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USF Tampa Graduate Theses and Dissertations

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Estudio Y Transcripción Semipaleográfica De La Relación Del Descubrimiento Del Río De Las Amazonas De Gaspar De Carvajal (Ms. Bne Res/257), Gonzalo Páez Mar 2015

Estudio Y Transcripción Semipaleográfica De La Relación Del Descubrimiento Del Río De Las Amazonas De Gaspar De Carvajal (Ms. Bne Res/257), Gonzalo Páez

USF Tampa Graduate Theses and Dissertations

This thesis examines the account of the discovery of the Amazon River written by Gaspar de Carvajal in the sixteenth century. In his Relación del descubrimiento del famoso río grande que, desde su nacimiento hasta el mar descubrió el capitán Francisco de Orellana, Carvajal describes the nine-month journey in which Orellana and his men crossed South America from the Andes to the Atlantic Ocean. In makeshift boats, they traveled through the river that we now know as the Amazon. The fact that the river has kept the name of the mythical warriors of European classical culture shows how the …


A Technical And Economic Comparative Analysis Of Sensible And Latent Heat Packed Bed Storage Systems For Concentrating Solar Thermal Power Plants, Jamie Trahan Mar 2015

A Technical And Economic Comparative Analysis Of Sensible And Latent Heat Packed Bed Storage Systems For Concentrating Solar Thermal Power Plants, Jamie Trahan

USF Tampa Graduate Theses and Dissertations

Though economically favorable when compared to other renewable energy storage technologies, thermal energy storage systems for concentrating solar thermal power (CSP) plants require additional cost reduction measures to help transition CSP plants to the point of grid-parity. Thermocline packed bed storage is regarded as one potential low cost solution due to the single tank requirement and low cost storage media. Thus sensible heat storage (SHS) and latent heat storage (LHS) packed bed systems, which are two thermocline varieties, are frequently investigated. LHS systems can be further classified as single phase change material (PCM) systems or cascaded systems wherein multiple PCMs …


Improving System Performance In Cellular And Wban Networks Via User-Specific Qos And Mimo In Vivo Technologies, Chao He Mar 2015

Improving System Performance In Cellular And Wban Networks Via User-Specific Qos And Mimo In Vivo Technologies, Chao He

USF Tampa Graduate Theses and Dissertations

This dissertation is composed of two independent studies: Cellular research and WBAN (Wireless Body Area Network) research. Both investigations are directed towards improving the system performance in wireless communication systems in terms of Quality of Service (QoS) and system capacity.

For the Cellular research part, this dissertation will present novel user-specific QoS requirements as defined by their respective Mean Opinion Score (MOS) formulas, and associated schedulers for wireless applications and systems that optimize spectral allocation. User-specific QoS requirements are defined and several methods to make use of such requirements to maximum the spectral utilization are presented. Five User-Specific QoS Aware …


The Encultured Mind: From Cognitive Science To Social Epistemology, David Alexander Eck Mar 2015

The Encultured Mind: From Cognitive Science To Social Epistemology, David Alexander Eck

USF Tampa Graduate Theses and Dissertations

There have been monumental advances in the study of the social dimensions of knowledge in the late twentieth and early twenty-first centuries. But it has been common within a wide variety of fields--including social philosophy, cognitive science, epistemology, and the philosophy of science--to approach the social dimensions of knowledge as simply another resource to be utilized or controlled. I call this view, in which other people's epistemic significance are only of instrumental value, manipulationism. I identify manipulationism, trace its manifestations in the aforementioned fields, and explain how to move beyond it. The principal strategy that I employ for moving beyond …


"Tell Me, Where Am I From?": A Study Of The Performance Of Geek Identity At Comic Book Conventions, Eric Kahler Mar 2015

"Tell Me, Where Am I From?": A Study Of The Performance Of Geek Identity At Comic Book Conventions, Eric Kahler

USF Tampa Graduate Theses and Dissertations

The performance of identity is an often studied subject matter. One identity, Geek, and the larger subculture to which it is attached (Geek culture) has become a growing field of study in since the turn of the millennium, mirroring the growth of the subculture itself. The question then is how do Geek's perform this identity and create an idea of what a Geek is? If there is a place to examine this performance then it is the growing event of comic book conventions. At these events thousands of individuals gather to celebrate, interact with, purchase and play with the commodities …


