Digital Commons Network^™

Perspective On Lessons Not Learned: From Coley’S Toxins To Microbial Drug Delivery, Guidance For Institutional Review Boards (Irbs), Brian P. Hanley, Alejandro J. Betancourt, Gustavo Gross, Wilbur (Bo) Bowne

School of Medicine Publications

The bacterial and toxin methods of cancer treatment date back 130 years. This paradigm rests on nonspecific bacterial-toxin-generated immunotherapy. This high-risk oncology research is experiencing a renaissance of methods that are among the most effective yet. Glioblastomas and other resistant cancers are the modern touchpoint, because of remission history following sepsis. Spurred by recent research deaths, we discuss protocols IRBs should consider in live bacterial or synthetic immuno-stimulatory trials. Human systemic inflammatory response syndrome immunology is unique due to non-functioning SIGLEC-13 and 17, which control excessive Toll-like receptor 4 (TLR-4) signaling. This is not a technicality like human CD8+/CD4+ T …

Staying Safe In The Heat: What Can Be Learned From The World Cup's Hydration Breaks, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Daniel Lewis V. Superintendent Phoenix Sci

2026 Decisions

USDC for the Eastern District of Pennsylvania

Resignation Typology And Its Impact On Entrepreneurial Intention And Action, Shuaijun Zhang, Wanrong Hou, Sibin Wu

Management Faculty Publications

By categorizing resignees into “genius,” “traditional,” “forced,” and “trapped,” this study examines the relationship between different types of resignees and entrepreneurial intention and action. Furthermore, we argue that anticipated regret and dormant tie reactivation moderate this relationship. An analysis of survey data from 781 participants in the United States indicates that the types of resignees exert varying influences on entrepreneurial intention and action. Compared with “traditional” and “trapped,” but not “forced,” the “genius” group have high intention of starting their own enterprises. However, the “trapped” group engage in more entrepreneurial activities than “genius.” Further, the “trapped” group with high anticipated …

Occ Joinder In Debtor's Motion Re: Opt Out Ballot

Catholic Dioceses in Bankruptcy

No abstract provided.

What The Supreme Court Didn’T Answer About Trump’S Section 301 Tariffs |, Marc L. Busch, Barry Appleton

Other Publications

No abstract provided.

Rocha V. State Of Nevada, 142 Nev. Adv. Op. 48 (Jul. 02, 2026), Rocco Marino

Nevada Supreme Court Summaries

A petitioner may file a new petition for judicial review of an adverse agency ruling following a district court’s remand of the matter and final administrative proceedings.

2026 July 2 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Final Basinwide Quality Management Plan (Qmp) – 2026-2030, Revision 0, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Clark V. Marin, 142 Nev. Adv. Op. 47 (July 2, 2026), Francesca Manz

Nevada Supreme Court Summaries

The Nevada Supreme Court held that contingency fees are incurred as work is performed, requiring NRCP 68 attorney-fee awards to exclude pre-offer work, and that a judgment debtor’s claims against an insurer become assignable when final judgment is entered.

Lytle Trust Et Al V. Gerry R. Zobrist & Jolin G. Zobrist Family Trust Et Al, 142 Nev. Adv. Op. 50 (July 2, 2026), William Mcadorey

Nevada Supreme Court Summaries

Under NRS 22.100(3), attorney fee awards under the lodestar method are generally calculated using the billed rate the prevailing party is actually charged, absent distinct circumstances.

Human Cancer Genomes Harbor The Mutational Signature Of Tobacco-Specific Nitrosamines Nnn And Nnk, Michael Korenjak, Nuri Alpay Temiz, Stéphane Keita, Bérénice Chavanel, Claire Renard, Cécilia Sirand, Jiehong Guo, Et Al.

