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Statistical Content In Middle Grades Mathematics Textbooks, Maria Consuelo (Suzie) Capiral Pickle
Statistical Content In Middle Grades Mathematics Textbooks, Maria Consuelo (Suzie) Capiral Pickle
USF Tampa Graduate Theses and Dissertations
Statistical Content in Middle Grades Mathematics Textbooks
Maria Consuelo (Suzie) Capiral Pickle
Abstract
This study analyzed the treatment and scope of
statistical concepts in four, widely-used, contemporary, middle
grades mathematics textbook series: Glencoe Math Connects,
Prentice Hall Mathematics, Connected Mathematics Project, and
University of Chicago School Mathematics Project. There were
three phases for the data analysis. Phase 1 addressed the location
and sequence of the statistical concepts. Phase 2 focused upon an
examination of the lesson narrative, its components and scope.
Phase 3 analyzed the level of cognitive demand required of the
students to complete the exercises, and the total …
Occupational Stressors Among Providers Of Hiv Prevention And Support Services, Mackenzie Kaye Rapp
Occupational Stressors Among Providers Of Hiv Prevention And Support Services, Mackenzie Kaye Rapp
USF Tampa Graduate Theses and Dissertations
Much literature has documented the high levels of burnout, stress, and grief in HIV physicians and nurses due to the challenging nature of the chronic, fatal disease with which they deal on a daily basis. Providers of social and HIV prevention services face similar challenges while working with stigmatized, terminally ill clients. However, since these latter occupations deal with social, rather than clinical interventions, their experiences may differ from those of medical personnel. Through open-ended interviews with HIV counselors, educators, case managers, and outreach workers, this exploratory study assesses the occupational stressors of providers of social and HIV prevention services …
Use Of Adventitious Roots For The Determination Of Hydroperiod In Isolated Wetlands, Michael Joseph Reyes
Use Of Adventitious Roots For The Determination Of Hydroperiod In Isolated Wetlands, Michael Joseph Reyes
USF Tampa Graduate Theses and Dissertations
Abstract
Accurate measurement of the hydroperiod in isolated wetlands currently relies upon the installation and frequent monitoring of devices such as piezometers and staff gauges. Observations of biological indicators of the hydroperiod may be able to supplement data collected from these devices and could potentially replace them as a means of accurately determining this hydrologic interval. The study objective was to determine whether adventitious root formation and maturation on buttonbush (Cephalanthus occidentalis) could be used as a viable indicator of the hydroperiod in isolated wetlands. Buttonbush seedlings were flooded in a controlled environment over a three month period in the …
Effects Of G-Csf On Monocytes And Neurons: In Vitro And In Vivo Studies In A Mouse Model Of Alzheimer's Disease, Amanda Renee Pennington
Effects Of G-Csf On Monocytes And Neurons: In Vitro And In Vivo Studies In A Mouse Model Of Alzheimer's Disease, Amanda Renee Pennington
USF Tampa Graduate Theses and Dissertations
G-CSF is routinely used to treat neutropenia/leukopenia or to increase hematopoietic stem cell generation in bone marrow donors. G-CSF and its receptor, G-CSFR, are produced by various cell types both in the peripheral circulation and within brain. As a consequence, exogenous administration of G-CSF results in a broad spectrum of effects involving hematopoietic, immune and central nervous systems.
