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USF Tampa Graduate Theses and Dissertations

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The Effects Of Systematic Reinforcement On Academic Performance In Precision Teaching: An Investigation Of Acquisition, Retention, And Endurance, Victoria Ann Hoch Mar 2014

The Effects Of Systematic Reinforcement On Academic Performance In Precision Teaching: An Investigation Of Acquisition, Retention, And Endurance, Victoria Ann Hoch

USF Tampa Graduate Theses and Dissertations

The use of positive reinforcement in acquisition programming is a hallmark of Applied Behavior Analysis; however, the Precision Teaching literature reveals a lack of reporting on the use of reinforcement. The present study utilized a groups design and single case analyses to investigate the effect of programming systematic tangible reinforcement on acquisition performance, retention and endurance of academic skills with 10 typically developing students ranging from 5-7 years of age. Results indicate that for both control and experimental participants, an increase in accuracy on both See/Say sight words and math problems occurred; however, the experimental group performed better on See/Say …


Water Availability As The Driving Factor Of Growth And Physiological Function Of Co-Occurring Scrub Species In Central Florida, Tammy Foster Mar 2014

Water Availability As The Driving Factor Of Growth And Physiological Function Of Co-Occurring Scrub Species In Central Florida, Tammy Foster

USF Tampa Graduate Theses and Dissertations

Florida scrub is a xeromorphic upland shrub community dominated by evergreen oaks that resprout after fire, occurring on moderately to excessively well-drained nutrient-poor sand. Scrub is home to several threatened and endangered animal species (e.g., Florida scrub-jay, gopher tortoise, and indigo snake) and rare and endemic plants. Urban development and agriculture has greatly reduced and fragmented scrub habitat, and because of this Florida scrub is considered one of the most endangered ecosystems in the United States. Climate change is a further threat to Florida scrub. Under a warmer and drier climate, scrub species will be exposed to more frequent and …


Karenia Brevis Harmful Algal Blooms: Their Role In Structuring The Organismal Community On The West Florida Shelf, Alisha Marie Gray Mar 2014

Karenia Brevis Harmful Algal Blooms: Their Role In Structuring The Organismal Community On The West Florida Shelf, Alisha Marie Gray

USF Tampa Graduate Theses and Dissertations

Karenia brevis dinoflagellate blooms off the west coast of Florida can create devastating effects on marine communities when they release a neurotoxin known as a brevetoxin. These blooms, informally referred to as red tides, can cause massive fish kills, necessitate closures of shellfish fisheries, and can even leave lingering toxins that impact shelf communities long after the bloom has dissipated. As a result, much effort has been put into studying K. brevis bloom initiation and dynamics. However, how K. brevis blooms impact Florida's fisheries is not fully understood because the relationship between K. brevis cell counts and fish mortality is …


Human Trafficking From Southern Mexico, Honduras, El Salvador, And Guatemala: Why These Victims Are Trafficked Into Modern Day Florida, Timothy Adam Golob Mar 2014

Human Trafficking From Southern Mexico, Honduras, El Salvador, And Guatemala: Why These Victims Are Trafficked Into Modern Day Florida, Timothy Adam Golob

USF Tampa Graduate Theses and Dissertations

Florida is ranked as one of the United States' top three destination states for human trafficking; many of those victims originate from Mesoamerica--Southern Mexico, Guatemala, Honduras, and El Salvador. Human trafficking is a growing problem which hinders universal human rights for hundreds of new victims in Florida every year. Mesoamericans have a high risk of becoming victims due to the situations in their home countries. The issue of human trafficking has only recently gained the national and state attention of law makers and law enforcement officers.

This study uses several human trafficking cases to educate and exemplify why Mesoamerican victims …


Digital Modeling And Non-Destructive Technological Examination Of Artifacts And Safety Harbor Burial Practices At Picnic Mound 8hi3, Hillsborough County, Florida, James Bart Mcleod Mar 2014

Digital Modeling And Non-Destructive Technological Examination Of Artifacts And Safety Harbor Burial Practices At Picnic Mound 8hi3, Hillsborough County, Florida, James Bart Mcleod

