Digital Commons Network^™

Minocycline Treatment And The Necessity To Develop A Novel Outcome Measure For Children With Angelman Syndrome, Joseph Christopher Grieco

USF Tampa Graduate Theses and Dissertations

Angelman syndrome (AS) is a rare genetic disorder affecting 1/10,000 to 1/20,000 births. This disorder arises through the genetic disruption of the maternal UBE3A allele, which when coupled with epigenetic silencing of the paternal allele UBE3A allele, gives rise to an absence of UBE3A protein in the central nervous system. Clinical manifestations of the syndrome vary in severity and include poor motor function, deficits in language and severe intellectual impairments. Previous research in the Angelman syndrome mouse model revealed abnormalities in dendritic spine density and morphology of hippocampal pyramidal cells. As seen in humans with AS, mice show abnormal behavioral …

Neuroinflammatory Alterations Via Cd-36 In Traumatic Brain Injury, Diana G. Hernandez-Ontiveros

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) has become an increasingly unmet clinical need due to intense military conflicts worldwide. Directly impacted brain cells suffer massive death, with neighboring cells succumbing to progressive neurodegeneration accompanied by inflammatory and other secondary cell death events. Subsequent neurodegenerative events may extend to normal areas beyond the core of injury, thereby exacerbating the central nervous system’s inflammatory response to TBI. Recently CD-36 (cluster of differentiation 36/fatty acid translocase (FAT), a class B scavenger receptor of modified low-density lipoproteins (mLDLs) in macrophages, has been implicated in lipid metabolism, atherosclerosis, oxidative stress, and tissue injury in cerebral ischemia, and …

Situating Contraceptive Practices And Public Health Strategy In The Bronx: Perspectives From Female Youth, Healthcare Workers, And Reproductive Health Leaders, Hannah Louise Helmy

USF Tampa Graduate Theses and Dissertations

In the United States, concerns about adolescent childbearing and its perceived corollaries – negative health outcomes for mother and child, the disintegration of the nuclear family, and “over-dependence” on public resources – began to circulate widely in policy spheres and popular media in the 1970’s, resulting in a proliferation of policies, programs, and services designed to address its prevention. Although national birth rates among adolescents are currently at their lowest since peaking in the early 1990’s, this decline masks persistent and significant disparities between groups of young people by race, ethnicity, geography, and poverty level. The concomitant existence of social …

Heart Of The Beholder: The Pathos, Truths And Narratives Of Thermopylae In _300_, James Christopher Holcom

USF Tampa Graduate Theses and Dissertations

This thesis argues that critical understanding of historical narratives needn’t be limited to cold, clinical applications of logic and reason. By doing a close textual reading of Frank Miller and Lynn Varley’s graphic novel, 300 and Zack Snyder’s 2007 film adaptation, I posit that critical analysis of popular narratives is better served when pathos takes a central role. Traditional rhetorical criticism tends to favor empirical evidence and fact over emotional, narrative truth. Yet, the writing, recounting and interpretation of history are more akin to arts than sciences. Historical narratives are subject to the same influences and techniques that make poetry, …

Tampa Electric Company's Big Bend Utility Plant In Hillsborough County, Florida: A Case Study, Lynne M. Hodalski-Champagne

USF Tampa Graduate Theses and Dissertations

This is an in-depth analysis of coal fire burning power plants, their effects on human health and the environment. It also employed case study data from Tampa Electric Company’s Big Bend facility to examine environmental infractions at that facility. Tampa Electric Company’s Big Bend Utility Plant, violated the Clean Air Act, which led to a lawsuit filed by the Department of Justice on behalf of the United States Environmental Protection Agency and the Florida Department of Environmental Protection in 1997. This case study details the lawsuit, and subsequent settlement as well as Tampa Electric Company’s record of compliance since 2000. …

Evidence Of Things Not Seen: A Semi-Automated Descriptive Phrase And Frame Analysis Of Texts About The Herbicide Agent Orange, Sarah Beth Hopton

USF Tampa Graduate Theses and Dissertations

From 1961 to 1971 the United States and the Republic of South Vietnam used chemicals to defoliate the coastal and upload forest areas of Viet Nam. The most notorious of these chemicals was named Agent Orange, a weaponized herbicide made up of two chemicals that, when combined, produced a toxic byproduct called TCDD-dioxin. Studied suggest that TCDD-dioxin causes significant human health problems in exposed American and Vietnamese veterans, and possibly their children (Agency, U.S. Environmental Protection, 2011). In the years since the end of the Vietnam War, volumes of discourse about Agent Orange has been generated, much of which is …

