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USF Tampa Graduate Theses and Dissertations

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Stable Adaptive Control Systems In The Presence Of Unmodeled And Actuator Dynamics, Kadriye Merve Dogan Feb 2020

Stable Adaptive Control Systems In The Presence Of Unmodeled And Actuator Dynamics, Kadriye Merve Dogan

USF Tampa Graduate Theses and Dissertations

In adaptive control of physical systems, it is well-known that the presence of actuator and/or unmodeled dynamics in feedback loops can yield to unstable closed-loop system trajectories. Motivated by this standpoint, this dissertation presents novel model reference and distributed adaptive control architectures with stability and performance guarantees for uncertain sole and multiagent dynamical systems with unmodeled and/or actuator dynamics.

Specifically, model reference and distributed adaptive control architectures are powerful theoretical tools for both sole and multiagent systems, where they have the capability to suppress the effect of exogenous disturbances and system uncertainties for achieving a desired level of closed-loop system …


Global And Stochastic Dynamics Of Diffusive Hindmarsh-Rose Equations In Neurodynamics, Chi Phan Feb 2020

Global And Stochastic Dynamics Of Diffusive Hindmarsh-Rose Equations In Neurodynamics, Chi Phan

USF Tampa Graduate Theses and Dissertations

This dissertation consisting of three parts is the study of the open problems of global dynamics of diffusive Hindmarsh-Rose equations, random dynamics of the stochastic Hindmarsh-Rose equations with multiplicative noise and additive noise respectively, and synchronization of boundary coupled Hindmarsh-Rose neuron networks.

In Part I (Chapters 2, 3 and 4) of this dissertation, we study the global dynamics for the single neuron model of diffusive and partly diffusive Hindmarsh-Rose equations on a three-dimensional bounded domain. The existence of global attractors as well as its regularity and structure are established by showing the absorbing properties and the asymptotically compact characteristics, especially …


Restricted Isometric Projections For Differentiable Manifolds And Applications, Vasile Pop Feb 2020

Restricted Isometric Projections For Differentiable Manifolds And Applications, Vasile Pop

USF Tampa Graduate Theses and Dissertations

The restricted isometry property (RIP) is at the center of important developments in compressive sensing. In RN, RIP establishes the success of sparse recovery via basis pursuit for measurement matrices with small restricted isometry constants δ2s < 1=3. A weaker condition, δ2s < 0:6246, is actually sufficient to guarantee stable and robust recovery of all s-sparse vectors via l1-minimization. In infinite Hilbert spaces, a random linear map satisfies a general RIP with high probability and allow recovering and extending many known compressive sampling results. This thesis extends the known restricted isometric projection of sparse datasets of vectors embedded in the Euclidean spaces RN down into low-dimensional subspaces Rm ,m << N …


Efficient Forward-Secure And Compact Signatures For The Internet Of Things (Iot), Efe Ulas Akay Seyitoglu Feb 2020

Efficient Forward-Secure And Compact Signatures For The Internet Of Things (Iot), Efe Ulas Akay Seyitoglu

USF Tampa Graduate Theses and Dissertations

In the modern Internet of Things (IoT) applications, the system entities collect security-sensitive information that must be cryptographically protected. In particular, authentication and integrity, as foundational security services, are essential for any IoT applications. Digital signatures provide both authentication and integrity to these applications. Nevertheless, once an IoT device is compromised, its signature private key is leaked to an adversary. Forward-secure digital signatures mitigate the impact of such key compromises by incorporating a key-evolving mechanism into the authentication process. However, existing forward-secure signatures suffer from large signature/key sizes, heavy computational overhead, and some prominent variants that can only sign a …


Psidb: A Framework For Batched Query Processing And Optimization, Mehrad Eslami Feb 2020

Psidb: A Framework For Batched Query Processing And Optimization, Mehrad Eslami

USF Tampa Graduate Theses and Dissertations

Techniques based on sharing data and computation among queries have been an active research topic in database systems. While work in this area developed algorithms and systems that are shown to be effective, there is a lack of logical foundation for query processing and optimization. In this paper, we present PsiDB, a system model for processing a large number of database queries in a batch. The key idea is to generate a single query expression that returns a global relation containing all the data needed for individual queries. For that, we propose the use of a type of relational operators …


Exploration Of Factors Associated With Perceptions Of Community Safety Among Youth In Hillsborough County, Florida: A Convergent Parallel Mixed-Methods Approach, Yingwei Yang Feb 2020