G-CSF administration in a mouse model of Alzheimer's disease (AD) has revealed both cognitive benefits and disease modifying effects: a) decreased Aβ plaque burden, b) increased microgliosis, c) increased neurogenesis and d) improved performance in radial arm water maze (RAWM). In clinical …
Fit To Lead? Supervisors' Health Behaviors, Well-Being, And Leadership Behaviors, Kristin Saboe
Fit To Lead? Supervisors' Health Behaviors, Well-Being, And Leadership Behaviors, Kristin Saboe
USF Tampa Graduate Theses and Dissertations
This study proposes a model to test the relationships amongst supervisors' health behaviors and leadership behaviors. Specifically, 107 supervisor-subordinate pairs responded to a cross-sectional survey. Supervisors provided self-reports of their health behaviors (physical activity, diet, sleep, alcohol/tobacco use) and perceived well-being. Subordinates rated the supervisors' perceived leadership style and the quality of relationships they share at work. Results were mixed with support largely being found for previously established relationships between (a) physical activity, sleep duration and quality, and well-being, and (b) leadership behaviors and supervisor-subordinate relationship quality. The primary thesis of this study--that leaders with improved health behaviors and well-being …
The Effect Of Mortgage Liberalization On Housing Patterns In Tampa Bay, Jason Richardson
The Effect Of Mortgage Liberalization On Housing Patterns In Tampa Bay, Jason Richardson
USF Tampa Graduate Theses and Dissertations
This study seeks to determine whether the process of mortgage finance liberalization, manifested in concurrent activities of securitization, deregulation, and neo-liberal policy, have resulted in changes to the tenure of residents in neighborhoods in Tampa Bay. It makes use of existing literature on gentrification and mortgage finance and compares those findings with three sample neighborhoods in and around the city of Tampa. To do so the thesis employs data collected from lenders pursuant to the Home Mortgage Disclosure Act, court records of sales and mortgages filed with the Clerk of the Circuit Court of Hillsborough County, and interviews with stakeholders …
On The Spatial And Temporal Variability Of Upwelling In The Southern Caribbean Sea And Its Influence On The Ecology Of Phytoplankton And Of The Spanish Sardine (Sardinella Aurita), Digna Tibisay Rueda-Roa
On The Spatial And Temporal Variability Of Upwelling In The Southern Caribbean Sea And Its Influence On The Ecology Of Phytoplankton And Of The Spanish Sardine (Sardinella Aurita), Digna Tibisay Rueda-Roa
USF Tampa Graduate Theses and Dissertations
The Southern Caribbean Sea experiences a strong upwelling process along the coast from about 61°W to 75.5°W and 10-13°N. In this dissertation three aspects of this upwelling system are examined: (A) A mid-year secondary upwelling that was previously observed in the southeastern Caribbean Sea between June-July, when land based stations show a decrease in wind speed. The presence and effects of this upwelling along the whole southern Caribbean upwelling system were evaluated, as well as the relative forcing contribution of alongshore winds (Ekman Transport, ET) and wind-curl (Ekman Pumping, EP). (B) Stronger upwelling occurs in two particular regions, namely the …
Investigation Of Reservoirs Of Fecal Indicator Bacteria And Water Quality On The Presence Of Allochthonous Pathogens And The Ecology And Virulence Of Vibrio Vulnificus, Christopher Staley
Investigation Of Reservoirs Of Fecal Indicator Bacteria And Water Quality On The Presence Of Allochthonous Pathogens And The Ecology And Virulence Of Vibrio Vulnificus, Christopher Staley
USF Tampa Graduate Theses and Dissertations
The quality of recreational and shellfishing waters has historically been monitored using commensal, allochthonous bacteria shed in feces (fecal indicator bacteria, FIB). The fate of FIB in the environment should mimic that of bacterial, protozoan, and viral human pathogens, which may also be allochthonous (e.g. Salmonella, Cryptosporidium, or enteric viruses) or autochthonous (e.g. Vibrio spp.) to aquatic environments. FIB are contributed to water from human and animal sources; however, pollution source cannot be determined by conventional FIB measurements. Because fecal source determination is important for pollution remediation and assessment of human health risks, microbial source tracking (MST) methods are …
Autism Spectrum Disorders (Asd): Knowledge, Training, Roles And Responsibilities Of School Psychologists, Stacey Small
Autism Spectrum Disorders (Asd): Knowledge, Training, Roles And Responsibilities Of School Psychologists, Stacey Small
USF Tampa Graduate Theses and Dissertations
The number of students with autism spectrum disorders (ASD) has increased over the years and therefore it seems inevitable that school psychologists will encounter these students as part of their roles in assessment, consultation, and/or intervention. There are a multitude of articles and books on the signs and symptoms of ASD, as well as suggestions for assessment and intervention, but there are no published data related to school psychologists' knowledge, training, and roles and responsibilities for students with ASD. Therefore, the current study sought to inform the field of school psychology with respect to these issues. One hundred members of …
Modulating The Pharmacokinetics Of Bioflavonoids, Adam John Smith
Modulating The Pharmacokinetics Of Bioflavonoids, Adam John Smith
USF Tampa Graduate Theses and Dissertations
One of the largest obstacles in drug development is to overcome solubility and bioavailability problems. Preformulation strategies such as nanoparticle formation are often employed but sometimes create new issues and are limited in their effectiveness and applications. Since the majority of drugs are marketed and sold as solid forms, drug delivery systems are not always desirable. This is where solid-state chemistry becomes important. Traditional solid-state chemistry approaches are often successful but are sometimes too restrictive and cannot be applied to certain compounds. Cocrystals have emerged as an alternative solid-state technique that can be applied to a broad range of compounds. …
Sugar Consumption And Cognitive Aging In The Swedish Adoption/Twin Study Of Aging, Shyam Seetharaman
Sugar Consumption And Cognitive Aging In The Swedish Adoption/Twin Study Of Aging, Shyam Seetharaman
USF Tampa Graduate Theses and Dissertations
Abstract
Consumption of foods high in sugar content has been linked with the development of metabolic abnormalities such as cardiovascular disease and type II diabetes, major sources of global health concerns. Although the detrimental consequences of high intake of sugar on abnormal metabolic processes are established, it is not known how this association affects (or accelerates) cognitive aging.
