Digital Commons Network^™

Investigating A Potential Sting Modulator, Jaret J. Crews

USF Tampa Graduate Theses and Dissertations

The work contained in this thesis introduces a protein known as STING, an acronym for STimulator of INnterferon Genes, an immunosurveillance ER-membrane bound adapter protein critical to regulating the innate immune response in humans. The first chapter provides an overview of the STING pathway, outlines STING’s potential as a therapeutic target of interest, and delineates the primary challenges researchers encounter when designing small molecules to modulate the activity of STING. Current efforts in developing STING modulators have focused on devising agonists to up-regulate the STING pathway as a possible therapeutic for human cancers based on the chemical scaffold of STING’s …

Microheater Stimulation Platform For Neural Cells, Haley Royce

USF Tampa Graduate Theses and Dissertations

Electrical stimulation is the basis of many biomedical devices like cochlear implants,pacemakers, and retinal implants. In these systems, current is applied to a desired tissue to effectively stimulate it. Unfortunately, this is not localized as the current will spread through the tissue, limiting the spatial resolution. Thus, alternative forms of stimulation are needed to improve device precision and resolution. This project explores microheaters as a stimulation platform that can be easily integrated with existing biomedical devices. Microheaters produce heat via the Joule heating effect wherein electrical current is run through high resistance materials to output thermal energy. They are highly …

Securing Critical Cyber Infrastructures And Functionalities Via Machine Learning Empowered Strategies, Tao Hou

USF Tampa Graduate Theses and Dissertations

Machine learning plays a vital role in understanding threats, vulnerabilities, and security policies. In this dissertation, two machine learning empowered approaches on improving the security of critical cyber infrastructures and functionalities will be discussed.

The first work focuses on preventing attacks that use adversarial, active end-to-end topology inference to obtain the topology information of a target network. The topology of a network is fundamental for building network infrastructure functionalities. In many scenarios, enterprise networks may have no desire to disclose their topology information. To this end, we propose a Proactive Topology Obfuscation (ProTO) system that adopts a detect-then-obfuscate framework: (i) …

Video Anomaly Detection: Practical Challenges For Learning Algorithms, Keval Doshi

USF Tampa Graduate Theses and Dissertations

Anomaly detection in surveillance videos is attracting an increasing amount of attention. Despite the competitive performance of several existing methods, they lack theoretical performance analysis, particularly due to the complex deep neural network architectures used in decision making. Additionally, real-time decision making is an important but mostly neglected factor in this domain. Much of the existing methods that claim to be online, depend on batch or offline processing in practice. Furthermore, several critical tasks such as continual learning, model interpretability and cross-domain adaptability are completely neglected in existing works. Motivated by these research gaps, in this dissertation we discuss our …

Are All Pictures Worth 1,000 Words? An Investigation Of Fit Between Graph Type And Performance On Accounting Data Analytics Tasks, Shawn Paul Granitto

USF Tampa Graduate Theses and Dissertations

The usefulness of accounting data is directly dependent on the presentation and interpretation of the data (DeSanctis and Jarvenpaa 1989; Brown-Liburd et al. 2015; Cao et al. 2015). While both corporate accounting and public accounting have a large focus on data analytics and visualizations, accountants in both fields have reported to have minimal experience creating visualizations and observe a growing use of visualizations within their role (Krumwiede 2019; Buchheit et al. 2020; Gibson et al. 2020). Vessey (1991) finds that the appropriateness of a visualization can impact a user’s decision-making performance. Although prior studies have provided suggestions of when to …

The Maternal Oral Microbiome Throughout Pregnancy, Rebecca Koerner

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation was to longitudinally examine the salivary microbiome during the second and third trimesters of pregnancy and explore its associations amongst adverse pregnancy outcomes (preterm birth, gestational diabetes mellitus, and hypertensive disorders of pregnancy), perceived stress and depression, and hair/salivary cortisol levels. The specific aims were to (1) explore the literature for studies longitudinally examining the oral microbiome during pregnancy using a scoping review guided by the Arskey and O’Malley framework; (2) to examine the salivary microbiome for changes in diversity and abundance during the second and third trimesters during pregnancy and its association with adverse …

Synthesis And Antibacterial Testing Of Novel Thiosulfonate Compounds, Lindsay I. Blume

