Digital Commons Network^™

Elucidating The Binding Site Of The Arrestin-Biased Agonist Icl1-20, Kesara Wein, Roger Armen, Jeffrey L. Benovic, Charles P. Scott

Alpha Omega Alpha Research Symposium Posters

Background and Purpose: 6.7 million Americans live with congestive heart failure (CHF). In CHF, catecholamines are released into cardiac tissue, bind β-adrenergic receptors (βARs), and activate G-protein signaling cascades, causing ischemia and apoptosis. Accordingly, β-blockers are used to antagonize catecholamine binding to βARs and suppress apoptotic downstream effects. However, β-blockers have dose-limiting hypotension, bradycardia and fail to stimulate the cardioprotective β-arrestin signaling pathway. These limits create opportunities for the development of drugs that selectively stimulate β-arrestin signaling while suppressing cardiotoxic G protein signaling. We have previously reported a biased agonist of the β-arrestin pathway (ICL1-20) that selectively stimulates β-arrestin recruitment …

Survival Impact Of Intraoperative Co2 Dysregulation In Patients Undergoing Pancreaticoduodenectomy For Pancreatic Ductal Adenocarcinoma, Ashley Wetzel, Andrea Feci, Joseph Gorman, Isabel Lavine, Edoardo Manca, Richard Zheng, Md, Nader Hanna, Md, Harish Lavu, Md, Charles J. Yeo, Md, Avinoam Nevler, Md

Alpha Omega Alpha Research Symposium Posters

Purpose: Pancreatic ductal adenocarcinomas (PDAC) are aggressive malignancies with poor prognoses. Emerging evidence suggests tissue hypercapnia (elevated CO₂) promotes aggressive, treatment resistant tumor biology. End-tidal CO₂ (ETCO₂) offers a composite measure of ventilation, systemic perfusion, and tissue CO₂ production. During curative-intent pancreaticoduodenectomy, we hypothesized that intraoperative ETCO₂ could serve as a marker of tissue CO₂ dyscapnia; both low levels indicating decreased circulatory reserves and high levels indicating tissue hypercapnia may result in worse outcomes.

Methods: We conducted a retrospective review (2017-2023) of 343 patients undergoing pancreaticoduodenectomy for PDAC. Intraoperative ETCO₂ data …

Evaluating The Impact Of Bard1 Isoform Targeting On Pdac Growth And Response To Olaparib, Lily Zekavat, Samuel Zion, Boxuan Wei, Avinoam Nevler, Aditi Jain

Alpha Omega Alpha Research Symposium Posters

Background

• BRCA-Associated Ring Domain 1 (BARD1), a heterodimeric binding partner of the tumor suppressor BRCA1, plays an essential role in homologous recombination-mediated DNA repair. Mutations in BARD1 increase cancer susceptibility and result in a molecular phenotype that predicts sensitivity to poly (ADP-ribose) polymerase inhibition (PARPi), including Olaparib.
• Several alternatively spliced isoforms of BARD1, including BARD1δ and BARD1φ, have also been implicated in tumor progression. These isoforms, characterized by deletion of exons 2-6 and 3-6, respectively, lack the RING domain required for BRCA1 interaction (Figure 1). 
• Upregulation of BARD1 isoforms is associated with poor prognosis in several tumor types. However, the …

Student Life E-Newsletter February 2, 2026, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

Recommended Budget, Expenditures By Object And Funding By Source, Fiscal Year 2026-2027, Tennessee. Department Of Finance & Administration.

Budget Publications

No abstract provided.

State Of Tennessee, The Budget, Fiscal Year 2026-2027, Tennessee. Department Of Finance & Administration.

Budget Publications

No abstract provided.

Jackson-Pratt Drain-Related Challenges And A Potential Explanation For Associated Surgical Site Pain Variability Following Breast Mastectomy And Reconstruction, Spencer Haber, Bs, Krishna Koka, Bs, Elizabeth Simon, Bs, Devin Williams, Bs, Andrew Newman, Md

Alpha Omega Alpha Research Symposium Posters

Background: The Jackson-Pratt (JP) drain is a closed suction drain used in surgeries throughout the body. This prevents seroma formation through continual negative pressure drainage while resisting collapse and obstruction. JP drains are mainstays in breast reconstruction and mastectomy.