Equifinality And Multifinality In Psychopathology: Can Cognitive And Emotional Processes Differentiate Internalizing, Externalizing, And Co-Occurring Psychopathology, Brittany Jordan-Arthur

USF Tampa Graduate Theses and Dissertations

Despite our knowledge of environmental risk factors for psychopathology, the equifinality and multifinality observed in the extant literature reveals how little is known about the role of these risk factors in the development of psychopathology. The purpose of this study was to identify processes that differentiate internalizing, externalizing and co-occurring psychopathology. Specifically, emotion identification skill and cognitive appraisal style were examined as processes where individual differences may contribute to the development of mental illness. To date no study has been conducted to examine whether emotion identification and appraisal style may differentiate forms of internalizing, externalizing and co-occurring psychopathology and lack …

Tornado Fatalities: An In-Depth Look At Physical And Societal Influences, Heather Joann Key

USF Tampa Graduate Theses and Dissertations

The purpose of this study is to model and determine significant predictors of tornado death index values, and to investigate these significant predictors and what makes people vulnerable to tornado fatalities through expert interviews. This study also provides an understanding of the study participant’s perceptions of their county’s vulnerability to tornado fatality and demonstrates a true integration of methods and fields by studying geographic, meteorological, and sociological phenomena by use of quantitative and qualitative methods. The study consists of two parts: 1) A quantitative exploration of variables hypothesized to predict Tornado Death Index (TDI) values, 2) A qualitative investigation to …

Outcomes Of A Combined Mindfulness, Stuttering Modification, And Fluency Shaping Intervention For Children Who Stutter, Jennifer Kordell

USF Tampa Graduate Theses and Dissertations

A week-long intervention for five school-age children who stutter was implemented using techniques of fluency shaping, stuttering management, and mindfulness training. The purpose of this study was to investigate if children who stutter stuttered less frequently, stuttered with less struggle, and demonstrated changes in mindfulness measures after the completion of this week-long intervention. Pre- to post-treatment measures were analyzed by individual and group-level results. A comparative analysis between reading and narrative tasks was also performed. Findings indicate that three out of five children reduced the total number of disfluencies during the reading task, and two children reduced this total during …

The Role Of Anxiety Sensitivity In The Relationship Between Posttraumatic Stress Symptoms And Negative Outcomes In Trauma-Exposed Adults, Brittany Belle Kugler

USF Tampa Graduate Theses and Dissertations

Background: The development of posttraumatic stress symptoms (PTS) following a traumatic event is related to significant functional impairment, diminished quality of life, and physical health issues. Yet it is not entirely clear why some traumatized individuals experience negative outcomes while others do not. The purpose of this study is to determine the role of several influential factors related to PTS severity and negative outcomes, such as diminished quality of life and physical health issues, following traumatic events. Method: One hundred and twenty-two trauma-exposed adults were recruited through the University of South Florida’s SONA system and through flyers on campus. Subjects …

The Relationship Between Nurses' Emotional Intelligence And Patient Outcomes, Mary Kutash

USF Tampa Graduate Theses and Dissertations

Heart Failure readmissions (HFR) significantly contribute to all cause hospital readmissions rates. Current evidence on the effectiveness of interventions for reduction of HFR is inconclusive. Recent research suggests that nurses’ emotional intelligence (EI) may be associated with better patient outcomes.

The purpose of this study was to examine if nurses’ EI is significantly related to HFR and if that relationship is mediated through patient satisfaction with care. One hundred and thirty six Registered Nurses were recruited from 11 in-patient units at a large teaching hospital in the south eastern United States. Two surveys were mailed to eligible participants; the Bar-On …

Schreibersite: Synthesis, Characterization And Corrosion And Possible Implications For Origin Of Life, Nikita Latesha La Cruz

USF Tampa Graduate Theses and Dissertations

We present study of the synthesis and reactions of an analog of the meteoritic mineral schreibersite with formula (Fe,Ni)3P, believed to be a prebiotic source of reactive phosphorus that may have prompted the formation of phosphorylated biomolecules near the time of the origin of life (Pasek and Lauretta, 2005). The mineral was synthesized by mixing stoichiometric proportions of elemental iron, nickel and phosphorus and heating in a tube furnace at 820°C for approximately 235 hours under argon or under vacuum, a modification of the method of Skála and Drábek (2002). The mineral was characterized using X-ray diffractometry (XRD), X-ray photoelectron …

