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Clinically Applied Anthropology: A Syndemic Intervention., Jason W. Wilson

USF Tampa Graduate Theses and Dissertations

This dissertation demonstrates that a critical, clinically applied anthropology is possible by testing a hypothesis that a syndemic intervention, and use of a structural vulnerability assessment tool, can achieve improved healthcare outcomes. A critical, clinically applied anthropology integrates social scientists into healthcare delivery, alongside biomedical providers, through the co-creation of new diagnostic and patient care pathways that utilize anthropological methods (ethnographically informed care, syndemics, thematic/mixed methods data analysis) and advance anthropological theory (biomedicine and culture, structural violence, structural competency/vulnerability, ontology, assemblage theory, and entanglements) to decrease healthcare inequities.

Medical anthropology has previously engaged biomedicine and other attempts at a clinical …

Thermodynamic Frustration Of Tad2 And Prr Contribute To Autoinhibition Of P53, Emily Gregory

USF Tampa Graduate Theses and Dissertations

The intrinsically disordered transcription factor and tumor suppressor p53 binds to promoter response element DNA upon cellular stress and activates genes associated with cell cycle arrest, senescence, and apoptosis. Disruption of sequence specific binding to target gene promoters is heavily implicated in human health, where a majority of cancers contain mutations localized to the DNA binding domain (DBD) of p53. p53 DNA binding is regulated by posttranslational modifications, associations with cellular factors, and by an autoinhibitory intramolecular interaction. The autoinhibitory intramolecular interaction occurs when the disordered N-terminal transactivation domain (TAD) interacts with the ordered DBD. Previous work in the Daughdrill …

The Effect Of Psychopathy Trait Descriptions On Mock Juror Decision-Making, Bailey A. Hall

USF Tampa Graduate Theses and Dissertations

Layperson misconceptions and stigma surrounding mental illness can have devastating consequences in criminal trials, especially capital (death penalty) cases. Psychopathy is a particularly stigmatizing disorder often used as an aggravating factor in capital cases. The present experimental study examined how case vignettes that included descriptions of psychopathic traits (i.e., criterion effects) differentially influenced juror decision-making. Specifically, undergraduate participants read case facts about a convicted defendant and were randomly assigned to read one of five expert witness testimony conditions describing the defendant using: interpersonal-affective psychopathy traits (e.g., superficially charming, manipulative), antisocial-lifestyle traits (e.g., reckless, aggressive), combined interpersonal-affective and antisocial-lifestyle traits, or …

The Social Anxiety Stigma Scale (Sass): Development, Factor Structure, And Validation, Ruba Rum

USF Tampa Graduate Theses and Dissertations

The primary reason people with social anxiety disorder (SAD) do not seek treatment is due to stigma concerns. Yet, our understanding of SAD stigma hinges heavily on measures that assess general mental illness stigma, which may not capture the distinct aspects of SAD. The goal of this research program was to develop and validate a measure of social anxiety stigma that assesses personal stigma towards people with SAD: the Social Anxiety Stigma Scale (SASS). The SASS was evaluated across three studies. In Study 1 (N = 221), an initial item analysis was conducted on 33 items to remove weak items …

Cervical Cancer Screening Modalities: A Study Of Decision-Making Processes, Heather N. Owens

USF Tampa Graduate Theses and Dissertations

This dissertation includes three studies, and the purpose was to explore cervical cancer screening adherence and factors related to screening behaviors among women.

The purpose of the first study was to examine cervical cancer screening recommendation adherence trends in a nationally representative sample using Behavioral Risk Factor Surveillance System 1995-2018 data. Adherence rates declined for every definition of adherence evaluated over time. Social determinants of health predictors and their impacts varied based on the years of data included in and the data source.

The second study examined the hypothesized factor structure underlying multiple scales (i.e., Health Belief Model constructs and …

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation And Progression, Janine M. Deblasi

USF Tampa Graduate Theses and Dissertations

NRF2 is a redox-responsive transcription factor the directs the antioxidant program and several critical metabolic processes. Mutations in NRF2 or its negative regulator KEAP1 occur in up to one third of non-small cell lung cancers (NSCLCs) and are often associated with resistance to therapy and poor outcomes. In the present studies, murine alleles of the Keap1 and Nrf2 mutations found in human NSCLC were developed and I comprehensively investigated their impact on tumor initiation and progression. I observed that chronic Nrf2 stabilization by Keap1 loss-of-function or Nrf2 activating mutation was not sufficient to cause lung tumor initiation, even when p53 …

Determinants Of Hormonal Contraceptive Use Among Adolescent Females In The Republic Of Benin, Marlene Joannie Bewa

USF Tampa Graduate Theses and Dissertations

Introduction: Globally, 17 million adolescent girls—ages 15-19-- give birth every year, which affects educational and professional outcomes such as school completion, future employment, and economic empowerment. In Benin, adolescent girls have a substantial unmet need for sexual and reproductive health (SRH) information and services. More specifically, the need for hormonal contraceptive products and services, as well as accurate, age-appropriate, and comprehensive sexuality education, is not met universally.

