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Investigations Into The Non-Mevalonate Isoprenoid Biosynthesis Pathway's First Two Enzymes Utilizing Hybrid Qm/Mm Techniques, Justin K. White

USF Tampa Graduate Theses and Dissertations

Molecular drug design begins with the identication of a problem to solve. This work identies the growing resistance among human pathogens to current treatments. Once the problem is identied and understood, solutions must be proposed. This one is straight forward, we need new antimicrobial drugs. More specically, we need to identify novel targets to inhibit. A large portion of antibiotics focus on disruption of macromolecular production while only a few target metabolic systems. Finally, you need to propose solutions based on the information gathered. In order to avoid existing resistance, it is important to avoid the macromolecular route and focus …

18f-Fdg Pet/Ctct-Based Radiomics For The Prediction Of Radiochemotherapy Treatment Outcomes Of Cervical Cancer, Badereldeen Abdulmajeed Altazi

USF Tampa Graduate Theses and Dissertations

Cervical cancer remains the third most commonly diagnosed gynecological malignancy in the United States and throughout the world despite being potentially preventable. Patients diagnosed with cervical cancer may develop local recurrence in the cervix and surrounding structures (vaginal apex, parametrial, or paracervical), regional recurrence in pelvic lymph nodes, distant metastasis, or a combination of all. The management of such treatment outcomes has not been subject to rigorous investigation. Therefore, there is a need for studies and clinical trials that focus on decision making to support the choice of the best treatment modality that leads to the minimal number of adverse …

Glomerular Hyperfiltration And Hypertension In Diabetes, Jie Zhang

USF Tampa Graduate Theses and Dissertations

In the present study, we investigated the pathophysiological mechanisms of the hemodynamic alteration in diabetes. Glomerular hyperfiltration occurs in the early stage of diabetes mellitus and has been recognized to promote the pathogenesis of diabetic nephropathy. We determine the role of TGF response and the vascular tone of Af-Art in diabetic hyperfiltration and we found that 1) tubular high glucose directly activates NOS1 and increases NO generation in the macula densa, which inhibits TGF response and increases GFR; 2) high glucose dilates renal Af-Art through GLUT1 and mediated by NOS3-derived NO generation; 3) in diabetes, blunted TGF mediated by NOS1 …

Bayesian Inference On Quantile Regression-Based Mixed-Effects Joint Models For Longitudinal-Survival Data From Aids Studies, Hanze Zhang

USF Tampa Graduate Theses and Dissertations

In HIV/AIDS studies, viral load (the number of copies of HIV-1 RNA) and CD4 cell counts are important biomarkers of the severity of viral infection, disease progression, and treatment evaluation. Recently, joint models, which have the capability on the bias reduction and estimates' efficiency improvement, have been developed to assess the longitudinal process, survival process, and the relationship between them simultaneously. However, the majority of the joint models are based on mean regression, which concentrates only on the mean effect of outcome variable conditional on certain covariates. In fact, in HIV/AIDS research, the mean effect may not always be of …

Full-Time Teleworkers Sensemaking Process For Informal Communication, Sheila A. Gobes-Ryan

USF Tampa Graduate Theses and Dissertations

Organizations have traditionally accomplished connectivity among their workers by co-locating them in shared organizational workplaces. However, information and communication technologies (ICTs) are offering alternative ways to accomplish this kind of connection. This change raises important questions about what it is possible to accomplish through such mediated communicative connections, and if there are work activities that are best accomplished face-to-face. Practitioners and researchers have historically identified informal communication as a process essential to organizational success that is difficult or impossible to accomplish outside of shared physical environments. This study documents the ways full-time teleworkers are accomplishing informal communication without being in …

Evaluation Of A Microsphere-Based Immunoassay (Mia) In Measuring Diagnostic And Prognostic Markers Of Dengue Virus Infection, Jason H. Ambrose

USF Tampa Graduate Theses and Dissertations

Infections with dengue viruses (DENV) constitute both a global problem as well as locally in Florida. DENV comprise four distinct serotypes of single-stranded RNA viruses and belong to the family Flaviviridae. DENV are among the most medically important arboviruses in the world and cases may currently exceed 400 million per annum. Additionally, dengue established its first recorded endemic transmission cycle in the state of Florida in over a half century, first within the Florida Keys during 2009-10 followed by an unrelated outbreak in Martin County in 2013. The clinical profile of DENV infections ranges from a mild febrile illness …

