Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (325382)
- Arts and Humanities (174389)
- Social and Behavioral Sciences (129939)
- Education (65985)
- Medicine and Health Sciences (63037)
-
- Life Sciences (53918)
- Creative Writing (44609)
- Physical Sciences and Mathematics (43056)
- Religion (39547)
- Business (36638)
- History (32046)
- Engineering (27525)
- Sociology (27125)
- International Law (23125)
- Communication (23116)
- Constitutional Law (20757)
- English Language and Literature (19375)
- Criminal Law (19094)
- Higher Education (17475)
- Poetry (17420)
- Public Affairs, Public Policy and Public Administration (15965)
- Accounting (15758)
- Library and Information Science (15345)
- Art and Design (12999)
- Mass Communication (12573)
- Journalism Studies (11879)
- Fiction (11285)
- Environmental Law (11175)
- Intellectual Property Law (11139)
- Public Health (11097)
- Institution
-
- University of South Florida (92087)
- Brigham Young University (41625)
- TÜBİTAK (28451)
- Chulalongkorn University (22505)
- University of Michigan Law School (18625)
-
- University of New Mexico (17983)
- University of Mississippi (17656)
- Universitas Indonesia (16246)
- University of Northern Iowa (15447)
- Purdue University (14991)
- Southern Methodist University (13958)
- University of Denver (13434)
- San Jose State University (13134)
- Nova Southeastern University (12721)
- Association of Arab Universities (12610)
- Western Michigan University (11061)
- Butler University (10981)
- Fordham Law School (10981)
- Osgoode Hall Law School of York University (10771)
- Duke Law (10152)
- Grand Valley State University (9996)
- DePaul University (9930)
- University of South Carolina (9609)
- U.S. Naval War College (9481)
- St. John's University School of Law (9330)
- Northwestern Pritzker School of Law (9160)
- Case Western Reserve University School of Law (9056)
- University of North Carolina School of Law (8692)
- UC Law SF (8194)
- Duquesne University (8148)
- Keyword
-
- Newspaper (11462)
- Spartan Daily (11411)
- Poetry (7911)
- UAB (7295)
- Book review (5125)
-
- The U.S. Naval War College (4492)
- Linguistics (4264)
- Literary (4039)
- Litmag (4016)
- History (3915)
- Law (3710)
- Education (3672)
- Literature (3516)
- Poem (3282)
- Mormon studies (2880)
- Fiction (2789)
- Journal (2769)
- Book Review (2724)
- COVID-19 (2569)
- United States (2512)
- Newsletter (2485)
- Texas (2363)
- Archaeology (2343)
- Western Australia (2291)
- Technology (2203)
- Women (2201)
- Afghanistan Newspaper (2187)
- Human rights (2155)
- Constitutional law (2085)
- Higher education (1998)
- Publication Year
-
- 2026 (39887)
- 2025 (45084)
- 2024 (75653)
- 2023 (42454)
- 2022 (44730)
-
- 2021 (45143)
- 2020 (41976)
- 2019 (38363)
- 2018 (43062)
- 2017 (41406)
- 2016 (36664)
- 2015 (34409)
- 2014 (31404)
- 2013 (32760)
- 2012 (33075)
- 2011 (23341)
- 2010 (21517)
- 2009 (19282)
- 2008 (18686)
- 2007 (17946)
- 2006 (17376)
- 2005 (17060)
- 2004 (16330)
- 2003 (15655)
- 2002 (15016)
- 2001 (14696)
- 2000 (14718)
- 1999 (14658)
- 1998 (13945)
- 1997 (12763)
- Publication
-
- The Auk (22791)
- Michigan Law Review (12811)
- Condor (11821)
- Spartan Daily (School of Journalism and Mass Communications) (11411)
- Wilson Bulletin (9476)
-
- Saudi Medical Journal (7869)
- Naval War College Review (7484)
- Against the Grain (7173)
- Journal of Extension (6963)
- Journal of Accountancy (6807)
- Journal of Criminal Law and Criminology (6734)
- Proceedings of the Iowa Academy of Science (6507)
- Denver Law Review (6370)
- St. John's Law Review (6345)
- Louisiana Law Review (6126)
- North Carolina Law Review (6028)
- Journal of Undergraduate Research (5570)
- The Prairie Light Review (5566)
- Children's Book and Media Review (5535)
- Food and Machinery (5403)
- West Virginia Law Review (5339)
- University of Chicago Law Review (5248)
- Turkish Journal of Medical Sciences (5123)
- Fordham Law Review (5115)
- Word Ways (4969)
- Indiana Law Journal (4903)
- International Journal of Exercise Science: Conference Proceedings (4890)
- Kentucky Law Journal (4652)
- Marquette Law Review (4437)
- BYU Studies (4341)
Articles 4381 - 4410 of 1268422
Full-Text Articles in Entire DC Network
From Constraint To Freedom, George Rodriguez
From Constraint To Freedom, George Rodriguez
Fresh Voices: Composition at Cal Poly
No abstract provided.