USF Tampa Graduate Theses and Dissertations

Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA) are increasing concerns in the medical community. In addition to the threat of Staphylococcus aureus, the increase in number and severity of infections caused by other antibiotic-resistant bacteria is problematic to human health, particularly among the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter). The antibiotics like the penicillins and cephalosporins used commonly to treat MRSA, VRSA, and ESKAPE pathogens have continued to decline in the effectiveness. Our laboratory has developed a number of new families of anti-MRSA and anti-VRSA antibacterial compounds. In this thesis, …

The Effect Of Aac-Modeling Intervention (Aac-Mod) Within Dialogic Reading On Vocabulary Learning In Children With Down Syndrome, Emily A. Mchugh

USF Tampa Graduate Theses and Dissertations

The purpose of the current study was to evaluate the effect of aided Alternative and Augmentative Communication-Modeling (AAC-MOD) intervention on the communication skills of preschool-age children with Down syndrome (DS) during dialogic book reading. The study investigated to what extent AAC-MOD is effective in increasing the acquisition of target vocabulary and expressive communication acts by children with DS who use few words functionally. Two children aged 3;10 and 5;4, with repertoires of less than 75 intelligible words were selected. A repeated acquisition experimental design was used to examine the effects of instruction on target vocabulary word learning and symbolic communication. …

Complaint Patterns In Us Nursing Homes: 2013-2017, Kallol Kumar Bhattacharyya

USF Tampa Graduate Theses and Dissertations

Complaints provide valuable information to consumers about nursing homes (NHs). Complaints that are substantiated often lead to an investigation and potentially a deficiency citation. In recent years, Nursing Home Quality data show mixed results. According to some Federal reports, one of the four data sets that measure residents’ quality of care in NHs, consumer complaints, suggest that residents’ concerns over quality have increased. In contrast, the other three datasets, i.e., deficiencies through annual recertification surveys, staffing levels, and clinical quality measures, reveal potential improvement in NH quality of services. The purpose of this dissertation is to carry out analyses of …

Boredom, Interoceptive Ability, And Emotional Eating, Erica Ahlich

USF Tampa Graduate Theses and Dissertations

Emotional eating is a commonly described phenomenon reported by individuals across the weight spectrum. Not only does existing evidence suggest it is not an effective emotion regulation strategy, but emotional eating is also associated with difficulty losing weight during weight loss interventions and other negative health outcomes. The majority of existing work in the area of emotional eating has focused on the broad dimensions of negative and positive affect. Yet, there are data suggesting that different emotions appear to produce different changes in eating behaviors, suggesting the importance of investigating the influence of discrete emotions on eating. The lack of …

The Multidimensional Test Anxiety Scale: A Latent Profile Analysis And An Examination Of Measurement Invariance, Gabrielle Francis

USF Tampa Graduate Theses and Dissertations

Standardized testing is an integral part of the English and American education systems. The objectives of these tests are to evaluate students, teachers, and schools. However, this evaluation has unintended consequences, one of which is test anxiety. Over the last 50 years, there has been an increase in studies on test anxiety because of the widespread use of standardized tests (Hembree, 1988; von der Embse et al., 2019). However, two areas that have seen little attention are the measurement invariance of test anxiety scales across demographic groups, and the creation of classification standards for these test anxiety scales to increase …

Determinations Of Chemical Equilibria In Natural Waters Using Spectrophotometric Techniques, Katelyn M. Schockman

USF Tampa Graduate Theses and Dissertations

Accurate characterizations of chemical equilibria and thermodynamic processes in natural waters are key components for assessing the current state of our global climate and predicting future changes, especially for observations of small rates of change over long time scales. One of the most important chemical systems in natural waters is the system of inorganic carbon species comprised of carbon dioxide (CO2), bicarbonate, and carbonate. The bicarbonate dissociation constant, K2, describes the relationship between pH and the relative concentrations of bicarbonate and carbonate ions at thermodynamic equilibrium. The carbonate/bicarbonate equilibrium quotient is required in nearly all CO2 system calculations relevant to …

Data-Driven Design And Analysis Of Next Generation Mobile Networks For Anomaly Detection And Signal Classification With Fast, Robust And Light Machine Learning, Muhammed Furkan Küçük

USF Tampa Graduate Theses and Dissertations

This research focuses on machine (and deep) learning applications (including clustering,anomaly detection and signal classification) for self-organizing and next generation mobile networks in wireless communications. Specifically, this dissertation document will address the three different topics.

