Digital Commons Network^™

Chyd1 Solution Phase Synthesis Optimization And The Development Of A Novel Human Growth Hormone Antagonist And Agonist, Philip Murray

USF Tampa Graduate Theses and Dissertations

Inhibiting protein-protein interactions to achieve a therapeutically desired effect has been a goal in the field of drug discovery for decades. Recently, advances in peptidomimetics have led researches to the use of cyclized peptides to achieve this goal. Cyclization of linear peptides restricts the number of conformations of the peptide, increasing the peptide's affinity to binding to the desired target. Cyclization also stabilizes the peptide, allowing the peptide to be resistant to proteases. This study explores the optimization of solution phase synthesis of an important integrin-mediated cell adhesion cyclic peptide for the therapeutic inhibition of multiple myeloma, cHYD1. cHYD1 was …

Encapsulation Of High Temperature Phase Change Materials For Thermal Energy Storage, Rupa Nath

USF Tampa Graduate Theses and Dissertations

Thermal energy storage is a major contributor to bridge the gap between energy demand (consumption) and energy production (supply) by concentrating solar power. The utilization of high latent heat storage capability of phase change materials is one of the keys to an efficient way to store thermal energy. However, some of the limitations of the existing technology are the high volumetric expansion and low thermal conductivity of phase change materials (PCMs), low energy density, low operation temperatures and high cost. The present work deals with encapsulated PCM system, which operates at temperatures above 500°C and takes advantage of the heat …

Multiple Intelligences In The Text: Examining The Presence Of Mi Tasks In The Annotated Teacher's Editions Of Four High School United States History Textbooks, Carey Mullican

USF Tampa Graduate Theses and Dissertations

The current state of the social studies classroom comprises one of uninspired students using unexciting textbooks as their guide for learning U.S. history (Hope, 1996; NCES, 1993; Banks, 1990; Wakefield, 2006). With multiple intelligences gaining popularity in education, renewed hope exists for social studies to produce quality textbooks with differentiated instruction to reach all learners. The purpose was to design a rubric for measuring the presence of multiple intelligences structured tasks in teacher's editions of four 11th grade U.S. history textbooks. Using 1995 to 2007 as a purposeful sample of consistent authorships and similar publications, the study looked at teacher's …

Defining Earth Smarts: A Construct Analysis For Socioecological Literacy Based On Justly Maintaining Quality Of Life, Bryan H. Nichols

USF Tampa Graduate Theses and Dissertations

This paper describes the creation and validation of a new educational construct. Socioecological literacy, or earth smarts, describes the qualities we need to justly maintain or improve our quality of life in a changing world. It was created using construct analysis techniques and systems tools, drawing on an extensive, transdisciplinary body of literature. Concepts related to environmental, ecological and scientific literacy, sustainability and citizenship were combined with educational frameworks, new research in science education, and modern cognitive psychology. After the initial formulation, the results were considered by a variety of experts and professionals from the fields of ecology, environmental science …

Mangroves, Mudbanks And Seawalls: Political Ecology Of Adaptation To Sea Level Rise In Suriname, Ravic Nijbroek

USF Tampa Graduate Theses and Dissertations

This study seeks to understand how global discourses of sea level rise (SLR) and mangrove ecology influence national climate change adaptation policy to reduce coastal vulnerability in Suriname. A majority of the Surinamese population lives along the low elevation coastal zone and is highly exposed to projected SLR. Failure by the international community to reach agreement on climate change mitigation means that vulnerable coastal communities must adapt. The Suriname coast is predominantly shaped by mudbanks and mangroves which together provide protection against coastal erosion and trap sediments resulting in coastal accretion. Knowledge claims of mangrove ecology and utility in SLR …

Micronekton And Macrozooplankton Of The Western Antarctic Peninsula And The Eastern Ross Sea: Contrast Between Two Different Thermal Regimes, Melanie Leigh Parker

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Micronekton and macrozooplankton were sampled from the Western Antarctic Peninsula (WAP) and eastern Ross Sea regions. Samples were collected over the course of six research cruises to the Southern Ocean. Four of those cruises were conducted in the Marguerite Bay region of the WAP during the austral fall and winter of 2001 and 2002. A fifth cruise sampled faunal assemblages at nine sites, ranging from Joinville Island at the northern tip of the WAP to Charcot Island near the southern extent of the WAP, during austral fall 2010. A sixth cruise was conducted in the pack ice within the …

Field And Laboratory Comparison Of The Hydraulic Performance Of Two Ceramic Pot Water Filters, Duncan Peabody

USF Tampa Graduate Theses and Dissertations

Currently 884 million people worldwide are living without access to an improved source of drinking water (WHO/UNICEF, 2011). Piped-water on premises is the ultimate goal of World Health Organization (WHO) due to the ability to treat all of the water and distribute it safely in pressurized pipes. However, Household Water Treatment and Safe Storage (HWTS) is an option for improving the quality of drinking water where that infrastructure is not yet developed, especially where there is a risk of recontamination between point of collection and point of use (Clasen, 2006).

