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Novel Therapeutic Strategies In Lung Cancer, Courtney A. Kurtyka

USF Tampa Graduate Theses and Dissertations

Lung cancer is the leading cause of cancer-related death and the second most diagnosed cancer in the United States. Unfortunately, many patients either do not have any common mutations for which there are already targetable agents, or they eventually become resistant to these compounds. As such, there is a high demand for new, effective methods of treating this disease as well as predicting patient prognosis and potential benefit from chemotherapy. In this work, numerous strategies for treating lung cancer are explored.

The first method described here is through the use of a pan-early 2 factor (E2F) inhibitor, HLM006474, which is …

Differentiating Geo-Spatiotemporal Aquatic Larval Habitats Of Anopheles Gambiae Complex In Urban Agriculture And Urban Non-Agriculture Environments In Accra, Ghana, Samia Mckeever

USF Tampa Graduate Theses and Dissertations

To meet the rising food demands of communities in Accra,Ghana, urban agriculture has been popularized as a way to increase food security and improve nutrition (Donovan et al., 2012). Urban agriculture is defined as "the cultivation of crops at both the subsistence and commercial levels including the keeping of livestock in open spaces in urban areas (Adjaye, n.d.). In Accra, urban agriculture covers 1,091 hectares, employs over one thousand people, and supplies residents with 90% of its vegetables ("Accra Metropolitan", n.d.). Further, 60% of households in Accra participate in backyard farming ("Accra Metropolitan", n.d.). Although urban agriculture provides many benefits …

Investigation Of Enhanced Titanium And Zinc Oxide Semiconductors For The Photodegradation Of Aqueous Organic Compounds, Innocent Udom

USF Tampa Graduate Theses and Dissertations

Growing demand and shortages of potable water sources due to industrialization have become a great concern worldwide. Various approaches and solutions have been adopted to provide cleaner and quality water. In a preliminary study, a method of treating wastewater was investigated in which algae were used to remove nutrients (nitrogen and phosphorous) from wastewater and then the algae were harvested for use as a biofuel. The results from this investigation are included in the Appendix B. Employing traditional oxidants, such as hydrogen peroxide, chlorine, and ozone, for treatment of recalcitrant organic compounds have achieved less promising results. However, photocatalysis, an …

Design And Validation Of An Evaluation Checklist For Organizational Readiness For Evaluation Capacity Development, Connie F. Walker-Egea

USF Tampa Graduate Theses and Dissertations

Evaluation capacity development (ECD) has been acknowledged as a system of processes to help organizations achieve sustainable evaluation practice. Examining the existing evaluation capacity of an organization before starting an ECD process is necessary and will increase the possibilities of success, determined by the establishment or strengthening of an evaluation system into the organization. In response to this need, this study involved the designing of the Organizational Readiness for Evaluation Capacity Development (ORECD) checklist and its initial validation, using a mixed method research design. The study was conducted in four phases, including: (a) the design of the ORECD checklist based …

Family Accommodation In Adults With Obsessive-Compulsive Disorder: Psychometric Properties Of The Family Accommodation Scale - Patient Version, Monica S. Wu

USF Tampa Graduate Theses and Dissertations

Family accommodation is a salient construct within the context of obsessive-compulsive disorder (OCD) and occurs in a large majority of affected individuals and their families. Accommodating behaviors can manifest in various ways, including participation in the patient's rituals, modifying everyday routines, facilitating compulsive behaviors, or providing reassurance. It has been repeatedly linked to negative outcomes, such as attenuated treatment response, increased obsessive-compulsive symptom severity, higher levels of family distress, and lower levels of functioning. As such, it is of significant clinical importance to have a standardized measure that is able to be used in research and clinical practice.

The Family …

Self-Control And Alcohol Expectancies, John M. Ray

USF Tampa Graduate Theses and Dissertations

Research on self-control suggests that people do not do as well at self-control after they have already exerted self-control on something else. Despite the obvious importance of self-control in drinking behavior, few studies have examined alcohol consumption as an outcome measure in the context of self-control depletion and the potential role of cognitive processes in the self-control to drinking relationship remains largely unexplored. Although it is widely agreed that alcohol expectancies play an important role in one's decision to drink, no study has examined the role of expectancies in self-control's influence on drinking. This study addresses this important gap in …

Perspectives Of Hiv + Women On The Mother To Child Transmission Of Hiv In Addis Ababa, Ethiopia, Kimberly Anne Fleek

