Digital Commons Network^™

Integrating Risk And Vulnerability: Exploring A Unified Model For Supply Chain Resiliency, William G. Cook

USF Tampa Graduate Theses and Dissertations

The world has entered an era of retreating globalization, mounting geo-political tensions, rising protectionism, and increasing focus on the fragility of complex supply chains. The negative impacts of supply chain disruptions have been increasingly documented since the turn of the century. Given the global scale of recent disruptions, supply chain resiliency has become a national imperative. The Global Financial Crisis, the Covid-19 pandemic, and other major disruptive events demonstrate the active role of government in mitigating damage, the enduring effects of regulation, and the resultant re-evaluation of supply chain strategies by the private and public sectors. In this environment, supply …

Selective Pericyte Recruitment To Ec-Lined Tubes, Vessel Assembly Enhancement Through Pericyte Timp-3 Induction, And Pericyte Tbx2 In Capillary Formation And Maturation, Ksenia Marilyn Yrigoin Kaluguina

USF Tampa Graduate Theses and Dissertations

Capillaries, the smallest blood vascular networks, are formed by narrow and elongated endothelial cell (EC)-lined tubes with associated pericytes anchored to the abluminal tube surface. Our laboratory demonstrated that dynamic interactions between ECs and pericytes during capillary tube network assembly are required for basement membrane matrix deposition and maturation. We have also shown that key EC-derived factors promote pericyte recruitment, proliferation, and pericyte-induced basement membrane formation during capillary assembly. In the first section, we aim to identify if vascular smooth muscle cells (VSMCs) respond to the same factors and have the same invasive ability as pericytes since they are both …

Operational Variations In State-Owned Hotels And International Branded Hotels In China: A Qualitative Analysis Of Practitioners' Perspectives And Implications, Wen Wei

USF Tampa Graduate Theses and Dissertations

This study examines experienced hoteliers' perspectives on essential operational practices for delivering consistent, high-quality customer experiences, focusing on operational differences between Chinese State-Owned Hotels (SOHs) and International Branded Hotels (IBHs) in China. Through semi-structured interviews with 24 experienced hoteliers from SOHs and IBHs, the research identifies operational practices in IBHs that are perceived as more effective than those in SOHs. Additionally, the study explores operational practices that SOHs and IBHs could adopt and adapt to succeed in China’s post-pandemic hotel market. The analysis is framed by the Resource-Based View (RBV), Dynamic Capabilities (DCs), Market Orientation (MO), and the role of …

Thriving Or Surviving In Virtual Sales: The Connection Between Virtual Work And Job Satisfaction Amongst Salespeople In The Pharmaceutical Industry, Amit Garg

USF Tampa Graduate Theses and Dissertations

The post COVID 19 sales environment for salespeople in pharmaceuticals has shifted to becoming hybridized within a continuum of face-to-face and virtual interactions, when engaging with health care professionals. This dissertation reports on a study investigating the relationship of virtual work with job satisfaction and burnout. There were two questions that were addressed in this study to understand the impact virtual work has had on overall job satisfaction and burnout. First, what is the relationship of virtuality to job satisfaction and burnout in the pharmaceutical sales environment? Second, which facets of job satisfaction and burnout are most strongly related to …

Performance Comparison Of Two Binary Diagnostic Tests With Incomplete Data, Meng Wang

USF Tampa Graduate Theses and Dissertations

Diagnostic tests are medical examinations essential for patient care, as they help detect the presence of diseases and rule out certain conditions. However, diagnostic tests can make errors, and misdiagnoses resulting from these errors can potentially lead to treatment delays or inappropriate treatments. Therefore, comprehensively evaluating the performance of the diagnostic tests and ensuring test accuracy is a fundamental priority in diagnostic studies. When a new diagnostic test is developed, it is customary to compare it with an existing test in a paired study. However, incomplete test results commonly occur in practice. The maximum likelihood-based method can be used to …

The Attitudes, Perceptions, And Motivations Of Student-Athletes In Intermediate Algebra, Alexandra Green

USF Tampa Graduate Theses and Dissertations

This research delves into the attitudes, perceptions, and motivations of student-athletes enrolled in Intermediate Algebra courses. It focuses on the distinct challenges they encounter in juggling academic and athletic responsibilities at a southeastern university in the United States. Employing a mixed-methods approach, the study gathered quantitative data through surveys to assess students' attitudes, perceptions, and motivations toward learning mathematics, as well as to determine the influence of their instructors on these factors. The qualitative segment provided deeper insights into their personal experiences, shedding light on their prior encounters with mathematics, their most memorable moments during the current course, and their …