On Going Long Term And Avoiding The Thanksgiving Turkey Drop, Liana Meffert
On Going Long Term And Avoiding The Thanksgiving Turkey Drop, Liana Meffert
Fresh Voices: Composition at Cal Poly
No abstract provided.
Writing With Images, Brenda Helmbrecht
Writing With Images, Brenda Helmbrecht
Fresh Voices: Composition at Cal Poly
No abstract provided.
Slo Streets: Analysis, David Maxson
Slo Streets: Analysis, David Maxson
Fresh Voices: Composition at Cal Poly
No abstract provided.
Government Censorship In Comedy, Campbell E. Gavin
Government Censorship In Comedy, Campbell E. Gavin
The Dialogue
This paper examines the role of public administration in shaping and restricting comedic expression in the United States, specifically focusing on the FCC’s regulation of broadcast media, targeting stand-up comedians and late-night show hosts. By applying Weber's and Wilson's theories of bureaucracy the paper analyzes how administrative power influences the boundaries of acceptable speech, through legal frameworks and discourse theory. An important court case involving governmental regulation of comedic speech was the FCC v. Pacifica Foundation. This case sets the stage for administrative power to grow in terms of limiting freedom of speech and paving the way for new administrations, …
The Effects Of Short-Term Individual Development Account For Young Workers In South Korea, Intae Yoon, Dong-Ho Jang
The Effects Of Short-Term Individual Development Account For Young Workers In South Korea, Intae Yoon, Dong-Ho Jang
Journal of Social Work in the Global Community
This study evaluated a short-term individual development account for young workers (SIDAY) with low income in Gwangju Metropolitan City, South Korea. SIDAY used random sampling methods to form an experimental group (n = 191) and a control group (n = 106) out of 2,589 applications. The experimental group received a 100,000 Korean Won (KRW), which is the equivalent to an $85 USD monthly savings match for 10 months, as well as financial capability programs and services, such as online financial mentoring, spending plan consultations, and electronic financial newsletters. Upon completion of SIDAY, the experimental group on average had …
Adjunctive Probiotic Use During Antibiotic Exposure In Very Preterm Infants: A Narrative And Translational Review, Mustafa Törehan Aslan, Mustafa Altındiş, Fahri Ovalı
Adjunctive Probiotic Use During Antibiotic Exposure In Very Preterm Infants: A Narrative And Translational Review, Mustafa Törehan Aslan, Mustafa Altındiş, Fahri Ovalı
Journal of Pediatric Infectious Diseases
Infants born before 32 weeks of gestation are highly susceptible to late-onset sepsis because of immune immaturity, impaired intestinal barrier function, and frequent broad-spectrum antibiotic exposure. Whether probiotics should be continued or initiated during antibiotic therapy remains unresolved and is often conflated with routine prophylaxis in stable infants. This SANRA-guided structured narrative and translational review synthesized clinical, microbiome, resistome, mechanistic, and safety evidence identified in PubMed/MEDLINE, Scopus, and Web of Science through July 1, 2026, across three contexts: stable antibiotic overlap, suspected sepsis, and confirmed or unstable sepsis. Pooled prophylactic analyses suggest a small, heterogeneous reduction in late-onset infection (risk …
Paradoxical Reaction Presenting As Sacroiliitis In Brucellosis: A Case Report And Literature Review, Azer Karaman, Sümeyye Bayram, Hatice Gaber Kurt
Paradoxical Reaction Presenting As Sacroiliitis In Brucellosis: A Case Report And Literature Review, Azer Karaman, Sümeyye Bayram, Hatice Gaber Kurt
Journal of Pediatric Infectious Diseases
Although brucellosis is one of the most common zoonotic infections worldwide, the development of a paradoxical reaction during treatment hasrarely been reported in the literature. We present a 17-year-old patient who developed acute sacroiliitis in the second week of treatment for olecranon bursitis brucellosis, despite her initial clinical findings showing signs of improvement. After excluding other potential etiologies for sacroiliitis, clinical and radiological recovery was achieved by adding anti-inflammatory therapy without modifying the existing antimicrobial regimen. Consequently, the clinical picture was evaluated as a paradoxical reaction. This case emphasizes that new symptoms or clinical worsening during brucellosis treatment should not …
Analysis Of Risk Factors And A Predictive Model For Recurrent Febrile Seizures Within A Single Febrile Illness In Children, Zheng Ge, Pao Yu, Kun Chen, Bi Zhou