USF Tampa Graduate Theses and Dissertations

Purpose and rationale: In 2012, an estimated 9,500 infants in Ethiopia were born with HIV. Mortality for these infants is high, and preventing infection offers the best hope for reducing the childhood death rates. Effective measures exist which can reduce the likelihood of a child acquiring HIV from its mother to less than 2%, and the necessary anti-retroviral medications are free and accessible to Ethiopian women. However, Prevention of Mother to Child Transmission of HIV (PMTCT) efforts in the country have not kept pace with the global reduction in infant infections over the last decade, and the Ethiopian MTCT rate …

Improving Middle School Students' Subjective Well-Being: Efficacy Of A Multi-Component Positive Psychology Intervention Targeting Small Groups Of Youth And Parents, Rachel Anne Roth

USF Tampa Graduate Theses and Dissertations

A dual-factor model of mental health conceptualizes mental health status as a combination of both psychopathology and subjective well-being. Current literature indicates that complete mental health (i.e., low psychopathology, high subjective well-being) is associated with the best academic and social functioning among youth. Thus, the absence of psychopathology alone is not sufficient for student success. While research on interventions for improving subjective well-being, termed positive psychology interventions (PPIs), is increasing, PPIs for youth in particular lag behind similar interventions for adults. Additionally, a majority of youth-focused PPIs have targeted singular constructs (e.g., gratitude, character strengths), have neglected to include relevant …

Understanding Factors Determining Early Termination From A Government Assistance Program For Maternal And Child Health: The Special Supplemental Nutrition Program For Women, Infants And Children (Wic), Anthony Dominic Panzera

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation is to understand why individuals enrolled in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) fail to retrieve food vouchers, miss WIC appointments, and become inactive in program components. In Kentucky, mothers who fail to pick up food instruments for 60 days are automatically terminated from the program. The specific research questions that guided this study are: (1) Which segments of enrollees are at greatest and least risks of nonparticipation in the WIC program? (2) How do predisposing, enabling and need characteristics impact WIC nonparticipation among eligible mothers? (3) How do WIC …

A Contingency Model Of Team Leadership For Emergency Medical Teams, Andeneshea Shacardia Kemp

USF Tampa Graduate Theses and Dissertations

Emergency medical teams operate under unusual circumstances. They assemble for a singular, temporary purpose, potentially change in size and composition, and their performance can influence whether a patient lives or dies. Although leadership is a critical component to team success, it is rarely investigated in the context of emergency medical teams. This study sought to examine the relationship between directive leadership behaviors and team performance outcomes. It was hypothesized that directive leadership would be particularly effective for emergency medical teams. In addition, a contingency model was proposed. Specifically, it was hypothesized that the effectiveness of directive leadership is contingent upon …

Developmental Trajectories Of Physical Aggression And Nonaggressive Rule-Breaking Among At-Risk Males And Females During Late Childhood And Early Adolescence, Eugena Givens

USF Tampa Graduate Theses and Dissertations

Criminological, psychological, and developmental researchers have relentlessly explored behavioral characteristics and juvenile justice outcomes in an effort to establish the most appropriate means of analyzing childhood and adolescent problem behaviors. Cross-discipline, empirical evidence and factor analytic research has consistently identified the presence of two predictive concepts, physical aggression and nonaggressive rule-breaking. Research pertaining to the risk factors and correlates of these two distinct substructures of offending align with theoretically postulated typologies of delinquency and offending as well as the frequently cited patterns of delinquency and offending within reviews of longitudinal research. Using longitudinal data from a sample of 756 at-risk, …

Science Teachers' Understandings Of Science Practices Before And After The Participation In An Environmental Engineering Research Experiences For Teachers (Ret) Program, Dilek Özalp

USF Tampa Graduate Theses and Dissertations

In 2012, National Research Council published a new science education framework that explains the science practices and its importance in understanding the process of knowledge development. The students were expected to engage in all the practices by grade 12. All science teachers need some kind of support to improve their understandings of these science practices (NRC, 2012). An important key component of engaging teachers in scientific investigations is to have the teacher participate in a research laboratory experience (NRC, 1996). Research Experiences for Teachers programs (RET) serve as a promising form of professional development to achieve this goal. These programs …

Validation Of The Scores Of The Instructional Pedagogical And Instructional Student Engagement Components Of Fidelity Of Implementation, Sandra F. Naoom

