugbane (Actaea Laciniata), Nora Dunkirk

Institute for Natural Resources Publications

Oregon state conservation status assessment for Mt. Hood Bugbane (Actaea laciniata) using NatureServe methodology, 2026.

Perspective On Lessons Not Learned: From Coley’S Toxins To Microbial Drug Delivery, Guidance For Institutional Review Boards (Irbs), Brian P. Hanley, Alejandro J. Betancourt, Gustavo Gross, Wilbur (Bo) Bowne

School of Medicine Publications

The bacterial and toxin methods of cancer treatment date back 130 years. This paradigm rests on nonspecific bacterial-toxin-generated immunotherapy. This high-risk oncology research is experiencing a renaissance of methods that are among the most effective yet. Glioblastomas and other resistant cancers are the modern touchpoint, because of remission history following sepsis. Spurred by recent research deaths, we discuss protocols IRBs should consider in live bacterial or synthetic immuno-stimulatory trials. Human systemic inflammatory response syndrome immunology is unique due to non-functioning SIGLEC-13 and 17, which control excessive Toll-like receptor 4 (TLR-4) signaling. This is not a technicality like human CD8+/CD4+ T …

Staying Safe In The Heat: What Can Be Learned From The World Cup's Hydration Breaks, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Daniel Lewis V. Superintendent Phoenix Sci

2026 Decisions

USDC for the Eastern District of Pennsylvania

Resignation Typology And Its Impact On Entrepreneurial Intention And Action, Shuaijun Zhang, Wanrong Hou, Sibin Wu

Management Faculty Publications

By categorizing resignees into “genius,” “traditional,” “forced,” and “trapped,” this study examines the relationship between different types of resignees and entrepreneurial intention and action. Furthermore, we argue that anticipated regret and dormant tie reactivation moderate this relationship. An analysis of survey data from 781 participants in the United States indicates that the types of resignees exert varying influences on entrepreneurial intention and action. Compared with “traditional” and “trapped,” but not “forced,” the “genius” group have high intention of starting their own enterprises. However, the “trapped” group engage in more entrepreneurial activities than “genius.” Further, the “trapped” group with high anticipated …

Occ Joinder In Debtor's Motion Re: Opt Out Ballot

Catholic Dioceses in Bankruptcy

No abstract provided.

What The Supreme Court Didn’T Answer About Trump’S Section 301 Tariffs |, Marc L. Busch, Barry Appleton

Other Publications

No abstract provided.

Rocha V. State Of Nevada, 142 Nev. Adv. Op. 48 (Jul. 02, 2026), Rocco Marino

Nevada Supreme Court Summaries

A petitioner may file a new petition for judicial review of an adverse agency ruling following a district court’s remand of the matter and final administrative proceedings.

2026 July 2 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.