Exploration Of Factors Associated With Perceptions Of Community Safety Among Youth In Hillsborough County, Florida: A Convergent Parallel Mixed-Methods Approach, Yingwei Yang

USF Tampa Graduate Theses and Dissertations

Introduction: Youth perceived safety is not only linked to crime and violence in a neighborhood but is also associated with health risk behaviors and certain neighborhood characteristics. The purpose of this mixed-methods study was to measure the co-occurring effects of individual and community risk factors by conducting a secondary data analysis using structural equation modeling (SEM) and to explore reasons for youth feeling safe/unsafe in their community using photovoice methodology.

Methods: Syndemic theory/model served as the theoretical framework to guide this mixed-methods study with a convergent parallel design. The quantitative strand (first manuscript) utilized an existing dataset collected from middle …


Development And Application Of Computational Models For Biochemical Systems, Fiona L. Kearns Feb 2020

Development And Application Of Computational Models For Biochemical Systems, Fiona L. Kearns

USF Tampa Graduate Theses and Dissertations

Chemistry is the study of matter and its transformations. Computational chemistry uses computer models to study chemistry in all its intricate complexity. In this thesis I hope to accessibly introduce fundamental concepts central for computational chemistry including quantum mechanics, molecular mechanics, and multiscale modeling. I then present several works which I have conducted throughout my graduate career employing many different computational methods. The investigations described here can be summarized as follows. Chapter 2.1 modeling proteins involved in crustacean molting, and identifying possible inhibitors to this molting. Chapter 2.2 modeling d-fructose bound to synthetic saccharide receptors with hopes of improving saccharide …


Shallow Water Seafloor Geodesy: Gps On An Anchored Spar Buoy, Surui Xie Feb 2020

Shallow Water Seafloor Geodesy: Gps On An Anchored Spar Buoy, Surui Xie

USF Tampa Graduate Theses and Dissertations

Measuring seafloor motion in shallow coastal water is challenging due to strong and highly variable oceanographic effects. Such measurements are potentially useful for monitoring near-shore coastal subsidence, subsidence due to petroleum withdrawal, strain accumulation/release processes in marine shelves and submerged volcanoes, and certain fresh water applications, such as volcano deformation in caldera-hosted lakes. I participated in a project to develop a seafloor geodetic system for this environment based on an anchored spar buoy topped by high precision GPS. Orientation of the buoy is measured using a digital compass that provides heading, pitch, and roll information. The combined orientation and GPS …


Bayesian Reliability Analysis Of The Power Law Process And Statistical Modeling Of Computer And Network Vulnerabilities With Cybersecurity Application, Freeh N. Alenezi Feb 2020

Bayesian Reliability Analysis Of The Power Law Process And Statistical Modeling Of Computer And Network Vulnerabilities With Cybersecurity Application, Freeh N. Alenezi

USF Tampa Graduate Theses and Dissertations

As most of mankind now lives in an era of high dependence on multiple technologies and complex systems to store and manage sensitive information, researchers are constantly urged to obtain and improve measurements and methodologies that have the ability to evaluate systems reliability and security. The objectives of the present dissertation are to improve the Bayesian reliability estimation of a software package where the Power Law Process, also known as Non-Homogeneous Poisson Process, is the underlying failure model and to develop a set of statistical models evaluating computer operating systems vulnerabilities. Furthermore, we develop a reliability function of a computer …


Evaluation Of Optimal Technique For Left Breast Irradiation, Amitpal Singh Saini Feb 2020

Evaluation Of Optimal Technique For Left Breast Irradiation, Amitpal Singh Saini

USF Tampa Graduate Theses and Dissertations

Numerous studies have indicated that radiation therapy reduces the risk of the local recurrence of breast cancer in several cases and that it has increased the overall survival rate. Although radiation therapy is beneficial for the treatment of breast cancer, it is known to increase the risk of both radiation toxicity and secondary breast cancer. In left-sided breast cancer, radiation therapy treatment often leads to the heart and its components—such as the left ventricle and left anterior descending artery—being exposed to high doses of radiation because of the proximity of the heart to the left breast, resulting in cardiac complications …