Navigating Collective Activity Systems: An Approach Towards Rhetorical Inquiry, Katherine Jesse Royce Mar 2015

Navigating Collective Activity Systems: An Approach Towards Rhetorical Inquiry, Katherine Jesse Royce

USF Tampa Graduate Theses and Dissertations

The purpose of this formative intervention was to design a professional and technical communications course around rhetorical inquiry. The participants, undergraduate health sciences majors (N=22 for section A, N=20 section B), were observed throughout the fall semester of the 2014-2015 academic year. A rhetorical inquiry framework was applied via activity systems, and data were collected using several methodologies including participant observations, research questionnaires, as well as participant deliverables, and were transcribed using Daisy Mwanza's Eight-Step Model. Results demonstrated students successfully used activity systems as a means of approaching rhetorical inquiry. Furthermore, students indicated a high level of engagement in the …


Investigation Of Opuntia Ficus-Indica Mucilage Nanofiber Membrane Filtration For Water Systems, Rasudha Muppaneni Mar 2015

Investigation Of Opuntia Ficus-Indica Mucilage Nanofiber Membrane Filtration For Water Systems, Rasudha Muppaneni

USF Tampa Graduate Theses and Dissertations

This work investigates the fabrication, characterization and testing of Opuntia ficus-indica mucilage nanofibers to be utilized in water filtration systems. These mucilage nanofibers are formed using different polymers through a process called electrospinning. The polymers used to promote the formation of nanofibers are poly vinyl alcohol (PVA) and polystyrene (PS). The mucilage is a jelly like substance extracted from the pads of the cactus plant. It is a mixture of proteins, complex polysaccharides and monosaccharaides. It is an inexpensive, non-toxic, biodegradable and biocompatible material which is present in abundance. The mucilage extracted from the pads is mixed with acetic acid …


Speaking Their Language: Textisms In Today's Communication, Adam Lloyd Drum Mar 2015

Speaking Their Language: Textisms In Today's Communication, Adam Lloyd Drum

USF Tampa Graduate Theses and Dissertations

This study is an exploratory look into the use of text-based slang, or textisms, in modern communication. People use textisms in multiple media of communication, whether it is in text messages, emails, and various types of social media. This study asked a focus group about their uses and gratifications from textisms. The focus group delved into their appreciations as both users and receivers. Participants reflected on their personal experience and preferences with textisms for their personal communications as well as their opinion for various types of businesses using them in their larger message design efforts.

The participants were comprised of …


Parent-Child Interaction Therapy As A Treatment For Adhd In Early Childhood: A Multiple Baseline Single-Case Design, Kendall Jeffries Deloatche Mar 2015

Parent-Child Interaction Therapy As A Treatment For Adhd In Early Childhood: A Multiple Baseline Single-Case Design, Kendall Jeffries Deloatche

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to examine the effectiveness of PCIT as an alternative to medication in managing symptoms and behavior problems of preschool-aged children with ADHD. Using a multiple baseline single-case design, the study measured the impact of PCIT on four preschool-aged children's problem behaviors and ADHD symptoms, parenting practices, and mothers' attitudes towards therapy. Outcome measures included the Child Behavior Checklist, Eyberg Child Behavior Inventory, Behavior Assessment System for Children, ADHD Symptom Observation form, Dyadic Parent-Child Interaction Coding System, Parenting Practices Interview, and Therapy Attitude Inventory. Results from visual analyses, a visual permutation test, and hierarchical linear …


Let's Go To The Carnival: Hybridization Of Heterotopian Spaces In The Films Of Kevin Smith, Anthony L. Sylvester Mar 2015

Let's Go To The Carnival: Hybridization Of Heterotopian Spaces In The Films Of Kevin Smith, Anthony L. Sylvester

USF Tampa Graduate Theses and Dissertations

This paper argues against the charges of puerility in the films of Kevin Smith. I analyze Mallrats (1995), Clerks II (2006) and Zack and Miri Make a Porno (2008). To illustrate my contention, I offer close readings of the director's films, particularly the protagonists' bodily/linguistic performances. My efforts will vindicate my assertion that through these specialized performances, through the forceful assertion of their marginal identities, the films' protagonists encroach upon, and finally appropriate, historically dominant spaces. As a result, the spaces they appropriate acquire a new, characteristic hybridity. Michel Foucault's concept of heterotopia provides a framework for delineating the dominant …