Historical And Current Population Patterns Of The Staghorn Coral (_Acropora Cervicornis_) In Dry Tortugas National Park, Kaitlyn Lizza

USF Tampa Graduate Theses and Dissertations

Acropora cervicornis was once one of the dominant reef building corals of the Caribbean, Florida Keys, and Dry Tortugas (DRTO), but since the 1970’s populations have been decimated throughout their geographic range. Recently, a repopulation was documented through detailed benthic surveys conducted by the U.S. Geological Survey at three locations (Pulaski Shoal, East Key, and Loggerhead Key) within DRTO. Benthic surveys using the U.S Geological Survey’s Along-Track Reef Imaging System (ATRIS) revealed hundreds of previously undocumented colonies.

These discoveries have provided a unique data-set, allowing a comparison between the historical (1883, 1976) and contemporary distributions (2009, 2011) of A. cervicornis. …

The Meaning Of Stories Without Meaning: A Post-Holocaust Experiment, Tori Chambers Lockler

USF Tampa Graduate Theses and Dissertations

Dissonance exists in efforts to communicate about suffering and despair. Showcasing common societal flawed reactions to despair begs for discourse to create a more communicatively healthy response. Attempting to communicate the suffering of others and feeling like I was failing at that goal led to my own suffering. Using writing as a method of personal healing created an intersection of personal narratives of suffering and victim’s narratives (which can arguable only allow for the co-opting of the story and narcissism). Grappling with the limits of writing to heal provided a lens to see the victim’s narratives in such a way …

Effects Of Solids Retention Time And Feeding Frequency On Performance And Pathogen Fate In Semi-Continuous Mesophilic Anaerobic Digesters, Nathan Daniel Manser

USF Tampa Graduate Theses and Dissertations

Anaerobic digestion is a biochemical process in which organic carbon is biodegraded in an oxygen free environment through a microbial consortium. Engineered biological systems used for resource recovery often utilize anaerobic digestion to treat anthropogenic organic wastes by reclaiming the carbon as energy (methane gas) and a soil amendment (biosolids). Small-scale, or household, semi-continuous anaerobic digesters have been used in developed and developing countries for many decades to produce biogas from human and livestock waste, which is used for heating, lighting, and cooking. This application has been shown to improve the quality of life of the user. Although there is …

'She Shall Not Be Moved': Black Women's Spiritual Practice In Toni Morrison's The Bluest Eye, Beloved, Paradise, And Home, Rondrea Danielle Mathis

USF Tampa Graduate Theses and Dissertations

‘She Shall Not Be Moved’: Black Women’s Spiritual Practice in Toni Morrison’s The Bluest Eye, Beloved, Paradise, and Home argues that from The Bluest Eye, Morrison’s debut novel, to her 2012 novel, Home, Morrison brings her female characters to voice, autonomy, and personal divinity through unconventional spiritual work. The project addresses the history of Black women’s activist and spiritual work, Toni Morrison’s engagement with unconventional spiritual practice, and closes with a personal interrogation of the author’s connection to Black women’s spiritual practice.

Documenting Perceived Effectiveness Of Community-Based Health Promotion Coalitions: A Grounded Theory Approach, Alyssa Brooke Mayer

USF Tampa Graduate Theses and Dissertations

Introduction: Community coalitions with public health-related missions are formal, semi-permanent, action-oriented partnerships comprised of community members, representatives of government agencies, policymakers, and academic partners. Despite their potential to promote sustainable change, coalitions have had mixed success in effecting long-term improvements in community health. There is a need to assist them in developing strategies for improving and sustaining their functionality. The purpose of this study was to improve understanding of the elements of coalition success and sustainability that are vital to health-related community-based participatory research.