Methods: Through a literature review using keywords such as “Surgical Site Infection” (SSI), “Quality of Life” (QOL), and “Surgical Site Pain” (SSP), we summarized JP drain-related complications in breast reconstruction and mastectomy. Although the drain effectively reduces seroma formation, there has been a lack of innovation in addressing these issues. There is no standardized approach to JP drain post-operative care or …

Hangout Hour: A Safe Space Fostering Community Within The Adolescent Young Adult (Aya) Community, Brooke Ashmore, Makena Krier

2025

Pacific Rxtracts - February 2026, Pacific Rxtracts

Pacific RxTracts

Articles:

• Reducing Proteinuria – FDA Accelerates Approval of Sibeprenlimab
• FDA Approves Oral Semaglutide as First GLP-1 Pill for Weight Loss
• New First-Line Digital Treatment for Generalized Anxiety Disorder
• Ammoxetine: A Potential New Antidepressant For Major Depressive
• Extended-Release Buprenorphine Dosing in Individuals With High-Risk Opioid Use
• Managing Acute Agitation Without Injections: Oral Medications in the ED
• Prescription Stimulant Continuation in Pregnancy and Birth Outcomes
• Zoliflodacin - A New Treatment For Gonorrhea
• Intranasal Dexmedetomidine for Postoperative Sleep Quality After Gynecologic Laparoscopy
• FDA Approves Depemokimab, the First Twice-Yearly Biologic for Severe Eosinophilic Asthma Cancer Care
• Engineering Allogeneic CD7-Targeted CAR-T Cells Through Targeted Base …

Which Law School Is Right For Me? Admissions Q&A With Dean Estrada, New York Law School

NYLS Community News

No abstract provided.

The Rider (2026-02-02), Daniela Chapa-Reyes

The Rider Archives

Vol. 11, No. 17

Intouch Week Of February 2, 2026, New York Medical College

InTouch

• Campus Illumination and Panel Discussion Honors Holocaust Remembrance Day
• Where Experience Becomes Evidence: Advancing Transplant Education at NYMC
• D.P.T. Student Experience
• Love at NYMC

Chimes: February 2, 2026, Calvin University

Chimes

Provost Noah Toly to step down by Maya Oeverman

Michigan's Supreme Court to hear Joseph Kuilema v. Calvin University by Ashley Hamons

Student Senate welcomes new advisors, sets vision for Spring Semester by Ellery Johnson

Students face snowy start to spring semester by Ian Tjoelker

New year, new me: Accomplishing your goals and resolutions by McKenna Wilkinson

Men's volleyball starts strong under first-year head coach Aaron Sagraves by Zach Kern & Hendrik Beelen

Effective Education Prevents Readmission Rates, Taylor Johnson, Gabby Belanger, Ben Mittleman, Bella Ferguson

Nurse Residency

PICOT Question: In older adult patients, does nurse-driven education, compared with standard care, reduce hospital readmission rates?

Library News February 2026, Research Medical Library

Library News 2026

• Tips for Using Track Changes in Microsoft Word
• How to Navigate Author Instructions (part 2): 10 Tips for Formatting Your Manuscript
• FWCI: a Level Playing Field for Article Impact
• When to Use Latin Abbreviations, eg, "ie" versus "eg"

Bard Observer Vol. 24 No.4 (February 2026), Bard College

Bard Observer, 2020 - 2029

No abstract provided.

[Bhm] Black History Month 2026 - Government Docs, Raquel Estrada

Library Display Posters

Poster showcasing U.S. Government documents relating to Black History Month.