Michigan Tech Publications

BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in tobacco products remains underexplored. The tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN), both International Agency for Research on Cancer (IARC) Group 1 carcinogens, form pre-mutagenic pyridyloxobutyl (POB) DNA adducts, yet little is known about the associated genomic mutation landscape(s) in humans. METHODS: We applied bulk and error-corrected next-generation sequencing to a battery of experimental systems comprising mammalian cell lines and animals exposed to NNK or NNN, …

A Scholarship, A Calling, And A Bright Future, July 02, 2026, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

Ai-Driven Detection Of Neurodevelopmental Disorder From Emotional Speech Using A Hybrid Cnn–Bilstm–Attention Framework, Nayarah Shabir, Parveen Lehana, Sheema Khan

School of Medicine Publications

Neurodevelopmental disorders (NDDs) are associated with impairments in communication, behavior, and social interaction, making accurate diagnosis clinically challenging. Autism Spectrum Disorder (ASD), a major NDD, often exhibits atypical speech patterns characterized by altered prosody and reduced emotional expressiveness. The study proposes a hybrid dual-path framework for ASD detection from emotional speech using two strategies: PCA–GMM-based acoustic modeling and a CNN–BiLSTM–Attention architecture for spectral–temporal feature learning. The proposed framework captures probabilistic, spectral, and temporal speech characteristics for robust ASD classification. Acoustic analysis demonstrated clear separability between ASD and non-ASD speech, while the deep learning framework achieved stable and reliable performance across …

Successful Management Of A Large Pediatric Traumatic Pneumothorax Using A Thoracic Vent Device After Blunt Chest Injury: A Case Report, Jayanjali Bodavula, Melika Babadi, Morgan W. Stewart, Brett Dunbar

Student Publications

Traumatic pneumothorax is a common complication of blunt thoracic trauma and is traditionally managed with tube thoracostomy, particularly in larger or symptomatic cases requiring pleural decompression. Thoracic vent devices, such as the UreSil Thora-Vent, represent a less invasive pleural drainage option for the management of spontaneous or iatrogenic pneumothorax. However, literature regarding their use in traumatic pneumothorax, particularly in pediatric patients, remains limited. We present a case of a 13-year-old girl who developed a large left-sided traumatic pneumothorax after blunt thoracic trauma sustained during a softball collision. Computed tomography demonstrated a large left-sided pneumothorax and a nondisplaced left sixth rib …

Condos V. Herrera

All Decisions

After trial in this GCEL no-grounds/nonrenewal holdover, the court denied the landlord's post-trial motion to conform the pleadings to proof to claim the small landlord exemption under RPL § 214(1) and dismissed the petition. Although the evidence at trial's end tended to show the landlord owned fewer than 10 units, the court declined to overlook the landlord's lack of candor and inconsistent representations throughout the proceeding regarding her ownership interests in New York State residential units.

Zhen Yue Lin V. Veras

All Decisions

In this no-grounds/non-renewal holdover, the court grants the tenant's motion to dismiss because the Notice of Petition is defective, containing confusing and contradictory language including instructions appropriate for a nonpayment proceeding rather than a holdover. The court finds the notice did not comply with the spirit and intent of the form prescribed by 22 NYCRR § 208.42(b) and Administrative Order 163/19.

Yan's Realty Inc. V. Guo

All Decisions

In this no-grounds/non-renewal holdover involving an allegedly unregulated apartment, the court denies the tenant's motion for summary judgment but grants discovery on the landlord's claim of the small landlord exemption to the Good Cause Eviction Law. Public records suggest the landlord may be connected to a different corporate entity owning additional units in New York state.

An Automated Electrochemistry Platform For Accelerating The Characterization Of Enzymatic Electrochemistry, Michael A. Pence, Zachary A. Nguyen, Luke G. Kays, Dylan G. Boucher, Joaquín Rodríguez-López, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Enzymatic electrochemistry harnesses the selectivity of enzymes to enable electrochemical applications spanning sensing, synthesis, and energy conversion. However, the sequential nature of electroanalytical experiments limits throughput, restricting the scale at which enzyme-electrode systems can be screened. Here we demonstrate the capabilities of an automated electrochemistry platform, eLab, to increase the throughput of enzymatic electrochemistry investigations. We used the eLab to collect over 10,000 cyclic voltammograms across a large parameter space consisting of two enzyme variants (promiscuous and wild-type glucose oxidase), 20 saccharide substrates, 21 concentrations, and four scan rates, with measurements being made all in triplicate. The expansive dataset enabled …

Height Does Not Impair The Hydraulic System Of The Tallest Tropical Dipterocarp Trees, Paulo Bittencourt, Arne Scheire, Palasiah Jotan, Jehova Lourenço-Junior, Lindsay F. Banin, Mohd. Aminur Faiz Bin Suis, David Frp Burslem, Bradley O. Christoffersen, David Coomes, Peter Groenendijk