Using Function Based Self-Monitoring To Teach Functional Communication Skills And Decrease Problem Behavior For Middle School Students With Asd, Lanease Ganey

USF Tampa Graduate Theses and Dissertations

This study examined the effects of a function-based self-monitoring procedure on functional communicative response (FCR) and problem behavior in middle school students with autism spectrum disorder. Three middle school age students diagnosed with and autism spectrum disorder and displaying challenging behavior and their respective classroom teachers and supporting staff (paraprofessionals) participated in this study. The study employed a multiple baseline design across participants to evaluate the effect of function-based self-monitoring on FCR, task engagement, and problem behavior. Following a 30-min training, the students and staff independently implemented the function-based self-monitoring procedure with fidelity which led to desired changes in student …

Exploring Saudi Arabian Teachers' Perceptions Of Smartboard Instruction For Students With Communication Disorders, Mohammed Alqahtani

USF Tampa Graduate Theses and Dissertations

Using smartboards with students with communication needs in the classroom is one way to apply technology in educational settings. Research has shown the benefits of using the smartboard with students with disabilities (SWDs) and second-language learners. There is still a need to understand further teachers’ perceptions towards using the smartboard in their classrooms with students with communication needs. Therefore, I conducted an exploratory qualitative study to explore Saudi teachers' perceptions regarding the use of smartboards with students with communication needs in the classroom. I collected data via in-depth interviews, smartboard screen recordings, and audio recordings of teachers’ lessons taught using …

Perceived Workplace Obstacles And Compensatory Strategies Used By School Psychologists With Disabilities, Gary E. Schaffer

USF Tampa Graduate Theses and Dissertations

Despite efforts to recruit and retain school psychologists from diverse backgrounds, there has been little focus on school psychologists with disabilities. This oversight is concerning given that school psychologists deliver extensive support to students with disabilities yet simultaneously remain largely absent from diversity, equity, and inclusion efforts. The current study sought to learn about school psychologists with disabilities by providing much-needed demographic information on this population while also focusing on their workplace experiences. Two-hundred-fifty-five participants were asked about their perceptions regarding the systemic challenges they encountered, personal challenges they faced, reasons they disclosed or did not disclose their disability, and …

Essays On Information Technology In Healthcare, Gleb Zavadskiy

USF Tampa Graduate Theses and Dissertations

Information technologies (IT) and information systems (IS) have profound significance across various sectors of society, including healthcare, business, education, government, and beyond. First, IT facilitates instant communication globally through email, messaging apps, video conferencing, and social media, revolutionizing how individuals and organizations interact, collaborate, and share information (Hacker et al. 2020; Tang and Hew 2020).

Secondly, the Internet and digital libraries provide worldwide access to vast amounts of information, what makes knowledge and education available to everyone, empowering individuals to learn and stay informed on diverse topics (Haleem et al. 2022). Another aspect of IT systems in various industries is …

The Association Between Oral Microbiome, Oral Inflammation, Periodontal Disease, And Systemic Metabolism In Individuals With/Without Type 1 Diabetes, Mianli Xiao

USF Tampa Graduate Theses and Dissertations

This study explores the associations between oral microbiomes, periodontal disease (PD), and systemic metabolism in individuals with and without Type 1 diabetes (T1D). Data were obtained from 208 participants (99 with T1D, 109 non-diabetic) in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) pilot study and 283 participants from the Oral Microbiome ancillary cohort study. Both studies included the collection of saliva or subgingival plaque samples. Microbial DNA was extracted, and the V4 region of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. Machine learning models, including Random Forest (RF) and Multi-layer Perceptron (MLP), were applied …

The Pilling Process: Significance Quest, Self-Verification, And Fusion In Online Incel Forums, Gregory J. Rousis

USF Tampa Graduate Theses and Dissertations

Incels (short for “involuntary celibates) are an online community of men who blame women for their reputed sexual and romantic failures. The misogyny of their worldview, called the blackpill, has inspired multiple instances of real-world violence against women. Alarmingly, we know little about the temporal processes whereby an incel goes from joining an online community to becoming deeply aligned (i.e., “fused”) with the group. This project sought to address this by scraping incels’ most popular web forum and using text analysis to identify psychological mechanisms that could be responsible for incels’ fusion. The resulting dataset consisted of 1,097,841 unique discussion …

Unravelling The Impact Of Blood Metabolites, And Lifestyle Factors On Periodontal Disease Using Mendelian Randomization, Rhea Charles