Objective: This research objective is to understand personal, behavioral, and environmental barriers and facilitators to the access and uptake of modern contraceptive methods among adolescents in Benin. This will inform recommendations for improving …

Development Of Bioactive Peptidomimetics, Lei Wang

USF Tampa Graduate Theses and Dissertations

In the past two decades, a lot of different peptidomimetics, such as β-peptides, oligoureas, azapeptides, peptoids, aromatic oligoamides, and others, have been developed. These peptidomimetics with distinctive scaffolds have shown potential in protein surface recognition and mimicry, PPI regulation, catalysis, etc. Moreover, these bioactive peptidomimetics demonstrate much better bioavailability and biostability than the bioactive peptides. To expand the application of peptidomimetics, our group have developed a new sequence-specific peptidomimetics- γ-AApeptide, which is derived from chiral γ-PNA. It shows excellent advantages including highly resistant to various proteolytical degradations and has the potential to increase chemodiversity. γ-AApeptide also exhibits remarkable biomedical applications, …

Role Of Short Interspersed Nuclear Elements (Sines) Of Maternally Imprinted Microrna Clusters In Hemochorial Placental Antiviral Immunity, Ishani Wickramage

USF Tampa Graduate Theses and Dissertations

The evolution of hemochorial placentas in which the fetal trophoblast is bathed in maternal blood has vastly improved fetal development and survival in primates and rodents, due to the enhanced efficiency of nutrient, gas and waste exchange between the mother and the fetus. However, the extensive contact between the fetal tissues and maternal blood in these placentas also poses an increased risk of vertical transmission of pathogens such as viruses from the mother to the fetus. In response to this selection pressure, hemochorial placentas have evolved robust defense mechanisms to protect the immunologically naive fetus. Unlike somatic cells that require …

Synthesis Of Tools For The Investigation And Treatment Of Infectious Diseases, Grant Lawrence

USF Tampa Graduate Theses and Dissertations

Modern medicine’s ability to treat a wide array of diseases is due mainly to the development of small-molecule drug discovery. Thousands of years of traditional medicines have been dwarfed in less than a hundred years. In addition, drug discovery has becoming a more consistent process with the introduction of the clinical trials process as well.Plasmodium is a genus of tropical parasites that have the potential to wreak havoc on billions of people globally. Current methods of drug discovery aimed at defeating these parasites require expensive assays that use radioactive material. By using an alkyne-labeled agent instead of a tritium-labeled agent, …

Synthesis Of Small Molecule Modulators Of Non-Traditional Drug Targets, Jamie Nunziata

USF Tampa Graduate Theses and Dissertations

This work details the effort toward structure-activity-relationship (SAR) studies and synthesis of the small molecule modulators of two non-traditional drug targets. The first part of this manuscript (chapters 1–2) will discuss the collaborative work and synthesis of an inhibitor of Slingshot Homology 1 (SSH1) with the potential therapeutic application toward Alzheimer’s Disease (AD) treatment. The second part (chapters 3–6) will discuss the synthetic efforts toward modulation of a protein target known as STING, or stimulator of interferon genes, with the therapeutic application toward autoimmune disease or anti-tumor activity.