The current project was based on data from the Swedish Adoption/Twin Study of Aging (SATSA) to test the hypothesis that high refined sugar intake contributes to accelerated trajectories of cognitive decline assessed longitudinally. Trajectories of cognitive change were assessed as a function …
Analysis And Remediation Of Chlorinated Hydrocarbons In Environmental Media, Jonathan Ticknor
Analysis And Remediation Of Chlorinated Hydrocarbons In Environmental Media, Jonathan Ticknor
USF Tampa Graduate Theses and Dissertations
The two objectives of this work were to develop a simplified method for the analysis of chlorinated organics in water samples and to improve an existing soil remediation technology. The contaminants considered for these studies were chlorinated hydrocarbons because of their relative frequency of appearance at contaminated sites. The first half of this study involved the analysis of chlorinated ethenes by gas chromatography with flame ionization detection (GC-FID). I tested the hypothesis that the FID response factor is the same for all chlorinated ethene compounds. The rationale for this investigation is that if the hypothesis is correct, a single calibration …
A Dual-Factor Model Of Mental Health In High School Students: Group Characteristics And Social Functioning, Amanda Lynn Thalji
A Dual-Factor Model Of Mental Health In High School Students: Group Characteristics And Social Functioning, Amanda Lynn Thalji
USF Tampa Graduate Theses and Dissertations
A dual-factor model of psychological functioning examines the presence of wellness (i.e., subjective well-being; SWB) and psychopathology (i.e., internalizing and externalizing behavior problems) in explaining youth mental health functioning. Using a dual-factor model, previous research has yielded four unique groups of elementary and middle school youth as well as college-age adults with distinct levels of wellness and psychopathology. The present empirical investigation included valid data from 500 adolescents from two high schools (grades 9 to 11). This exploratory study produced four groups of students with unique mental health profiles aligned with previous studies investigating the dual-factor model. Tukey-Kramer comparisons determined …
Statistical Estimation Of Physiologically-Based Pharmacokinetic Models: Identifiability, Variation, And Uncertainty With An Illustration Of Chronic Exposure To Dioxin And Dioxin-Like-Compounds., Zachary John Thompson
Statistical Estimation Of Physiologically-Based Pharmacokinetic Models: Identifiability, Variation, And Uncertainty With An Illustration Of Chronic Exposure To Dioxin And Dioxin-Like-Compounds., Zachary John Thompson
USF Tampa Graduate Theses and Dissertations
Assessment of human exposure to environmental chemicals is inherently subject to uncertainty and variability. There are data gaps concerning the inventory, source, duration, and intensity of exposure
as well as knowledge gaps regarding pharmacokinetics in general. These gaps result in uncertainties in exposure assessment.