This study analyzed one such HWTS, the ceramic pot water …

Cell Adhesion And Migration On Ndga Cross-Linked Fibrillar Collagen Matrices For Tendon Tissue Engineering, Ana Ysabel Rioja

USF Tampa Graduate Theses and Dissertations

Tendons, essential tissues that connect muscles to bones, are susceptible to rupture/degeneration due to their continuous use for enabling movement. Often surgical intervention is required to repair the tendon; relieving the pain and fixing the limited mobility that occurs from the damage. Unfortunately, post-surgery immobilization techniques required to restore tendon properties frequently lead to scar formation and reduced tendon range of motion. Our ultimate goal is to create an optimal tendon prosthetic that can stabilize the damaged muscle-bone connection and then be remodeled by resident cells from the surrounding tissues over time to ensure long-term function. To achieve this, we …

Experimental And Numerical Investigation Of An Electrospray Rf Ion Funnel, Eric Miguel Tridas

USF Tampa Graduate Theses and Dissertations

Using experimental techniques along with computational fluid dynamics and electrodynamic simulations the performance of the first of three focusing elements in an electrospray macromolecular patterning system was assessed. The performance of this element, the ion funnel, was analyzed by varying the parameters and electric field applied to the system including electrospray emitter to atmosphere-vacuum interface capillary distance, temperature of the desolvating heater, injection rate of solution and the voltage applied to the jet disruption element. Results indicated that processes involved in injecting larger droplets into the chamber resulted in a less effective transmission of the ions through the funnel. Droplet …

Shelf-Scale Mapping Of Fish Distribution Using Active And Passive Acoustics, Carrie Christy Wall

USF Tampa Graduate Theses and Dissertations

Fish sound production has been associated with courtship and spawning behavior. Acoustic recordings of fish sounds can be used to identify distribution and behavior. Passive acoustic monitoring (PAM) can record large amounts of acoustic data in a specific area for days to years. These data can be collected in remote locations under potentially unsafe seas throughout a 24-hour period providing datasets unattainable using observer-based methods. However, the instruments must withstand the caustic ocean environment and be retrieved to obtain the recorded data. This can prove difficult due to the risk of PAMs being lost, stolen or damaged, especially in highly …

Something Is Askew In Florida's Water: Arguing For A Better Descriptive Statistic For Positively Skewed Water-Quality Data, Amie October West

USF Tampa Graduate Theses and Dissertations

ABSTRACT

It may be of no surprise that water quality data is right-skewed, but what appears to be overlooked by some is that the arithmetic mean and standard deviation most often fail as measures of central tendency in skewed data. When using the arithmetic mean and arithmetic standard deviation with nutrient data, one standard deviation about the arithmetic mean can capture nearly all of the data and extend into negative values. Representing nutrient data this way can be misleading to viewers who are using the statistics, and making assumptions, to understand the characteristics of those waters. Through an in-depth statistical …

Asymmetric Intra- And Intermolecular Cyclopropanation By Co(Ii)- Based Metalloradical Catalysis, Xue Xu

USF Tampa Graduate Theses and Dissertations

Metal-catalyzed cyclopropanation of olefins with diazo reagents has attracted research interest because of its fundamental and practical importance. The resulting cyclopropyl units are recurrent motifs in biologically important molecules and can serve as versatile precursors in organic synthesis. Since they were first introduced in 2004, Co(II) complexes of D₂-symmetric chiral amidoporphyrins [Co(D₂-Por*)] have emerged as a new class of catalysts for asymmetric cyclopropanation. These metalloradical catalysts have been shown to be highly effective for asymmetric intermolecular cyclopropanation of a broad scope of substrates with different classes of carbene sources, particularly including electron-deficient olefins and acceptor/acceptor-substituted …

The Impact Of Socioscientific Issues Based Curriculum Involving Environmental Outdoor Education For Fourth Grade Students, Karey Burek