School of Integrative Biological & Chemical Sciences Faculty Publications

Half of the aboveground biomass in forests is stored in a disproportionately small number of very tall trees. These giants are predicted to be more vulnerable to drought-induced damage because height impairs their hydraulic system. We evaluated whether the hydraulic system of world’s tallest tropical tree species—Southeast Asian dipterocarps—are negatively affected by their height. The more negative xylem pressures caused by tree height were fully compensated for through adjustment of vessel anatomy and leaf hydraulic traits, and the trees suffered no height-related loss in growth during a severe drought. Therefore, height does not make the hydraulic systems of the world’s …

Oregon State Rank Assessment For Deschutes Milkvetch (Astragalus Tegetarioides), Nora Dunkirk, Gabriel Campbell, Sue Vrilakas

Institute for Natural Resources Publications

Oregon state conservation status assessment for Deschutes Milkvetch (Astragalus tegetarioides) using NatureServe methodology, 2026.

Bi-Allelic Loss-Of-Function Variants In Tmem63b Cause Syndromic Surfactant Dysfunction Disorder, Sock Hoai Chan, Audra N Iness, Jill A Rosenfeld, Mir Reza Bekheirnia, Lindsay C Burrage, Matthew Hoi Kin Chau, Chaerish Eint Myet Chae Htoo, Eric C Kao, Shamika Ketkar, Wan Wan Lim, Xi Luo, Rifhan Mazlan, Elizabeth Mizerik, Kein Seong Mun, Kalyani R Patel, Lorraine Potocki, Christina K Rapp, Xavier Roca, Ana Saianda, Ignacio Iglesias-Serrano, Everlyn C Siew, Donald Yuhui Sim, David R Spielberg, Sok-Kun Tae, Jing Xian Teo, Julian Warfsmann, Fan Xia, Child-Eu Registry, Saumya S Jamuar, Ee Shien Tan, Matthias Griese, Weng Khong Lim, Meow-Keong Thong, Keren Machol

Faculty, Staff and Students Publications

Transmembrane protein 63B gene (TMEM63B) encodes a mechanosensitive ion channel expressed in alveolar type II epithelial cells, where it mediates stretch-induced surfactant secretion. While heterozygous gain-of-function variants in TMEM63B have been associated with developmental and epileptic encephalopathy, no human disorder has previously been linked to bi-allelic loss-of-function variants. Here, we report five individuals from four unrelated families with childhood interstitial lung disease and bi-allelic predicted loss-of-function variants in TMEM63B. Affected individuals presented with early-onset respiratory distress, chronic hypoxemia, and diffuse parenchymal lung abnormalities on chest imaging. One individual died in infancy, two underwent bilateral lung transplantation, and two require oxygen …

Soil And Crop Productivity Under On-Farm Vermiculture-Based Farming System At Smallholder Rates In The Sub-Humid Tropics, Felix Matheri, Edward Karanja, David Bautze, Milka Kiboi

All Peer-Reviewed Publications

Introduction – Vermiculture-based manures such as vermicompost and its byproducts like vermiculture are gaining importance as viable alternative soil amendments. This is practically feasible, especially in subsistence farming, by replacing common organic and synthetic inputs that are often costly and inaccessible to farmers. However, the effectiveness of vermiculture tea as a sole amendment or in combination with other inputs has not been tested under field conditions. Moreover, its longterm impact on soil and crop productivity has not been established. Methods – We conducted an on-farm field study in farmers' fields to evaluate the effects of sole vermiculture tea (Vermi), in …

The Fingers-Based Occlusion Effect Triggering Methodology That Will Be Utilized For Creating Visual Imagery And Visual Patterns Utilizing A Pen Tool Where The Pen Tool Can Be Utilized To Create Visual Imagery And Visual Patterns On Physical Surfaces And On 3-Dimensional Virtual Space Areas., Punarjeewa Abeysekera