AD is a progressive and degenerative illness that holds the title of …

Examining Treatment Differences In Anxiety Disorders And Body-Focused Repetitive And Related Disorders In A Pediatric Clinic Sample, Katrina Scarimbolo

USF Tampa Graduate Theses and Dissertations

Anxiety disorders are one of the most common mental health concerns that affect youth. It is estimated about 9.4% of youth have an anxiety disorder such as panic disorder, generalized anxiety disorder, social anxiety disorder, separation anxiety disorder or specific phobias (CDC, 2022). The present study includes obsessive compulsive disorder and post-traumatic stress disorder as a part of the definition of anxiety disorders. Anxiety disorders can be comorbid with many mental health conditions. The focus of this study was on the comorbidity between anxiety disorders and body-focused repetitive behaviors (BFRBs) and related disorders. BFRBs are behaviors that involve repeated picking, …

Exposure Characteristics Of Environmental Chemicals By Life Stages, Nisha Vijayakumar

USF Tampa Graduate Theses and Dissertations

Environmental chemicals are ubiquitous and can contribute to human exposure. These exposures can result in long-term health consequences if they occur in early life. However, exposures to environmental chemicals are not evenly distributed throughout childhood. As a result, there exists variation in the levels of chemical exposure depending on the developmental stages, pathways of exposure, and broader systemic factors. However, in early life, limited research exists on exposures to environmental chemicals, particularly phthalates, pesticides, and polycyclic aromatic hydrocarbons (PAHs). In addition, environmental exposures to phthalates, pesticides, and PAHs, considering life stages, have not been fully explored. Hence it is imperative …

From Counter-Strike To Counterterrorism: How The Cheater Reconfigures Our Understanding Of Asymmetric Warfare, Enya C. Silva

USF Tampa Graduate Theses and Dissertations

Around the turn of the century, as the United States increased its military presence in the Middle East in what was widely known as the War on Terror, computer games were also rising in popularity. Military inspired narratives and settings are very common in video games, especially in the genre known as the first person shooter – characterized by a single player, first person point of view. Alexander Galloway provides a vocabulary for understanding the video game, and the first person shooter in particular, derived from the framework of game studies. Scholarship around video games usually either seeks to affirm …

Machine Learning Approach For Static Ransomware Analysis, Aldin Vehabovic

USF Tampa Graduate Theses and Dissertations

Ransomware is a form of malware which uses encryption methods to make data inaccessible to legitimate users. This cyberthreat has emerged as one of the most serious security challenges today, and a wide range of ransomware families have been developed and deployed, causing immense damage to governments, corporations, and private users. As this malware type continues to expand, governments across the world are taking serious steps to limit its reach. In addition, researchers have proposed a range of ransomware detection and attribution schemes, most of which use advanced machine learning (ML) techniques to process and analyze real-world empirical data from …

Meta-Analysis Of United States Seabird Populations Based On Ocean Biodiversity Information System (Obis) Records (1965–2018), Savannah Hartman

USF Tampa Graduate Theses and Dissertations

Understanding the distribution of organisms is an important priority for society as we live through ecosystem transformations that threaten the well-being of all organisms. I have approached the dynamic and complex issue of studying biodiversity by using open-access seabird data collected along the Americas since the 1960s. I explained how these data have changed over time and space, how certain species populations could have shifted over time, and possible correlations between this potential geographic change and select environmental variables.

In Chapter 2 I evaluated the suitability of the open-access data archive Ocean Biodiversity Information System (OBIS) for supporting detailed inquiry …

Optimizing The Membrane-Assisted Recovery Of Solids (Mars) Technology For Nutrient Removal And Recovery From Concentrated Waste Streams, Ben Yamin Hoque

USF Tampa Graduate Theses and Dissertations

The effective management of nutrients, such as nitrogen and phosphorus, in decentralizedwastewater treatment environments is a pressing challenge. These nutrients pose significant risks to the environment and public health when discharged into water bodies, while their recovery and reuse can help alleviate nutrient shortages in various industries, including agriculture. Conventional biological treatment methods used in centralized facilities are not suitable for decentralized systems due to operational complexities and space limitations. Chemical treatment mechanisms, such as adsorption, ion exchange, precipitation, and air-stripping, offer potential solutions but are accompanied by challenges like high costs and logistical issues. Therefore, finding a sustainable and …

Enhancing And Securing Wireless Medical Technology For Diagnosis And Treatment Of Lower Urinary Tract Dysfunction, Farhath Zareen

USF Tampa Graduate Theses and Dissertations

Lower urinary tract dysfunction (LUTD) is a debilitating medical condition that affects millions of individuals worldwide. Urodynamics is the current gold standard for diagnosing LUTD but uses non-physiologically fast, retrograde cystometric filling to obtain a brief snapshot of bladder function. Current state-of-the-art research in bladder monitoring includes ambulatory urodynamics using wireless implantable devices to evaluate bladder function during natural filling for long-term monitoring. However, there are various challenges and limitations to this multi-sensor approach. This research focuses on developing frameworks for automated event detection, data analysis, and optimization of long-term bladder recordingsto improve the diagnosis and treatment of LUTD. In …