USF Tampa Graduate Theses and Dissertations

There is a divide between what students are being taught within the science classroom and what they experience out in the real world. This study sought to explore possible relationships between a socioscientific issues embedded curriculum and outcome variables addressing environmental attitude and knowledge, oral and written argumentation and critical thinking skills. Both quantitative and qualitative methods were used to examine both within and between class differences as well as individual differences between the beginning and end of a semester of elementary school. Results indicated that socioscientific issues assist students in developing their critical thinking skills while also providing students …

Hamiltonian Sets Of Polygonal Paths In 4-Valent Spatial Graphs, Tilahun Abay Muche

USF Tampa Graduate Theses and Dissertations

Spatial graphs with 4–valent rigid vertices and two single valent endpoints, called assembly graphs, model DNA recombination processes that appear in certain species of ciliates. Recombined genes are modeled by certain types of paths in an assembly graph that make a ”oper pendicular ” turn at each 4–valent vertex of the graph called polygonal paths. The assembly number of an assembly graph is the minimum number of polygonal paths that visit each vertex exactly once. In particular, an assembly graph is called realizable if the graph has a Hamiltonian polygonal path.

An assembly graph ɣ^{^} obtained from a given …

Global Csr And Photographic Credibility: Exploring How International Companies Portray Efforts Through Photographs In Csr Reports, Janel Lynn Norton

USF Tampa Graduate Theses and Dissertations

We are living in the age of the visual. Imagery is an important element in constructing and deriving meaning through symbols, colors, and context. Images may hold persuasive power, be used as evidence, or simply provide a moment of beauty. Organizations rely on photographs to help them convey an image to their stakeholders within annual reports. Telling an organizations' story through photographs has become an intrinsic part of their efforts to convey sustainability. We live in the age of transparency, and organizations that construct an image that is not truthful will face consequences in today's socially connected and conscious world. …

Occurrence, Toxicity, And Diversity Of Pseudo-Nitzschia In Florida Coastal Waters, Sheila O'Dea

USF Tampa Graduate Theses and Dissertations

Domoic acid (DA), a potent neurotoxin that has the potential to cause amnesic shellfish poisoning (ASP), is produced by members of the marine diatom genus Pseudo-nitzschia. Outbreaks of ASP in humans and of DA poisoning in birds and marine mammals have been reported across the United States and Canada since the late 1980's. Pseudo-nitzschia species can be extremely abundant in Florida waters, with densities often exceeding 10⁶ cells/L, and sometimes exceeding 10⁷ cells/L. Based on preliminary data, it is evident that at least nine species of Pseudo-nitzschia are found in Florida coastal waters. At least six of …

Sellars In Context: An Analysis Of Wilfrid Sellars's Early Works, Peter Jackson Olen

USF Tampa Graduate Theses and Dissertations

Although Wilfrid Sellars's work holds a prominent place in recent analytic philosophy, little work has been done to situate his early approaches to normativity and the philosophy of language in their proper context. What little work has been done tends to emphasize Sellars's connection to a then dominant logical empiricism at the expense of marginalizing other American philosophical schools. On top of this historical issue, most scholars attempting to explain Sellars's systematic philosophy tend to ignore a developmental picture of Sellars's positions and focus on explicating the systematic character of his thought. My dissertation attempts to correct both of these …

Statistical Content In Middle Grades Mathematics Textbooks, Maria Consuelo (Suzie) Capiral Pickle

USF Tampa Graduate Theses and Dissertations

Statistical Content in Middle Grades Mathematics Textbooks

Maria Consuelo (Suzie) Capiral Pickle

Abstract

This study analyzed the treatment and scope of

statistical concepts in four, widely-used, contemporary, middle

grades mathematics textbook series: Glencoe Math Connects,

Prentice Hall Mathematics, Connected Mathematics Project, and

University of Chicago School Mathematics Project. There were

three phases for the data analysis. Phase 1 addressed the location

and sequence of the statistical concepts. Phase 2 focused upon an

examination of the lesson narrative, its components and scope.

Phase 3 analyzed the level of cognitive demand required of the

students to complete the exercises, and the total …

A Statically Balanced Shape-Shifting Surface, Joseph Eugene Pishnery

USF Tampa Graduate Theses and Dissertations

ABSTRACT

This paper presents a concept for producing a Statically Balanced Shape-Shifting Surface (SB-SSS). In this context, an SB-SSS is a surface that can require near-zero magnitude force changes to accomplish a change in shape while retaining effectiveness as a physical barrier. This paper focuses on how to statically balance a specifically-designed compliant mechanism and how to incorporate this mechanism into a polygonal cell.