USF Tampa Graduate Theses and Dissertations

Periodontal disease remains a global public health concern. Despite the availability of preventive and therapeutic strategies, the multifactorial nature of periodontitis complicates its understanding and management. Periodontal disease is associated with an increased risk of chronic conditions, including ischemic heart disease (IHD), gestational hypertension, respiratory diseases such as COPD and bronchitis, and various cancers, including kidney and pancreatic cancers. Moreover, individuals with diabetes, autoimmune diseases like lupus and Crohn’s disease, and osteoporosis are more likely to develop periodontitis. The ambiguity in the direction of causality between periodontal disease and its associated conditions poses challenges for effective treatment. Mendelian randomization offers …

Perceptions Of Rural America: Exploring College Students' Views And Career Priorities Post-Graduation, Tom Hall

USF Tampa Graduate Theses and Dissertations

The problems facing rural America are wide ranging and multilayered. Perceptions can often be reality for those unfamiliar with rural life, which can pose a hurdle for businesses to overcome. With an in-depth literature review and research study, this dissertation aims to provide context and understanding to the problems and misconceptions of rural America. Without context, it is easy to interpret rural America as a dying, outdated part of the country, but the reality is far more complex. A research study was conducted that surveyed 400 actively enrolled college students from schools in 19 American states on three things: 1) …

Transition Aged Youth Substance Use At Electric Dance Music Events In The Tampa Bay Area: A Qualitative Study Of Awareness And Prevention, Danielle Vinciguerra

USF Tampa Graduate Theses and Dissertations

The study investigates substance use among Transitional Aged Youth (TAY), particularly focusing on Electronic Dance Music (EDM) events in the Tampa Bay area. TAY, defined as individuals aged 18-29, experience significant psychological, biological, and developmental changes, which can lead to increased vulnerability to substance use. The study examines the prevalence and patterns of substance use, specifically ketamine and cocaine, among TAY at EDM events. Exploratory qualitative data collection method was utilized for the study. Applying Social Learning Theory as a framework, the research explores the beliefs, attitudes, experiences, and community influences that contribute to substance use within this demographic. Data …

Empowering Entrepreneurial Evolution: A Beyond Founder Strategic Approach To Small Business Growth, D. Jared Knisley

USF Tampa Graduate Theses and Dissertations

Growing a business beyond its founder’s capacities and talents presents a challenging undertaking. When a founder is no longer involved or motivated to grow the business, firm decline is a likely outcome. Small businesses often have a deep and, at times, hindering reliance on their early founders for development. Therefore, a continuous engaging plan to advance entrepreneurial success is needed to grow a small business.

My research objective aims to find methods and designs, through academic literature and practitioner interviews, that transition leadership responsibilities and increase team empowerment within a small business, enabling these firms to continue growing as the …

Integrating Multiple Biodiversity Metrics To Assess Diatom Diversity And Diatom/Macrophyte Host Specificity In Four Florida Benchmark Lakes, Alana Jade Bronk

USF Tampa Graduate Theses and Dissertations

Biodiversity is declining across all natural environments, however, freshwater systems are thought to be among the most threatened. Quantifying and understanding trends in freshwater biodiversity has become more urgent as rapid biodiversity loss continues. To provide a robust ecological assessment, more than one bioindicator should be used, along with multiple biodiversity metrics. Macrophytes and diatoms are important components of aquatic systems, especially in shallow lakes. The relationship between macrophytes and epiphytic diatoms, though, is not clearly understood, and has not been well-studied, particularly in Florida, which has the largest abundance of natural freshwater lakes in the southeastern U.S This study …

A School Leader’S Experiences With Ableism In An Educational System, Scottie Basham

USF Tampa Graduate Theses and Dissertations

The current organizational autoethnographic study aims to problematize ableism as an ideology that permeates and contributes to the inequities students with disabilities face in education. I share how I came to see ableism as an ideology that permeates and contributes to recursive practices in special education and share experiences that illustrate to school leaders ableist assumptions that are ingrained in leading a Special Education Center. Using organizational autoethnography, I share my experience as a first-year principal to provide a first-hand account of recursive practices within the educational organization, rooted in ableism, and discuss how those practices affected both myself, as …

Childbirth, Later-Life Cardiovascular Disease, Mortality, And Health-Related Quality Of Life In Postmenopausal Women, Zailing Xing