Evaluating The Accuracy Of Inertial Measurment Units In Detecting Gait Parameters For Lower Limb Prosthesis And Orthosis Users, Bryce Fuller

USF Tampa Graduate Theses and Dissertations

A Gait Extraction System (GES) was developed to investigate the accuracy of wearable sensors by producing gait parameters, to be compared against a gold standard motion capture system. Two inertial measurement units (IMUs) were placed in the lower limb region, specifically in the shank region of each leg. The GES uses algorithms to extract the gait cycle from raw acceleration data to produce gait parameters such as stride length, stride time, step length, step time, stance time, swing time and cadence. There were three main trials that consisted solely of a flat road, a road with small hills and a …

Optimization Techniques For Machine Learning Inference And Near Memory Image Processing In Hardware For Highly Constrained Iot Edge Nodes, Rajeev Joshi

USF Tampa Graduate Theses and Dissertations

The growing demand for fast and energy-efficient hardware for resource-constrained Internet of Things (IoT) edge devices has highlighted the limitations of conventional computing architectures. This research focuses on addressing the demand for fast, optimized, and energy-efficient machine learning inference engines as well as image processing in IoT edge applications. In this work, we address three challenging research problems and devise efficient solutions. Our investigation involved comprehensive exploration and analysis, leading to the proposal of effective approaches for overcoming these demanding issues. Through our work, we contribute novel solutions that offer improved efficiency and effectiveness in handling these research problems.

First, …

Case Study And Fidelity Assessment Development For The Family Intervention Specialist (Fis) Program, Areana Cruz

USF Tampa Graduate Theses and Dissertations

This dissertation involved an in-depth analysis of the Family Intervention Specialist (FIS) program and the development of an FIS fidelity assessment. Three studies were conducted for this analysis. Study one analyzed FIS administrative data from one Managing Entity to determine the extent that the quality assurance measures align with the core program policies and procedures established by the Department of Children and Families. Study two included a content analysis of FIS policies and procedures manuals for alignment regarding implementation practices and qualitative interviews with FIS stakeholders regarding FIS implementation, strengths, challenges, and adherence to established policies and procedures. Study three …

Supervision Needs At 2 And 5 Years Post Traumatic Brain Injury: A Veterans Affairs Tbi Model Systems Study, Deveney M. K. Ching

USF Tampa Graduate Theses and Dissertations

The present study assessed the supervision needs, with the Supervision Rating Scale [SRS] (Boake, 1996) of Veterans and Service Members enrolled in the Veterans' Affairs (VA) Traumatic Brain Injury Model System (TBIMS) at 2- and 5-year follow-ups after moderate to severe traumatic brain injury (TBI). A cross sectional analysis was conducted at 2-year follow-up (N=428) where it was found that 35% of subjects still needed supervision. At 5-year follow-up (N=295) it was found that 32% of subjects needed supervision. Finally, a multilevel model of supervision (N=164) found that the relationship of supervision needs remains a constant linear line over the …

Enhancing The Safety And Reliability Of Closed-Loop Medical Control Systems, Shakil Mahmud

USF Tampa Graduate Theses and Dissertations

The Internet of Medical Things (IoMT) is a rapidly advancing field that relies heavily on semi- or closed-loop Wearable and Implantable Medical Devices (WIMDs). In recent years, there has been renewed interest in clinical automation, with researchers looking for innovative solutions for Physiological Closed-Loop Control Systems (PCLCS). However, these devices can have various security issues, including vulnerabilities in software and firmware, physical attacks, weak encryption/authentication, and compromised system components. Government agencies, including the US Food and Drug Administration (FDA) and European Medicines Agency (EMA), emphasize the importance of ensuring the safety and reliability of PCLCS since malfunctioning medical devices can …

Counting Every Death When Every Death Counts: A Mixed-Methods Study Of Hurricane Michael Excess Mortality, Blake L. Scott

USF Tampa Graduate Theses and Dissertations

Vulnerable populations have been shown to be disproportionately impacted by natural disasters, such as hurricanes. Hurricane Michael, a Category 5 storm, in October of 2018 hit the rural and socioeconomically vulnerable area of the Florida Panhandle, causing 50 fatalities in Florida, massive destruction to area including the healthcare infrastructure, and led a prolonged recovery period. The purpose of the research was to examine long-term impacts to health in Florida Panhandle after Hurricane Michael; changes to mortality trends, changes to health of survivors, and changes to their access to health care using a mixed-methods, sequential, explanatory study design.