Promoting Genome Stability Via Multiple Dna Repair Pathways, Scott Cukras Feb 2015

Promoting Genome Stability Via Multiple Dna Repair Pathways, Scott Cukras

USF Tampa Graduate Theses and Dissertations

Maintaining genome integrity is indispensible for cells to prevent and limit accruement of deleterious mutations and to promote viable cell growth and proliferation. Cells possess a myriad of mechanisms to detect, prevent and repair incurred cellular damage. Here we discuss various proteins and their accompanying cellular pathways that promote genome stability. We first investigate the NEDD8 protein and its role in promoting homologous recombination repair via multiple Cullin E3 ubiquitin ligases. We provide specific mechanisms through which, UBE2M, an E2 conjugating enzyme, neddylates various Cullin ligases to render them catalytically active to degrade their substrates by the proteasome. We show …


A Functional Chlorophyll Biosynthesis Pathway Identified In The Kleptoplastic Sea Slug, Elysia Chlorotica, Julie A. Schwartz Feb 2015

A Functional Chlorophyll Biosynthesis Pathway Identified In The Kleptoplastic Sea Slug, Elysia Chlorotica, Julie A. Schwartz

USF Tampa Graduate Theses and Dissertations

The sacoglossan sea slug, Elysia chlorotica, feeds upon and sequesters plastids from the heterokont alga, Vaucheria litorea, and maintains the metabolically active organelles for up to nine months under starvation conditions while utilizing the photosynthate to survive and reproduce. The photosynthetic pigment, chlorophyll a (Chla), is found in all oxygenic photosynthetic organisms and is responsible for capturing photons of light and converting them into chemical energy. Chlorophyll and its associated proteins involved in the light capturing process are subject to photo oxidative damage and must be continually replaced for ongoing photosynthesis to continue; however, genes encoding these proteins are present …


Effects Of Gender And Aggression Type On Perceptions Of Aggressive Behavior At Work, Jason Donovan Way Feb 2015

Effects Of Gender And Aggression Type On Perceptions Of Aggressive Behavior At Work, Jason Donovan Way

USF Tampa Graduate Theses and Dissertations

This dissertation sought to examine the interactive effects of participant gender, aggression type (physical vs. relational), aggressor gender, and target gender on two sets of dependent variables. The first set consisted of a performance rating, the acceptability of the aggression, the perceived aggressiveness of the aggressor, and the perceived aggressiveness of the act. The second set consisted of perceived masculinity, perceived femininity, and perceived gender ideal. The main hypothesis was that gender stereotypes of aggression would influence performance evaluations of aggressive behavior. Other hypotheses were based on previous research regarding the effect of gender and aggression type on the acceptability …


Learning Preferences Of Commercial Fishermen, Robert W. Miller Feb 2015

Learning Preferences Of Commercial Fishermen, Robert W. Miller

USF Tampa Graduate Theses and Dissertations

This study surveyed 435 commercial fishermen across eight coastal regions of the United States where commercial fishing takes place. The regions of the study included: Northeast Atlantic, Mid-Atlantic, Southeast Atlantic, Gulf of Mexico, Great Lakes, Southern Pacific, Pacific Northwest, and Alaska. Participants were asked to complete the Commercial Fishing Worker Survey (CFWS), which is a survey instrument consisting of an approved, adapted version of the Index of Learning Styles instrument (ILS) combined with a demographic section which included questions designed to obtain data regarding the four variables of the study: age, education level, captain's license status, and method of fishing. …


An Evaluation Of An Electronic Student Response System In Improving Class-Wide Behavior, Ashley Horne Jan 2015

An Evaluation Of An Electronic Student Response System In Improving Class-Wide Behavior, Ashley Horne

USF Tampa Graduate Theses and Dissertations

A student response system is a technology that allows an entire classroom of students to respond to questions and receive immediate feedback from teachers during instruction. However, little research has examined the use of student response systems to support student behavior in elementary schools. This study focused on using an electronic student response system to improve class-wide behavior in two general elementary school classrooms. An ABAB and ABA reversal designs embedded within a multiple baseline design across classrooms was employed to evaluate the outcome of the intervention. Although limited, the results indicated that the classroom teachers implemented the electronic student …


Design, Testing And Implementation Of A New Authentication Method Using Multiple Devices, Cagri Cetin Jan 2015

Design, Testing And Implementation Of A New Authentication Method Using Multiple Devices, Cagri Cetin

USF Tampa Graduate Theses and Dissertations

Authentication protocols are very common mechanisms to confirm the legitimacy of someone’s or something’s identity in digital and physical systems.