USF Tampa Graduate Theses and Dissertations

Introduction: The associations between childbirth and future maternal cardiovascular disease (CVD) and mortality have been inconclusive. Limited studies have focused on the association between childbirth and HRQoL. Objective: We aimed to examine the long-term effects of parity and age at childbirth on women's CVD and mortality based on propensity score matching. Methods: This study used data from the Women’s Health Initiative study (1993-2022). We used propensity score matching to produce matched samples, then employed multilevel Cox proportional hazard models for hazard ratios (HRs) to estimate the associations of parity and age at childbirth with CVD and mortality. We used mixed-effects …

Business Failure Mode And Effects Analysis: A Risk Based Holistic Strategy To Improve Success Rates Of Small Technology Businesses, Krishnakumar R. Nair

USF Tampa Graduate Theses and Dissertations

Multiple US and global statistics show that small businesses are vital to economic development but fail at a startling rate. Small technology businesses (STBs) are around 35% of this small business segment. The central problem addressed in this research is to reduce their short lives and enable growth and stability. The solution is a significant business management strategy iteratively developed by working with business owners and practitioners. A holistic approach to view the business as a whole to address premature failures is not available, and this research presents a comprehensive approach to solving that problem. The study developed a novel …

Modification Of 2d Chalcogenides By Metal Vapor Reaction, Vimukthi Viraj Perera Pathirage

USF Tampa Graduate Theses and Dissertations

The interest in studying 2D materials has increased over time due to their unique physical and chemical properties, which have the potential to lead to numerous applications in technology. For instance, their small size makes them useful for technology that requires greater efficiency, faster processing speeds, and less physical space. Transition metal dichalcogenides (TMDs) are a type of 2D material that is composed of one transition metal layer sandwiched between two chalcogen layers. The study of TMDs is of significant importance due to their layer-dependent properties and the fact that different phases exhibit distinct properties, including electronic properties. However, it …

Malat1 Mediates Tet2 Loss Of Function-Driven Oncogenic Inflammation Via Rna Shielding Of Nf- Kappa B P65, Nana Adjoa Ben-Crentsil

USF Tampa Graduate Theses and Dissertations

TET2 is a dioxygenase that regulates gene expression and hematopoiesis by oxidizing 5-methylcytosine residues on DNA to 5-hydroxymethylcytosine. TET2 mutations are common genetic events in hematological disorders. For example, TET2 is the most frequently mutated gene in Chronic Myelomonocytic Leukemia and occurs in about 33% of other myeloid malignancies. It is also the second commonest mutation in clonal hematopoiesis of indeterminate potential (CHIP), a common premalignant condition in the elderly. TET2 mutations arise in founding clones and are implicated in many non-hematological sequelae seen in CHIP like atherosclerotic disease, chronic liver disease, and severe microbial infections.

The development of TET2-deficient …

Expanding On The Factor Structure And Construct Validity Of The Short-Term Assessment Of Risk And Treatability (Start), Haomin Chen

USF Tampa Graduate Theses and Dissertations

Research finds better reentry/recidivism program outcome when individuals receive service that matches their risks and needs. It is thus essential to measure recidivism risks and needs appropriately. The Short-Term Assessment of Risk and Treatability (START) is a clinically-oriented instrument that assesses risks of future violence/offending and identifies areas for treatment. We see its potential use as an assessment tool for reentry/recidivism programming. More empirical evidence is needed to identify the psychometric properties of the instrument in this setting before it may be used in practice. The current thesis explored the factor structure of the START strengths and vulnerabilities scales using …

Overcoming Microenvironmentally Mediated Resistance In Targetable Non-Small Cell Lung Cancer, Bina Desai

USF Tampa Graduate Theses and Dissertations

The introduction of targeted therapies has resulted in immense success in treating lung cancer patients, where many patients experience long-term remission. Yet, the tumors relapse into an advanced state of disease, and ultimately, treatment failure. This can be ascribed to incomplete eradication of tumor cells by targeted therapies, which enables the residual tumor cells to propagate resistant tumors and cause subsequent relapse in patients. Therapy sensitivity is influenced not only by cell-intrinsic mechanisms but also by inputs from the stromal microenvironment. Despite widespread recognition of the stromal microenvironment's role in modulating therapy sensitivity, its contribution to therapeutic responses in vivo …

A Shield-Bearer’S Tale: Elucidating The Roles Of Estradiol And Choline In Mitigating Chemotherapy-Related Cognitive Impairment, Robert W. Botelho Jr.