Second-Generation Bruja: Transforming Ancestral Shadows Into Spiritual Activism, Lorraine E. Monteagut

USF Tampa Graduate Theses and Dissertations

The aim of this dissertation is to develop and illustrate a spiritually centered narrative method for transforming disorder into agency and action. I use my own position as a second-generation Hispanic female immigrant to show how training in a spiritual practice that mirrors my ancestral traditions helped me productively move through a sense of displacement, illness, and lack of purpose. My research includes travel to Havana, Cuba, and immersion in a five-week shamanic counseling training program in Tampa, Florida, during which I learned how to narrate my experiences as I engaged in shamanic journeying. As I reflect on these …

A Historical Assessment Of Asbestos Exposure, Abatement Methods And Containment Efficacy During Asbestos Containing Material Removal Activities At A Large Federal Facility, Daniel A. Newfang

USF Tampa Graduate Theses and Dissertations

Asbestos sampling and monitoring data, starting from 2003, located in a large federal facility’s Asbestos Air Database Management (AADM) repository will be queried and analyzed on airborne asbestos fiber concentrations generated from abatement activities of asbestos-containing materials (ACM) and asbestos-containing building materials (ACBM). Historically, concerns expressed by personnel outside of the containment areas, whether adjacent to or quite a distance from the asbestos abatement activities present operational challenges for the project manager, potential angst and uneasiness to personnel residing next to the abatement activity as well as programmatic concerns to the building/facility managers. The concerned individuals working outside the abatement …

Design, Synthesis, Applications Of Polymers And Dendrimers, Alekhya Nimmagadda

USF Tampa Graduate Theses and Dissertations

WHO has reported that antibiotic resistance is the third major cause of human death all over the globe. Recent study, has focused on the development of new antibacterial resistance drugs. Herein, we tried to synthesis a series of polymers that can mimic the HDPs. HDPs can target the bacterial cell membrane and they have less chances to develop bacterial resistance. We synthesized the amphiphilic polycarbonates that are highly selective to Gram-positive bacteria, including multidrug resistant pathogens. The membrane disruption activity of these polymers was proved by fluorescence and TEM studies and the drug resistance study showed that the polymers don’t …

Ambient Ozone And Cadmium As Risk Factors For Congenital Diaphragmatic Hernia, Rema Ramakrishnan

USF Tampa Graduate Theses and Dissertations

Congenital diaphragmatic hernia (CDH) results from a defect in the diaphragm through which abdominal contents enter the thorax displacing the heart and the lungs. This causes lung hypoplasia and varying degrees of pulmonary hypertension resulting in high rates of morbidity and mortality. Though CDH has a prevalence rate of 2.61 per 10,000 live births it is an expensive birth defect with an estimated annual cost of nearly $250 million for all CDH survivors. Maternal exposure to air pollutants have not been studied as risk factors for CDH in humans. Ambient ozone has been found to be risk factors for certain …

Contributions Of Appetitive And Aversive Motivational Systems To Decision-Making, Heather E. Soder

USF Tampa Graduate Theses and Dissertations

Optimal decision-making entails outcome evaluation, comparing received costs and benefits with predicted costs and benefits. The anterior cingulate cortex (ACC), a brain area with major connections to the appetitive and aversive motivation systems, may provide the neural substrate of this evaluation process. One way to measure the relative contribution of these systems on decision-making is to measure individual differences in risk-taking behaviors. For individuals who make risky choices, this evaluation step may be biased: some show a preference for immediate, short-term rewards (increased appetitive system), while devaluing the long-term consequences of their choices (decreased aversive system). However, most studies supporting …

Design And Synthesis Of Cpg-Lytic Peptide Conjugate, Brachytherapy Beads And A Combinatorial Library Of Primary Amines Used As Potential Therapeutics In The Treatment Of Cancers, Josanne-Dee Woodroffe