The initial phase …

Development Of Antimicrobial Guanidinylate Polycarbonates, Menglin Xue

USF Tampa Graduate Theses and Dissertations

The World Health Organization (WHO) has identified the emergence of antibiotic resistance as one of the top 10 threats to public health. This is exemplified by serious threats such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF), and the urgent threat posed by Clostridioides difficile to human health. As part of a multifaceted combat strategy against these pathogenic bacteria, host-defense peptide (HDP)-mimicking polymers have proven to be resourceful and promising. However, a vast majority of antibiotic polymer applications were limited to topical applications due to their potential systematic toxicity. Herein, we report the design and synthesis of a …

Vascular And Auditory Changes After Repetitive Traumatic Brain Injury, Courtney Lynn Penn

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) affects over 2.87 million people in the US each year. The large majority of these injuries can be classified as mild. However, evidence suggests that even mild TBIs can lead to long-lasting symptoms that greatly impact quality of life. This is particularly true when an individual sustains multiple TBIs (repetitive TBI, rTBI). Much of the damage caused by rTBI is due to secondary injury mechanisms that cause the initial injury site to spread and worsen over time. No therapies currently exist which can mitigate secondary injury, and monitoring this phase of rTBI is difficult. Development of …

The Relationship Between First-Year Expectations And Persistence For Students Who Self-Identify As Having Not Declared A Major, Shane Combs

USF Tampa Graduate Theses and Dissertations

This research aligned with protocols established by the Florida Board of Governors in 2016 to form a new funding model tied to the institution's performance. The literature review highlighted a disparity between students' expectations and the reality of college which could negatively impact persistence, and therefore funding to the institution. This quantitative study utilized the Beginning of College Survey of Student Engagement (BCSSE) to explore the correlation between incoming, undeclared FTIC students' expectations of co-curricular involvement, faculty interaction, and learning support services utilization and their persistence to the end of the second fall semester. The sample consisted of 1,042 respondents …

A Novel Jazz Music Curriculum For Young Children: Results Of A Pilot Study, Jazmin D. Ghent

USF Tampa Graduate Theses and Dissertations

Jazz improvisation is known as the highest-known art form concerning improvisation due to its frequency and development of creative ideas (Feldman 1964). Research shows that the art of spontaneous creation can contribute to children’s ability to problem-solve, social and emotional well-being, and academic success into adulthood (Biasutti, 2017; Heble & Laver, 2016; Kiehn, 2003; Kuzmich, 1980; Solis, 2009). Improvisation is crucial for developmentally comprehensive music programs; however, improvisation is scarce in elementary music classrooms and curricula. For this pilot study, a group of 31 children aged 5-8 and considered at-risk participated in a study where they were randomly assigned to …

Reframing Resistance, Resilience, And Racial Equity In Maternal Health: A Mixed Methods Exploration Of Paternal Involvement And The Racial Disparity In Severe Maternal Morbidity, Marshara G. Fross

USF Tampa Graduate Theses and Dissertations

Background: The preventable, persistent racial inequity observed in maternal and infant death has lasting impacts on African American communities and families. Fathers, partners, and co-parents are important supports during the sensitive and vulnerable perinatal period. Emerging research has begun to demonstrate a concerted effort to move beyond the sphere of medicine and quality improvement, towards exploring and integrating social factors into targeted intervention strategies to address racial inequality in health outcomes. However, sparse literature concentrates on understanding the role of fathers and partners in peripartum care and maternal health outcomes. This study aimed to explore, understand, and describe the role …

Understanding How Cancer Adapts To Stress And Therapy Using Evolutionary Game Theory, Mariyah Pressley

USF Tampa Graduate Theses and Dissertations

Adaptive responses in cancer promote disease initiation, progression, and resistance to treatment. Understanding the underlying evolutionary dynamics behind these adaptive responses is crucial for developing effective therapeutic strategies. Evolutionary game theory (EGT) has proven a useful tool in analyzing how different cellular behaviors and evolutionary forces shape the dynamics of tumor growth, response to therapy, and the emergence of resistance. In this dissertation, we utilize EGT to understand the adaptive responses of cancer through the lens of ecology and evolution. By employing fitness-generating models and exploring various ecological contexts, we aimed to unveil critical factors influencing aggressive cell phenotypes, treatment …