Methods: Although the literature describes coalition functions for effecting sustainable programs and policies, most research reports …

Effects Of A Brief Relaxation Intervention On Stress-Related Eating, Laura Lynn Mayhew-Purcell

USF Tampa Graduate Theses and Dissertations

The experience of stress may contribute to increased food consumption and selection of unhealthy food options. Resource depletion theory suggests stress temporarily depletes resources needed to regulate behavior. Depletions of self-control may result in subsequent failure to regulate eating behaviors, which is particularly salient in restrained eaters. Restraint theory posits people high in dietary restraint require significant effort to control eating. Emotional eating theory further suggests palatable foods may be used to regulate emotional stress reactions. Relaxation exercises to mitigate stress reactions are recommended in eating and weight management programs, but lack quality scientific support. The current study examined the …

Looking At Levels Of Medicalization In The Institutional Narrative Of Substance Use Disorders In The Military, Chase Landes Mccain

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to examine the institutional narrative of substance use disorders (SUDs) in the U.S. military and the extent to which it reflects the medicalization process. Three general research questions guided my analysis of the narrative surrounding SUDs in the military: (1) How does the military characterize the problems and resolutions of SUDs? (2) How and to what extent does this narrative reflect medicalization? (3) What are the limitations inherent in the institutional narrative of SUDs in the military? In order to address these questions, I draw on three conceptual lenses: (1) The work of Loseke …

Ecological Sanitation In Uganda: Promotion Through Demonstration Facilities And Potential For Ascaris Reduction By Free Ammonia Inactivation Using Stored Urine, John Thomas Trimmer

USF Tampa Graduate Theses and Dissertations

As Uganda works to transform itself into an industrialized, middle-income country in the coming decades, the country is faced with a number of problematic trends that could hinder this transition. High population growth and urbanization are quickly forcing small towns to deal with issues of limited space and the aesthetic conditions within sanitation systems, while declining soil fertility in surrounding rural areas calls into question the future nutritional security of the growing population. Ecological Sanitation (Eco-San) systems, which are designed to recover nutrients from human excreta, may help to address these trends.

Improved sanitation coverage in Uganda is currently estimated …

Efficacy And Resistance Potential Of Jpc-3210 In Plasmodium Falciparum, Siobhan Marie Flaherty

USF Tampa Graduate Theses and Dissertations

Combating drug resistant malaria has been historically challenging, and remains so today. Recent reports from Southeast Asia show that Plasmodium falciparum is developing resistance to even our best defenses; artemisinin-based therapies. This development threatens to become a significant challenge in controlling malaria infections worldwide, making research into developing and characterizing new antimalarial drugs increasingly important. The purpose of this study was to characterize the resistance potential of novel antimalarial compound JPC-3210 in vitro using P. falciparum clones. JPC-3210 is a new long acting drug with potential to be used in combination with fast-acting drugs like artemisinins to cure drug resistant …

Half Empty/Half Full: Absence, Ethnicity, And The Question Of Identity In The United States, Ashley Josephine Martinez

USF Tampa Graduate Theses and Dissertations

This study helps us understand the complexities of transnational abandonment, and transnational abandonment in the context of Saudi heritage in particular. Based on a textual analysis of narratives on a blog by individuals abandoned by their Saudi fathers, my findings suggest that they discursively construct their identity in three ways: a) by negotiating their illegitimate status as perceived by many Saudis, and the validity of their search; b) by making sense of the absence of father and the cultural knowledge of the paternal side, while negotiating the inevitable presence of the father in many other ways and their ethnic difference; …

The Characterization Of The Neuropathological Consequences Of Plac1 Ablation In A Mutant Mouse Model, Jacob Robert Bourgeois

USF Tampa Graduate Theses and Dissertations

Placenta-specific 1 (Plac1) is an X-linked gene that is essential for normal placental development. Previous studies have shown that Plac1 is also expressed in the fetal brain and paternally imprinted. Its expression in the fetal brain is markedly downregulated immediately after birth. Plac1 ablation predisposes Plac1-null males and X^m-X Hets (inactive maternal allele) to an increased risk of developing lethal postnatal hydrocephalus suggesting a functional role for Plac1 during embryonic development. The objective of this study was to characterize the effect of Plac1 on brain development and postnatal function. In order to address this, a …

2,4-Disubstituted Quinazolines With Antileishmanial Or Antibacterial Activity, Megan Marie Barber

USF Tampa Graduate Theses and Dissertations

Herein 47 2,4-disubstituted quinazolines were synthesized and tested against Leishmania donovani intracellular amastigotes. A structure-activity relationship was conducted and lead to the identification of quinazolines with EC50s in the single digit and high nanomolar range with favorable antileishmanial selectivity indexes. Quinazoline 2.6 and 2.31 underwent in vivo efficacy studies in murine models of visceral leishmaniasis, reducing liver parasitemia by 12 % and 24 %, respectively, when given by the intraperitoneal route at 15 mg/kg/day x 5 days. The antileishmanial efficacy and easy of synthesis make the 2,4-disubstituted quinazoline compound series a suitable platform for the future development of antileishmanial agents. …