Analysis Of Risk Factors And A Predictive Model For Recurrent Febrile Seizures Within A Single Febrile Illness In Children, Zheng Ge, Pao Yu, Kun Chen, Bi Zhou
Journal of Pediatric Infectious Diseases
Objective: To investigate predictive factors for seizure recurrence in children with febrile seizures (FS) within a single febrile illness, providing a basis for early clinical identification and preventive measures. Methods: We conducted a retrospective analysis of children with FS admitted to the Department of Pediatrics, Suzhou Hospital Affiliated to Anhui Medical University, from April 2023 to December 2025. A total of 337 children met the inclusion criteria. Children with more than one seizure within the same febrile ilness were classified as the recurrent febrile seizures (RFS) group, and those with a single seizure as the non-recurrent febrile seizures (NRFS) group. …
Beyond Pneumonia: Nonspecific And Extrapulmonary Manifestations Of Mycoplasma Pneumoniae Infection In Children, Svjetlana Mikulić
Beyond Pneumonia: Nonspecific And Extrapulmonary Manifestations Of Mycoplasma Pneumoniae Infection In Children, Svjetlana Mikulić
Journal of Pediatric Infectious Diseases
Mycoplasma pneumoniae is a well-recognized cause of respiratory infection in children, but its clinical spectrum extends beyond the lungs. Extrapulmonary manifestations may occasionally precede respiratory symptoms or dominate the presentation, making the diagnosis more difficult. This narrative clinical review focuses on nonspecific and extrapulmonary manifestations reported in pediatric patients, including neurological, mucocutaneous, hematological, cardiovascular, hepatic, gastrointestinal, and musculoskeletal complications. Relevant literature published between 2000 and 2026 was reviewed using PubMed/MEDLINE, Scopus, and Google Scholar. Most reported extrapulmonary manifestations appear to be immune-mediated, although direct microbial effects and vascular or prothrombotic mechanisms may contribute in selected cases. Clinical presentations range from …
Divergent Outcomes In Two Pediatric Cases Of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis, Zhang Kai-Jing, Li Ran, You Deng-Xia, Li Yinjie, Qin Tian-Tian, Liang Xiao-Jing, Huang Jing
Divergent Outcomes In Two Pediatric Cases Of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis, Zhang Kai-Jing, Li Ran, You Deng-Xia, Li Yinjie, Qin Tian-Tian, Liang Xiao-Jing, Huang Jing
Journal of Pediatric Infectious Diseases
This study retrospectively analyzed the clinical data of two 19-month-old children diagnosed with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) who received treatment with a dexamethasone combined with etoposide (VP-16) regimen. Both children met the early remission criteria for body temperature, IL-10, and IFN-γ within 48-72 hours after treatment initiation, but their clinical outcomes were markedly different. In Case 1, the EBV-DNA load decreased significantly during the initial treatment phase, and platelet counts steadily increased after treatment; the patient had a favorable prognosis at the 2-year follow-up. In Case 2, the EBV-DNA load did not decrease but instead increased during the initial …
Age-Dependent Variations In Clinical Presentation, Laboratory Parameters, And Coronary Outcomes In Kawasaki Disease: A 10-Year Retrospective Cohort Study Of 480 Pediatric Patients In Eastern China, Zhuying Zhou, Chen Wang, Aole Li, Saeed Saboor, Xiaoli Li, Xiaowei Li, Xianmei Huang, Chunming Jiang
Age-Dependent Variations In Clinical Presentation, Laboratory Parameters, And Coronary Outcomes In Kawasaki Disease: A 10-Year Retrospective Cohort Study Of 480 Pediatric Patients In Eastern China, Zhuying Zhou, Chen Wang, Aole Li, Saeed Saboor, Xiaoli Li, Xiaowei Li, Xianmei Huang, Chunming Jiang
Journal of Pediatric Infectious Diseases
Objective: This study investigated the age-dependent clinical characteristics of Kawasaki disease (KD) in pediatric patients and assessed the influence of age on disease presentation and outcomes. Methods: A retrospective analysis was conducted of 480 children diagnosed with KD who were admitted to Hangzhou First People's Hospital between 2013 and 2022. Subjects were stratified into two cohorts based on age: <2 years and 2-14 years). Demographic data, clinical manifestations, laboratory parameters, comorbidities, and coronary artery abnormalities were comprehensively evaluated across the age groups. Results: Time from symptom onset to diagnosis was significantly prolonged in the older cohort (z=-2.70, P=0.007). The incidence of cervical lymphadenopathy was markedly higher in older children (χ²=15.12, P<0.001), while peripheral extremity changes were significantly less frequent (χ²=5.79, P=0.016). The younger cohort