Non-Associative Algebraic Structures In Knot Theory, Emanuele Zappala Feb 2020

Non-Associative Algebraic Structures In Knot Theory, Emanuele Zappala

USF Tampa Graduate Theses and Dissertations

In this dissertation we investigate self-distributive algebraic structures and their cohomologies, and study their relation to topological problems in knot theory. Self-distributivity is known to be a set-theoretic version of the Yang-Baxter equation (corresponding to Reidemeister move III) and is therefore suitable for producing invariants of knots and knotted surfaces. We explore three different instances of this situation. The main results of this dissertation can be, very concisely, described as follows. We introduce a cohomology theory of topological quandles and determine a class of topological quandles for which the cohomology can be computed, at least in principle, by means of …


Classifying Emotions With Eeg And Peripheral Physiological Data Using 1d Convolutional Long Short-Term Memory Neural Network, Rupal Agarwal Feb 2020

Classifying Emotions With Eeg And Peripheral Physiological Data Using 1d Convolutional Long Short-Term Memory Neural Network, Rupal Agarwal

USF Tampa Graduate Theses and Dissertations

Recognizing emotions is very important while building robust and interactive Affective Brain-Computer Interfaces as it allows the machines to have some degree of emotional intelligence with the help of which they can understand the changing emotional state of users. In the past, emotions have been recognized via unimodal data such as electroencephalography (EEG) signals, speech, facial expressions or peripheral physiological signals. However, emotions are complex as they are a combination of human behavior, thinking and feeling. Therefore, as compared to unimodal methods, multi-modal techniques, recognize emotions with more reliability. This thesis aims to recognize and classify human emotions into high/low …


Advancing Equity Amongst General Chemistry Students With Variable Preparations In Mathematics, Vanessa R. Ralph Feb 2020

Advancing Equity Amongst General Chemistry Students With Variable Preparations In Mathematics, Vanessa R. Ralph

USF Tampa Graduate Theses and Dissertations

Reducing the inequities propagating the lack of representation in Science, Technology, Engineering, and Mathematics (STEM) careers has become a national imperative made increasingly complex given the inequitable preparations in science and mathematics students experience before college. A common institutional-level approach to promoting equity is the use of math and science prerequisites to prepare students who seek to enroll in lower-level STEM coursework. However, the literature does not support the efficacy of this approach, finding no substantive improvement to student performance despite considerable financial and time costs to students, instructors, and universities alike. Set in first-semester General Chemistry courses taken early …


Differential Mobility Spectrometry-Mass Spectrometry (Dms-Ms) For Forensic And Nuclear-Forensic Applications, Ifeoluwa Ayodeji Jan 2020

Differential Mobility Spectrometry-Mass Spectrometry (Dms-Ms) For Forensic And Nuclear-Forensic Applications, Ifeoluwa Ayodeji

USF Tampa Graduate Theses and Dissertations

In forensics and nuclear-forensics, the current lab-based analytical technique employed can be laborious, time consuming, and less suitable for in-situ and real time screening. However, it is important to develop fast and fieldable instrumental technique, without a tradeoff for its high throughput, for drug screening and radionuclear analysis. The underlying factors to be considered in the instrument development ranges from: high potency of samples, even at very low concentration; complex nature of samples in the surrounding environment; real-time chemical composition variation; and instrument size, weight and power (SWAP) consideration. Differential mobility spectrometry (DMS), also known as field asymmetric waveform ion …


Rainfall, Precipitation, And Drought Patterns Associated With Wintertime Transmission Of Eastern Equine Encephalitis Virus (Eeev) In Florida, Bestami Cevher Jan 2020

Rainfall, Precipitation, And Drought Patterns Associated With Wintertime Transmission Of Eastern Equine Encephalitis Virus (Eeev) In Florida, Bestami Cevher

USF Tampa Graduate Theses and Dissertations

Eastern Equine encephalitis virus (EEEV) is a highly pathogenic alphavirus that causes disease in humans and horses. EEEV cases are common in the eastern North America, especially in horses in the State of Florida. EEEV cases are most common in Florida during May to August but also occur year-round, unlike most other locations. According to the Florida Department of Health, 65 EEEV horse cases were documented in the winter months between 2005 and 2018. This study investigates the meteorological activities that affect the wintertime transmission of the EEEV virus to horses. In this, we examined meteorological data up to a …


Male And Female Students’ Persistence In Stem Fields In Community Colleges: A Secondary Analysis Of Nces Bps:12/14 Data, Ying Hu Jan 2020

