Digital Commons Network^™

Perceptions Of Quality Of Life, Peer Relationships, And Health Literacy In Adolescents With Phenylketonuria (Pku), Katherine L. Wesley

USF Tampa Graduate Theses and Dissertations

Phenylketonuria (PKU) is a rare inborn error of metabolism that can be managed through lifelong treatment adherence to a restricted diet and supplemental medical formula (Vockley et al., 2014). Untreated PKU can result in severe intellectual disability, anxiety, depression, executive functioning deficits, and seizures (Cappelletti et al., 2013; Moyle et al., 2007). Even individuals who are continuously treated for PKU can experience high rates of anxiety and depression, executive functioning deficits, social difficulties, and lower full-scale IQ scores than their siblings and parents (Bosch et al., 2015; Manti et al., 2016; Waisbren et al., 2007). Additionally, adolescents are at risk …

Statistical Analysis And Modeling Of Cyber Security And Health Sciences, Nawa Raj Pokhrel

USF Tampa Graduate Theses and Dissertations

Being in the era of information technology, importance and applicability of analytical statistical model an interdisciplinary setting in the modern statistics have increased significantly. Conceptually understanding the vulnerabilities in statistical perspective helps to develop the set of modern statistical models and bridges the gap between cybersecurity and abstract statistical /mathematical knowledge. In this dissertation, our primary goal is to develop series of the strong statistical model in software vulnerability in conjunction with Common Vulnerability Scoring System (CVSS) framework. In nutshell, the overall research lies at the intersection of statistical modeling, cybersecurity, and data mining. Furthermore, we generalize the model of …

An Evaluation Of Pit Latrines And User Perception Of Excrement In Ngäbe Communities In Panama, James A. Libby

USF Tampa Graduate Theses and Dissertations

At the end of the Millennium Development Goal (MDG) period in 2015, 2.3 billion people, 31% of the global population, still did not have access to even basic sanitation services. Of these people, 892 million still practice open defecation, and 856 million people use unimproved facilities such as pit latrines without a slab or platform or hanging latrines or bucket latrines (JMP 2017). Sustainable Development Goal (SDG) Target 6.2 now aims to achieve adequate and equitable sanitation and hygiene for all and sets the ambitious target of eradicating open defecation by 2030. While the number of people open defecating was …

A Latent Profile Analysis Of Benefactor And Beneficiary Organizational Citizenship Behaviors Toward Individuals, Seulki Jang

USF Tampa Graduate Theses and Dissertations

Although organizational citizenship behaviors toward individuals (OCB-I) have been studied over decades, the beneficiary side of OCB-I has been understudied. The co-existing and interactive possibility of benefactor OCB-I and beneficiary OCB-I within individuals has been ignored. Therefore, this research adopted a person-centered approach and examined different profiles of benefactor OCB-I and beneficiary OCB-I on the basis of Grant’s (2013) theory. Results from Study 1 data (cross-sectional data) and Study 2 data (multiple waves of data) revealed the three profile groups: vigorous (high benefactor OCB-I and high beneficiary OCB-I), moderate (moderate benefactor OCB-I and moderate beneficiary OCB-I), and passive OCB-I groups …

A Behavioral Analysis Of Households Using Reclaimed Water In Irrigation: Case Of Pinellas County, Florida, Natalie Kuraya-Ziyadeh

USF Tampa Graduate Theses and Dissertations

In order to tend to the world’s dwindling freshwater supplies, sustainable alternative methods need to be integrated in order to keep up with the world’s increasing demand. Reclaimed water (RW) is one of the sustainable methods adopted by some Floridian cities such as Tampa, Tallahassee, and St. Pete that provide an alternative water source for non-potable uses. However, despite this alleviating effect RW has on freshwater supplies, it is crucial to recognize the potential harm it poses on neighboring waterbodies due to the residual contaminants it still contains, including Nitrogen (N) and Phosphorous (P). As such, studying residents’ knowledge and …

Do All “Good Mothers” Breastfeed? How African American Mothers’ Values And Experiences Of Early Motherhood Influence Their Infant Feeding Choices, Airia S. Papadopoulos

USF Tampa Graduate Theses and Dissertations

The food an infant is fed can reflect many things: a source of nutrition, the social and cultural circumstances into which an infant is born, or even a family’s beliefs about the body and breast milk as a source of nutrition. Exclusive breastfeeding, currently the gold standard for infant feeding in the United States (US), is often identified as an expectation in discourses on being a “good mother.” African American mothers in particular are the least likely group in the US to breastfeed in any capacity and many efforts are underway to increase the breastfeeding rates of this population.