First, in the study titled “Performance analysis of neural network topologies and hyperparameters for deep clustering”, we explore the relationship between the clustering performance and network complexity. Deep learning found its initial footing in supervised applications such as image and voice recognition successes of which were followed by deep generative models across similar domains. In recent years, researchers have proposed creative learning representations to utilize …

Alpha Synuclein: A Therapeutic Target And Biomarker For Parkinson’S Disease, Max Chase

USF Tampa Graduate Theses and Dissertations

Parkinson’s Disease is the second most common neurodegenerative disease after Alzheimer’s Disease, and the most common motor disorder. In fact, nearly a third of those with AD have PD. A major hallmark of PD is the appearance of Lewy Bodies, proteinaceous cytoplasm inclusions, that build up and spread throughout the CNS in a prion like fashion. The major component of these Lewy Bodies is a protein called alpha-synuclein. Alpha-syn is a 14kDa protein made of 140 amino acids and found in the presynaptic ends of CNS neurons, acting as a chaperone and regulator. The protein is also found in the …

A Functional Optimization Approach To Stochastic Process Sampling, Ryan Matthew Thurman

USF Tampa Graduate Theses and Dissertations

The goal of the current research project is the formulation of a method for the estimation and modeling of additive stochastic processes with both linear- and cycle-type trend components as well as a relatively robust noise component in the form of Levy processes. Most of the research in stochastic processes tends to focus on cases where the process is stationary, a condition that cannot be assumed for the model above due to the presence of the cyclical sub-component in the overall additive process. As such, we outline a number of relevant theoretical and applied topics, such as stochastic processes and …

A Model-Based Fault Diagnosis In Dynamic Systems Via Asynchronous Motors System Identification Or Testing, And Control Engineering Observers, Kenelt Pierre

USF Tampa Graduate Theses and Dissertations

Induction machines are the workhorse of many military and commercialtypes of equipment. They are asynchronous machines referred to in this dissertation as induction motors. They are widely used due to their reliability in Naval Unmanned Systems like Remotely Operated Vehicles (ROV), Unmanned Untethered Underwater Vehicles (UUV), Autonomous Undersea Vehicles (AUV), and platforms like Missiles and Satellites. These induction motors are mainly controlled using variable speed drive functions, i.e., thrusters, propellers, and actuators. Though they are very robust, to harness the full technical benefits of induction motors, state-of-the-art drivers or controllers must be used to control such motors.

In model-based fault …

Isotopic Study Of The Waters From The Sulphur Springs Catchment, Tampa, Florida, Esra Zengin

USF Tampa Graduate Theses and Dissertations

A stable isotope study was carried out using precipitation, spring water, groundwater well sample, and a seawater sample during the wet season in the Sulphur Springs watershed in Tampa, Florida. Studies that track long term isotopic variation over wet seasons are limited in the region. To fill this knowledge gap, this study aims to quantify the contributions of precipitation and diffuse sources to discharge in Sulphur Springs. A three-component mixing model was applied using δ18O and δ2H values to determine different source water contributions to spring water discharge. The three-component mixing model calculations suggest spring water consists mainly of diffuse …

A Comparison Of Accumulated And Distributed Reinforcer Arrangements In A Classroom, Alexandra Gingras

USF Tampa Graduate Theses and Dissertations

Though effective classroom management can increase student academic achievement and decrease disruptive behavior (e.g., Beaman & Wheldall, 2000; Marzano et al., 2003), many classroom teachers receive inadequate training on effective classroom management strategies (Reinke et al., 2011; U.S. Department of education 2000). Reinforcement-based interventions using differing reinforcer arrangements (e.g., accumulated, distributed) have been shown to be effective at reducing disruptive behavior (Fulton et al., 2019; Robinson & St. Peter, 2019); however, previous studies have not evaluated the relative efficacy of different reinforcer arrangements as teacher implemented classroom management strategies. Therefore, the purpose of this study was to assess the efficacy …

Measuring Sustainable Development Through Tax Increment Financed Brownfield Redevelopment Statutes: A Florida Case Study, Jeff Burton

USF Tampa Graduate Theses and Dissertations

This research measures the theoretically sustainable development synergy of United States’ redevelopment, tax increment, and brownfield statutes and questions local redevelopment professionals on this combination’s implementation. This policy’s integration and application measurements guide increased knowledge and best practice methods in the path of America’s population migration into urbanized areas, thus managing the economic, environmental, and social impacts for future generations.