[Bhm] Black History Month 2026 - Library Resources, Raquel Estrada, Emily Gomez

Library Display Posters

Collection of posters created celebrating Black History Month 2026. It highlights films, books, and archival materials that celebrate Black arts, storytelling, leadership, and local history. The posters also showcase streaming films with public performance rights, literature, biographies of influential figures, and archival profiles of African American educators from the Rio Grande Valley/

February '26 Bookmark Of The Month: Visit The Heated Library!, Iwasaki Library

Monthly Iwasaki Library Bookmarks

The February limited-edition bookmark debuted for the Emerson community in early February 2026. Inspired by the wildly popular book and TV show, Heated Rivalry, February in Boston saw multiple snowstorms and cold temperatures. The front of the bookmark is designed like the cover of the Heated Rivalry book, and the back features an ode to ice skating and hockey (just in time for the 2026 Olympics!) The QR code on the back allows viewers to explore a full list of Iwasaki Library resources.

Into The Woods, Lynn University

Drama Programs

Sponsored by: Harvey and Susan Hendler

James Lapine and Stephen Sondheim take everyone's favorite storybook characters and bring them together for a timeless, yet relevant, piece ... and a rare modern classic. The Tony Award-winning book and score are both enchanting and touching.

The story follows a baker and his wife, who wish to have a child; Cinderella, who wishes to attend the King's Festival; and Jack, who wishes his cow would give milk. When the baker and his wife learn that they cannot have a child because of a witch's curse, the two set off on a journey to …

Vol7iss1 Cover, Hca Healthcare

HCA Healthcare Journal of Medicine Covers

Cover for Volume 7 Issue 1 of the HCA Healthcare Journal of Medicine.

Vacancies Filled By Voters’ Voices: A Call For Open Special Elections With Ranked Choice Voting In New York, Fordham Law School Rule Of Law Clinic, Dani D'Annunzio, Dawn Edelman, David Zwick

Rule of Law Clinic

New York’s special election system for filling vacancies in the U.S. House of Representatives and the State Legislature excludes voters from the candidate selection process. Instead of voters selecting nominees, political party leaders designate their parties’ respective candidates. In this report, the Fordham Law School Rule of Law Clinic recommends reforming this system by implementing open special elections using ranked choice voting. All candidates who meet petition signature requirements, regardless of party affiliation, would compete in a single election. This reform would improve participation, representation, and accountability without sacrificing efficiency.

The Synapse, February 2026, School Of Medicine Student Senate, New York Medical College

The Synapse

No abstract provided.

Baystate Health Nursing: Together In Excellence Newsletter - February 2026, Brenda Simpson Rn

Baystate Health Nursing: Together in Excellence Newsletters

Baystate Health Nursing: Together in Excellence Newsletter - February 2026

Improvements In Eeg Tracing Following Initiation Of Cannabidiol: A Case Report, Katherine Horman, Ara Hall, Kailash Pawar

Posters

No abstract provided.

Language, Literature, And Culture Newsletter, Thirteenth Edition (February 2026), Language, Literature, And Culture Department, Clark University

Language, Literature, and Culture

The thirteenth issue of the Language, Literature, and Culture department newsletter, which went out in February 2026. The Language, Literature, and Culture department newsletter aims to "share stories, news, ideas, achievements, and important information about and within our academic department that can be helpful to the campus community at large".

Building Tennessee's Tomorrow: Anticipating The State's Infrastructure Needs July 2024 Through June 2029

Infrastructure Reports

No abstract provided.

Criminal Caselaw Notebook 2026, Hon. Ronald Kessler

Washington State Books

This publication from King County Superior Court judge Ronald Kessler is updated semi-annually and is distributed free of charge. It includes citations to Washington state case law on a variety of criminal law topics.

Teaching Professional Resistance, Darlene Peterson Md

Faculty Development Tips

No abstract provided.

International Panther Monthly, February 2026, University Of Northern Iowa. Office Of International Engagement.

Office of International Engagement newsletter

Contents:

--- From the Director's Desk
--- Last Month With OIE
--- Student Spotlight
--- UNI's World Window
--- Did You Know?
--- Behind the Scenes
--- Next Month's Activities
--- Find Connection at OIE
--- Get Involved