USF Tampa Graduate Theses and Dissertations

This project reexamines field notes and artifacts from a Works Progress Administration excavation of the Picnic Mound (8Hi3), a Safety Harbor-period burial mound located in Hillsborough County, Florida. The goals are to reconstruct burial practices digitally using a Geographic Information Systems approach to test Ripley Bullen's model of Woodland and Safety Harbor burial practices, and demonstrate ways that modern technologies can be used to provide new information from past investigations. This thesis also presents new information from a pXRF study about prehistoric ceramic manufacturing in the Tampa Bay area, and discusses additional archaeological resources associated with the Picnic Mound. This …


Influence Of Diet On Element Incorporation In The Shells Of Two Bivalve Molluscs: Argopecten Irradians Concentricus And Mercenaria Mercenaria, William Noland Elsaesser Mar 2014

Influence Of Diet On Element Incorporation In The Shells Of Two Bivalve Molluscs: Argopecten Irradians Concentricus And Mercenaria Mercenaria, William Noland Elsaesser

USF Tampa Graduate Theses and Dissertations

Recently, biogenic carbonates have received much attention as potential proxies of environmental change; however, a major pathway of elemental incorporation is often overlooked when making interpretations or designing experiments. This research experimentally examines the influence of diet on elemental composition in juvenile shells of the bay scallop, Argopecten irradians concentricus, and the northern quahog, Mercenaria mercenaria.

Exploratory trials were conducted using Argopecten irradians concentricus juveniles fed different algal diets: Isochrysis, Chaetoceros, Pavlova, Tetraselmis, or a mix of all four in a 2:1:2:2 ratio. No differences between the left and right valves were revealed, thus, subsequent analysis of the dietary influence …


Beyond Performance: Rhetoric, Collective Memory, And The Motive Of Imprinting Identity, Brenda M. Grau Mar 2014

Beyond Performance: Rhetoric, Collective Memory, And The Motive Of Imprinting Identity, Brenda M. Grau

USF Tampa Graduate Theses and Dissertations

This thesis reconsiders Maurice Halbwachs' theory of collective memory in terms of rhetoric. My purpose is to examine specifically how fading generations conform the present to the past as they fight to maintain and defend their collective identities. Although rhetoric and memory studies have often focused on the complex matters of national collectives, Halbwachs was also concerned with the individual and his or her interaction among those groups that matter in everyday living and memory's role in generational shifts that slowly transform culture. Halbwachs' theory helps determine exactly how attempts at conflict resolution are sometimes guarded defenses against threats to …


Transcriptional Control Of Toxoplasma Development, Joshua Byran Radke Mar 2014

Transcriptional Control Of Toxoplasma Development, Joshua Byran Radke

USF Tampa Graduate Theses and Dissertations

Toxoplasma gondii is an obligate intracellular protozoan parasite of animals and man. The asexual life cycle of Toxoplasma involves three very distinct, but tightly coordinated developmental stages. In nature, the sporozoite (contained within an oocyst) and bradyzoite (contained within a tissue cyst) initiate infection of the intermediate host, followed by rapid differentiation into the actively replicating tachyzoite. When countered by an effective host response, the tachyzoite differentiates back into the latent bradyzoite and this unique ability of Toxoplasma to interconvert between the replicating tachyzoite and the latent bradyzoite within a single host is the cause of life long infection. The …


Baseline Studies Of Selected Polybrominated Diphenyl Ethers In The Air Of The Nandamojo Watershed, Costa Rica, Mary Sophia Geesey Mar 2014

Baseline Studies Of Selected Polybrominated Diphenyl Ethers In The Air Of The Nandamojo Watershed, Costa Rica, Mary Sophia Geesey

USF Tampa Graduate Theses and Dissertations

Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants in a number of common household and commercial products around the world. PBDEs enter the environment in a variety of ways, such as through emissions, leaching from end-of-life electronics in landfills, and incineration. While many countries have phased out the manufacturing of penta-, octa-, and deca-PBDEs or have banned the manufacture and use of these congeners altogether, these persistent organic pollutants (POPs) continue to be detected in humans and the environment.