This …

Egos Gone Wild: Threat Detection And The Domains Indicative Of Toxic Leadership, Matthew S. Arbogast

USF Tampa Graduate Theses and Dissertations

Toxic leaders are a serious problem, but shockingly, there is no standard detection tool that is both efficient and accurate. Compounding the problem are the various definitions and descriptions used to operationalize toxic leadership. This research sought to align the literature, offer a concise definition, and assess the domains indicative of toxic leadership through two conceptually compatible studies. Study 1 involved development of a toxic leader threat detection scale. Results using a variable-centered approach indicated that follower perceptions (n = 357) of leader empathy (4-item scale; α = .93) and the need for achievement recognition (4-item scale; α = .83) …

Rumination And Worry: Factor Structure And Predictive Utility, Andrew Mark Kiselica

USF Tampa Graduate Theses and Dissertations

Criticism of discrete classification systems for mental disorders has led to a focus on identification of mechanisms that cut across symptom clusters, known as transdiagnostic factors. One such proposed factor is negative repetitive thought (NRT), or a perseverative, often uncontrollable, focus on negative information, experiences, or expectations. Worry and rumination are two major constructs thought to compose NRT. No confirmatory factor analyses have investigated whether worry and rumination might compose a general NRT factor, discrete factors, or some combination of the two. The first purpose of the current study was to use confirmatory factor analyses to uncover whether worry and …

Physical And Social Systems Resilience Assessment And Optimization, Daniel Romero Rodriguez

USF Tampa Graduate Theses and Dissertations

Resilience has been measured using qualitative and quantitative metrics in engineering,economics, psychology, business, ecology, among others. This dissertation proposes a resilience metric that explicitly incorporates the intensity of the disruptive event to provide a more accurate estimation of system resilience. A comparative analysis between the proposed metric and average performance resilience metrics for linear and nonlinear loss and recovery functions suggests that the new metric enables a more objective assessment of resilience for disruptions with different intensities. Moreover, the proposed metric is independent of a control time parameter. This provides a more consistent resilience estimation for a given system and …

Occupational Noise Exposure Evaluation Of Airline Ramp Workers, Adekunle Ogunyemi

USF Tampa Graduate Theses and Dissertations

Noise exposure is a common hazard to workforce in general although at varying degrees depending on the occupation, as many workers are exposed for long periods of time to potentially hazardous noise.

Every year, twenty-two million workers are exposed to potentially damaging noise at work. In 2015 U.S. businesses paid over $1.5 million in penalties for not protecting workers from noise. (OSHA, 2016). There may be a direct or indirect consequence of the possibilities of overexposure to noise notwithstanding the compulsory hearing protection requests for the occupations with potential hazards, and these exposures usually arise from the various types of …

Studies Aimed At The Synthesis Of Anti-Infective Agents, Ankush Kanwar

USF Tampa Graduate Theses and Dissertations

Infectious diseases continue to be a major concern worldwide. They are the second leading cause of death after heart disease. Factors such as an increasing global population, travel, urbanization, global climate change and evolution of pathogens have made infectious diseases more common. Infectious diseases, particularly neglected tropical diseases (NTDs) result in many deaths worldwide. Malaria and leishmaniasis are two common (NTDs) which affect low income countries around the globe. Low cost drugs with novel mechanism of action are required to tackle the growing resistances of parasites against current drugs used in the developing world, where most of the cases occur. …

Identification Of Novel Hits Against, Ala A. Azhari

USF Tampa Graduate Theses and Dissertations

Leishmaniasis is a disease caused by obligate intracellular parasites of the genus Leishmania, including 20 species that are pathogenic to humans. Female sand fly is the known vector that can transmit the disease. Visceral leishmaniasis is the severe form of the disease that affects internal organs and can be fatal with inappropriate diagnosis or treatment. Leishmania donovani is the causative agent of visceral leishmaniasis. Approximately 350 million in 89 countries are at risk of infection. Around 2 million new cases are reported annually with 500,000 of these are visceral leishmaniasis. Current drug therapies are inadequate due to their toxicity, high …

The Association Of Size Variation In The Dental Arch To Third Molar Agenesis For A Modern Population, Devin N. Williams