USF Tampa Graduate Theses and Dissertations

Chemotherapy-Related Cognitive Impairments (CRCIs) are significant consequences of chemotherapy that affect a substantial portion of breast cancer survivors, potentially persisting long after treatment cessation. This series of studies investigated the neuroprotective roles of estradiol and choline against CRCIs induced by cyclophosphamide and doxorubicin (CYP/DOX), commonly known as Adriamycin/Cytoxan (AC) chemotherapy. Utilizing the MMTV-PyVT mouse model of breast cancer, this body of work spans several experimental studies, the first of which evaluates the impact of dietary choline supplementation on spatial memory and cholinergic function in tumor-bearing mice undergoing chemotherapy. The subsequent study tests whether impaired ovarian function and resulting reductions in …

Development And Initial Validation Of The Musical Discrimination And Styles Task: Measuring Children And Adolescent Music Aptitude And Achievement, Dawn R. Mitchell White

USF Tampa Graduate Theses and Dissertations

This dissertation had two purposes: 1) to create and document the development of a new music achievement test entitled the Musical Discrimination and Styles Task (MDAST), and 2) to describe the strength of the evidence supporting the validity and reliability of this new developmentally appropriate music aptitude and achievement instrument. I created a theoretical framework based on 1) the cognitive theory of child development of Jean Piaget, 2) the phase model of artistic development by David Hargreaves, and 3) the theoretical models of music discrimination, audiation, and music achievement by Edwin Gordon. The MDAST’s design assessed students’ abilities to evaluate …

Development Of Peptidomimetics Based On Γ-Aapeptide Molecular Scaffolds To Modulate Amyloid Peptide Aggregation, Heng Liu

USF Tampa Graduate Theses and Dissertations

Many proteins contain fragments that become structured upon binding to specific targets or through self-association. Notable examples of such disorder-to-order transitions include amyloidogenic proteins like amyloid-β peptide (Aβ) and tau peptide in Alzheimer's disease, α-Synuclein in Parkinson's disease, and hIAPP in type 2 diabetes, and so on. These regions can aggregate into amyloid fibrils through β -sheet stacking, contributing to amyloidosis and related diseases. Although direct link between amyloid formation and neurodegenerative disease development is not fully understood, developing effective inhibitors of these amyloid peptides remains promising both for fundamental research and therapeutical advance.

We have developed a new class …

Presence Of Pharmaceuticals And Personal Care Products In Sinkhole Lakes In West-Central Florida, Elzbieta Bialkowska-Jelinska

USF Tampa Graduate Theses and Dissertations

Pharmaceuticals and personal care products (PPCPs) are essential for human health, improving quality of life, and extending life expectancy. However, many of these chemicals have become significant environmental pollutants, particularly in lentic (lake) environments. One unintended source of PPCPs in natural environments is onsite wastewater treatment systems (OWTS), commonly known as septic tanks.

This study examines whether the seasonal variability of rainfall and soil saturation affects the assemblages and concentrations of PPCPs in a residential lake. The general premise of the dissertation was that with the onset of the wet season, PPCPs that had collected in the drainfields of the …

Improvements In Computational Techniques For Determining Ideal Class Groups And Class Numbers, Muhammed Rashad Erukulangara

USF Tampa Graduate Theses and Dissertations

The ideal class group is a fundamental concept in algebraic number theory, providing insights into the structure and factorization properties of the ring of integers of a number field. It measures the extent to which unique factorization fails in the ring of integers. Efficiently computing the ideal class group is crucial for exploring unproved heuristics in number theory and solving Diophantine equations. Additionally, the computation of the ideal class group has several cryptographic applications, such as schemes based on the Discrete Logarithm Problem (DLP), the computation of isogenies, and groups of unknown order. Despite its importance, much about the ideal …

Regioselective Hydroamination Of Unactivated Olefins With Diazirine And Total Synthesis Of Nostodione A And Scytonemin, Qingyu Xing

USF Tampa Graduate Theses and Dissertations

As an atom-economic way of carbon-nitrogen bond formation, hydroaminations are great tool for make amines, hydrazines, and other nitrogen-containing heterocycles. Specifically, radical hydroamination is a useful approach for functionalization of unactivated olefins, especially in sterically hindered environments. Diversification remains a challenge for radical hydroaminated products, since the nitrogen sources are carefully designed. In the first chapter of this dissertation, we report a highly diversifiable radical hydroamination reaction with diazirine as a nitrogen source and its potential applications in synthesis of several pharmaceutical interested compounds. Cobalt catalyzed regioselective hydroamination with diazirine shows wide function group tolerance, like phenyl thioether, ketones, esters, …