This study investigates spatial and temporal variations of selected PBDEs in the air of the Nandamojo watershed area in …


Insights Into [Aacute]-Aa Peptides And Ã-Aa Peptides As Broad Spectrum Antimicrobial Peptidomimetics And As Anti-Biofilm Agents, Shruti Padhee Mar 2014

Insights Into [Aacute]-Aa Peptides And Ã-Aa Peptides As Broad Spectrum Antimicrobial Peptidomimetics And As Anti-Biofilm Agents, Shruti Padhee

USF Tampa Graduate Theses and Dissertations

The emergent resistance of bacteria against the conventional antibiotics has motivated the search for novel antimicrobial agents. Nature abounds with a number of antimicrobial peptides that are a part of our innate immune system and protect us against a variety of pathogenic bacteria. While they are broad-spectrum in their activity and show less drug-resistance induction, their intrinsic metabolic stability limits their potential therapeutic applications. Herein we describe the development of novel broad-spectrum bioactive antimicrobial peptidomimetics AA-peptides. AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides that are resistant to proteolysis and capable of mimicking peptides. Two …


Sustainable Energy And Nutrient Recovery From Swine Waste, Adib Amini Mar 2014

Sustainable Energy And Nutrient Recovery From Swine Waste, Adib Amini

USF Tampa Graduate Theses and Dissertations

Swine production represents approximately 40% of the world's meat production, and swine wastes contain high concentrations of organic matter, nitrogen (N) and phosphorus (P). Swine production is intensifying as meat demand increases and concentrated animal feeding operations (CAFOs) are becoming increasingly common, making it difficult to treat the waste generated. A system for holistic treatment of swine waste produced in CAFOs was investigated in this study that sustainably generates energy and recovers N and P as saleable fertilizers. The system uses anaerobic digestion (AD) for methane production and solids stabilization, followed by precipitation of struvite (MgNH4PO4*6H2O) and recovery of N …


Epibenthic Mobile Invertebrates Along The Florida Reef Tract: Diversity And Community Structure, Kristin Netchy Mar 2014

Epibenthic Mobile Invertebrates Along The Florida Reef Tract: Diversity And Community Structure, Kristin Netchy

USF Tampa Graduate Theses and Dissertations

Benthic mobile invertebrates are important components of coral-reef diversity and community structure, though, in most cases, their ecological contributions are poorly known. Baseline information on their diversity, prevalence, assemblages, and ecological roles is needed to aid in the conservation of coral-reef habitats. The objectives of this study are to 1) describe diversity and assemblages of epibenthic, mobile invertebrates in shallow water coral-reef communities in Florida, 2) evaluate their ecological roles by reviewing published literature on diet, and 3) measure the degree of linear dependence between mobile invertebrates and scleractinian corals. Underwater surveys were conducted in the summer of 2013 at …


Exploration Of Mutations In Erythroid 5-Aminolevulinate Synthase That Lead To Increased Porphyrin Synthesis, Erica Jean Fratz Mar 2014

Exploration Of Mutations In Erythroid 5-Aminolevulinate Synthase That Lead To Increased Porphyrin Synthesis, Erica Jean Fratz

USF Tampa Graduate Theses and Dissertations

5-Aminolevulinate synthase (ALAS; EC 2.3.1.37) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the first committed step of heme biosynthesis in animals, the condensation of glycine and succinyl-CoA yielding 5-aminolevuliante (ALA), CoA, and CO2. Murine erythroid-specific ALAS (mALAS2) variants that cause high levels of PPIX accumulation provide a new means of targeted, and potentially enhanced, photosensitization. Transfection of HeLa cells with expression plasmids for mALAS2 variants, specifically for those with mutated mitochondrial presequences and a mutation in the active site loop, caused significant cellular accumulation of PPIX, particularly in the membrane. Light treatment of HeLa cells expressing mALAS2 variants revealed …


Aeschynē In Aristotle's Conception Of Human Nature, Melissa Marie Coakley Mar 2014

Aeschynē In Aristotle's Conception Of Human Nature, Melissa Marie Coakley

USF Tampa Graduate Theses and Dissertations

This dissertation provides a thorough examination of the role of aeschynē (as distinct from aidōs) in Aristotle’s conception of human nature by illuminating the political and ethical implications of shame and shamelessness and the effect of these implications in his treatises. It is crucial, both to one’s own personhood and eudaimonia as well as to the existence of a just and balanced state, that aeschynē be understood and respected because of the self-evaluating ability that it maintains.