The uncertainties compound further with variabilities due to population variations regarding stage of life, life style, and susceptibility,
etc. Use of physiologically-based pharmacokinetic (PBPK) models promises to reduce the uncertainties and enhance extrapolation between species, between routes, from high to low dose, and from acute to chronic exposure. However, fitting PBPK models is challenging because of …
Quality Of Life In Adult Obsessive-Compulsive Disorder: The Role Of Moderating And Mediating Variables, Brittany Belle Speisman
Quality Of Life In Adult Obsessive-Compulsive Disorder: The Role Of Moderating And Mediating Variables, Brittany Belle Speisman
USF Tampa Graduate Theses and Dissertations
Background: This study examined the contribution of various aspects of obsessive-compulsive disorder (OCD) on quality of life (QoL) in 102 adults with a principal diagnosis of OCD from an archival database. Method: Participants were assessed for DSM-IV diagnoses by trained clinicians using the Anxiety Disorders Interview Schedule, 4th Edition (ADIS-IV), the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and an unstructured interview. Further information was attained using the Beck Depression Inventory II (BDI-II), the Obsessive Compulsive Inventory Revised (OCI-R) and the Medical Outcome Study-36 (MOS-36). Results: Results indicated that obsessive-compulsive symptom severity was positively correlated with diminished emotional health, social …
Love And Risk: Intimate Relationships Among Female Sex Workers Who Inject Drugs And Their Non-Commercial Partners In Tijuana, Mexico, Jennifer L. Syvertsen
Love And Risk: Intimate Relationships Among Female Sex Workers Who Inject Drugs And Their Non-Commercial Partners In Tijuana, Mexico, Jennifer L. Syvertsen
USF Tampa Graduate Theses and Dissertations
This dissertation examines the influence of love and other emotions on sexual and drug-related HIV risk among female sex workers who inject drugs and their intimate, non-commercial partners in Tijuana, Mexico. My work on a public health study along the Mexico-U.S. border and independent ethnographic research in Tijuana suggests the importance of emotions in shaping sex workers' relationships and health risks.
Love is a universal human emotional experience embodied within broader cultural, social, and economic contexts. A growing body of cross-cultural research suggests that modern relationships have transformed to emphasize love and emotional intimacy over moral or kinship obligations. Particularly …
An Interactive Guide To Self-Discovery For Women, Elaine J. Taylor
An Interactive Guide To Self-Discovery For Women, Elaine J. Taylor
USF Tampa Graduate Theses and Dissertations
This project is a translation of ideas I have encountered in my journey through Women's Studies. With this interactive book, I offer a concise, understandable, and empowering method for self-discovery from one feminist's perspective. Traditional self-help materials often set the reader up as the one with the issue or problem and they rarely call out the functioning systems of oppression as a stumbling block or offer ways to circumvent them. With this project, I hope to shine light on the functioning systems of gender discrimination, racism, classism, and heterosexism, and to provide a framework for understanding. There are three main …
A Head Start To Learning: Exploration Of A Parent-Directed Intervention To Promote Early Literacy Skill Development, Ashley Nicole Sundman-Wheat
A Head Start To Learning: Exploration Of A Parent-Directed Intervention To Promote Early Literacy Skill Development, Ashley Nicole Sundman-Wheat
USF Tampa Graduate Theses and Dissertations
This study examined the effects of a parent-led intervention focused on developing children's early literacy skills within the home setting. The lesson plans contain scripted steps for completing activities to teach letter names and phonological awareness skills. Archival data were analyzed from a study conducted with 26 families from three Head Start centers. Thirteen families completed the intervention and thirteen families were enrolled in a control condition which provided information on shared reading strategies. Children in the intervention group performed at statistically significant higher levels on measures of letter naming, phonological awareness, vocabulary/oral language, and comprehension. Parents rated both the …
Competing Narratives: Hero And Ptsd Stories Told By Male Veterans Returning Home, Adam Gregory Woolf
Competing Narratives: Hero And Ptsd Stories Told By Male Veterans Returning Home, Adam Gregory Woolf
USF Tampa Graduate Theses and Dissertations
This qualitative study seeks to extend the existing body of scholarly literature on returned veteran civilian reintegration by exploring "hero" and "Post-Traumatic Stress Disorder" narratives. The character of the hero, as a social construct located within hegemonic notions of masculinity, is widely portrayed and believed to possess highly prized, extraordinary, almost superhuman personal qualities. However, this widely disseminated belief stands at odds with some of the stories returned veterans tell. This qualitative study explores and illuminates the enigmatic intersectionality of hero and PTSD narratives.