This thesis presents a new and robust authentication method based on users’ multiple devices. Due to the popularity of mobile devices, users are becoming more likely to have more than one device (e.g., smartwatch, smartphone, laptop, tablet, smart-car, smart-ring, etc.). The authentication system presented here takes advantage of these multiple devices to implement authentication mechanisms. In particular, the system requires the devices to collaborate with each other in order for the authentication to succeed. This new authentication protocol is robust …


An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis Jan 2015

An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis

USF Tampa Graduate Theses and Dissertations

Research misconduct has been generally considered a limited issue, occurring in a small percentage of research studies. Studies of the number of article retractions use retraction percentages to perpetuate the idea that research misconduct is not a common event, and use information in the retraction notice to quantify types of research misconduct and types or research error. However, retractions appear to be the wrong variable with which to assess misconduct rates and characteristics. Using final misconduct findings in hard science research from the Office of Research Integrity (ORI) for investigations closed from 1993 through 2013, the number of publications and …


Representations Of Gatsby: Ninety Years Of Retrospective, Christine Anne Auger Jan 2015

Representations Of Gatsby: Ninety Years Of Retrospective, Christine Anne Auger

USF Tampa Graduate Theses and Dissertations

Jay Gatsby, F. Scott Fitzgerald’s most famous character, has starred in a variety of stage and screen adaptations in the ninety years since he was first introduced in The Great Gatsby (1925). This dissertation explores the Gatsby character as depicted in six important adaptations of the novel, including two Broadway productions, Owen Davis’ 1926 drama and John Collins’ 2010s play, Gatz, and four major motion pictures: Herbert Brenon’s 1926 lost silent film (starring Warner Baxter); Elliott Nugent’s 1949 black and white film (starring Alan Ladd); Jack Clayton’s 1974 color film (starring Robert Redford); and Baz Luhrmann’s 2013 3-D film (starring …


Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck Jan 2015

Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck

USF Tampa Graduate Theses and Dissertations

Evidence suggests comorbidity of ADHD and eating disorders (EDs) among females. Capitalizing on the comorbidity of ADHD and EDs and subsequent obesity could lead to improved prevention and treatment of all three conditions. However, additional information regarding the comorbidity is necessary to develop such interventions, as little is known about how or why this co-occurrence exists. A comprehensive model of the underlying mechanisms associated with comorbid ADHD and EDs is needed to improve understanding of the development of the comorbidity. Moreover, while there are gender differences within each disorder, literature is limited regarding to the comorbidity among males, leading to …


Straight Benevolence: Preserving Heterosexual Authority And White Privilege, Robb James Bruce Jan 2015

Straight Benevolence: Preserving Heterosexual Authority And White Privilege, Robb James Bruce

USF Tampa Graduate Theses and Dissertations

This thesis analyzes three current and popular media sites, exploring a term I coin “straight benevolence.” An ostensibly supportive and progressive attitude adopted by heterosexuals and expressed toward gay men in the United States, straight benevolence surreptitiously subordinates gayness and further entrenches white masculine heterosexual privilege. In my examination of hip-hop artist Macklemore’s “Same Love,” seven Major League Baseball “It Gets Better” gay-advocacy videos, and the “Suddenly, Last Summer” episode of ABC’s primetime U.S. television series Modern Family, I take an intersectional approach to address the interanimation of sexuality, gender, and race. I ask: In what ways is gay male …


The Relation Between Adiposity And Anxiety In Youth: Analysis Of Peer Victimization, Teasing, Sociocultural Influences, And Internalization Of Appearance Ideals As Explanatory Variables, Natasha L. Burke Jan 2015

The Relation Between Adiposity And Anxiety In Youth: Analysis Of Peer Victimization, Teasing, Sociocultural Influences, And Internalization Of Appearance Ideals As Explanatory Variables, Natasha L. Burke