USF Tampa Graduate Theses and Dissertations

Cancer remains one of the most feared diseases affecting the modern world. Second to heart disease, it is the largest cause of deaths, affecting one in three persons. Cancer cells are formed when normal, healthy cells become damage, losing their normal regulatory mechanism that control cell growth. There are many different types and progression of these cancer cells that determine the type of treatment a patient receives. The primary focus of this dissertation is to propose three studies of anticancer agents. In Chapter one, a CpG-lytic peptide conjugate was designed to target receptors on the cell membrane to concentrate the …

Physical Layer Algorithms For Reliability And Spectral Efficiency In Wireless Communications, Zekeriyya Esat Ankarali

USF Tampa Graduate Theses and Dissertations

Support of many different services, approximately 1000x increase of current data rates, ultra-reliability, low latency and energy/cost efficiency are among the demands from upcoming 5G standard. In order to meet them, researchers investigate various potential technologies involving different network layers and discuss their trade-offs for possible 5G scenarios. Waveform design is a critical part of these efforts and various alternatives have been heavily discussed over the last few years. Besides that, wireless technology is expected to be deployed in many critical applications including the ones involving with daily life activities, health-care and vehicular traffic. Therefore, security of wireless systems is …

The Time To Love: Ideologies Of "Good" Parenting At A Family Service Organization In The Southeastern United States, Anna Davidson Abella

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to understand definitions of what it means to be a “good” parent as described by parents and child development specialists at a family service organization in the Southeastern United States. Previous research on social reproduction and concerted cultivation have opened up pathways to understanding how social and economic inequality manifest in family life and the social structures of which they are a part. This ethnographic study is an effort to contribute to an anthropology of parenting by unveiling the ways that definitions of “good” parenting in middle-class and wealthy communities reflect time-intensive, attachment-based ideologies …

The Time To Love: Ideologies Of "Good" Parenting At A Family Service Organization In The Southeastern United States, Anna Davidson Abella

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to understand definitions of what it means to be a “good” parent as described by parents and child development specialists at a family service organization in the Southeastern United States. Previous research on social reproduction and concerted cultivation have opened up pathways to understanding how social and economic inequality manifest in family life and the social structures of which they are a part. This ethnographic study is an effort to contribute to an anthropology of parenting by unveiling the ways that definitions of “good” parenting in middle-class and wealthy communities reflect time-intensive, attachment-based ideologies …

Neural And Behavioral Mechanisms Of Clear Speech, Jenna Silver Luque

USF Tampa Graduate Theses and Dissertations

Clear speech is a speaking style that has been shown to improve intelligibility in adverse listening conditions, for various listener and talker populations. Clear-speech phonetic enhancements include a slowed speech rate, expanded vowel space, and expanded pitch range. Although clear-speech phonetic enhancements have been demonstrated across a variety of talkers, only a subset of these changes may be required for listeners to benefit perceptually from clear speech. Furthermore, while current literature has provided some understanding of the phonetic enhancements that are typical of clear speech and the improvements in intelligibility resulting from its use, less is understood regarding how listeners …

Collaboration With Families: Perceptions Of Special Education Preservice Teachers And Teacher Preparation, Mehmet Emin Ozturk

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to explore the integration of family involvement in the courses and field experiences in an undergraduate special education program. This study also explored preservice teachers’ perceptions about what they learned in their program and the perceptions, and understandings of pre-service teachers regarding collaboration with families based on their past experiences with their families. This study used qualitative research methods to answer questions about perceptions of pre-service teachers’ perceptions of collaborating with families and the extent to which their perceptions are influenced by their own family backgrounds as well as their perceptions about what they …

Sol-Gel Niobia-Based Sorbents For The Enrichment Of Organophosphorus Compounds By Capillary Microextraction Online Coupled To High Performance Liquid Chromatography, Sheshanka Kesani

USF Tampa Graduate Theses and Dissertations

Sample preparation is a key step in chemical analysis, and includes isolation of target analytes, removal of interferences, preconcentration, and/or modification of target analytes (if needed). Sample preparation is also the most time-consuming and error-prone step in the whole analytical process. Traditional sample preparation techniques involve hazardous solvents. Considering the environmental and health safety, it is desirable to reduce or eliminate organic solvents in sample preparation. Solid phase microextraction (SPME) was introduced as a solvent free sample preparation technique. Capillary microextraction (CME) is one of the formats of SPME that can be easily coupled to high performance liquid chromatography (HPLC). …