Extant hero and PTSD narratives contain paradoxical implicit meanings embedded within them. The hero is understood …
Catalytic Tri-Reforming Of Biomass-Derived Syngas To Produce Desired H2:Co Ratios For Fuel Applications, Devin Mason Walker
Catalytic Tri-Reforming Of Biomass-Derived Syngas To Produce Desired H2:Co Ratios For Fuel Applications, Devin Mason Walker
USF Tampa Graduate Theses and Dissertations
This study focuses on upgrading biomass derived syngas for the synthesis of liquid fuels using Fischer-Tropsch synthesis (FTS). The process includes novel gasification of biomass via a tri-reforming process which involves a synergetic combination of CO2 reforming, steam reforming, and partial oxidation of methane. Typical biomass-derived syngas H2:CO is 1:1 and contains tars that deactivate FT catalyst. This innovation allows for cost-effective one-step production of syngas in the required H2:CO of 2:1 with reduction of tars for use in the FTS. To maximize the performance of the tri-reforming catalyst, an attempt to control oxygen mobility, thermal stability, dispersion of metal, …
Evaluation Of Repeated Biomarkers: Non-Parametric Comparison Of Areas Under The Receiver Operating Curve Between Correlated Groups Using An Optimal Weighting Scheme, Ping Xu
USF Tampa Graduate Theses and Dissertations
Receiver Operating Characteristic (ROC) curves are often used to evaluate the prognostic performance of a continuous biomarker. In a previous research, a non-parametric ROC approach was introduced to compare two biomarkers with repeated measurements. An asymptotically normal statistic, which contains the subject-specific weights, was developed to estimate the areas under the ROC curve of biomarkers. Although two weighting schemes were suggested to be optimal when the within subject correlation is 1 or 0 by the previous study, the universal optimal weight was not determined. We modify this asymptotical statistic to compare AUCs between two correlated groups and propose a solution …
Smart Packaging: A Novel Technique For Localized Drug Delivery For Ovarian Cancer, Eva Christabel Williams
Smart Packaging: A Novel Technique For Localized Drug Delivery For Ovarian Cancer, Eva Christabel Williams
USF Tampa Graduate Theses and Dissertations
Localized drug delivery is emerging as an effective technique due to its ability to administer therapeutic concentrations and controlled release of drugs to cancer sites in the body. It also prevents the contact of harsh chemotherapy drugs to healthy regions in the body that otherwise would become exposed to current treatments.
This study reports on a model chemotherapy drug delivery system comprising non-ionic surfactant vesicles (niosomes) packaged within a temperature-sensitive chitosan network. This smart packaging, or package-within-a package system, provides two distinct advantages. First, the gel prevents circulation of the niosomes and maintains delivery in the vicinity of a tumor. …
The Mediating Effect Of Distress Caused By Constipation On Predictors Of Quality Of Life Of Hospice Patients With Cancer., Abdel Alkhalouf
The Mediating Effect Of Distress Caused By Constipation On Predictors Of Quality Of Life Of Hospice Patients With Cancer., Abdel Alkhalouf
USF Tampa Graduate Theses and Dissertations
Abstract
The Mediating Effect of Distress Caused by Constipation on Predictors of Quality of Life of Hospice Patients with Cancer.
Key positive outcomes for hospice patients include the prevention and alleviation of physical and psychological distress, maintenance of physical and mental functioning and all aspects of quality of life. This research used secondary analysis of previously gathered data to answer new research questions with alternative strategies to examine relationships not previously analyzed. The researchers collected data from 717 cancer patients who had been admitted to one of two private hospices. The aim of their experimental intervention was to define the …
Economic Culture And Trading Behaviors In Information Markets, Khalid Nasser Alhayyan
Economic Culture And Trading Behaviors In Information Markets, Khalid Nasser Alhayyan
USF Tampa Graduate Theses and Dissertations
There are four main components for influencing traders' behaviors in an information market context: trader characteristics, organizational characteristics, market design, and external information. This dissertation focuses on investigating the impact of individual trader characteristics on trading behaviors. Two newly-developed constructs, highly relevant to information market contexts, were identified to increase our understanding about trading behaviors: trader's economic culture and trader independence. The theory of planned behavior is used as the theoretical basis to postulate hypotheses for empirical testing. Data collected from subjects through a series of web-based experiments shows that trader participation can be fostered through recruiting individuals who are …
Therapeutic Peptide-Based Vaccination Strategies Against Hpv-Induced Cancers, Kelly Barrios Marrugo
Therapeutic Peptide-Based Vaccination Strategies Against Hpv-Induced Cancers, Kelly Barrios Marrugo
USF Tampa Graduate Theses and Dissertations
There is an urgent need for the development of an effective therapeutic vaccine against cancer caused by human papilloma virus (HPV). We focused on HPV-induced malignancies because of their high worldwide prevalence (e.g., cervical carcinoma and head & neck cancer). A successful therapeutic vaccine could prevent the 250 000 deaths/year worldwide and the 2.25 billion dollars that
are expended in related care in the US.