Male And Female Students’ Persistence In Stem Fields In Community Colleges: A Secondary Analysis Of Nces Bps:12/14 Data, Ying Hu

USF Tampa Graduate Theses and Dissertations

Today, economic growth, technology advancement, and daily life are all driven by science, technology, engineering and math (STEM). American colleges and universities need to produce more STEM graduates in order to meet rapid job growth. The purpose of this study was to determine the significant factors that influence the persistence of STEM students in community colleges. The research described the characteristics of STEM students who persisted and of those who did not in STEM, as well as the different characteristics between male and female students. It also investigated student and institutional factors that influenced STEM students’ persistence. Furthermore, the study …


Gabbing While Gaming: Commandeering Commercial, Off-The-Shelf (Cots) Video Games To Structure Student-Centered Social Studies Discussion, Joshua M. Patterson Jan 2020

Gabbing While Gaming: Commandeering Commercial, Off-The-Shelf (Cots) Video Games To Structure Student-Centered Social Studies Discussion, Joshua M. Patterson

USF Tampa Graduate Theses and Dissertations

Amidst the current cultural backdrop of debilitating digital addiction and malicious misinformation campaigns, secondary social studies instructors require every possible tool to engage students stuck in the haze of simulated reality. While nationwide mastery of the subject area is wedged between failure (National Assessment of Educational Progress, 2020) and apathy, three-dimensional, entertainment-driven simulations are progressing at an exponential rate of adolescent adoption and historical accuracy. In this phenomenological case study, I capitalize on pupils’ preference for virtual integration by outlining a pedagogical approach that harnesses the trinity of content knowledge, discursive prowess, and video game aptitude. Video game titles were …


Gradient Boosting For Survival Analysis With Applications In Oncology, Nam Phuong Nguyen Jan 2020

Gradient Boosting For Survival Analysis With Applications In Oncology, Nam Phuong Nguyen

USF Tampa Graduate Theses and Dissertations

Cancer is one of the most deadly diseases that the world has been fighting against over decades. An enormous number of research has been conducted, via a wide scale of approaches, raging from genetic analysis to mathematical modeling. Survival analysis is a well-performed methodology frequently used to estimate the survival probability of a patient. Although there has been a large number of methods for survival analysis, efficient exploration of a high-dimensional feature space has been challenging due to its computational cost and complexity. This thesis adapts the component-wise gradient boosting algorithms for cancer survival analysis, and also proposes a new …


The Efficacy Of Comedy, Mark Anthony Castricone Dec 2019

The Efficacy Of Comedy, Mark Anthony Castricone

USF Tampa Graduate Theses and Dissertations

The Efficacy of Comedy: Focusing on the efficacy of comedy as a genre, utilizing Aristotle, Nietzsche, and Heidegger’s philosophy. It begins with a historical analysis of the efficacy of comedy in Ancient 4th and 5th century Athens focusing on Aristotle’s conceptions of comedy. It analyses what Aristotle wrote about comedy and attempts a reconstruction of what his book on comedy from the poetics may have said. It then examines the shift to aesthetics rather than the Philosophy of Art with a focus on Kant and the Critique of Judgment. Comedy here is used as an interpretive tool in order to …


Chemical Tools And Treatments For Neurological Disorders And Infectious Diseases, Andrea Lemus Nov 2019

Chemical Tools And Treatments For Neurological Disorders And Infectious Diseases, Andrea Lemus

USF Tampa Graduate Theses and Dissertations

Neurological disorders have multiple etiologies such as genetics and age. Stress related disorders are becoming more common and diagnosed more often. Mental health disorders are no longer being treated as purely psychological. Mechanisms into the underlying factors of these disorders continue to bring this area to new frontiers. Chapter 2 of this dissertation focuses on the efforts made to prove the association of the protein FKBP51 to the stress response. We synthesized and used a molecular tool to discover and prove these interactions.

The study of neurodegenerative diseases is of continued importance as the world reaches record numbers of an …


Antarctic Deep Sea Coral And Tropical Fungal Endophyte: Novel Chemistry For Drug Discovery, Anne-Claire D. Limon Nov 2019

Antarctic Deep Sea Coral And Tropical Fungal Endophyte: Novel Chemistry For Drug Discovery, Anne-Claire D. Limon

USF Tampa Graduate Theses and Dissertations

Considered the pulse controlling the biological interactions and contributing to the ecological survival of organisms, natural products have intrigued, challenged, and stimulated the scientific and non-scientific minds for millennia. Drug resistance and the lack of suitable potent drugs against neglected tropical diseases further motivate the biological activity assessment of these secondary metabolites, when possible.