The aim of this work is to show that a recognition and appreciation of aeschynē as understood in Aristotle’s conception of human …


Design, Simulation, Prototype, And Testing Of A Notched Blade Energy Generation System, Henry Cabra Mar 2014

Design, Simulation, Prototype, And Testing Of A Notched Blade Energy Generation System, Henry Cabra

USF Tampa Graduate Theses and Dissertations

This dissertation addresses the design, simulation, prototype, and test of a new energy generation system, which transforms rotational motion into electricity by the use of an innovative turbine-generator. The system is divided in two assembled subsystems that interact to finally transform kinetic energy into electricity. The first subsystem is a miniaturized notched impulse turbine system, and the second one is a millimeter permanent magnet generator (PMG) assembled into the turbine.

The conversion of biomechanical energy to electric energy, using clean and free energy produced by a living organism, is being increasingly researched [1]-[11]. These are all viable options, but advantages …


Juvenile And Adult Involvement In Double Parricide And Familicide In The U.S.: An Empirical Analysis Of 20 Years Of Data, Averi Rebekah Fegadel Mar 2014

Juvenile And Adult Involvement In Double Parricide And Familicide In The U.S.: An Empirical Analysis Of 20 Years Of Data, Averi Rebekah Fegadel

USF Tampa Graduate Theses and Dissertations

The killing of parents and stepparents by biological and stepchildren is a rare event. Incidents involving multiple parricide victims and/or multiple parricide offenders are an even rarer occurrence. The majority of studies on parricide involve a single victim and single offender. Using the National Incident-Based Reporting System (NIBRS), this study identified 603 single-victim, single-offender incidents, 22 single-victim, multiple-offender incidents, 60 single-offender double parricide incidents, 17 multiple-offender double parricide incidents, and 15 familicide incidents over the 20 year period 1990 to 2010. Univariate and bivariate analyses examined parricidal incidents involving single or multiple offenders and single or multiple victims with the …


The United States Prison System: A Comparative Analysis, Rachel O'Connor Mar 2014

The United States Prison System: A Comparative Analysis, Rachel O'Connor

USF Tampa Graduate Theses and Dissertations

Throughout history the penal system has been viewed as the paramount means of dealing with criminals, though its function has transformed throughout time. It has served as a pit for detaining suspected criminals, a home for the vagrant, an institution for the insane, a dreaded place of repute, quarters for cleansing and renewal, and an establishment of cataloged charges. The trials and transformations of history have developed and shaped the institution that we recognize today. Presently, the United States prison population far exceeds that of any other country in the world. The political climate, tough on crime policies, determinate sentencing, …


Sic For Advanced Biological Applications, Joseph Register Mar 2014

Sic For Advanced Biological Applications, Joseph Register

USF Tampa Graduate Theses and Dissertations

Silicon carbide (SiC) has been used for centuries as an industrial abrasive and has been

actively researched since the 1960's as a robust material for power electronic applications.

Despite being the first semiconductor to emit blue light in 1907, it has only recently been

discovered that the material has crucial properties ideal for long-term, implantable biomedical

devices. This is due to the fact that the material offers superior biocompatibility and

hemocompatibility while providing rigid mechanical and chemical stability. In addition, the material

is a wide-bandgap semiconductor that can be used for optoelectronics, light delivery, and optical

sensors, which is the …


Checking Out: A Qualitative Study Of Supermarket Cashiers' Emotional Response To Customer Mistreatment, Michael E. Lawless Mar 2014

Checking Out: A Qualitative Study Of Supermarket Cashiers' Emotional Response To Customer Mistreatment, Michael E. Lawless

USF Tampa Graduate Theses and Dissertations

In Western culture, and especially the United States, the increasingly service based economy focuses on creating an emotionally positive experience for customers. This leads to increasing pressures on service workers to hide and suppress their emotions even when mistreated by customers, in order to meet their employers', and general cultural, customer service standards. This thesis investigates the questions of what kinds of emotional challenges supermarket cashiers experience as a result of mistreatment from their customers, how do they manage to cope with these challenges, and whether there are any differences in challenges or coping strategies between younger and older cashiers, …


Using Video Feedback To Improve Horseback Riding Skills, Heather Kelley Mar 2014

Using Video Feedback To Improve Horseback Riding Skills, Heather Kelley

USF Tampa Graduate Theses and Dissertations

This study used video feedback to improve the horseback riding skills of advanced beginner riders. The study focused on three skill sets, those used in jumping over obstacles, dressage riding on the flat, and jumping position riding on the flat. Baseline consisted of standard lesson procedures. Intervention consisted of video feedback in which a recorded attempt at the target behaviors was immediately shown to the rider and the instructor. The rider and instructor reviewed the video while the instructor delivered feedback. Target behaviors were scored according to checklists that correspond to each skill. For all participants, video feedback increased their …