The mechanism consists of a compliant Peaucellier-Lipkin linkage layered with a pre-stressed link as the balancer. Previous work is presented that can show how a polygonal cell can be incorporated into a surface via a tiling …

Novel Blends Of Sulfur-Tolerant Water-Gas Shift Catalysts For Biofuel Applications, Timothy Michael Roberge

USF Tampa Graduate Theses and Dissertations

As traditional sources of energy become depleted, significant research interest has gone into conversion of biomass into renewable fuels. Biomass-derived synthesis gas typically contains concentrations of approximately 30 to 600 ppm H2S in stream. H2S is a catalyst poison which adversely affects downstream processing of hydrogen for gas to liquid plants. The water-gas shift reaction is an integral part of converting CO and steam to H2 and CO2. Currently, all known water-gas shift catalysts deactivate in sulfur concentrations typical of biomass-derived synthesis gas. Novel catalysts are needed to remain active in the presence of sulfur concentrations in order to boost …

Natural And Anthropogenic Influences On The Morphodynamics Of Sandy And Mixed Sand And Gravel Beaches, Tiffany Roberts

USF Tampa Graduate Theses and Dissertations

Beaches and coastal environments are dynamic, constantly shaped and reshaped by natural processes and anthropogenic modifications. The morphodynamics and influence of natural and anthropogenic factors of two different coasts at various temporal and spatial scales are discussed.

To quantify the performance of several beach nourishment projects at annual temporal and kilometer spatial scales on three adjacent microtidal low-wave energy barrier islands in west-central Florida, a total of 5,200 beach and nearshore-profiles spaced at 300 m were surveyed monthly to bi-monthly from 2006-2010. Beach nourishment performance is most significantly influenced by the interruption of longshore sediment transport by complex tidal-inlet processes. …

On The Spatial And Temporal Variability Of Upwelling In The Southern Caribbean Sea And Its Influence On The Ecology Of Phytoplankton And Of The Spanish Sardine (Sardinella Aurita), Digna Tibisay Rueda-Roa

USF Tampa Graduate Theses and Dissertations

The Southern Caribbean Sea experiences a strong upwelling process along the coast from about 61°W to 75.5°W and 10-13°N. In this dissertation three aspects of this upwelling system are examined: (A) A mid-year secondary upwelling that was previously observed in the southeastern Caribbean Sea between June-July, when land based stations show a decrease in wind speed. The presence and effects of this upwelling along the whole southern Caribbean upwelling system were evaluated, as well as the relative forcing contribution of alongshore winds (Ekman Transport, ET) and wind-curl (Ekman Pumping, EP). (B) Stronger upwelling occurs in two particular regions, namely the …

Sea Surface Height: A Versatile Climate Variable For Investigations Of Decadal Change, Philip Robert Thompson

USF Tampa Graduate Theses and Dissertations

Decadal variations in climate are important, because the magnitude of sustained decadal change is often much larger than the often discussed background trends. Climate variability at interannual and longer periods is most often discussed in the context of climate modes defined by sea level pressure (SLP) and sea surface temperature (SST) patterns. However, SLP and SST are not capable descriptors of ocean dynamics. The approximately two decades of global sea surface height (SSH) measurements from satellite altimetry reveal substantial low-frequency redistributions of heat and salt in the ocean, which may or may not be related to defined climate modes. In …

Statistical Estimation Of Physiologically-Based Pharmacokinetic Models: Identifiability, Variation, And Uncertainty With An Illustration Of Chronic Exposure To Dioxin And Dioxin-Like-Compounds., Zachary John Thompson

USF Tampa Graduate Theses and Dissertations

Assessment of human exposure to environmental chemicals is inherently subject to uncertainty and variability. There are data gaps concerning the inventory, source, duration, and intensity of exposure

as well as knowledge gaps regarding pharmacokinetics in general. These gaps result in uncertainties in exposure assessment.