Weakness Of Will: An Inquiry On Value, Michael Funke

USF Tampa Graduate Theses and Dissertations

One dominant scientific view holds that willpower is a type of muscle which can be weakened through use in the short term and strengthened through use over time. However, evidence from neuroscience, social psychology and behavioral economics suggest that willpower is regional, subverted through desire and strengthened by strategy--these are features a muscular account would not predict. It is better to think about willpower as a skill with a physiological component. Willpower strategies extend the brute effort of self-control through the use of reason and have the practical effect of increasing self-regulation. Willpower is "worth wanting" because there is a …

Associations Between Social Determinants Of Health And Adolescent Pregnancy: An Analysis Of Data From The National Longitudinal Study Of Adolescent To Adult Health, Sarah Britney Maness

USF Tampa Graduate Theses and Dissertations

This dissertation study utilized the National Longitudinal Study of Adolescent to Adult Health to analyze empirical relationships between social determinants of health and adolescent pregnancy. Although rates of adolescent pregnancy are at an all-time low in the United States, disparities persist. Examining relationships between the social determinants of health and adolescent pregnancy provides support for funding and interventions that expand on the current focus of individual and interpersonal level factors. Based on the Healthy People 2020 Social Determinants of Health Framework, proxy measures for social determinants of health were identified within the Add Health study and analyzed in relationship with …

Heidegger And The Problem Of Modern Moral Philosophy, Megan Emily Altman

USF Tampa Graduate Theses and Dissertations

The guiding question of this project is, "Why does it count as a critique of Heidegger that he does not defend a particular moral position?" A standard criticism levied against Heidegger is that, since he has nothing positive to say about post-Enlightenment moral theory, he has nothing to contribute to moral philosophy, and this marks his greatest shortcoming as a philosopher. Why is there a demand for Heidegger, or any other philosopher, to theorize about morality, when we do not have this expectation for, say, aesthetics, theology, or various other regional domains of human life? Why should we expect Heidegger …

Sexual Functioning And Body Image In Younger Breast Cancer Survivors, Carly Lynn Paterson

USF Tampa Graduate Theses and Dissertations

Younger breast cancer survivors often report problems related to sexuality following surgical and adjuvant treatment that often lead to sexual distress and body image distress. This research was conducted as an exploratory study within a larger R01 trial with the purpose to evaluate sexual distress and body image related-distress in younger women with breast cancer and to examine the extent to which the Mindfulness-Based Stress Reduction-Breast Cancer (MBSR(BC)) was efficacious in improving distress related to sexuality, i.e. sexual distress and body image related-distress. The aims of this study were to: 1) evaluate the efficacy of the MBSR(BC) program in improving …

Exploring The Role Of Intracellular Aminopeptidases In Staphylococcus Aureus Pathogenesis, Devon Nicole Marking

USF Tampa Graduate Theses and Dissertations

Staphylococcus aureus is a remarkably pathogenic bacterium that is widely prevalent among the human population. It is the leading agent of skin and soft tissue infections, and is also responsible for causing an array of severe and life threatening diseases. The invasiveness of the pathogen, coupled with increasing antibiotic resistance seen for S. aureus infections, makes this bacterium a prominent public health concern. The extended pathogenicity of S. aureus is largely due to its repertoire of virulence factors, which are typically characterized by being bound to the cell wall, or secreted into the extracellular environment. Previously, our lab identified a …

Endocrine-Disrupting Compounds: Measurement In Tampa Bay, Removal From Sewage And Development Of An Estrogen Receptor Model, Monica Mion Cook

USF Tampa Graduate Theses and Dissertations

The significance of endocrine-disrupting compounds (EDCs) in the environment has only recently come to the forefront of scientific research, policy debates, water utilities management and public awareness. EDCs have the ability to interfere with the normal functioning of the endocrine system of humans and other animals. Numerous chemicals are included in the class of compounds known as EDCs, and exposure is widespread. These compounds are found in a variety of environmental matrices (e.g., marine and freshwater systems, sediment, soil), transported there primarily through sewage effluent discharge and recycling of sewage sludge for topical fertilizer use. This transport to the environment …