We used an HPV-induced mouse cancer model to test vaccines
composed of a CD8 T cell peptide epitope administered with potent adjuvants designed to generate vast numbers of high avidity cytotoxic T lymphocytes specific for …
Behavioral And Immunological Phenotypes Of Transgenic Mice Overexpressing Human Secreted Amyloid Precursor Protein Alpha: Implications For Autism, Antoinette R. Bailey
Behavioral And Immunological Phenotypes Of Transgenic Mice Overexpressing Human Secreted Amyloid Precursor Protein Alpha: Implications For Autism, Antoinette R. Bailey
USF Tampa Graduate Theses and Dissertations
Autism is a heterogeneous neurodevelopmental disorder that is characterized by impaired social interaction and communication as well as restricted and repetitive behaviors and focused interests. In addition to the cardinal behavioral characteristics observed for diagnosis, autistic individuals exhibit a number of comorbid conditions as well as a variety of aberrant immunological features. Recent studies report that plasma from autistic children contained elevated levels of secreted amyloid precursor protein alpha (sAPP-á), the á-secretase cleavage product of the amyloid precursor protein (APP) which is ubiquitously expressed in the brain, spleen, thymus and other organs. Interestingly, the sAPP-á fragment functions as a neurotrophic …
A Framing Analysis: The Nba's "One-And-Done"Rule, Daniel Ryan Beaulieu
A Framing Analysis: The Nba's "One-And-Done"Rule, Daniel Ryan Beaulieu
USF Tampa Graduate Theses and Dissertations
In 2006, the NBA introduced the "one-and-done" rule that restricted high school graduates to enter directly into the NBA draft following high school. In turn, a high school prospect would essentially now have the option of playing professionally elsewhere (most likely overseas), enter the NBA's Developmental League, or play NCAA basketball. The rule has proved to be quite controversial, as it has had a great effect on both NBA and NCAA basketball, as well as the players. Various media outlets have been quite vocal not only about the rule itself, but the perceived effects it has had on both collegiate …
Good Men Grow Corn: Embodied Ecological Heritage And Health In A Belizean Mopan Community, Kristina Linda Baines
Good Men Grow Corn: Embodied Ecological Heritage And Health In A Belizean Mopan Community, Kristina Linda Baines
USF Tampa Graduate Theses and Dissertations
Recent developments in land rights and land use in the Toledo district, Belize has generated anthropological and activist interest surrounding traditional ecological knowledge and practice, and the role of heritage in communities. This study explores the connection between ecological knowledge and practices, and the concurrent construction of heritage, and community health and wellness, broadly defined. Developing and using the concept of "embodied ecological heritage," this dissertation takes a phenomenological approach to understanding the convergence of ecological heritage and health in multiple realms of everyday life, arguing that lived experience of participating in "traditional" practices is fundamentally connected to wellness in …
Cloning Of The Gene, Purification As Recombinant Protein And Functional Characterization Of Leishmania Mexicana Cytochrome B5 Reductase, Ala Azhari
USF Tampa Graduate Theses and Dissertations
Leishmania are protozoan parasites that are transmitted by a sand fly vector. These parasites affect not only humans but also wild animals including domestic dogs and rodents, which form an additional challenge and public health problem to control the disease. Leishmaniasis is an important disease with worldwide distribution, including Saudi Arabia, the Middle East, and other tropical and subtropical areas around the world. Due to the expansion of irrigation and agricultural activities, more exposure to sand fly occurs, which leads to the expansion of leishmaniasis infections as newly emerging disease.
Emerging drug resistance in leishmaniasis is an additional problem, contributed …
Drug Discovery From Floridian Mangrove Endophytes, Jeremy Beau
Drug Discovery From Floridian Mangrove Endophytes, Jeremy Beau
USF Tampa Graduate Theses and Dissertations
A significant challenge of the 21st century is the growing health threat stemming from drug-resistant infectious diseases. There is an undeniable need to discover new, safe and effective drugs with novel mechanisms of action to combat this threat. A study of drugs currently on the market showed that natural products account for approximately 75% of new anti-infective drugs, either as new agents or analogs based upon their structure. Unfortunately, major pharmaceutical companies have cut back tremendously in natural products research in part due to the frustrating obstacle of frequent rediscovery of compounds. Fungi in particular are difficult to work with …