USF Tampa Graduate Theses and Dissertations

Students cannot benefit from what they do not experience. Multiple reasons exist for why an intervention may not be delivered as it was designed. In this era of educational accountability and limited dollars to go around, understanding how an intervention is delivered in the classroom is key to understanding program outcomes. In order to assess whether a program has been implemented as intended, an assessment of fidelity is needed. However assessing fidelity is complex given varying conceptual interpretations, which then fosters inconsistent application of methods to measure the construct. Additionally the methods for validating fidelity measures are still unclear. The …

Risk Perception And Beliefs About Volcanic Hazards: A Comparative Study Of Puna District Residents, Melanie Marie Leathers

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to better understand how residents of communities located on the flanks of Kilauea, Hawai'i view the hazards associated with volcanic events taking into account hazard proximity, cultural beliefs, municipal trust, and evacuation planning. The study was conducted in the lower Puna district, an area with a rapidly growing population but limited infrastructure.

Data were collected though a questionnaire survey undertaken at venues throughout the district, including grocery markets, bakeries, farmers markets, the public pool, and other gathering places. Overall, the results indicated that people understand the natural hazards of the place but are generally …

Fear Of Cancer Recurrence In Breast Cancer Survivors Before And After Follow-Up Mammograms, Heather L. Mcginty

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to assess fear of cancer recurrence (FCR) in breast cancer survivors returning for regularly scheduled follow-up mammograms. FCR was hypothesized to increase prior to the mammogram, decrease from immediately pre- to immediately post-mammogram, and then increase following the mammogram. Based on the cognitive-behavioral model (CBM) of health anxiety, greater perceived risk of recurrence, worse perceived consequences of a recurrence, lower coping self-efficacy, and more engagement in reassurance-seeking behaviors were hypothesized to be associated with greater FCR in each time segment. Finally, exploratory analyses evaluated the various trajectories in FCR over time using growth mixture …

Karst Estuaries: A Newly Described Ecosystem Governed By Aquifer Hydrology, Damian M. Menning

USF Tampa Graduate Theses and Dissertations

The overall goal of this dissertation is to define the hydrological, geochemical, and biological characteristics of a Karst Estuary. These types of estuaries represent a unique ecosystem created by freshwater inputs from direct flow through karst conduits and/or diffuse flow through a karst matrix. In order to determine the characteristics of a Karst Estuary we monitored short-term tidal fluctuations, long-term rainfall patterns, aquifer levels, spring discharge, multiple geochemical parameters, microbial communities in the water column and sediment, and macrofaunal communities in the sediment along a transect from a submarine spring through the Gulf of Mexico. Four sites were selected along …

Changing Landscapes: End-Of-Life Care & Communication At A Zen Hospice, Ellen W. Klein

USF Tampa Graduate Theses and Dissertations

This dissertation examines end-of-life experiences at a small Zen hospice in the Pacific Northwest region of the United States. Through an exploration of how end-of-life communication, sense-making, decision-making, and care in this setting differ from that of typical clinical settings, this project highlights and interrogates the experiences of dying as spiritually, rhetorically, narratively, relationally, and communally bound events.

Keywords: Zen hospice, end of life, narrative sensemaking, medical-ethical decision making, spirituality, healing rhetoric, communities of practice

The Importance Of Family-Systems Theory In Masters-Level School School Counseling Curriculum: A Study Of Faculty Perceptions, Gwen Gold

USF Tampa Graduate Theses and Dissertations

This study examined the perceptions of Council for Accreditation of Counseling & Related Educational Programs (CACREP) master's-level school counseling program coordinators and faculty members about the importance and relevance of family systems theory and techniques coursework in their program curriculum. Family-systems theory coursework is lacking in two-thirds of those accredited programs, although mandated by their major accrediting body, CACREP. CACREP issued curriculum standards and guidelines to ensure proper training of school-counseling students and the American School Counselor Association--the foundation that expands the image and influence of professional school counselors through advocacy, leadership, collaboration, and systemic change--has issued guidelines for the …

The Tattoo: A Mark Of Subversion, Deviance, Or Mainstream Self-Expression?, Jocelyn Camacho