exhibited significantly elevated platelet counts, alanine aminotransferase, and NT-proBNP levels compared to older patients (z=-3.57, P<0.001; z=-2.39, P=0.02; z=-3.59, P<0.001, respectively). Coronary artery dilatation and aneurysm formation occurred more frequently in younger patients (z=7.70, P=0.006; z=14.63, P<0.001). However, coronary artery recovery rates following intravenous immunoglobulin therapy showed no significant inter-group differences (P>0.05). Conclusions: The clinical presentation of KD demonstrates significant age-dependent variation. Clinicians should maintain a high index of suspicion for KD in older children presenting with fever and cervical lymphadenopathy. In younger patients with KD, close monitoring of hepatic function, platelet …2>
A Case Of Hemophagocytic Lymphohistiocytosis Caused By Human Herpesvirus 6b, Lihong Gao, Yang Wen
A Case Of Hemophagocytic Lymphohistiocytosis Caused By Human Herpesvirus 6b, Lihong Gao, Yang Wen
Journal of Pediatric Infectious Diseases
Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory response syndrome. Common infectious triggers include Epstein Barr virus, cytomegalovirus, bacteria, and other pathogens. We report a case of HLH caused by human herpesvirus-6 (HHV-6) in a pediatric patient. Based on the HLH-2004 diagnostic criteria, the patient fulfilled 5 of 8 criteria, establishing a definitive diagnosis. HHV-6-associated HLH is rarely reported in the literature. The etiological diagnosis was confirmed through metagenomic next - generation sequencing, highlighting its utility in identifying underlying causes of HLH when the etiology remains unknown.
Advancing A Familial Understanding Of International Students, Prof-Collins Ifeonu Dr
Advancing A Familial Understanding Of International Students, Prof-Collins Ifeonu Dr
Critical Internationalization Studies Review
No abstract provided.
The Impact Of Temporary Housing Policies On Social Stability: A Case Study Of The Informal Settlements Development Project In Jeddah, Mansour Alshehri, Waleed Alzamil
The Impact Of Temporary Housing Policies On Social Stability: A Case Study Of The Informal Settlements Development Project In Jeddah, Mansour Alshehri, Waleed Alzamil
UB Journal for Humanities
This study examines the impact of temporary housing policies on social stability in the context of slum redevelopment in Jeddah, focusing on the effectiveness of transitional housing mechanisms in mitigating displacement impacts. It adopts a descriptive-analytical approach within a qualitative case study, drawing on theoretical frameworks, international standards, expert interviews, and analysis of official documents. The findings show that housing security was organizationally achieved through rental support, but remained limited due to its temporary nature and unclear continuity. They also reveal weakened social ties caused by the absence of policies preserving community networks, along with challenges in accessing services despite …
The Narrations Of Ḥumayd Ibn ʿAbd Al-Raḥmān Criticized Due To Differences In Their Transmission In ʿIlal Al-Dāraqutnī: A Compilation And Study, Nadiya Bint ʿAbd Al-Raḥmān Ibn ʿAbd Allāh Al-ʿAsbalī Al-Shahrī
The Narrations Of Ḥumayd Ibn ʿAbd Al-Raḥmān Criticized Due To Differences In Their Transmission In ʿIlal Al-Dāraqutnī: A Compilation And Study, Nadiya Bint ʿAbd Al-Raḥmān Ibn ʿAbd Allāh Al-ʿAsbalī Al-Shahrī
UB Journal for Humanities
The study focuses on collecting and examining the narrations of Ḥumayd ibn ʿAbd al-Raḥmān al-Ḥumayrī that were identified as defective due to discrepancies in their transmission, as recorded in al-Dāraquṭnī’s al-ʿIlal. One of the reasons for selecting this topic is that the researcher did not find any previous study devoted specifically to this subject. The significance of the study stems from the importance of the science of ʿIlal (hidden defects in ḥadīth) and, in particular, from the significance of al-Dāraquṭnī’s al-ʿIlal. The study aims to provide a biographical account of Ḥumayd ibn ʿAbd al- Raḥmān, collect and examine his defective …
From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan
From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan
Journal of Health Research
Background: Organizational readiness is essential for AI-enabled digital transformation as healthcare organizations increasingly integrate artificial intelligence (AI). However, empirical evidence regarding the relationship between AI readiness and organizational change, the mediating role of digital maturity, remains limited in healthcare settings. This study investigated the mediating role of digital maturity in the relationship between AI readiness and organizational change.