This thesis describes the chemical investigation of two marine organisms and the elucidation of eight novel structures.

The study of a deep sea Antarctic coral unveils six novel terpenoid structures from three different molecular classes: sesquiterpenoid alcyopterosins, a triterpene steroid, and three prostaglandins. While mass availability …


Reconstructing Geographic And Trophic Histories Of Fish Using Bulk And Compound-Specific Stable Isotopes From Eye Lenses, Amy A. Wallace Nov 2019

Reconstructing Geographic And Trophic Histories Of Fish Using Bulk And Compound-Specific Stable Isotopes From Eye Lenses, Amy A. Wallace

USF Tampa Graduate Theses and Dissertations

The present research examined the viability and utility of eye lenses as a source of lifetime stable-isotope records in fish. It is presented in three sections. The first section compared bulk isotopic variation (bulk analysis) within fish eye-lenses at two temporal resolutions and compared patterns obtained from left and right eyes. The first temporal resolution was lower in an attempt to expose broad-scale isotopic changes during life while reducing effort and cost. This approach did reveal lifetime patterns, but tended to miss certain life events, particularly during early life. The second resolution was higher and provided detail that was missed …


Innovating Green Stormwater Infrastructure For Nutrient Management: Long-Term Field And Modeling Studies Of Conventional And Modified Denitrifying Bioretention Systems, Emma V. Lopez-Ponnada Nov 2019

Innovating Green Stormwater Infrastructure For Nutrient Management: Long-Term Field And Modeling Studies Of Conventional And Modified Denitrifying Bioretention Systems, Emma V. Lopez-Ponnada

USF Tampa Graduate Theses and Dissertations

Urban stormwater and nutrient management are increasingly important topics to address globally, as coastal urbanization increases, disturbing the natural landscape, hydrology, and water quality. Untreated urban stormwater runoff carries pollutants that enter our waterways, such as rivers and marine environments, which serve as drinking water sources, recreational sites, and locations for economic livelihood. One pollutant and nutrient of concern for water quality is reactive nitrogen (N). Since pre-industrial time, reactive nitrogen has doubled from human activity. When found in excess in waterways, nitrogen causes an overabundant growth of algae, which can result in eutrophic and hypoxic conditions, impacting ecosystems, human …


The Peculiar Nature Of Florida’S Sandhill Wetlands, Ponds & Lakes— Their Ecohydrology, Relationship With The Regional Aquifer & Importance Within The Landscape., Renae Starr Nowicki Nov 2019

The Peculiar Nature Of Florida’S Sandhill Wetlands, Ponds & Lakes— Their Ecohydrology, Relationship With The Regional Aquifer & Importance Within The Landscape., Renae Starr Nowicki

USF Tampa Graduate Theses and Dissertations

This dissertation explores the ecohydrology of Florida’s peculiar and poorly studied sandhill wetland and water features, particularly those located in west-central Florida. The primary research goals include: compilation and summarization of the available ecohydrologic information for features across Florida; comparison of water level and water geochemistry data between sandhill wetlands and waters and the regional aquifer to provide evidence of regional hydrologic control; and use of geophysical applications to examine the hydraulic connections between sandhill wetlands and waters and the regional aquifer.

From this research, a natural history of sandhill wetland and water ecohydrology is presented, highlighting: the differences between …


Trajectory Based Traffic Analysis And Control Utilizing Connected Autonomous Vehicles, Yu Wang Nov 2019

Trajectory Based Traffic Analysis And Control Utilizing Connected Autonomous Vehicles, Yu Wang

USF Tampa Graduate Theses and Dissertations

Recent scholars have developed a number of stochastic car-following models that have successfully captured driver behavior uncertainties and reproduced stochastic traffic oscillation propagation. While elegant frequency domain analytical methods are available for stability analysis of classic deterministic linear car-following models, there lacks an analytical method for quantifying the stability performance of their peer stochastic models and theoretically proving oscillation features observed in the real world. To fill this methodological gap, this study proposes a novel analytical method that measures traffic oscillation magnitudes and reveals oscillation characteristics of stochastic linear car-following models. We investigate a general class of stochastic linear car-following …


Use Of Spectrofluorometry To Detect Petroleum Hydrocarbons In The Marine Environment, Mary Iris Abercrombie Nov 2019