USF Tampa Graduate Theses and Dissertations

The frequency with which individuals do not develop their third molars, or wisdom teeth, is increasing worldwide. This current topic of human evolution is relevant to the research of anthropologists, geneticists, dentists, and other researchers involved in the study of human dentition. Many explanations have been offered to account for the prevalence of molar agenesis including, evolutionary, environmental, and genetic theories. The purpose of this research project is to determine the frequency of third molar agenesis and investigate the relationship between third molar agenesis and maxillomandibular jaw dimensions in a sample of orthodontic patients. This research tests the hypotheses that: …

Initial Beam Access Schemes For Millimeter Wave Cellular Networks, Mohammed Jasim

USF Tampa Graduate Theses and Dissertations

Millimeter wave technologies present an appealing solution for increasing data throughputs as they provide abundant contiguous channel bandwidths as compared to conventional microwave networks. However, millimeter wave technologies suffer from severe propagation limitations and channel impairments such as atmospheric attenuation and absorption, path and penetration losses, and blockage sensitivity. Therefore, phased arrays and beamforming technologies are necessary to compensate for the degraded signal levels due to the aforementioned factors. Namely, base stations and mobile stations utilize directional transmission in the control- and data- plane for an enhanced channel capacity, which results in initial access challenges due to the absence of …

Targeting The Hsp90/Aha1 Complex For The Treatment Of Tauopathies, Lindsey Brooke Shelton

USF Tampa Graduate Theses and Dissertations

The microtubule associated protein, tau, is involved in regulating microtubule stability and axonal transport. When tau becomes hyperphosphorylated it can disassociate from the microtubules and start to aggregate. These tau aggregates are the hallmarks of many diseases known as tauopathies. The heat shock protein 90 kDa (Hsp90) chaperone network is highly involved in modulating client proteins, including tau. However, during aging and disease the Hsp90 chaperone network becomes highly imbalanced with some Hsp90/co-chaperone complexes increasing, while others are repressed. This imbalance in Hsp90/co-chaperone complexes could result in a worsening of tau pathology in Alzheimer’s disease.

Hsp90 inhibition has been of …

A Cultural Adaptation Of Functional Communication Training, Anna Rosio Garcia

USF Tampa Graduate Theses and Dissertations

Disparities in the use, quality, and outcomes of treatments, and the barriers that deter Hispanics from receiving healthcare services have been widely studied. Yet, similar efforts have been slow in the field of Applied Behavior Analysis (ABA). A way to decrease treatment disparities is to assess the influence of cultural variables in behavior analytic interventions, and to evaluate whether manipulations to these variables improve the overall results of the interventions among Hispanic families. During this study, we adapted functional communication training (FCT) to Hispanic parent’s cultural values, we assessed the preference for culturally adapted and non-culturally adapted functional communication responses …

Integration And Cross-Coupling Of A Notched-Turbine Symbiotic Power Source For Implantable Medical Devices, Samuel Perez

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to design and integrate a symbiotic notched-turbine energy generator for implantation as a cross-coupled system capable of continuously and perpetually powering an electronic implantable medical device (IMD), which is a device designed to operate inside the body of a higher mammal to enhance, correct or provide the body with a function that has deviated from the norm or has stopped altogether. The list of IMDs available for implantation keeps growing every year, one of the newest being the VBLOC, produced by EnteroMedics®, and approved by the Food and Drug Administration (FDA) on January 15th, …

Tgf-Β2 In Human Milk Research: Exploration Of A New Field Methodology And New Findings Of Biosimilar Tgf-Β2 In Non-Human Milk, Chlöe A. Sweetman

USF Tampa Graduate Theses and Dissertations

Objectives: There are three aims for this thesis: the first is to develop a field and laboratory protocol for the storage and analysis of transforming growth factor–beta 2 (TGF-β2) in human breastmilk; second, to validate this protocol and the immunoassay used to assess this new method; and lastly, to explore the ramifications of biosimilar TGF-β2 across multiple milks on human health, growth, and immunity through the review of laboratory findings and previous literature.