Defensive Publications Series

This paper describes a fingers-based occlusion effect triggering methodology that will be utilized for creating visual imagery and visual patterns utilizing a pen tool where the pen tool can be utilized to create visual imagery and visual patterns on physical surfaces and on 3-dimensional virtual space areas. The fingers-based occlusion effect triggering methodology will incorporate a pen tool, a built-in display that produce illumination, tracking markers and built-in camera configuration. The methodology will be required to utilize a power source that will be required to power the pen tool and its entities. And the methodology will be required to utilize …

Method For Trust-Aware And Language Model–Driven Email Threat Detection And Mitigation, Niranjan M M

Defensive Publications Series

Email remains the primary communication channel for enterprises and continues to be the most exploited attack vector for cyber threats. Modern email attacks increasingly rely on impersonation, social engineering, and contextual manipulation rather than traditional malware or malicious links, allowing them to evade existing detection mechanisms. At the same time, email security systems are adopting large language models (LLMs) to improve intent detection and contextual analysis, introducing new risks where email content itself can manipulate or degrade automated reasoning.

The proposal introduces a secure, trust-aware, and LLM-safe framework for automated email threat detection and remediation. The proposed system integrates sender …

Risk Authority Platform, Soumick Sinha, Mayank Johari, Lucas Fernando Müller, Sanjay Sawhney

Defensive Publications Series

Proposed herein is a Risk Authority platform that continuously computes an authoritative Trust Score and Trust Deficit for users or entities from heterogeneous security, identity, threat, compliance, privilege, and vendor-risk telemetry. The platform normalizes signals, applies configurable weighting and time decay, and maintains a versioned canonical trust state. A drift detection and reconciliation engine compares downstream trust states against the authoritative state and issues deterministic, idempotent reconciliation tokens when deviations or model-version mismatches occur. Software development kit (SDK) and application programming interface (API) integrations can validate schemas, verify tokens, and propagate risk updates. A closed-loop adaptive policy controller maps Trust …

Primitive For Finding Actionable Information In Time Series Based On Motif Locations, Michael Yeh, Yan Zheng, Junpeng Wang

Defensive Publications Series

The present disclosure relates to a system and method for finding actionable information in time series based on motif locations. The method includes an analysis computer that obtains time series data. The analysis computer generates a plurality of motifs. For each motif of the plurality of motifs, the analysis computer determines identified locations in the time series data that match the motif and determines a plurality of motif type scores based on the identified locations of the motif. The analysis computer determines a selected motif of the plurality of motifs based on the plurality of motif type scores for each …

Method, System, And Computer Program Product For Online Account Recovery, Elisa Duarte

Defensive Publications Series

Methods, systems, and computer program products are provided for online account recovery. An example method includes: receiving an account recovery request associated with a user account a user is unable to access, the account recovery request including identity data and payment device data, the payment device data obtained via short range wireless communication in response to the user arranging the payment device relative to a computing device; in response to receiving the account recovery request, authenticating the chip based on a cryptogram; in response to authenticating the chip, inputting a payment device identifier and the identity data into a model …

Optimally Scaled Low-Rank Adaptation For Efficient High-Rank Fine-Tuning, Yilang Zhang, Xiaodong Yang, Yiwei Cai

Defensive Publications Series

A method can be performed during a round of iteration during a loss function optimization process. The method can include a computer obtaining a first matrix and a second matrix. The computer can determine a selected scaling process from a first scaling process and a second scaling process. The computer can modify the first matrix and the second matrix using the selected scaling process to obtain a first modified matrix and a second modified matrix. The computer can determine a first moment and a second moment based on the first modified matrix and the second modified matrix. The computer can …

Autonomous Mobile Robot For Transferring Planar Workpieces Between Processing Stations Using An Orientation-Holding Con­Veyor Stage And A Self-Locking Kinematic Dock, Alexander Willer

Defensive Publications Series

An autonomous mobile robot (AGV / AMR) transfers a planar workpiece — for example a printed circuit board — between processing stations by carrying a transfer-conveyor segment on a powered stage that holds the segment’s orientation independently of the robot’s heading. This lets a minimal-footprint, non-holonomic robot present the conveyor to a station port facing any direction, in confined space, without sweeping the segment through its diagonal. At each station a docking interface is provided that separates location from clamping: passive kinematic features (a fully-locating feature plus a relieved one, optionally tapered) locate the segment, while one or more self- …