Use Of Spectrofluorometry To Detect Petroleum Hydrocarbons In The Marine Environment, Mary Iris Abercrombie

USF Tampa Graduate Theses and Dissertations

The genesis of this research was the Deepwater Horizon oil spill, which discharged petroleum and gas into the Gulf of Mexico for 87 days in 2010. High-resolution fluorescence spectroscopy was employed for the detection of petroleum in seawater samples following the oil spill. Fluorescence arises from the chemical structure of π-bonding in C=C bonds, especially those in aromatic structures. Spectrofluorometry was also used to observe and track the formation of petroleum plumes in seawater undergoing controlled physical dispersion in a wave tank, both with and without the addition of chemical dispersant. Further, the changing fluorescence characteristics of a broad range …


Ratios And Proportional Reasoning Representations In Open Educational Resources, Keisha L. Albritton Nov 2019

Ratios And Proportional Reasoning Representations In Open Educational Resources, Keisha L. Albritton

USF Tampa Graduate Theses and Dissertations

This study analyzed Open Educational Resource (OER) textbooks to determine similarities and differences between the resources in relation to the content addressing ratio and proportional reasoning standards. This study also analyzed whether the selected resources provided opportunities for students to engage with the Standards for Mathematical Practice. Data were collected from tasks within the 6th and 7th-grade textbooks from Engage NY, Open Up Resources and Utah Middle School Math Project. Each task was analyzed according to frameworks from Van de Walle (2007), Lamon (2012), Lesh et al. (1988) Tall and Vinner (1981), and Hunsader et al. (2014). The tasks were …


Development Of A Voxel-Based Monte Carlo Radiation Dosimetry Methodology For A Targeted Alpha Particle Therapy, Christopher John Tichacek Nov 2019

Development Of A Voxel-Based Monte Carlo Radiation Dosimetry Methodology For A Targeted Alpha Particle Therapy, Christopher John Tichacek

USF Tampa Graduate Theses and Dissertations

The use of targeted ligands to deliver radioisotopes directly to tumor cells is a promising therapeutic strategy. Because of the short path length and high LET of alpha particles, targeted alpha particles are ideal for treating metastatic disease while minimizing damage to non-targeted tissues. However, clinical methods for determining 3D radiation dosimetry in patients with multiple metastatic lesions are needed to support clinical translation of novel targeted alpha particle therapies for personalized treatment, especially in patients that have previously received radiotherapy. Recently interest in novel radiopharmaceutical development has grown significantly. However, compared to external beam radiation therapy, progress in customizing …


Effect Of Atypical Protein Kinase C Inhibitor (Dnda) On Cell Proliferation And Migration Of Lung Cancer Cells, Raja Reddy Bommareddy Nov 2019

Effect Of Atypical Protein Kinase C Inhibitor (Dnda) On Cell Proliferation And Migration Of Lung Cancer Cells, Raja Reddy Bommareddy

USF Tampa Graduate Theses and Dissertations

Lung cancer is the second most common cancer, and it is the leading cause of cancer death in both men and women. Elevated levels of PKC-ι and FAK are implicated in the progression of lung cancer and involved in cell proliferation, apoptosis, cell survival, and cell migration processes. Lung cancer diagnosis typically occurs in the late stages, which limits the treatment options. Hence, there is a dire need to develop drugs that are effective and safe to treat lung cancers. We used a novel aPKC inhibitor named DNDA (3,4-amino-2,7 napthalene disulfonic acid) to study the role of atypical PKCs (aPKCs) …


The Activity And Structure Of Cu2+-Biomolecules In Disease And Disease Treatment, Darrell Cole Cerrato Nov 2019

The Activity And Structure Of Cu2+-Biomolecules In Disease And Disease Treatment, Darrell Cole Cerrato

USF Tampa Graduate Theses and Dissertations

Despite its relatively low concentration in the human body, copper is an essential transition metal ion. Under normal circumstances, it is a well-regulated trace element that is introduced via diet or environment depending on the organism. Its strong reactivity and binding to some biologically essential chemicals can be detrimental to the host organism. Herein the oxidative chemistry of copper and its possible prevention in humans and agricultural organisms is discussed, as well as the potential avenues as metal-targeting disease treatment via novel-peptide and peptoid products.

In the first study, copper is implicated in the progression and onset of Alzheimer’s disease. …