USF Tampa Graduate Theses and Dissertations

While an estimated one-third of the United States population has a tattoo, tattoos are still seen as a sign of deviance. The appearance of the first tattoos in the United States were relegated to the bodies of the lower classes and outcasts of society. Over the past few decades tattoos have migrated on to the celebrity skin of today's pop culture icons. In the past twenty years, tattoos have moved from deviant subcultures to the mainstream, and yet are still considered to be a mark of the disfavored factions of society. The dominant culture continues to regard the bearers of …

"Having Our Say": Exploring The Processes And Feasibility Of A Community-Based Participatory Intergenerational Physical Activity Program For Grandparents Raising Grandchildren, Tiffany Lenell Young

USF Tampa Graduate Theses and Dissertations

Over the past twenty years, the number of grandparents raising grandchildren has increased substantially. In many cases, raising grandchildren can be stressful and may aggravate pre-existing health conditions. Grandchildren in these kinship relationships often experience poor health outcomes as well. Typically, both grandparents and grandchildren do not engage in positive health behaviors. Thus, there is a need to develop intergenerational health promotion interventions for grandparents raising grandchildren. This study used the community-based participatory research approach to develop and implement an eight-week intergenerational program for kinship families. The specific goals of this descriptive study were to understand the process and feasibility …

Accuracy Of /T/ Productions In Children With Cochlear Implants As Compared To Normal-Hearing, Articulation Age-Matched Peers, Terry Gier

USF Tampa Graduate Theses and Dissertations

Children who receive cochlear implants (CIs) demonstrate considerable variability in speech sound production. Investigations focused on speech sound development in children with CIs have shown initial accelerated growth, followed by a plateau where consonant order of acquisition generally mirrors that of NH children, but is slower (Blamey, Barry, & Pascale, 2001; Serry & Blamey, 1999; Spencer & Guo, 2013). A notable exception to this pattern, /t/, has been shown to be acquired later-than normal in several investigations (Blamey et al., 2001; Chin, 2003; Ertmer, True Kloiber, Jongmin, Connell Kirleis, & Bradford, 2012). The primary purpose of this investigation was to …

Ontogenetic Diet Shifts And Prey Preference Of A Generalist Predatory Fish, Brittany Jalene Scharf

USF Tampa Graduate Theses and Dissertations

Marine ecosystems are highly dynamic and contain a diverse faunal assemblage that are subject to various natural and anthropogenic variability. Globally, seagrass ecosystems are located adjacent to coastal areas that are heavily impacted by human development and urbanization potentially altering the community structure within these ecosystem. Complex food webs connect many components of these systems, often in unexpected ways, and are ultimately based on one of two pathways: benthic (i.e., seagrass, epiphytes, microalgae, detritus) and planktonic (i.e., phytoplankton). Understanding the pathway which the food web is based gives further insight regarding the biological balance of the ecosystem; thus it is …

Adolescent Behavioral Adjustment In Girls Adopted From China: Examining Pre-Adoption And Post-Adoption Factors, Derek Justin Powers

USF Tampa Graduate Theses and Dissertations

Despite research that indicates that internationally adopted children are at greater risk for poor developmental outcomes than their non-adopted peers (Bimmel, Juffer, IJzendoorn, Bakermans-Kranenburg, 2003; Juffer, & van IJzendoorn, 2005), girls adopted from China into Western culture tend to thrive, exhibiting high self-esteem, low behavior problems (i.e., both externalizing and internalizing), and excelling academically (Rojewski, Shapiro, & Shapiro, 2000; Tan & Jordan-Arthur, 2012). However, few studies have examined whether this trend continues into adolescence, as well as to what factors lead to these positive outcomes. The purpose of this study was to investigate predictors of mental health outcomes among internationally …

Managing Regional Water Resources Amidst Rapid Urbanization In Southwest Florida: A Case Study, Nicole Owusua Caesar

USF Tampa Graduate Theses and Dissertations

Experts and organizations involved in freshwater resources management have emphasized the importance of long-term urban resource planning and management that considers the tight coupling which exists between human - nature - technology systems. The resistance of contemporary urban growth efforts to consider resource carrying capacities and ecosystem requirements has led to costly unintended consequences including the deterioration of natural capital and their associated ecosystem services, and the degradation of water resource flows. As these problems continue to worsen, resource experts have called for the development of a new water resource management paradigm inclusive of various sustainability criteria.