The uncertainties compound further with variabilities due to population variations regarding stage of life, life style, and susceptibility,

etc. Use of physiologically-based pharmacokinetic (PBPK) models promises to reduce the uncertainties and enhance extrapolation between species, between routes, from high to low dose, and from acute to chronic exposure. However, fitting PBPK models is challenging because of …

Catalytic Tri-Reforming Of Biomass-Derived Syngas To Produce Desired H2:Co Ratios For Fuel Applications, Devin Mason Walker

USF Tampa Graduate Theses and Dissertations

This study focuses on upgrading biomass derived syngas for the synthesis of liquid fuels using Fischer-Tropsch synthesis (FTS). The process includes novel gasification of biomass via a tri-reforming process which involves a synergetic combination of CO2 reforming, steam reforming, and partial oxidation of methane. Typical biomass-derived syngas H2:CO is 1:1 and contains tars that deactivate FT catalyst. This innovation allows for cost-effective one-step production of syngas in the required H2:CO of 2:1 with reduction of tars for use in the FTS. To maximize the performance of the tri-reforming catalyst, an attempt to control oxygen mobility, thermal stability, dispersion of metal, …

Mapping And Assessing Urban Impervious Areas Using Multiple Endmember Spectral Mixture Analysis: A Case Study In The City Of Tampa, Florida, Fenqing Weng

USF Tampa Graduate Theses and Dissertations

The advance in remote sensing technology helps people more easily assess urban growth. In this study, the utility of multiple endmember spectral mixture analysis (MESMA) is examined in a sub-pixel analysis of Landsat Thematic Mapper (TM) imagery to map urban physical components in Tampa, FL. The three physical components of urban land cover (LC): impervious surface, vegetation and soil, were compared using the proposed MESMA with a traditional spectral mixture analysis (SMA). MESMA decomposes each pixel to address the heterogeneity of urban LC characteristic by allowing the number and types of endmembers to vary on a per pixel basis. This …

Stochastic Modeling Of Network-Centric Epidemiological Processes, Divine Wanduku

USF Tampa Graduate Theses and Dissertations

The technological changes and educational expansion have created the heterogeneity in the human species. Clearly, this heterogeneity generates a structure in the population

dynamics, namely: citizen, permanent resident, visitor, and etc. Furthermore, as the heterogeneity in the population increases, the human mobility between meta-populations patches

also increases. Depending on spatial scales, a meta-population patch can be decomposed into sub-patches, for examples: homes, neighborhoods, towns, etc. The dynamics of human

mobility in a heterogeneous and scaled structured population is still its infancy level. We develop and investigate (1) an algorithmic two scale human mobility dynamic model for a meta-population. Moreover,the two …

Molecular Dynamics Of The Rna Binding Cavity Of Influenza A Non-Structural Protein 1 (Ns1) Rna Binding Domain, Christi Leigh Whittington

USF Tampa Graduate Theses and Dissertations

Molecular dynamics simulations were performed on the influenza A non-structural protein 1 (NS1) RNA binding domain (RBD), a homodimer. Fourteen simulations were performed at 298K, nine ionized with 0.1M KCl and five with no ions. Several analysis techniques were employed to study RBD residue flexibility. The focus of the study was the RNA binding cavity formed by side chains of helix 2 (chain A) and helix 2’ (chain B) and cavity intermonomeric salt bridges. Opening of the salt bridges D29–R46’ and D29’–R46 was observed in several of the trajectories. The RNA binding cavity has large flexibility, where the dimension and …

Evaluation Of Repeated Biomarkers: Non-Parametric Comparison Of Areas Under The Receiver Operating Curve Between Correlated Groups Using An Optimal Weighting Scheme, Ping Xu

USF Tampa Graduate Theses and Dissertations

Receiver Operating Characteristic (ROC) curves are often used to evaluate the prognostic performance of a continuous biomarker. In a previous research, a non-parametric ROC approach was introduced to compare two biomarkers with repeated measurements. An asymptotically normal statistic, which contains the subject-specific weights, was developed to estimate the areas under the ROC curve of biomarkers. Although two weighting schemes were suggested to be optimal when the within subject correlation is 1 or 0 by the previous study, the universal optimal weight was not determined. We modify this asymptotical statistic to compare AUCs between two correlated groups and propose a solution …

Integrable Couplings Of The Kaup-Newell Soliton Hierarchy, Mengshu Zhang

USF Tampa Graduate Theses and Dissertations

By enlarging the spatial and temporal spectral problems within a certain Lie algebra, a hierarchy of integrable couplings of the Kaup-Newell soliton equations is constructed. The recursion operator of the resulting hierarchy of integrable couplings is explicitly computed. The integrability of the new coupling hierarchy is exhibited by showing the existence of infinitely many commuting symmetries.