Agriculture, Environmental Restoration And Ecosystem Services: Assessing The Costs Of Water Storage On Agricultural Lands In South Florida, Kayla Ouellette Mar 2014

Agriculture, Environmental Restoration And Ecosystem Services: Assessing The Costs Of Water Storage On Agricultural Lands In South Florida, Kayla Ouellette

USF Tampa Graduate Theses and Dissertations

A large part of the environmental restoration required by the Comprehensive Everglades Restoration Plan calls for more water-storage on lands south of Lake Okeechobee in order to restore the natural water flows of the Everglades watershed. The Everglades Agricultural Area (EAA) can be used for increased water storage in order to relieve coastal estuaries of excess water in the rainy season. This water storage can deliver additional ecosystem services of soil retention and reduced CO2 emissions that could compensate farmers for the cost of water storage by increasing long term farm profitability. The goals of this study were 1) to …


The Effect Of Fungal Growth On Potential Phthalate Ester Exposures From Plasticized Polyvinyl Chloride, Garrick Johnson Mar 2014

The Effect Of Fungal Growth On Potential Phthalate Ester Exposures From Plasticized Polyvinyl Chloride, Garrick Johnson

USF Tampa Graduate Theses and Dissertations

This study examined the effects of the presence of fungal growth on the phthalate ester content of plasticized polyvinyl chloride (pPVC) used as the vapor barrier component of metal building insulation and the impact the fungal growth may have on the resulting exposure potential to the workers in the building. Individual pieces of the pPVC material exhibiting fungal growth and individual pieces of the pPVC material exhibiting no fungal growth were collected from the building being investigated. Twenty-five pieces each of the pPVC material exhibiting fungal growth and of the pPVC material exhibiting no fungal growth were weighed, reduced to …


Testing The Feasibility Of Bioacoustic Localization In Urban Environments, Blaire O'Neal Mar 2014

Testing The Feasibility Of Bioacoustic Localization In Urban Environments, Blaire O'Neal

USF Tampa Graduate Theses and Dissertations

Bioacoustics is a relatively new field of research focused on studying the acoustic signals of vocal animal species. The field has been a topic of interest for many years due its passive approach and avoidance of species-level limitations, such as tracking rare or nocturnal species. It has been used to locate birds in terrestrial environments; however, localization in urban environments remains unstudied. This research aims to fill the gap by attempting to estimate the location of 30 discrete calls in eight unique, urban environments. Sites represented two distinct traffic scenarios: moderate traffic and high traffic. Three system arrays of three …


Still Waters Run Deep: Landscaping Practices, Community Perceptions, And Social Indicators For Stormwater Nonpoint Source Pollution Management In Manatee County, Florida, Ann Rebecca Persaud Mar 2014

Still Waters Run Deep: Landscaping Practices, Community Perceptions, And Social Indicators For Stormwater Nonpoint Source Pollution Management In Manatee County, Florida, Ann Rebecca Persaud

USF Tampa Graduate Theses and Dissertations

Stormwater nonpoint source pollution (NPSP) is a result of diffuse sources of pollutants transported by rainfall and surface runoff into stormwater ponds and drainage systems before percolating into the ground. In particular, the nutrients found in fertilizers, pesticides, and herbicides applied in excess by homeowners and landscapers can cause a range of issues in stormwater ponds from fish kills to eutrophication. As a result, Manatee County, Florida has issued a fertilizer ordinance with best management practices (BMPs) and a fertilizer black out period to reduce NPSP. This study is aimed at capturing the perceptions of residents which affect stormwater NPSP …


"Die Mauer Im Kopf": Aesthetic Resistance Against West-German Take-Over, Arwen Puteri Mar 2014

"Die Mauer Im Kopf": Aesthetic Resistance Against West-German Take-Over, Arwen Puteri

USF Tampa Graduate Theses and Dissertations

Even 24 years after the Fall of the Berlin Wall, modern day Germans are still preoccupied with the contentious dynamics of the post-Wall unification process. Concern with geo-political fractiousness is deeply rooted in German history and the reason for Germany's desire to become a unified nation. The Fall of the Wall, and the subsequent rejection of socialism, was a chance to recover and unify what was perceived to be an "incomplete" nation. Yet, despite these actions, social unity between East and West Germans has never occurred and the Wall still persists as a metaphorical barrier in the minds of German …