This examination used a pragmatic, qualitative, and quantitative mixed-method approach to identify, collect, code, and analyze redevelopment, tax increment, and state brownfields laws. An exhaustive literature review of the laws’ histories explained when and why they exist. In addition, a …

Desertification Risk Analysis For Wildlife In The Desert Renewable Energy Conversation Plan Area Of California, Serdar Sagdic

USF Tampa Graduate Theses and Dissertations

Desertification is one of the primary threats facing the sustainability of the Earths’s natural resources. Desertification it is an outcome of human impacts to ecosystems and alterations of climate patterns resulting in land degradation and adverse effect on natural resources, vegetation loss, soil infertility, and water scarcity. These changes influence the existence and distribution of wildlife by reducing the availability and quality of habitat that provides food, water, cover, and other life requisites. Therefore, this study aimed at evaluation of potential desertification risks on wildlife species in the Desert Renewable Energy and Conservation Plan (DRECP) area of California.

The DRECP …

Implementing The Break Pass Intervention With Differential Reinforcement To Improve Engagement In Play With Siblings For Children With Autism Spectrum Disorder, Shannon R. Shafmaster

USF Tampa Graduate Theses and Dissertations

This report describes the results from a study that examined the use of the break pass intervention to increase engagement in play with siblings for children with autism spectrum disorder. Two male children with ASD aged 6-years old, who had difficulty engaging in play activities with siblings participated in the study. The intervention used break passes to teach mands for breaks by providing the children with breaks throughout the play activity and to provide reinforcement for engaging in play with siblings in the absence of problem behavior. The impact of the intervention on engagement in play with siblings and disruptive …

Using Prevent-Teach-Reinforce For A High School Student With Emotional And Behavioral Disorder: A Case Study, Alexis Lopez

USF Tampa Graduate Theses and Dissertations

In the school setting school-based professionals have difficulty using function-based approaches to support students engaging in consistent problem behaviors, specifically in students with emotional and behavioral disorder (EBD). This study evaluated the use of the Prevent-Teach-Reinforce (PTR), an individualized function-based intervention model for a 16-year-old high school student with EBD who was served in an alternative education setting. Through a team-based planning process that included the student and his classroom teacher, a function-based PTR intervention plan was implemented to address the student’s disruptive behavior and teach replacement behaviors of academic engagement and asking for help. An A-B design was used …

Empirical And Modeled Δ13c And Δ15n Isoscapes In The Gulf Of Mexico And Their Application To Fish Eye Lens Migration Studies, Brianna Michaud

USF Tampa Graduate Theses and Dissertations

Isoscapes are depictions of the spatial patterns of isotopic values in a given area. Isoscapes can be created using measurements form samples (empirical isoscapes) or using statistical models of spatial isotopic variation (modeled isoscapes). Isoscapes have a wide variety of potential applications though, in the realm of marine ecology, they are most often used infer ecological processes, food web linkages, the origin of samples, and the movements of marine organisms.

However, to use isoscapes for these applications, it is necessary to have isoscapes at spatial scales relevant to the application in question. It is also necessary to have isoscapes that …

The Career Decision-Making Self-Efficacy And Career Action Steps Of Humanities Students: A Quantitative Survey Analysis, Catherine Gorman Cordova

USF Tampa Graduate Theses and Dissertations

In an era of governmentally controlled education systems sustained through performance-based funding metrics, the value of higher education is often considered justified by socioeconomic impact and degree employability. Although modern academia traces its roots to the humanities and liberal arts for its foundation, degrees without direct job relation, and the students seeking these degrees, are often considered less employable than majors directly linked to vocations. However, the humanities and labor market are not mutually exclusive. Influenced by Social Cognitive Career Theory (SCCT) (Lent, et al., 1994), Self-Efficacy Theory (Bandura, 1977), and Career Maturity Theory (Crites, 1973), this cross-sectional quantitative survey …

Collaboratively Building A Teaching Model (Tttc) In A Doctoral Science Education Program: An Autoethnography, Alton George Declaire

USF Tampa Graduate Theses and Dissertations

This autoethnography illustrates benefits of doctoral education consistent with the holistic paradigm underlying today’s society and development of a practice-research-practice cycle useful to science teacher educators. Emergent hypotheses indicate ways to increase a doctoral student’s well-being, intellectual risk taking, production of creative products, and expedite in-depth learning. The hypotheses were derived from the processes and pathways I used to make sense of the learning opportunities afforded me and features of my experience that led to my well-being and maintaining my enthusiasm despite the significant life challenges I encountered and the tedious parts of the doctoral process.The original research question was, …

Meditation And Mindfulness Practice: Mitigating Burnout And Promoting Wellbeing Among Faculty, Billy E. Thomas Jr.