Methods: This cross-sectional study involved 300 healthcare professionals from two Indonesian hospitals: Persahabatan Hospital (n = 165) and St. Carolus Hospital (n = 135). Data were collected using a questionnaire and analyzed through Partial Least Squares Structural Equation Modeling (PLS-SEM) to assess …
Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li
Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li
Journal of Food and Drug Analysis
Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …
Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan
Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …
Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed
Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …
Impact Of Erythropoietin Therapy On Inflammatory Biomarkers In Chronic Kidney Disease: A Comparative Study, Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi
Impact Of Erythropoietin Therapy On Inflammatory Biomarkers In Chronic Kidney Disease: A Comparative Study, Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Chronic kidney disease (CKD) is a progressive disorder frequently complicated by anemia and a persistent inflammatory state, both of which significantly contribute to morbidity and mortality. Reduced renal production of erythropoietin (EPO) is the primary cause of anemia in CKD. Emerging evidence suggests that EPO may exert anti-inflammatory and metabolic effects beyond its hematopoietic role. This study aimed to compare serum EPO levels and inflammatory biomarkers in CKD patients treated with EPO versus untreated CKD controls.
Material and Methods: This cross-sectional analytical study was conducted on 60 adult patients with CKD undergoing regular hemodialysis. Participants were divided into two …
Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh
Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …
Computational Design, Molecular Docking, Sar, And Admet Analysis Of Novel Jak1 Inhibitors As A Possible Treatment For Rheumatoid Arthritis, Sarah Ahmed Waheed
Computational Design, Molecular Docking, Sar, And Admet Analysis Of Novel Jak1 Inhibitors As A Possible Treatment For Rheumatoid Arthritis, Sarah Ahmed Waheed
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Rheumatoid arthritis is an inflammatory autoimmune disease affecting the joints which eventually leads to systemic comorbidities. Its pathogenesis was attributed to disturbances in the Janus Kinase/Signal Transducer and Activator of Transcription signaling pathway. In this research, an innovative lead compound C6 was created and docked toward Janus Kinase1 (JAK1). The docking process was confirmed by re-docking of the co-crystallized ligand MI1 (Tofacitinib). C6 showed a predicted docking score of -9.17 kcal/mol, with enhancement of 1.26 kcal/mol over Tofacitinib. Evaluation of the interactions showed a framework of five hydrogen bonds within the binding site involving an important contact with Glu966 as …
Diagnostic Accuracy Of Quantitative Coronary Analysis As Compared With Instantaneous Wave-Free Ratio In Intermediate Coronary Lesions: A Prospective Vessel-Level Study, Tamer Mosaad Ragab, Khaled Ahmed Alkhashab, Mohamed Zaki Hussain, Ibrahim Mohammed Nosseir, Marwa Salah Sayed, Waleed Khaled Ali Salem
Diagnostic Accuracy Of Quantitative Coronary Analysis As Compared With Instantaneous Wave-Free Ratio In Intermediate Coronary Lesions: A Prospective Vessel-Level Study, Tamer Mosaad Ragab, Khaled Ahmed Alkhashab, Mohamed Zaki Hussain, Ibrahim Mohammed Nosseir, Marwa Salah Sayed, Waleed Khaled Ali Salem
Journal of the Saudi Heart Association
Background: Instantaneous wave-free ratio (IFR) represents a new vasodilator-free innovative approach which is considered as a gold standard for functional assessment of the hemodynamic significance of intermediate coronary stenoses. Although relatively safe, iFR is still an invasive procedure that has its potential hazards, complications and cost. Two-dimensional quantitative coronary analysis (2D-QCA) is a non-invasive technique that has emerged robustly as an excellent and attractive tool for delineating coronary anatomy.