USF Tampa Graduate Theses and Dissertations

The purpose of the current study was to examine putative mediators and moderators in the association between adiposity and anxiety in a sample of overweight and obese youth. In addition, anxiety was examined as a potential moderator between adiposity and health-related quality of life (HRQOL). Participants were youth (N = 137) between 8 and 17 years old (M = 13.09, SD = 2.61) and their legal caregivers recruited from four medical clinics affiliated with the University of South Florida. Youth were primarily overweight (28.5%) or obese (64.2%) and ethnically diverse. Data were analyzed by path analysis. Weight-related teasing significantly mediated …


Latino Immigrant Workers’ Search For Justice After Occupational Injury, Carla Gabriela Castillo Jan 2015

Latino Immigrant Workers’ Search For Justice After Occupational Injury, Carla Gabriela Castillo

USF Tampa Graduate Theses and Dissertations

Latino immigrants encounter an entanglement of rights and policies after occupational injury or illness. In collaboration with an immigrant worker center, ethnographic research and a survey are used to analyze injured workers’ experiences. The center uses survey results to identify common threads and systematic problems, and to explore potential direct action. Through interviews with workers and medical and legal professionals, I investigate the barriers Latino immigrants face following occupational injury or illness, how their lived experiences relate to the greater medicolegal frameworks that demarcate most formal processes of compensation and treatment, and the experiences of professionals who mediate these structures. …


Crisis Communication And Celebrity Scandal: An Experiment On Response Strategies, Leah Champion Jan 2015

Crisis Communication And Celebrity Scandal: An Experiment On Response Strategies, Leah Champion

USF Tampa Graduate Theses and Dissertations

Recent allegations surrounding Bill Cosby presented an opportunity to combine, test, and extend situational crisis communication theory typology and image repair theory response strategies for celebrity use. Because Cosby did not respond to the numerous allegations against him, it presented an opportunity to experiment with new and existing typologies using a real case, as opposed to analyzing past response attempts or using a hypothetical case. This study used a 2 X 4 factorial design to test veracity of claims, a proposed concept, and response strategies via survey. Even though none of the hypotheses were supported, the present study opened up …


Computational Investigations Of Potential Energy Function Development For Metal-Organic Framework Simulations, Metal Carbenes, And Chemical Warfare Agents, Christian R. Cioce Jan 2015

Computational Investigations Of Potential Energy Function Development For Metal-Organic Framework Simulations, Metal Carbenes, And Chemical Warfare Agents, Christian R. Cioce

USF Tampa Graduate Theses and Dissertations

Metal-Organic Frameworks (MOFs) are three-dimensional porous nanomaterials with a variety of applications, including catalysis, gas storage and separation, and sustainable energy. Their potential as air filtration systems is of interest for designer carbon capture materials. The chemical constituents (i.e. organic ligands) can be functionalized to create rationally designed CO2 sequestration platforms, for example. Hardware and software alike at the bleeding edge of supercomputing are utilized for designing first principles-based molecular models for the simulation of gas sorption in these frameworks. The classical potentials developed herein are named PHAST -- Potentials with High Accuracy, Speed, and Transferability, and thus are designed …


High-Throughput Screening Of Age-Related Changes In Caenorhabditis Elegans, Neil Copes Jan 2015

High-Throughput Screening Of Age-Related Changes In Caenorhabditis Elegans, Neil Copes

USF Tampa Graduate Theses and Dissertations

This project was developed to identify novel methods for high-throughput culturing and screening of C. elegans to investigate age-related metabolic changes and to survey the proteomic and metabolomic factors associated with age-related changes. To accomplish these goals we developed a novel way to grow C. elegans in liquid culture in 96-well microplates for several weeks without suffering significant fluid loss due to evaporation and without needing to shake or unseal the plates for aeration. We also developed methods for assaying the total volume of live C. elegans in microplate cultures using a fluorescence microplate reader and for performing RNAi experiments …


Strategies For Preventing Age And Neurodegenerative Disease-Associated Mitochondrial Dysfunction, Vedad Delic Jan 2015

Strategies For Preventing Age And Neurodegenerative Disease-Associated Mitochondrial Dysfunction, Vedad Delic