Rational: Little anthropological research has been done on TGF-β2 in human milk. Anthropology as a discipline is well positioned to provide insight into TGF-β2, combining biocultural, evolutionary, …

Monetary Reinforcement For Increasing Walking In Adults With Intellectual Disabilities, Diego Valbuena

USF Tampa Graduate Theses and Dissertations

Physical inactivity is a widespread problem associated with numerous health problems. Individuals with intellectual disabilities are at a high risk of living a sedentary lifestyle. Although a few studies have examined interventions consisting of goal-setting and reinforcement for increasing PA, no studies have evaluated the use of monetary reinforcement. Interventions using monetary reinforcement have been shown to be effective for increasing PA with typically developing adults. The present studies evaluated monetary reinforcement for increasing PA in adults with intellectual disabilities. Study 1 evaluate a session-based intervention where participants earned monetary rewards for attaining step count goals as recorded by pedometers. …

Seeing Trauma: The Known And The Hidden In Nineteenth-Century Literature, Alisa M. Deborde

USF Tampa Graduate Theses and Dissertations

Trauma as an official diagnosis first entered the DSM in 1980 and literary theorists began employing the term to discuss literature not too long after. Since the 1990s, theorists have largely focused on twentieth-century trauma literature with Holocaust and Modernist texts garnering much of the critical interest. Yet, Victorian life was also marked by trauma-causing events. From railway catastrophes, to industrial accidents, to premature deaths, and infectious diseases, Victorians reckoned with wounds to the mind through their lived experience. Trauma scholars who do work with nineteenth-century texts, with few exceptions, consider trauma in terms of its modern theories. While the …

Novel Magneto-Lc Resonance Sensors For Industrial And Bioengineering Applications, Ongard Thiabgoh

USF Tampa Graduate Theses and Dissertations

The scientific studies associated with material engineering and device miniaturization are the core concepts for future technology innovation. The exploring and tailoring of material properties of amorphous magnetic microwires, recently, have revealed remarkable high sensitive magnetic field sensitivity down to the picoTesla regime at room temperature. This superior magnetometer is highly promising for active sensing and real-time monitoring building block for modern industrial devices and healthcare applications.

The low-field, high sensitivity regime of the GMI response over a wide frequency range (1 MHz - 1 GHz) in the Co-rich melt-extracted microwires was optimized through novel Joule annealing methods (single- and …

From Florida To Antarctica: Dereplication Strategies And Chemical Investigations Of Marine Organisms, Matthew A. Knestrick

USF Tampa Graduate Theses and Dissertations

In the fight against disease and illness, nature has provided mankind some of our best therapeutics in the form of secondary metabolites. The plant, fungi and animal phyla inhabiting the Earth produce diverse and unique chemistry that can be used in our fight against disease. In the growing threat of drug resistance and pathogen evolution, the field of natural products chemistry strives to explore new biological and chemical diversity sources, and develop innovative methodology to identify and isolate new chemistry faster than ever.

The dissertation herein presented is one such effort to find new, bioactive chemistry from the marine environments. …

Beyoncé As A Semiotic Resource: Visual And Linguistic Meaning Making And Gender In Twitter, Tumblr, And Pinterest, Addie L. Sayers China

USF Tampa Graduate Theses and Dissertations

At the intersection of digital identities and new language and social practice online is the concept of searchable talk (ST). ST describes the process of tagging discourse in a social networking service (SNS) with a hashtag (#), allowing it to be searchable by others. Although originating in Twitter, ST has expanded into other SNS, and is used therein not only to mark language-based posts, but also multimodal posts and images. While scholars have elucidated the structure and function of ST, their studies have primarily examined ST within language-based posts; few have researched ST with respect to images and other types …

An Examination Of Underlying Causes For Differences In Affect-Rich And Affect-Poor Choice, Elizabeth M. Fuller

USF Tampa Graduate Theses and Dissertations

Real life decision-making frequently involves some level of affect, and research has demonstrated that individuals decide differently when outcomes are more or less rich with feeling. This difference in choice has previously been attributed to probability insensitivity in the presence of affect. In a series of three studies, we explored this possibility, while also testing alternative explanations, namely, that differences exist because of outcome characteristics such as comparability or precision. Individuals made choices between affect-rich side effects and affect-poor monetary lotteries in either a strictly numeric format, or with the addition of an icon array. Across the three studies we …

Characterization Of Scanning Mobility Particle Sizers For Use With Nanoaerosols, Michael R. Henderson