Aims: To assess the ability of two-dimensional quantitative coronary analysis (2D-QCA) to guide decision-making for quantification of severity of intermediate coronary stenoses (40–80% diameter stenosis) in each of the three main …
Electrospun Pvp/Zno/Ha Coatings On Silane-Modified Zk60: Corrosion, Antibacterial Activity, And In Vitro Apatite Formation, Qasim Saad Abdulwahid, Akeel Dhahir Subhi, Iman Adnan Annon
Electrospun Pvp/Zno/Ha Coatings On Silane-Modified Zk60: Corrosion, Antibacterial Activity, And In Vitro Apatite Formation, Qasim Saad Abdulwahid, Akeel Dhahir Subhi, Iman Adnan Annon
Engineering and Technology Journal
This study investigated a two-stage surface modification strategy for ZK60 magnesium alloy based on 3-aminopropyltriethoxysilane (APTES) pretreatment followed by electrospun polyvinylpyrrolidone (PVP) nanofibers containing ZnO and hydroxyapatite (HA) nanoparticles. Three PVP/ZnO/HA formulations were prepared to examine the effect of nanoparticle loading, and corresponding coatings with and without APTES pretreatment were compared. The coatings were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDX), and a cross-hatch adhesion test. Corrosion behavior was evaluated in simulated body fluid (SBF) using open-circuit potential (OCP) monitoring and potentiodynamic polarization. Antibacterial activity was screened against S. …
Corrosion Inhibition By Carboxymethyl Cellulose Doped With Graphite Nanosheet And Silica Nanoparticles In Seawater Environment, Mohamed R. Mohssen, Sinan S. Hamdi, Rana A. Anaee, Mathew T. Mathew
Corrosion Inhibition By Carboxymethyl Cellulose Doped With Graphite Nanosheet And Silica Nanoparticles In Seawater Environment, Mohamed R. Mohssen, Sinan S. Hamdi, Rana A. Anaee, Mathew T. Mathew
Engineering and Technology Journal
This work aims to inhibit carbon steel surface as pipelines by adding carboxymethyl cellulose (CMC) with three concentrations (1, 3 and 5 g/L) in seawater environment at four temperatures in the range of 298 – 328 K. The investigation was done by recording Tafel plots and EIS curves to show that the lowest concentration is the best to protect the steel surface with efficiencies ranged between 95.68 – 89.36 % that decrease with increasing temperature due to the decomposition of CMC that begin after ≈ 308 K. An attempt to enhance the protection by CMC at higher temperature has been …
Reconfiguring Distribution Networks Using The Aco+Tnc Algorithm, Specifying The Location, Size, And Number Of Added Renewable Energy Sources, Mohammed Falah Hasan, Rana Ali Abttan
Reconfiguring Distribution Networks Using The Aco+Tnc Algorithm, Specifying The Location, Size, And Number Of Added Renewable Energy Sources, Mohammed Falah Hasan, Rana Ali Abttan
Engineering and Technology Journal
Distribution networks face increasing pressure from rising loads and renewable energy integration, making the simultaneous optimization of reconfiguration and distributed generation placement a critical engineering challenge, and conventional single-objective methods are insufficient for simultaneously addressing power losses, voltage profile degradation, and the structural constraints of radial networks. This paper proposes a hybrid framework that combines Ant Colony Optimization with the Truncated Newton Constrained method to jointly solve network reconfiguration alongside the optimal placement, sizing, and type selection of renewable distributed generation—both solar PV and wind—within a single unified model. The approach relies on a four-part weighted objective function covering active …
Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen
Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen
Turkish Journal of Botany
Adventitious root formation in stem cuttings of Phoebe bournei, an economically and ecologically significant woody species, is a major bottleneck in clonal propagation. To elucidate the impact of spectral quality on early adventitious root development, we characterized the morphological, hormonal, and transcriptomic dynamics of primordium initiation and differentiation under white, red, and blue light. Under red light, cuttings exhibited the earliest and most pronounced formation of white filamentous structures at lenticels, indicative of root primordium initiation, as early as 20 days after cutting, whereas white and blue light treatments showed delayed responses. Paraffin section analysis confirmed the induced origin of …
Creolized Baroque: Early Music In A Brazilian Key, Ellwood P. Colahan
Creolized Baroque: Early Music In A Brazilian Key, Ellwood P. Colahan
Soundboard Scholar
Review of Iberian and Afro-Brazilian Music of the 17th Century, by Ensemble Banza, Rogério Budasz, (Baroque guitar).