USF Tampa Graduate Theses and Dissertations

Mitochondrial dysfunction plays a pivotal role in the development of aging phenotypes and aging-associated neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS). Strategies that restore mitochondrial dysfunction may rescue the deficits of central metabolism in these disorders and improve cell survival. For example, we found that modulating the mTOR signaling pathway in a tissue culture model of aging-induced mitochondrial DNA mutation enhanced mitochondrial function as evidenced by increased oxygen consumption. Our previous melatonin studies also led us to hypothesize that caloric restriction and the hormone melatonin would reverse brain mitochondrial dysfunction in animal …


The Continuum Of Ethno-Racial Socialization: Learning About Culture And Race In Middle-Class Latina/O Families, Maria D. Duenas Jan 2015

The Continuum Of Ethno-Racial Socialization: Learning About Culture And Race In Middle-Class Latina/O Families, Maria D. Duenas

USF Tampa Graduate Theses and Dissertations

This thesis examines the discursive messages and specific practices that Latino families use to transmit messages about culture, race, and racism. Scholars have not fully explored the complexity and range of practices and discourses that are involved in Latinos’ ethno-racial socialization. The use of the phrase “ethno-racial socialization” is important because it combines the concepts of racial socialization and ethnic socialization in an effort to account for how the lived experiences of Latinos who mostly think of themselves as a racial group, are treated as one race, and thus, discuss race with family members. This research explores this process using …


Genomic Aberrations At The 3q And 14q Loci: Investigation Of Key Players In Ovarian And Renal Cancer Biology, Punashi Dutta Jan 2015

Genomic Aberrations At The 3q And 14q Loci: Investigation Of Key Players In Ovarian And Renal Cancer Biology, Punashi Dutta

USF Tampa Graduate Theses and Dissertations

Genomic aberrations are primary contributors to the pathophysiology of cancer [11]. Dysregulated expression of genes located within these aberrations are important predictors of chemoresistance, disease prognosis, and patient outcome [12]. This dissertation is focused on understanding the regulation and/or functions of specific genes located at dysregulated genomic regions such as 3q26 and 14q32 in the biology of ovarian and renal cancer, respectively.

Serous epithelial ovarian cancer (EOC) manifest amplification at the 3q26.2 locus [2], an observation consistent with the cancer genome atlas (TCGA) [13]. The most amplified gene in this region is EVI1 which has been extensively studied in hematological …


The Effects Of Supplemented Metabolites On Lifespan And Stress Response Pathways In Caenorhabditis Elegans, Clare B. Edwards Jan 2015

The Effects Of Supplemented Metabolites On Lifespan And Stress Response Pathways In Caenorhabditis Elegans, Clare B. Edwards

USF Tampa Graduate Theses and Dissertations

Understanding how metabolites contribute to anaplerosis, antioxidant effects, and hormetic pathways during aging is fundamental to creating supplements and dietary habits that may decrease age-associated disease and decline, thus improving the quality of life in old age. In order to uncover metabolic pathways that delay aging, the effects of large sets of metabolites associated with mitochondrial function on lifespan were investigated.

Malate, the tricarboxylic acid (TCA) cycle metabolite, increased lifespan and thermotolerance in C. elegans. Addition of fumarate and succinate also extended lifespan and all three metabolites activated nuclear translocation of the cytoprotective DAF-16/FOXO transcription factor and protected from paraquat-induced …


Mmv Malaria Box Activity Screening In Dormant Plasmodium Falciparum Phenotypes, Sandra Galusic Jan 2015

Mmv Malaria Box Activity Screening In Dormant Plasmodium Falciparum Phenotypes, Sandra Galusic

USF Tampa Graduate Theses and Dissertations

The causative agent of malignant tertian malaria, Plasmodium falciparum undergoes an arrested growth phenotype of its erythrocytic stage when under drug-stress. Recent artemisinin treatment failures seem to be indicative of such induction followed by recrudescence rather than actual therapeutic failure. Likewise, P. vivax hypnozoites are the prototypic dormants and the latent infections for which they are responsible prove most difficult to treat. Dihydroartemisinin, an artemisinin-derivative, can be used to exploit this mechanism by inducing a dormant state in ring-stage P. falciparum parasites and in turn, their recovery may be used as a screening period for compounds that inhibit or foster …