Manipulating Electromagnetic Waves With Enhanced Functionalities Using Nonlinear And Chiral Metamaterials, Sinhara Rishi Malinda Silva

USF Tampa Graduate Theses and Dissertations

Metamaterials are artificial structures, which periodically arranged to exhibit fascinating electromagnetic properties, not existing in nature. A great deal of research in the field of metamaterial was conducted in a linear regime, where the electromagnetic responses are independent of the external electric or magnetic fields. Unfortunately, in linear regime the desired properties of metamaterials have only been achieved within a narrow bandwidth, around a fixed frequency. Therefore, nonlinearity is introduced into metamaterials by merging meta-atoms with well-known nonlinear materials. Nonlinear metamaterials are exploited in this dissertation to introduce and develop applications in microwave frequency with broadband responses. The nonlinearity was …

Application Of Metamaterials To Rf Energy Harvesting And Infrared Photodetection, Clayton M. Fowler

USF Tampa Graduate Theses and Dissertations

Techniques for adapting metamaterials for the improvement of RF energy harvesting and infrared photodetection are demonstrated using experimental and computer simulation methods. Two methods for RF energy harvesting are experimentally demonstrated and supported by computer simulation. In the first method, a metamaterial perfect absorber (MPA) is made into a rectenna capable of harvesting RF energy and delivering power to a load by soldering Schottky diodes onto connected split ring resonator (SRR) structures composing the planar metasurface of the perfect absorber. The metamaterial rectenna is accompanied by a ground plane placed parallel to it, which forms a Fabry-Perot cavity between the …

Development Mems Acoustic Emission Sensors, Adrian Enrique Avila Gomez

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to develop MEMS based acoustic emission sensors for structural health monitoring. Acoustic emission (AE) is a well-established nondestructive testing technique that is typically used to monitor for fatigue cracks in structures, leaks in pressurized systems, damages in composite materials or impacts. This technology can offer a precise evaluation of structural conditions and allow identification of imminent failures or minor failures that can be addressed by planned maintenances routines. AE causes a burst of ultrasonic energy that is measured as high frequency surface vibrations (30 kHz to 1 MHz) generated by transient elastic waves that …

Rf Sensing System For Continuous Blood Glucose Monitoring, Fabiola Araujo Cespedes

USF Tampa Graduate Theses and Dissertations

The purpose of this research was to design a blood glucose sensing system based on the induced shift in the resonant frequency of an antenna patch operating in the ISM band (5.725 – 5.875 GHz). The underlying concept is the fact that when a person has variations in their blood glucose levels, the permittivity of their blood varies accordingly. This research analyzed the feasibility of using an antenna patch as a blood glucose sensing device in three configurations: 1) as an implantable active sensor, 2) as an implantable passive antenna sensor, and 3) as a non-invasive sensor. In the first …

Statistical Analysis And Modeling Of Stomach Cancer Data, Chao Gao

USF Tampa Graduate Theses and Dissertations

The objective of this study is to address some important questions associated with stomach cancer patients using the data from the Surveillance Epidemiology and End Results (SEER) program of the United States. To better understand the behavior of stomach cancer, we first perform parametric analysis for each patient group (white male, white female, African American male, African American female, other male and female) to identify the probability distribution function which can best characterize the behavior of the malignant stomach tumor sizes. We evaluate the effects of patients’ age, gender and race on the malignant stomach tumor sizes by developing quantile …

The Relationship Between Total Neuropathy Score-Reduced, Neuropathy Symptoms And Function., Ashraf Abulhaija

USF Tampa Graduate Theses and Dissertations

Chemotherapy Induced Peripheral Neuropathy (CIPN) is a common problem among cancer patients who receive a wide range of chemotherapy. This problem causes a decline in quality of life and increased disabilities. CIPN assessment instruments are either subjective, objective, or a combination of both. So far, there is no agreement on the best way for assessment. The goal of this study was to explore the relationships among subjective and objective CIPN assessment instruments. Specifically, this study aimed to 1) evaluate the relationship between the Total Neuropathy Score-reduced (mainly objective) and patients’ function, as measured by the interference scale of the Chemotherapy-Induced …