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to evaluate the performance of scanning mobility particle sizers in the characterization of nanoaerosols. A sampling chamber was constructed from aluminum and tempered glass, had a volume of 4.6 cubic feet, and was designed for the introduction of aerosols and dilution air, maintenance of aerosol concentration, and continuous exhaust of chamber air. Penetration and aerosol distribution tests were conducted within the chamber. An aerosol generation and measurement system comprised of nitrogen gas, BGI 3 jet Collison Nebulizer, diffusion dryer, aerosol charge neutralizer, mixing chamber, critical orifice, hygrometer, condensation particle counter, scanning mobility particle sizer, …

Investigation Of Alcohol-Induced Changes In Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics, Crystina Leah Kriss

USF Tampa Graduate Theses and Dissertations

Alcohol liver disease (ALD) is a major health concern throughout the world. Currently, in the United States, 17 million people suffer from alcoholism, of which 1.4 million people are receiving treatment [1, 2]. The link between ethanol metabolism, reactive oxygen species (ROS) and liver injury in ALD has been well characterized over the last couple decades [3-10]. Ethanol metabolism relies on the availability of the cofactor NAD+ for the oxidation of ethanol into acetate, consequently causing alterations in redox potential. Redox dysfunction within the mitochondria can affect multiple pathways important in maintaining cellular homeostasis. Chapter 1 provides an introduction to …

The Role Of Phosphohistidine Phosphatase 1 In Ethanol-Induced Liver Injury, Daniel Richard Martin

USF Tampa Graduate Theses and Dissertations

Chronic liver diseases, which includes alcoholic liver disease (ALD), are consistently among the top 15 leading causes of death in the United States. ALD is characterized by progression from a normal liver to fatty liver disease (hepatic steatosis), which can lead to cirrhosis, alcoholic hepatitis, and liver failure. We have identified a novel role of phosphohistidine signaling, mediated through phosphohistidine phosphatase 1 (PHPT1), in the onset of hepatic steatosis. We have identified PHPT1 as a target of selective oxidation following acute ethanol exposure as well as being downregulated following chronic ethanol exposure. We mapped the oxidative modification site and developed …

Parent Perceptions Of Family Quality Of Life Raising A Child With Autism Spectrum Disorder In The Bahamas, Sharlene Monique Smith

USF Tampa Graduate Theses and Dissertations

Numerous research showed having a child with autism spectrum disorder (ASD) can affect families in many ways (Brace, 2009; DeGrace, 2004; Fantaroni, 2012). The primary types of impact include family relationship (spousal and sibling relationships), finances, and access to resources and services to assist with caring for the social, emotional and academic development of a child with autism (Grindle & Remington, 2014; Harper et al., 2013; Koydemir & Tosun, 2009; Ludlow, Skelly, & Rohleder, 2011; Montes & Cianca, 2014). While extensive studies have shown similar findings of the impact of autism on family quality of life in America and other …

An Exploratory Study Of Health Promotion And Disease Prevention Communication Among Haitian Mother–Daughter Dyads In West Central Florida, Stacy Eileen Kratz

USF Tampa Graduate Theses and Dissertations

This exploratory study examined links between health communication and other constructs affecting health promotion and disease prevention among Haitian mother-daughter dyads living in West Central Florida, and the risk or protective factors for HIV. Risky sexual behaviors can be reduced with accurate and effective information provided through parent-adolescent communication (Coetzee et al, 2014; Ogle, Glasier & Riley, 2008; Hadley et al., 2009). In Haiti, a country that bears a disproportionate burden of HIV/AIDS, women are the most vulnerable (UNAIDS, 2016a); In the United States (U.S.), foreign-born Haitian women in the state of Florida experience health disparities in many areas and …

Analyzing The Effects Of Ca2+ Dynamics On Mitochondrial Function In Health And Disease, Patrick Toglia

USF Tampa Graduate Theses and Dissertations

Mitochondria plays a crucial role in cells by maintaining energy metabolism and directing cell death mechanisms by buffering calcium (Ca²⁺ )from cytosol. Therefore, the Ca²⁺ overload of mitochondria due to the upregulated cytosolic Ca²⁺ , observed in many neurological disorders is hypothesized to be a key pathway leading to mitochondrial dysfunction and cell death. In particular, Ca²⁺ homeostasis disruptions due to Alzheimer’ s disease (AD)-causing presenilins (PS1/PS2) and oligomeric forms of β-amyloid peptides Aβ commonly found in AD patients are presumed to cause detrimental effects on the mitochondria and its ability to function properly. We begin …