Ressentiment, Violence, And Colonialism, Jose A. Haro Mar 2014

Ressentiment, Violence, And Colonialism, Jose A. Haro

USF Tampa Graduate Theses and Dissertations

This project attempts a joint reading of the work of Friedrich Nietzsche and Frantz Fanon. This task, however, is problematic because this body of work is in tension or contradictory. These problems are so acute that a careful reading method is necessary to successfully carry out this reading. In order to facilitate this reading I elaborate and apply a particular philosophical methodology, Mestizaje. The methodology is intended to address works that are contradictory by attempting to read the texts as they are presented while at the same time balancing their positions. The goal is to honestly reflect the thought of …


Sobering Anxieties: Alcohol, Tobacco, And The Intoxicated Social Body In Dutch Painting During The True Freedom, 1650-1672, David Beeler Feb 2014

Sobering Anxieties: Alcohol, Tobacco, And The Intoxicated Social Body In Dutch Painting During The True Freedom, 1650-1672, David Beeler

USF Tampa Graduate Theses and Dissertations

During the second half of the seventeenth century, alcohol and tobacco were consumed at all levels of the social strata in the Dutch Republic. These products and their consumption were important to long standing traditions and were vital to the Dutch economy. Paradoxically, however, moralists and ministers attempted to curb intoxication by associating it with the loss of one's masculinity or femininity. Intoxicated men and women were stigmatized as morally inept, unruly, and a threat to the family, community, and even the nation. Dutch genre paintings depicting alcohol and tobacco consumption are often described as moral warnings or didactic messages, …


"We're Taking Slut Back": Analyzing Racialized Gender Politics In Chicago's 2012 Slutwalk March, Aphrodite Kocieda Feb 2014

"We're Taking Slut Back": Analyzing Racialized Gender Politics In Chicago's 2012 Slutwalk March, Aphrodite Kocieda

USF Tampa Graduate Theses and Dissertations

This thesis examined bodied activism in Chicago's Slutwalk 2012 march, a contemporary movement initiated in Toronto, Canada that publicly challenged the mainstream sentiment that women are responsible for their own rape and victimization. Adopting an intersectional approach, I used textual analysis to discuss photographs posted on the official Chicago Slutwalk website to explore the ways this form of public bodied protest discursively engages women's empowerment from movement feminism as well as third wave and postfeminisms. I additionally analyzed the overall website and its promotional materials for the Slutwalk marches as well as how Chicago's photographic representations privilege the white female …


Immature Myeloid Cells Promote Tumor Formation Via Non-Suppressive Mechanism, Myrna Lillian Ortiz Feb 2014

Immature Myeloid Cells Promote Tumor Formation Via Non-Suppressive Mechanism, Myrna Lillian Ortiz

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Although there is ample evidence linking chronic inflammation with cancer, the cellular mechanisms involved in early events leading to tumor development remain unclear. Myeloid cells are an intricate part of inflammation. They consist of mature cells represented by macrophages, dendritic cells and granulocytes and a population of Immature Myeloid Cells (IMC), which in healthy individuals are cells in transition to mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a result, these cells acquire the ability to suppress immune responses and are …


Ube3a Role In Synaptic Plasticity And Neurodevelopmental Disorders.The Lessons From Angelman Syndrome., Irina Filonova Feb 2014

Ube3a Role In Synaptic Plasticity And Neurodevelopmental Disorders.The Lessons From Angelman Syndrome., Irina Filonova

USF Tampa Graduate Theses and Dissertations

Angelman Syndrome (AS) is a severe neurodevelopmental disorder that affects 1:12000 newborns. It is characterized by mental retardation, delayed major motor and cognitive milestones, seizures, absence of speech and excessive laughter. The majority of AS cases arise from deletions or mutations of UBE3A gene located on the chromosome 15q11-13. UBE3A codes for E3-ubiquitin ligase that target specific proteins for degradation. To date, a wide variety of Ube3a substrates has been identified. The accumulation of Ube3a-dependent proteins and their effect on the multitude of signal transduction pathways are` considered the main cause of the AS pathology. While the majority of research …