The Suffering South: 1878 Yellow Fever Narratives And Post-Reconstruction Southern Identity, Jessica Wells

USF Tampa Graduate Theses and Dissertations

The Suffering South offers a cultural history of a yellow fever epidemic that swept through the Mississippi Valley in 1878. It argues that the yellow fever narratives created during this epidemic constituted a discursive attempt by Southerners to renegotiate Southern identity and social hierarchy following the Civil War and Reconstruction. White Southerners, in particular, used the epidemic as an occasion to foster a return to a more traditional foundation of white supremacy and patriarchy as the basis for Southern identity and belonging. The narratives written by these Southerners, in which they described their experiences with yellow fever and the effects …

Education And Health Impacts Of An Affirmative Action Policy On Minorities In India, Robin Dhakal

USF Tampa Graduate Theses and Dissertations

Article 334 of the Constitution of India (1950) stipulates that certain electoral districts in each state should be reserved for minority groups, namely the “Scheduled Caste”(SC) and the Scheduled Tribe”(ST), through the reservation of seats in the states' legislative assemblies. Even though the original article stated that the reservation policy would be in place for just twenty years, it has been amended several times and is still in effect. This dissertation examines the impact of the policy on the education and health outcomes of the SC population. Variations in seat quotas are generated by the timing of elections in different …

Hidden: A Case Study On Human Trafficking In Costa Rica, Timothy Adam Golob

USF Tampa Graduate Theses and Dissertations

This is a case study on human trafficking that was conducted on the small Central American country of Costa Rica via a mixed-methods approach which included document review, surveys, and interviews. It was selected due to Costa Rica’s history of fluctuation between Tier 2 and Tier 2 Watch List status on the Trafficking in Persons Report, issued by the U.S. Department of State, over the last ten years. This ranking average indicates that it is one of the worst performing Central American states in efforts to combat trafficking in persons. This finding breaks with Costa Rica’s traditional placement as one …

An Exploration Of First-Year Students’ Engagement In A Postsecondary Common Reading Program, Kali L. Morgan

USF Tampa Graduate Theses and Dissertations

This study used the narrative engagement framework from the communication discipline to explore first-year college students’ engagement in common reading program events and activities, engagement with the text’s narrative, and students’ affirmation of attitudes espoused in the text’s narrative. A total of 325 first-year students enrolled at Texas State University responded to a web-based survey of about their experiences with the 2016-2017 Common Reading Program book, What It Is Like to Go To War (Marlantes, 2011). The book, a memoir of Marlantes’ experiences as a Marine Lieutenant during the Vietnam War, features scholarly reflections on the nature of war and …

Multi-Step Tokenization Of Automated Clearing House Payment Transactions, Privin Alexander

USF Tampa Graduate Theses and Dissertations

Since its beginnings in 1974, the Automated Clearing House (ACH) network has grown into one of the largest, safest, and most efficient payment systems in the world. An ACH transaction is an electronic funds transfer between bank accounts using a batch processing system.

Currently, the ACH Network moves almost $43 trillion and 25 billion electronic financial transactions each year. With the increasing movement toward an electronic, interconnected and mobile infrastructure, it is critical that electronic payments work safely and efficiently for all users. ACH transactions carry sensitive data, such as a consumer's name, account number, tax identification number, account holder …

Adverse Childhood Experiences And Its Association With Cognitive Impairment In Non- Patient Older Population, Mohini D. Dutt

USF Tampa Graduate Theses and Dissertations

This study explores cognitive impairment and its correlation to early- life adverse experiences in non-patient population between the ages of 50 to 65. This developmental approach and observational study design explores cognition in pre-clinical Alzheimer’s disease (AD). Using a standardized neuropsychological instrument, the Montreal Cognitive Assessment (MoCA) and clinically administered questionnaire, the ACE (Adverse Childhood Experiences), I hypothesized that participants with high ACE scores will inversely have low MoCA scores.

My goal was to use a multiple linear regression model with 3 covariates and 1 predictor of interest (ACEs). At 80% power, a sample size of 40 was calculated as …