USF Tampa Graduate Theses and Dissertations

The purpose of this autoethnography was to explore meditation and mindfulness to mitigate burnout and promote wellbeing among faculty. I explored how meditation and mindfulness shaped me personally and professionally as an educator. I explored the methods I used to promote my own wellbeing and to deal with my experiences of burnout, anxiety, and depression. Self Determination Theory and Flow helped to inform this autoethnography, as well as mindfulness and meditation as tools for promoting faculty wellbeing. By telling my personal and professional story and how I have benefited from meditation and mindfulness practices, I hope to provide a road …

High-Risk Traffic Crash Pattern Recognition And Identification Using Econometric Models And Machine Learning Models, Runan Yang

USF Tampa Graduate Theses and Dissertations

Roadway crashes have become a major cause of human deaths and injuries and caused much economic damage. According to World Health Organization (WHO), about 1.35 million people died in traffic crashes and over 50 million people injured from traffic crashes in the year of 2016 (World Health Organization, 2020). Nationally, in the U.S., the latest decade witnessed an increase of over 10% in traffic fatalities (National Highway Traffic Safety Administration (NHTSA), 2019). Similarly, in state of Florida, the fatal crashes increased by 4.62% from 2019 to 2020 (Florida Department of Highway Safety and Motor Vehicles, 2021). To prevent injuries and …

Origin And Epigenetic Regulation Of Cutaneous T Cell Lymphoma, Carly M. Harro

USF Tampa Graduate Theses and Dissertations

The pathogenesis of Cutaneous T cell lymphoma (CTCL) remains unclear. Using conditional knockout mice, we found that ablation of the genomic organizer Special AT-rich sequence-binding protein-1 (Satb1) caused malignant transformation of mature, skin-homing, Notch-activated CD4+ and CD8+ T cells into progressively fatal lymphoma. Mechanistically, Satb1 restrained Stat5 phosphorylation and the expression of skin-homing chemokine receptors in mature T cells. H3K27 and H3K9 trimethylation occluded the SATB1 promoter in Sézary cells, while inhibition of SUV39H1/2 methyltransferases (unlike EZH2 inhibition), restored protective SATB1 expression and selectively abrogated the growth of primary Sézary cells more effectively than romidepsin. Additionally, using single-cell RNA/TCR sequencing …

Training Board Certified Behavior Analysts Via Telehealth To Conduct The Trial-Based Functional Analysis, Karie S. John

USF Tampa Graduate Theses and Dissertations

Although many behavior analysts recognize the value of conducting a functional analysis (FA), some report being hesitant to conduct the assessment (Oliver et al., 2015). Two potential barriers to conducting FAs include setting limitations (Roscoe et al., 2015) and lack of trained staff (Deochand et al., 2020). Researchers have addressed these limitations by developing variations of the traditional FA and demonstrating that those procedures could be taught across various populations. Perhaps the issue related to training has less to do with the ability to train FA procedures, and more to do with the accessibility of such trainings. Study 1 addressed …

Defining And Modeling Pericyte-Induced Capillary Network Assembly, Capillary Regression Preceding Pericyte-Stimulated Fibrosis, And Lymphatic Capillary Regression, Scott Stephen Kemp

USF Tampa Graduate Theses and Dissertations

Capillary formation and maturation can only occur through a series of highly orchestrated events that requires the coordinated efforts of both endothelial cells (ECs) and pericytes. While ECs are perfectly capable of creating tube networks on their own, the maturation and stabilization of these tube networks require the presence of a second cell type, pericytes, to create stable capillary networks. Previous studies have identified factors required for pericyte recruitment to EC tube networks, however, we hypothesized that there were still unaccounted for EC-derived molecules that were contributing to pericyte recruitment. In the first part of this study, we used serum-free, …