Historically water-rich Florida …

Risk Of Compliance: Tracing Safety And Efficacy In Mef-Lariam's Licensure, Julie Marie Gerdes

USF Tampa Graduate Theses and Dissertations

The Walter Reed Institute of Army Research developed the antimalarial drug mefloquine then collaborated with Hoffman-La Roche to produce the drug under its brand name "Lariam," after Food and Drug Administration (FDA) approved licensure in 1989. For over twenty years, the Army used this pill as its "drug of choice" for soldiers deployed to endemic regions until 2009, and in 2013 the Food and Drug Administration warned that the drug's neurotoxic effects could be lasting, if not permanent. The sociopolitical exigence of developing a new biochemical antimalarial drug rushed the development and licensure processes, and the modern craving for certainty …

"Wake Up The Knowledge That You Have": An Assessment Of Community Food Security In Fellsmere, Florida, Susan Marie Tyler

USF Tampa Graduate Theses and Dissertations

In the global industrial agricultural system many people lack access to high-quality nutritious foods and food production techniques are often inefficient and reliant on harsh chemical inputs. While numerous strategies exist to address the disparities present in the global food system, increasingly researchers and practitioners are looking to local food systems for solutions to strengthen community food security (CFS). CFS emphasizes small-scale production strategies such as farmer's markets, community gardens, and consumer supported agriculture. As these efforts evolve, research is needed to understand how these strategies affect communities. To explore a local CFS initiative, qualitative data were collected from community …

Opuntia Ficus-Indica Mucilage Potential To Remove Nuclear Active Contaminants From Water Based On A Surrogate Approach, Jose Adan Leon

USF Tampa Graduate Theses and Dissertations

Potable water is a necessity and unfortunately, it can be contaminated in many different ways. This paper specifically addresses the case scenario when, water has been contaminated by radionuclides. The mucilage of Opuntia ficus-indica (OFI), has been proven to be a great flocculating agent, turbidity reducer, crude oil dispersant and an environmentally friendly substance as an absorbent of water contaminants. In this work, the OFI mucilage was investigate to evaluate its capacity to separate radioactive ions from water. The surrogate approach is modeled based on water studies performed by Willi A. Brand, who proved that radioactive isotopes behave similar to …

Statistical Modeling And Prediction Of Hiv/Aids Prognosis: Bayesian Analyses Of Nonlinear Dynamic Mixtures, Xiaosun Lu

USF Tampa Graduate Theses and Dissertations

Statistical analyses and modeling have contributed greatly to our understanding of the pathogenesis of HIV-1 infection; they also provide guidance for the treatment of AIDS patients and evaluation of antiretroviral (ARV) therapies. Various statistical methods, nonlinear mixed-effects models in particular, have been applied to model the CD4 and viral load trajectories. A common assumption in these methods is all patients come from a homogeneous population following one mean trajectories. This assumption unfortunately obscures important characteristic difference between subgroups of patients whose response to treatment and whose disease trajectories are biologically different. It also may lack the robustness against population heterogeneity …

Development Of An Efficient Human Hepatocyte Culture Platform For Assessing Novel Therapeutic Efficacy Against Plasmodium Liver Parasites, Steven Patrick Maher

USF Tampa Graduate Theses and Dissertations

Malaria is a critical and global public health problem, affecting over 200 million people every year, resulting in over 500,000 deaths. A vaccine is not currently available and only one drug, primaquine, is effective against the dormant stages of Plasmodium vivax. Preclinical assessment of novel therapeutic drugs and vaccines is hampered by the lack of an in vitro liver model for P. falciparum and P. vivax. To provide a stable human hepatocyte-based culture platform for parasite development, we engineered a microfluidic bilayer device capable of both simple and complex culture methods, including perfusion and co-culture, to better understand the requirements …

Connecting Institutional Discourses And Everyday Understandings Of Climate Change: Viewpoints From A Suburban Neighborhood In Tampa, Florida, Christopher Metzger

USF Tampa Graduate Theses and Dissertations

Despite a general consensus regarding anthropogenic global climate change across the international scientific community, many of the major greenhouse gas producers in the world, especially the United States, are hesitant to implement strict emissions regulations. According to some prominent atmospheric scientists, such as James Hansen and Michael Mann, if industrialized countries continue to produce carbon emissions at current rates, an irreversible planetary tipping point of raising temperatures 2°C above pre-industrial levels could be reached in less than 40 years. Societies have a wealth of information from the natural sciences to understand the climate problem and currently possess the technological means …